412 research outputs found
SAM domain-dependent activity of PfTKL3, an essential tyrosine kinase-like kinase of the human malaria parasite Plasmodiumfalciparum
- Author
- A Sharma
- AB Sidhu
- Abdirahman Abdi
- AM Dondorp
- BT Harada
- C Doerig
- C Doerig
- C Fennell
- C Wu
- CA Kim
- CE Tognon
- Christian Doerig
- CL Lannon
- CM Armstrong
- D Dorin
- D Dorin-Semblat
- DJ Ferguson
- E Ingley
- G Camarda
- G Tzivion
- H Ma
- J Zhang
- JA Wells
- K Hu
- K Tamura
- K Tokuhiro
- KG Le Roch
- L Reininger
- Luc Reininger
- M Arkin
- M Schreiber
- M Singh
- MJ Gubbels
- MK Baron
- NJ White
- P Ward
- R Carter
- RE Sinden
- RL Montfort van
- RW Snow
- SK Hanks
- SN Ho
- Sylvain Eschenlauer
- T Aviv
- YJ Choi
- Publication venue
- SP BirkhÀuser Verlag Basel
- Publication date
- 01/01/2010
- Field of study
Over the last decade, several protein kinases inhibitors have reached the market for cancer chemotherapy. The kinomes of pathogens represent potentially attractive targets in infectious diseases. The functions of the majority of protein kinases of Plasmodium falciparum, the parasitic protist responsible for the most virulent form of human malaria, remain unknown. Here we present a thorough characterisation of PfTKL3 (PF13_0258), an enzyme that belongs to the tyrosine kinase-like kinase (TKL) group. We demonstrate by reverse genetics that PfTKL3 is essential for asexual parasite proliferation in human erythrocytes. PfTKL3 is expressed in both asexual and gametocytes stages, and in the latter the protein co-localises with cytoskeleton microtubules. Recombinant PfTKL3 displays in vitro autophosphorylation activity and is able to phosphorylate exogenous substrates, and both activities are dramatically dependent on the presence of an N-terminal âsterile α-motifâ domain. This study identifies PfTKL3 as a validated drug target amenable to high-throughput screening
Dichotomy of Tyrosine Hydroxylase and Dopamine Regulation between Somatodendritic and Terminal Field Areas of Nigrostriatal and Mesoaccumbens Pathways
- Author
- A Cheramy
- A Saraf
- AF Hoffman
- AF Hoffman
- BJ Hoffer
- Brandon S. Pruett
- BS Pruett
- BT Chen
- CM Keller
- CP Ford
- D Zhang
- DM Gash
- DM Gash
- DM Yurek
- DR Andersson
- E Tachikawa
- EA Jackson
- F Bergquist
- G Bustos
- GS Robertson
- H Lou
- H Nissbrandt
- Harada
- J Lavicky
- J Wang
- JC Waymire
- JC Waymire
- JP Mitchell
- JR Connor
- JT Trevitt
- JW Haycock
- JW Haycock
- JW Haycock
- JW Haycock
- JW Haycock
- K Hakansson
- L Bobrovskaya
- L Lu
- L Lu
- LR Bevilaqua
- M Levitt
- ME Rice
- MF Salvatore
- MF Salvatore
- MF Salvatore
- MF Salvatore
- MF Salvatore
- MF Salvatore
- Michael F. Salvatore
- N Lindgren
- PR Dunkley
- PR Vulliet
- R Grondin
- RK Leak
- S Cragg
- S Nimitvilai
- S Sarre
- Silvana Gaetani
- SR Jones
- T Nagatsu
- VH Morgenroth
- X Peng
- Y Ai
- Publication venue
- Public Library of Science
- Publication date
- 05/01/2012
- Field of study
Measures of dopamine-regulating proteins in somatodendritic regions are often used only as static indicators of neuron viability, overlooking the possible impact of somatodendritic dopamine (DA) signaling on behavior and the potential autonomy of DA regulation between somatodendritic and terminal field compartments. DA reuptake capacity is less in somatodendritic regions, possibly placing a greater burden on de novo DA biosynthesis within this compartment to maintain DA signaling. Therefore, regulation of tyrosine hydroxylase (TH) activity may be particularly critical for somatodendritic DA signaling. Phosphorylation of TH at ser31 or ser40 can increase activity, but their impact on L-DOPA biosynthesis in vivo is unknown. Thus, determining their relationship with L-DOPA tissue content could reveal a mechanism by which DA signaling is normally maintained. In Brown-Norway Fischer 344 F1 hybrid rats, we quantified TH phosphorylation versus L-DOPA