294 research outputs found
Designing and implementing a massive open online course: Lessons learnt
•In this paper, we describe the design, implementation, and evaluation of a Massive Open Online Course, or MOOC, on good practice in the application of Intellectual Property. It is aimed primarily at teachers and students, and taught in Spanish. We have used the Spanish legislation on Intellectual Property. This paper outlines the structure and content of a course developed on an ad-hoc basis, and describes its evaluation by participants in questionnaires and a final survey. The results of the initial questionnaire are framed by a) the participant''s profile, and b) by consideration of the MOOC''s implementation, given the results of the satisfaction survey. In this paper we describe the advantages of the MOOC and identify areas for improvement
Evidences of the Cerium Oxide-Catalysed DPF Regeneration in a Real Diesel Engine Exhaust
The active phase Ce0.5Pr0.5O2 has been loaded on commercial substrates (SiC DPF and cordierite honeycomb monolith) to perform DPF regeneration experiments in the exhaust of a diesel engine. Also, a powder sample has been prepared to carry out soot combustion experiments at laboratory. Experiments performed in the real diesel exhaust demonstrated the catalytic activity of the Ce–Pr mixed oxide for the combustion of soot, lowering the DPF regeneration temperature with regard to a counterpart catalyst-free DPF. The temperature for active regeneration of the Ce0.5Pr0.5O2-containing DPF when the soot content is low is in the range of 500–550 °C. When the Ce0.5Pr0.5O2-containing DPF is saturated with a high amount of soot, pressure drop and soot load at the filter reach equilibrium at around 360 °C under steady state engine operation due to passive regeneration. The uncoated DPF reached this equilibrium at around 440 °C. Comparing results at real exhaust with those at laboratory allow concluding that the Ce0.5Pr0.5O2-catalysed soot combustion in the real exhaust is not based on the NO2-assisted mechanism but is most likely occurring by the active oxygen-based mechanism.The authors thank the financial support of Generalitat Valenciana (Project Prometeo 2009/047), Spanish Ministry of Science and Innovation (project CIT-420000-2009-48) and EU (FEDER funding)
Non-alcoholic fatty liver in hereditary fructose intolerance
Background: Non-alcoholic fatty liver disease (NAFLD) is characterized by fat accumulation affecting >5% of the liver volume that is not explained by alcohol abuse. It is known that fructose gives rise to NAFLD and it has been recently described that the ingestion of fructose in low amounts in aldolase B deficient mice is associated with the development of fatty liver. Therefore, it is reasonable that patients with HFI (Hereditary Fructose Intolerance) present fatty liver at diagnosis, but its prevalence in patients treated and with adequate follow-up is not well documented in the literature. The aim of this study is to analyze the association between HFI and NAFLD in treated patients.
Methods: A cross-sectional observational study was conducted. The population comprised 16 genetically diagnosed HFI patients aged from 3 years to 48 and in dietary treatment of fructose, sorbitol and sacarose exclusion at least for two years. Blood samples were obtained for analytical studies and anthropometric measurements of each patient were performed.
Results: Patients presented a Body Mass Index (BMI) of 17.9 ± 2.9 kg/m 2 . The HOMA index and Quick index were in normal range for our population. The S-adenosyl-methionine (SAM)/S-adenosyl-L-homocysteine (SAH) ratio was increased in the patients in whom this analysis was performed. By imaging techniques it was observed that 9 of the 16 patients presented fatty liver (7 by hepatic MRI). Of these 9 patients, only 3 presented hepatomegaly. 7 of 9 patients affected by the c.448G > C mutation had fatty infiltration, of which three of them presented in addition hepatomegaly.
Conclusions: There is a high prevalence of fatty liver in HFI patients and it is not related to obesity and insulin resistance. The diagnosis of fatty liver in HFI patients and, above all, the identification of new therapeutic approaches, can positively impact the quality of life of these patients
Magnetic field diagnostics and spatio-temporal variability of the solar transition region
Magnetic field diagnostics of the transition region from the chromosphere to
the corona faces us with the problem that one has to apply extreme UV
spectro-polarimetry. While for coronal diagnostic techniques already exist
through infrared coronagraphy above the limb and radio observations on the
disk, for the transition region one has to investigate extreme UV observations.
However, so far the success of such observations has been limited, but there
are various projects to get spectro-polarimetric data in the extreme UV in the
near future. Therefore it is timely to study the polarimetric signals we can
expect for such observations through realistic forward modeling.