accumulation. After inhibition of aromatic acid decarboxylase, L-DOPA tissue content per recovered TH protein was greatest in NAc, matched by differences in ser31, but not ser40, phosphorylation. The L-DOPA per catecholamine and DA turnover ratios were significantly greater in SN and VTA, suggesting greater reliance on de novo DA biosynthesis therein. These compartmental differences reflected an overall autonomy of DA regulation, as seen by decreased DA content in SN and VTA, but not in striatum or NAc, following short-term DA biosynthesis inhibition from local infusion of the TH inhibitor α-methyl-p-tyrosine, as well as in the long-term process of aging. Such data suggest ser31 phosphorylation plays a significant role in regulating TH activity in vivo, particularly in somatodendritic regions, which may have a greater reliance on de novo DA biosynthesis. Thus, to the extent that somatodendritic DA release affects behavior, TH regulation in the midbrain may be critical for DA bioavailability to influence behavior
Th2 Cell-Intrinsic Hypo-Responsiveness Determines Susceptibility to Helminth Infection
- Author
- A Schietinger
- A Seidl
- AG Zaretsky
- AV Villarino
- BT Fife
- C Martin
- C Steel
- CL King
- DL Barber
- E Sartono
- EJ Wherry
- G Borkow
- G Petit
- Hideo Yagita
- IL King
- JE Allen
- JJ Taylor
- JL Grogan
- JR Brahmer
- K Ishiwata
- K Mohrs
- KA Smith
- LI Terrazas
- LM Fahey
- M Gallin
- M Mohrs
- M Yazdanbakhsh
- Matthew D. Taylor
- MD Taylor
- MD Taylor
- MD Taylor
- MD Taylor
- MD Taylor
- ME Keir
- Miyuki Azuma
- MS Wilson
- MS Wilson
- N van der Werf
- Nienke van der Werf
- NS Butler
- P Loke
- P Loke
- P Smith
- P'ng Loke
- PJ Cooper
- PJ Hotez
- R Bhadra
- RH Schwartz
- RL Reinhardt
- RM Maizels
- RM Maizels
- RM Maizels
- RM Maizels
- RT Semnani
- S Amu
- S Babu
- S Huber
- S Scheu
- SA Babayan
- SC Liang
- SL Topalian
- Stephen A. Redpath
- T Platts-Mills
- T Yamazaki
- T Yamazaki
- W Hoffmann
- Y Harada
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/03/2013
- Field of study
The suppression of protective Type 2 immunity is a principal factor driving the chronicity of helminth infections, and has been attributed to a range of Th2 cell-extrinsic immune-regulators. However, the intrinsic fate of parasite-specific Th2 cells within a chronic immune down-regulatory environment, and the resultant impact such fate changes may have on host resistance is unknown. We used IL-4gfp reporter mice to demonstrate that during chronic helminth infection with the filarial nematode Litomosoides sigmodontis, CD4(+) Th2 cells are conditioned towards an intrinsically hypo-responsive phenotype, characterised by a loss of functional ability to proliferate and produce the cytokines IL-4, IL-5 and IL-2. Th2 cell hypo-responsiveness was a key element determining susceptibility to L. sigmodontis infection, and could be reversed in vivo by blockade of PD-1 resulting in long-term recovery of Th2 cell functional quality and enhanced resistance. Contrasting with T cell dysfunction in Type 1 settings, the control of Th2 cell hypo-responsiveness by PD-1 was mediated through PD-L2, and not PD-L1. Thus, intrinsic changes in Th2 cell quality leading to a functionally hypo-responsive phenotype play a key role in determining susceptibility to filarial infection, and the therapeutic manipulation of Th2 cell-intrinsic quality provides a potential avenue for promoting resistance to helminths
Regulation of type 1 diabetes development and B-cell activation in nonobese diabetic mice by early life exposure to a diabetogenic environment
- Author
- A Cooke
- A De Riva
- A El-Sheikh
- A Lehuen
- AD Kostic
- AD Tyler
- AK Alkanani
- Alessandra De Riva
- Andrew Sage
- Anne Cooke
- BJ Miller
- BM Greenwood
- BM Greenwood
- BT Fife
- C Alam
- C King
- C Mauri
- CC Patterson
- CC Patterson
- CH Hansen
- CJ Foltz
- CL Thompson
- CT Brown
- D Endesfelder
- DP Strachan
- DV Serreze
- EH Leiter
- F Mackay
- Francesca Ronchi
- G Zekavat
- GM Brodie
- GX Song-Zhao
- HJ Wu
- I Guleria
- Ian Goodfellow
- J Peng
- JA Pane
- JC Barrett
- JC Gower
- JG Caporaso
- JG Fox
- JG Markle
- JM Ward
- JU Scher
- Kathy D. McCoy
- KD McCall
- KY Ebino
- L Wen
- LG Ng
- LM Francisco
- LS Wicker
- Lucy Thorne
- M Ben Nasr
- M Harada
- M Mahler Convenor
- MA Atkinson
- MA Kriegel
- Maja WĂ„llberg
- MC de Goffau
- MC Kullberg
- MD Pescovitz
- ME Keir
- ME Mejia-Leon
- MH Sofi
- Miyuki Azuma
- MJ Ansari
- MJ Redondo
- N Tormo-Badia
- O Soave
- P Fiorina
- P Fiorina
- P Pozzilli
- P Zaccone
- Paolo Fiorina
- PG Larsson
- PG Miller
- PR Hutchings
- RC Edgar
- Richard Coulson
- RM Hinman
- RM Hinman
- Robert Busch
- S Brode
- S Feng
- S Gupta
- S Kleffel
- S Makino
- SA Newland
- SE Denman
- VS Banday
- W Nicklas
- WJ 3rd Quinn
- Y Xiu
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2017
- Field of study
Microbes, including viruses, influence type 1 diabetes (T1D) development, but many such influences remain undefined. Previous work on underlying immune mechanisms has focussed on cytokines and T cells. Here, we compared two nonobese diabetic (NOD) mouse colonies, NODlow and NODhigh, differing markedly in their cumulative T1D incidence (22% vs. 90% by 30 weeks in females). NODhigh mice harbored more complex intestinal microbiota, including several pathobionts; both colonies harbored segmented filamentous bacteria (SFB), thought to suppress T1D. Young NODhigh females had increased B-cell activation in their mesenteric lymph nodes. These phenotypes were transmissible. Co-housing of NODlow with NODhigh mice after weaning did not change T1D development, but T1D incidence was increased in female offspring of co-housed NODlow mice, which were exposed to the NODhigh environment both before and after weaning. These offspring also acquired microbiota and B-cell activation approaching those of NODhigh mice. In NODlow females, the low rate of T1D was unaffected by cyclophosphamide but increased by PD-L1 blockade. Thus, environmental exposures that are innocuous later in life may promote T1D progression if acquired early during immune development, possibly by altering B-cell activation and/or PD-L1 function. Moreover, T1D suppression in NOD mice by SFB may depend on the presence of other microbial influences. The complexity of microbial immune regulation revealed in this murine model may also be relevant to the environmental regulation of human T1D
Structure Activity Relationship of Dendrimer Microbicides with Dual Action Antiviral Activity
- Author
- A Adachi
- A Hantson
- Adam Johnson
- B Etemad-Moghadam
- BJ Boyd
- BK Nanjwade
- BP Roberts
- BR Mathews
- BT Galen
- C Lackman-Smith
- CC Huang
- CD Rizzuto
- CF Price
- CJ Birch
- CJ Lacey
- CJ Springer
- CS Dezzutti
- D Binder
- D Huskens
- David Tyssen
- DI Bernstein
- DM Butler
- E Gong
- EE Freeman
- F Gao
- Gareth R. Lewis
- Gilda Tachedjian
- Guy Krippner
- IA Scordi-Bello
- J Balzarini
- J Liu
- J O'Loughlin
- J Sterjovski
- JA Levy
- Jasminka Sterjovski
- JE Cummins Jr
- Jennifer La
- Jeremy R. A. Paull
- JF Salazar-Gonzalez
- JM Brown
- JP Moore
- Katie Moore
- L Gray
- L Van Damme
- LM Kaminskas
- M Chisembele
- M Moulard
- M Witvrouw
- Mark Zanin
- Michael P. Giannis
- MJ McElrath
- MJ Wawer
- MY Chen
- N Bourne
- Paul A. Ramsland
- Paul R. Gorry
- Peter Karellas
- PG Spear
- PJ Feldblum
- PM Mesquita
- PR Gorry
- PS Fletcher
- QA Karim
- R Pauwels
- R Wyatt
- RA Cone
- Richard Cone
- RJ Shattock
- S Harada
- S Rusconi
- S Skoler-Karpoff
- S Sonza
- S Sonza
- S Weller
- SA Karim
- Scott A. Henderson
- Secondo Sonza
- SH Yap
- SR Abner
- Steve Wesselingh
- TD McCarthy
- TJ Ketas
- Tom McCarthy
- V Gajbhiye
- W Tao
- X Wei
- YH Jiang
- YJ Zhang
- Zandrea Ambrose
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2010
- Field of study