We employ a 3D MHD forward model of the solar corona and synthesize the
Stokes I and Stokes V profiles of C IV 1548 A. A signal well above 0.001 in
Stokes V can be expected, even when integrating for several minutes in order to
reach the required signal-to-noise ratio, despite the fact that the intensity
in the model is rapidly changing (just as in observations). Often this
variability of the intensity is used as an argument against transition region
magnetic diagnostics which requires exposure times of minutes. However, the
magnetic field is evolving much slower than the intensity, and thus when
integrating in time the degree of (circular) polarization remains rather
constant. Our study shows the feasibility to measure the transition region
magnetic field, if a polarimetric accuracy on the order of 0.001 can be
reached, which we can expect from planned instrumentation.Comment: Accepted for publication in Solar Physics (4.Mar.2013), 19 pages, 9
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Present and Future Bounds on Non-Standard Neutrino Interactions
We consider Non-Standard neutrino Interactions (NSI), described by
four-fermion operators of the form , where is an electron or first generation quark. We
assume these operators are generated at dimension , so the related
vertices involving charged leptons, obtained by an SU(2) transformation
, do not appear at tree level. These related
vertices necessarily arise at one loop, via exchange. We catalogue current
constraints from measurements in neutrino scattering, from
atmospheric neutrino observations, from LEP, and from bounds on the related
charged lepton operators. We estimate future bounds from comparing KamLAND and
solar neutrino data, and from measuring at the near detector
of a neutrino factory. Operators constructed with and should
not confuse the determination of oscillation parameters at a factory,
because the processes we consider are more sensitive than oscillations at the
far detector. For operators involving , we estimate similar
sensitivities at the near and far detector.Comment: Erratum added at the end of the documen
Proof of concept of the SCR of NOx in a real diesel engine exhaust using commercial diesel fuel and a full size Pt/beta zeolite/honeycomb monolith
The Selective Catalytic Reduction (SCR) of NOx has been performed in a real diesel exhaust stream with commercial diesel fuel by using a full size home-made Pt/beta zeolite/honeycomb prototype catalyst. Fuel was injected upstream the catalyst to achieve total hydrocarbons concentrations between 1000 and 5000 ppm, and the SCR behaviour observed was similar to that typically reported in laboratory experiments performed with model hydrocarbons. Typical NOx removal volcano-shape profiles, with maxima at 250 °C for all THC inlet concentrations, were obtained, with an optimum THC concentration of 3000 ppm.The authors thank the financial support of Generalitat Valenciana (Project Prometeo 2009/047), the Spanish ministries of Economy and Competitiveness (Project CTQ2012-30703) and Science and Innovation (Project CIT-420000-2009-48), and EU for the FEDER resources
Sobrevivência de operárias de Atta sexdens rubropilosa Forel (Hymenoptera: Formicidae) isoladas do formigueiro e alimentadas com dietas artificiais
Nucleon Decay Searches with large Liquid Argon TPC Detectors at Shallow Depths: atmospheric neutrinos and cosmogenic backgrounds
Grand Unification of the strong, weak and electromagnetic interactions into a single unified gauge group is an extremely appealing idea which has been vigorously pursued theoretically and experimentally for many years. The detection of proton or bound-neutron decays would represent its most direct experimental evidence. In this context, we studied the physics potentialities of very large underground Liquid Argon Time Projection Chambers (LAr TPC). We carried out a detailed simulation of signal efficiency and background sources, including atmospheric neutrinos and cosmogenic backgrounds. We point out that a liquid Argon TPC, offering good granularity and energy resolution, low particle detection threshold, and excellent background discrimination, should yield very good signal over background ratios in many possible decay modes, allowing to reach partial lifetime sensitivities in the range of 1034−1035 years with exposures up to 1000 kton×year, often in quasi-background-free conditions optimal for discoveries at the few events level, corresponding to atmospheric neutrino background rejections of the order of 105. Multi-prong decay modes like e.g. p→μ−π+K+ or p→e+π+π− and channels involving kaons like e.g. p→K+ν¯, p→e+K0 and p→μ+K0 are particularly suitable, since liquid Argon imaging (...)This work was in part supported by ETH and the Swiss National Foundation. AB, AJM and SN have been supported by CICYT Grants FPA-2002-01835 and FPA-2005-07605-C02-01. SN acknowledges support from the Ramon y Cajal Programme. We thank P. Sala for help with FLUKA while she was an ETH employee
Physics of Solar Prominences: II - Magnetic Structure and Dynamics
Observations and models of solar prominences are reviewed. We focus on
non-eruptive prominences, and describe recent progress in four areas of
prominence research: (1) magnetic structure deduced from observations and
models, (2) the dynamics of prominence plasmas (formation and flows), (3)
Magneto-hydrodynamic (MHD) waves in prominences and (4) the formation and
large-scale patterns of the filament channels in which prominences are located.
Finally, several outstanding issues in prominence research are discussed, along
with observations and models required to resolve them.Comment: 75 pages, 31 pictures, review pape
Application of isotope-selective non-dispersive infrared spectrometry for the evaluation of the 13C-urea breath test: comparison with three concordant methods
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