Topical microbicides, used by women to prevent the transmission of HIV and other sexually transmitted infections are urgently required. Dendrimers are highly branched nanoparticles being developed as microbicides. However, the anti-HIV and HSV structure-activity relationship of dendrimers comprising benzyhydryl amide cores and lysine branches, and a comprehensive analysis of their broad-spectrum anti-HIV activity and mechanism of action have not been published.Dendrimers with optimized activity against HIV-1 and HSV-2 were identified with respect to the number of lysine branches (generations) and surface groups. Antiviral activity was determined in cell culture assays. Time-of-addition assays were performed to determine dendrimer mechanism of action. In vivo toxicity and HSV-2 inhibitory activity were evaluated in the mouse HSV-2 susceptibility model. Surface groups imparting the most potent inhibitory activity against HIV-1 and HSV-2 were naphthalene disulfonic acid (DNAA) and 3,5-disulfobenzoic acid exhibiting the greatest anionic charge and hydrophobicity of the seven surface groups tested. Their anti-HIV-1 activity did not appreciably increase beyond a second-generation dendrimer while dendrimers larger than two generations were required for potent anti-HSV-2 activity. Second (SPL7115) and fourth generation (SPL7013) DNAA dendrimers demonstrated broad-spectrum anti-HIV activity. However, SPL7013 was more active against HSV and blocking HIV-1 envelope mediated cell-to-cell fusion. SPL7013 and SPL7115 inhibited viral entry with similar potency against CXCR4-(X4) and CCR5-using (R5) HIV-1 strains. SPL7013 was not toxic and provided at least 12 h protection against HSV-2 in the mouse vagina.Dendrimers can be engineered with optimized potency against HIV and HSV representing a unique platform for the controlled synthesis of chemically defined multivalent agents as viral entry inhibitors. SPL7013 is formulated as VivaGel(R) and is currently in clinical development to provide protection against HIV and HSV. SPL7013 could also be combined with other microbicides
Cognitive Reserve and the Prevention of Dementia: the Role of Physical and Cognitive Activities
- Author
- A Bruandet
- A Burggren
- A Lampit
- A Maass
- A Maass
- A Robitaille
- A Soldan
- A Tolppanen
- Alzheimerâs Disease International
- AS Buchman
- B Dubois
- BM Brown
- BM Gelder van
- BT Gold
- C Boraxbekk
- C Groot
- C Qiu
- CB Hall
- CE Sexton
- CK Tamnes
- CL Grady
- CM Gidicsin
- CM Roe
- CM Yeung
- CN Harada
- CP Boyle
- CR Jack Jr
- D Thompson
- DC Park
- DE Sörman
- DM Lawton
- EA Boots
- EA Maguire
- EP Helzner
- F Clément
- F Gunning-Dixon
- G Kempermann
- G Vinetti
- GTY Leung
- H Kishimoto
- H Noack
- HA Lindstrom
- J Au
- J Gong
- J Karbach
- J Rahe
- J Verghese
- JA Anguera
- JD Churchill
- JR Best
- JY Wang
- K Herzig
- K Mehlig
- K Uemura
- K Wijndaele
- KI Erickson
- KI Erickson
- KI Erickson
- KY Liang
- L Krajcovicova
- L Vaughan
- LC Lam
- LCW Lam
- LF Brinke ten
- LJ Drew
- M Hamer
- M Melby-LervÄg
- M Mobasseri
- M Wirth
- MA Hirsch
- MA McDaniel
- ME Raichle
- MJ Valenzuela
- MT Sturman
- MW Beckett
- N Gates
- N Raz
- P Reuter-Lorenz
- PB Baltes
- PB Baltes
- PJ Smith
- PS Barreto
- R Nouchi
- R Ruscheweyh
- R Taylor-Piliae
- RE Marioni
- RL Buckner
- RP Almeida
- RS Wilson
- RS Wilson
- S Alladi
- S Colcombe
- S Dekhtyar
- S Heinzel
- S Llamas-Velasco
- S Norton
- S Rovio
- S Vaughan
- S Wang
- S-T Cheng
- S-T Cheng
- S-T Cheng
- S-T Cheng
- Sheung-Tak Cheng
- SJ Colcombe
- SM Landau
- SW Davis
- T Luck
- T Ngandu
- TA Rosness
- TF Hughes
- TN Akbaraly
- Y Nishida
- Y Stern
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Purpose of Review: The article discusses the two most significant modifiable risk factors for dementia, namely, physical inactivity and lack of stimulating cognitive activity, and their effects on developing cognitive reserve. Recent Findings: Both of these leisure-time activities were associated with significant reductions in the risk of dementia in longitudinal studies. In addition, physical activity, particularly aerobic exercise, is associated with less age-related gray and white matter loss and with less neurotoxic factors. On the other hand, cognitive training studies suggest that training for executive functions (e.g., working memory) improves prefrontal network efficiency, which provides support to brain functioning in the face of cognitive decline. Summary: While physical activity preserves neuronal structural integrity and brain volume (hardware), cognitive activity strengthens the functioning and plasticity of neural circuits (software), thus supporting cognitive reserve in different ways. Future research should examine whether lifestyle interventions incorporating these two domains can reduce incident dementia
Imaging in-vivo tau pathology in Alzheimerâs disease with THK5317 PET in a multimodal paradigm
- Author
- A Delacourte
- A Hammers
- A Nordberg
- Agneta Nordberg
- Anders Wall
- B Dubois
- B Winblad
- BF Boeve
- BT Hyman
- CR Jack Jr
- DT Chien
- G McKhann
- Gunnar Antoni
- H Braak
- H Braak
- H Braak
- I Bergman
- I Litvan
- Irina Savitcheva
- JC Steele
- Jonas Eriksson
- KA Johnson
- KA Josephs
- Konstantinos Chiotis
- L Buee
- L Lemoine
- LA Nguyen
- Laure Saint-Aubert
- M Dani
- M Jonasson
- M Maruyama
- Mark Lubberink
- MJ Armstrong
- ML Gorno-Tempini
- MM Mesulam
- MS Forman
- My Jonasson
- Ove Almkvist
- P Giannakopoulos
- Pia Andersen
- R Casanova
- R Harada
- R Harada
- R Muller
- RC Petersen
- T Tago
- TE Nichols
- Vesna Jelic
- VL Villemagne
- VL Villemagne
- WE Klunk
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Measurement and interpretation of same-sign W boson pair production in association with two jets in pp collisions at s = 13 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abeling K
- Abicht NJ
- Abidi SH
- Aboulhorma A
- Abramowicz H
- Abreu H
- Abulaiti Y
- Abusleme Hoffman AC
- Acharya BS
- Adam Bourdarios C
- Adamczyk L
- Adamek L
- Addepalli SV
- Addison MJ
- Adelman J
- Adiguzel A
- Adye T
- Affolder AA
- Afik Y
- Agaras MN
- Agarwala J
- Aggarwal A
- Agheorghiesei C
- Ahmad A
- Ahmadov F
- Ahmed WS
- Ahuja S
- Ai X
- Aielli G
- Aikot A
- Ait Tamlihat M
- Aitbenchikh B
- Aizenberg I
- Akbiyik M
- Akimov AV
- Akiyama D
- Akolkar NN
- Al Khoury K
- Alberghi GL
- Albert J
- Albicocco P
- Albouy GL
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexopoulos T
- Alfonsi F
- Algren M
- Alhroob M
- Ali B
- Ali HMJ
- Ali S
- Alibocus SW
- Aliev M
- Alimonti G
- Alkakhi W
- Allaire C
- Allbrooke BMM
- Allen JF
- Allendes Flores CA
- Allport PP
- Aloisio A
- Alonso F
- Alpigiani C
- Alvarez Estevez M
- Alvarez Fernandez A
- Alves Cardoso M
- Alviggi MG
- Aly M
- Amaral Coutinho Y
- Ambler A
- Amelung C
- Amerl M
- Ames CG
- Amidei D
- Amor Dos Santos SP
- Amos KR
- Ananiev V
- Anastopoulos C
- Andeen T
- Anders JK
- Andrean SY
- Andreazza A
- Angelidakis S
- Angerami A
- Anisenkov AV
- Annovi A
- Antel C
- Anthony MT
- Antipov E
- Antonelli M
- Anulli F
- Aoki M
- Aoki T
- Aparisi Pozo JA
- Aparo MA
- Aperio Bella L
- Appelt C
- Apyan A
- Aranzabal N
- Arcangeletti C
- Arce ATH
- Arena E
- Arguin J-F
- Argyropoulos S
- Arling J-H
- Arnaez O
- Arnold H
- Artoni G
- Asada H
- Asai K
- Asai S
- Asbah NA
- Assamagan K
- Astalos R
- Atashi S
- Atkin RJ
- Atkinson M
- Atmani H
- Atmasiddha PA
- Augsten K
- Auricchio S
- Auriol AD
- Austrup VA
- Avolio G
- Axiotis K
- Azuelos G
- Babal D
- Bachacou H
- Bachas K
- Bachiu A
- Backman F
- Badea A
- Bagnaia P
- Bahmani M
- Bailey AJ
- Bailey VR
- Baines JT
- Baines L
- Bakalis C
- Baker OK
- Bakos E
- Bakshi Gupta D
- Balakrishnan V
- Balasubramanian R
- Baldin EM
- Balek P
- Ballabene E
- Balli F
- Baltes LM
- Balunas WK
- Balz J
- Banas E
- Bandieramonte M
- Bandyopadhyay A
- Bansal S
- Barak L
- Barakat M
- Barberio EL
- Barberis D
- Barbero M
- Barel MZ
- Barends KN
- Barillari T
- Barisits M-S
- Barklow T
- Baron Moreno DA
- Baron P
- Baroncelli A
- Barone G
- Barr AJ
- Barr JD
- Barranco Navarro L
- Barreiro GuimarĂŁes da Costa J
- Barreiro F
- Barron U
- Barros Teixeira MG
- Barsov S
- Bartels F
- Bartoldus R
- Barton AE
- Bartos P
- Basan A
- Baselga M
- Bassalat A
- Basso MJ
- Basson CR
- Bates RL
- Batlamous S
- Batley JR
- Batool B
- Battaglia M
- Battulga D
- Bauce M
- Bauer M
- Bauer P
- Bazzano Hurrell LT
- Beacham JB
- Beau T
- Beauchemin PH
- Becherer F
- Bechtle P
- Beck HP
- Becker K
- Becot C
- Beddall AJ
- Bednyakov VA
- Bee CP
- Beemster LJ
- Beermann TA
- Begalli M
- Begel M
- Behera A
- Behr JK
- Beirer JF
- Beisiegel F
- Belfkir M
- Bella G
- Bellagamba L
- Bellerive A
- Bellos P
- Beloborodov K
- Belyaev NL
- Benchekroun D
- Bendebba F
- Benhammou Y
- Benoit M
- Bensinger JR
- Bentvelsen S
- Beresford L
- Beretta M
- Bergeaas Kuutmann E
- Berger N
- Bergmann B
- Beringer J
- Bernardi G
- Bernius C
- Bernlochner FU
- Bernon F
- Berry T
- Berta P
- Berthold A
- Bertram IA
- Bethke S
- Betti A
- Bevan AJ
- Bhamjee M
- Bhatta S
- Bhattacharya DS
- Bhattarai P
- Bhopatkar VS
- Bi R
- Bianchi RM
- Bianco G
- Biebel O
- Bielski R
- Biglietti M
- Billoud TRV
- Bindi M
- Bingul A
- Bini C
- Biondini A
- Birch-sykes CJ
- Bird GA
- Birman M
- Biros M
- Biryukov S
- Bisanz T
- Bisceglie E
- Biswal JP
- Biswas D
- Bitadze A
- BjĂžrke K
- Bloch I
- Blocker C
- Blue A
- Blumenschein U
- Blumenthal J
- Bobbink GJ
- Bobrovnikov VS
- Boehler M
- Boehm B
- Bogavac D
- Bogdanchikov AG
- Bohm C
- Boisvert V
- Bokan P
- Bold T
- Bomben M
- Bona M
- Boonekamp M
- Booth CD
- Borbély AG
- Bordulev IS
- Borecka-Bielska HM
- Borgna LS
- Borissov G
- Bortoletto D
- Boscherini D
- Bosman M
- Bossio Sola JD
- Bouaouda K
- Bouchhar N
- Boudreau J
- Bouhova-Thacker EV
- Boumediene D
- Bouquet R
- Boveia A
- Boyd J
- Boye D
- Boyko IR
- Bracinik J
- Brahimi N
- Brandt G
- Brandt O
- Braren F
- Brau B
- Brau JE
- Brener R
- Brenner L
- Brenner R
- Bressler S
- Britton D
- Britzger D
- Brock I
- Brooijmans G
- Brooks WK
- Brost E
- Brown LM
- Bruce LE
- Bruckler TL
- Bruckman de Renstrom PA
- Bruni A
- Bruni G
- Bruschi M
- Bruscino N
- BrĂŒers B
- Buanes T
- Buat Q
- Buchin D
- Buckley AG
- Bulekov O
- Bullard BA
- Burdin S
- Burgard CD
- Burger AM
- Burghgrave B
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- Zhemchugov A
- Zheng J
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- Zheng X
- Zheng Z
- Zhong D
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- Zhuang X
- Zhukov K
- Zhulanov V
- Zimine NI
- Zinsser J
- Ziolkowski M
- Zoccoli A
- Zoch K
- Zorbas TG
- Zormpa O
- Zou W
- Zwalinski L
- Ă kesson TPA
- Ăncel ĂO
- ĆœeniĆĄ T
- ĆœivkoviÄ L
- Publication venue
- Springer Nature
- Publication date
- 01/04/2024
- Field of study
This paper presents the measurement of fducial and diferential cross sections for both the inclusive and electroweak production of a same-sign W-boson pair in association with two jets (W±W±jj) using 139 fbâ1 of proton-proton collision data recorded at a centre-of-mass energy of âs = 13 TeV by the ATLAS detector at the Large Hadron Collider. The analysis is performed by selecting two same-charge leptons, electron or muon, and at least two jets with large invariant mass and a large rapidity diference. The measured fducial cross sections for electroweak and inclusive W±W±jj production are 2.92 ± 0.22 (stat.) ± 0.19 (syst.)fb and 3.38±0.22 (stat.)±0.19 (syst.)fb, respectively, in agreement with Standard Model predictions. The measurements are used to constrain anomalous quartic gauge couplings by extracting 95% confdence level intervals on dimension-8 operators. A search for doubly charged Higgs bosons H±± that are produced in vector-boson fusion processes and decay into a same-sign W boson pair is performed. The largest deviation from the Standard Model occurs for an H±± mass near 450 GeV, with a global signifcance of 2.5 standard deviations
Search for pair production of squarks or gluinos decaying via sleptons or weak bosons in final states with two same-sign or three leptons with the ATLAS detector
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- Zhemchugov A
- Zheng K
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- Zhulanov V
- Zimine NI
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- Ă kesson TPA
- Ăncel ĂO
- ĆœeniĆĄ T
- ĆœivkoviÄ L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 15/02/2024
- Field of study
A search for pair production of squarks or gluinos decaying via sleptons or weak bosons is reported. The search targets a final state with exactly two leptons with same-sign electric charge or at least three leptons without any charge requirement. The analysed data set corresponds to an integrated luminosity of 139 fbâ1 of proton-proton collisions collected at a centre-of-mass energy of 13 TeV with the ATLAS detector at the LHC. Multiple signal regions are defined, targeting several SUSY simplified models yielding the desired final states. A single control region is used to constrain the normalisation of the WZ + jets background. No significant excess of events over the Standard Model expectation is observed. The results are interpreted in the context of several supersymmetric models featuring R-parity conservation or R-parity violation, yielding exclusion limits surpassing those from previous searches. In models considering gluino (squark) pair production, gluino (squark) masses up to 2.2 (1.7) TeV are excluded at 95% confidence level
Measurements of differential cross-sections in top-quark pair events with a high transverse momentum top quark and limits on beyond the Standard Model contributions to top-quark pair production with the ATLAS detector at âs = 13 TeV
- Author
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- Abbott B
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- Abhayasinghe DK
- Abidi SH
- Aboulhorma A
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- Milic A
- Milke CD
- Miller DW
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- Milov A
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- Mince L
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- Mindur B
- Mineev M
- Minegishi Y
- Mino Y
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- Mir LM
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- Mitani T
- Mitra A
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- Miyazaki Y
- Mizukami A
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- Mobius S
- Mochizuki K
- Moder P
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- Morisbak V
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- Moskvitina P
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- Munoz DC
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- Nurse E
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- Poblete PAU
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- Roberts BR
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- Schroeder TV
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- Sciolla G
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- Sebastiani CD
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- Sekula SJ
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- Senthilkumar V
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- Serkin L
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- Sindhu S
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- Sinha S
- Sioli M
- Siral I
- Sivoklokov SY
- Sjolin J
- Skaf A
- Skorda E
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- Smakhtin V
- Smart BH
- Smiesko J
- Smirnov SY
- Smirnov Y
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- Snesarev AA
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- Tikhonov YA
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- Tzanis P
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- Vujinovic OV
- Vukotic I
- Wada S
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- Wahdan S
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- Whiteson D
- Wickremasinghe L
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- Wiik-Fuchs LAM
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- Winklmeier F
- Winter BT
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- Wobisch M
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- Wollrath J
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- Wongel AF
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- Wosiek BK
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- Wu SL
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- Wu Y
- Wu Z
- Wuerzinger J
- Wyatt TR
- Wynne BM
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- Xiang J
- Xiao X
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- Xiotidis I
- Xu D
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- Xu W
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- Xu Z
- Yabsley B
- Yacoob S
- Yamaguchi N
- Yamaguchi Y
- Yamauchi H
- Yamazaki T
- Yamazaki Y
- Yan J
- Yan S
- Yan Z
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- Yang HT
- Yang S
- Yang T
- Yang X
- Yang X
- Yang Y
- Yang Z
- Yao WM
- Yap YC
- Ye H
- Ye J
- Ye S
- Ye X
- Yeletskikh I
- Yexley MR
- Yildiz HD
- Yin P
- Yorita K
- Young C
- Young CJS
- Yuan M
- Yuan R
- Yue X
- Zaazoua M
- Zabinski B
- Zacharis G
- Zagazeta LFG
- Zaid E
- Zaitsev AM
- Zakareishvili T
- Zakharchuk N
- Zambito S
- Zanzi D
- Zaplatilek O
- Zeissner SV
- Zeitnitz C
- Zeng JC
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- Zenin O
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- Zerradi S
- Zerwas D
- Zhang B
- Zhang DF
- Zhang G
- Zhang J
- Zhang K
- Zhang L
- Zhang M
- Zhang R
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- Zhang X
- Zhang X
- Zhang Z
- Zhao H
- Zhao P
- Zhao T
- Zhao Y
- Zhao Z
- Zhemchugov A
- Zheng Z
- Zhong D
- Zhou B
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- Zhu HL
- Zhu J
- Zhu Y
- Zhuang X
- Zhukov K
- Zhulanov V
- Zieminska D
- Zimine NI
- Zimmermann S
- Zinsser J
- Ziolkowski M
- Zoccoli A
- Zoch K
- Zorbas TG
- Zormpa O
- Zou W
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Cross-section measurements of top-quark pair production where the hadronically decaying top quark has transverse momentum greater than 355 GeV and the other top quark decays into âÎœb are presented using 139 fbâ1 of data collected by the ATLAS experiment during proton-proton collisions at the LHC. The fiducial cross-section at s = 13 TeV is measured to be Ï = 1.267 ± 0.005 ± 0.053 pb, where the uncertainties reflect the limited number of data events and the systematic uncertainties, giving a total uncertainty of 4.2%. The cross-section is measured differentially as a function of variables characterising the ttÂŻ system and additional radiation in the events. The results are compared with various Monte Carlo generators, including comparisons where the generators are reweighted to match a parton-level calculation at next-to-next-to-leading order. The reweighting improves the agreement between data and theory. The measured distribution of the top-quark transverse momentum is used to search for new physics in the context of the effective field theory framework. No significant deviation from the Standard Model is observed and limits are set on the Wilson coefficients of the dimension-six operators OtG and Otq(8), where the limits on the latter are the most stringent to date. [Figure not available: see fulltext.]
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