On Free Quotients of Complete Intersection Calabi-Yau Manifolds

In order to find novel examples of non-simply connected Calabi-Yau threefolds, free quotients of complete intersections in products of projective spaces are classified by means of a computer search. More precisely, all automorphisms of the product of projective spaces that descend to a free action on the Calabi-Yau manifold are identified.Comment: 39 pages, 3 tables, LaTe

Candida albicans pathogenicity mechanisms

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Supersymmetric Hidden Sectors for Heterotic Standard Models

Within the context of the weakly coupled E 8 × E 8 heterotic string, we study the hidden sector of heterotic standard model compactifications to four-dimensions. Specifically, we present a class of hidden sector vector bundles — composed of the direct sum of line bundles only — that, together with an effective bulk five-brane, renders the heterotic standard model entirely N = 1 supersymmetric. Two explicit hidden sectors are constructed and analyzed in this context; one with the gauge group E 7 × U(1) arising from a single line bundle and a second with an SO(12) × U(1) × U(1) gauge group constructed from the direct sum of two line bundles. Each hidden sector bundle is shown to satisfy all requisite physical constraints within a finite region of the Kähler cone. We also clarify that the first Chern class of the line bundles need not be even in our context, as has often been imposed in the model building literature

Two-Particle Correlations in Relativistic Heavy-Ion Collisions

Two-particle momentum correlations between pairs of identical particles produced in relativistic heavy-ion reactions can be analyzed to extract the space-time structure of the collision fireball. We review recent progress in the application of this method, based on newly developed theoretical tools and new high-quality data from heavy-ion collision experiments. Implications for our understanding of the collision dynamics and for the search for the quark-gluon plasma are discussed.Comment: 44 pages, LaTeX, 11 Figures, uses special style files (included), prepared for Ann. Rev. Nucl. Part. Sci. 49 (1999). Error in Chapt. 1 corrected and a few references adde

Numerical Hermitian Yang-Mills Connections and Vector Bundle Stability in Heterotic Theories

A numerical algorithm is presented for explicitly computing the gauge connection on slope-stable holomorphic vector bundles on Calabi-Yau manifolds. To illustrate this algorithm, we calculate the connections on stable monad bundles defined on the K3 twofold and Quintic threefold. An error measure is introduced to determine how closely our algorithmic connection approximates a solution to the Hermitian Yang-Mills equations. We then extend our results by investigating the behavior of non slope-stable bundles. In a variety of examples, it is shown that the failure of these bundles to satisfy the Hermitian Yang-Mills equations, including field-strength singularities, can be accurately reproduced numerically. These results make it possible to numerically determine whether or not a vector bundle is slope-stable, thus providing an important new tool in the exploration of heterotic vacua.Comment: 52 pages, 15 figures. LaTex formatting of figures corrected in version 2

Numerical Hermitian Yang-Mills Connections and Kahler Cone Substructure

We further develop the numerical algorithm for computing the gauge connection of slope-stable holomorphic vector bundles on Calabi-Yau manifolds. In particular, recent work on the generalized Donaldson algorithm is extended to bundles with Kahler cone substructure on manifolds with h^{1,1}>1. Since the computation depends only on a one-dimensional ray in the Kahler moduli space, it can probe slope-stability regardless of the size of h^{1,1}. Suitably normalized error measures are introduced to quantitatively compare results for different directions in Kahler moduli space. A significantly improved numerical integration procedure based on adaptive refinements is described and implemented. Finally, an efficient numerical check is proposed for determining whether or not a vector bundle is slope-stable without computing its full connection.Comment: 38 pages, 10 figure

Heterotic Line Bundle Standard Models

In a previous publication, arXiv:1106.4804, we have found 200 models from heterotic Calabi-Yau compactifications with line bundles, which lead to standard models after taking appropriate quotients by a discrete symmetry and introducing Wilson lines. In this paper, we construct the resulting standard models explicitly, compute their spectrum including Higgs multiplets, and analyze some of their basic properties. After removing redundancies we find about 400 downstairs models, each with the precise matter spectrum of the supersymmetric standard model, with one, two or three pairs of Higgs doublets and no exotics of any kind. In addition to the standard model gauge group, up to four Green-Schwarz anomalous U(1) symmetries are present in these models, which constrain the allowed operators in the four-dimensional effective supergravity. The vector bosons associated to these anomalous U(1) symmetries are massive. We explicitly compute the spectrum of allowed operators for each model and present the results, together with the defining data of the models, in a database of standard models accessible at http://www-thphys.physics.ox.ac.uk/projects/CalabiYau/linebundlemodels/index.html. Based on these results we analyze elementary phenomenological properties. For example, for about 200 models all dimension four and five proton decay violating operators are forbidden by the additional U(1) symmetries.Comment: 55 pages, Latex, 3 pdf figure

F-theory on Genus-One Fibrations

We argue that M-theory compactified on an arbitrary genus-one fibration, that is, an elliptic fibration which need not have a section, always has an F-theory limit when the area of the genus-one fiber approaches zero. Such genus-one fibrations can be easily constructed as toric hypersurfaces, and various $SU(5)\times U(1)^n$ and $E_6$ models are presented as examples. To each genus-one fibration one can associate a $\tau$-function on the base as well as an $SL(2,\mathbb{Z})$ representation which together define the IIB axio-dilaton and 7-brane content of the theory. The set of genus-one fibrations with the same $\tau$-function and $SL(2,\mathbb{Z})$ representation, known as the Tate-Shafarevich group, supplies an important degree of freedom in the corresponding F-theory model which has not been studied carefully until now. Six-dimensional anomaly cancellation as well as Witten's zero-mode count on wrapped branes both imply corrections to the usual F-theory dictionary for some of these models. In particular, neutral hypermultiplets which are localized at codimension-two fibers can arise. (All previous known examples of localized hypermultiplets were charged under the gauge group of the theory.) Finally, in the absence of a section some novel monodromies of Kodaira fibers are allowed which lead to new breaking patterns of non-Abelian gauge groups.Comment: 53 pages, 9 figures, 6 tables. v2: references adde

The MSSM Spectrum from (0,2)-Deformations of the Heterotic Standard Embedding

We construct supersymmetric compactifications of E_8 \times E_8 heterotic string theory which realise exactly the massless spectrum of the Minimal Supersymmetric Standard Model (MSSM) at low energies. The starting point is the standard embedding on a Calabi-Yau threefold which has Hodge numbers (h^11,h^21) = (1,4) and fundamental group Z_12, which gives an E_6 grand unified theory with three net chiral generations. The gauge symmetry is then broken to that of the standard model by a combination of discrete Wilson lines and continuous deformation of the gauge bundle. On eight distinct branches of the moduli space, we find stable bundles with appropriate cohomology groups to give exactly the massless spectrum of the MSSM.Comment: 37 pages including appendice

The Set3/Hos2 Histone Deacetylase Complex Attenuates cAMP/PKA Signaling to Regulate Morphogenesis and Virulence of Candida albicans

Candida albicans, like other pleiomorphic fungal pathogens, is able to undergo a reversible transition between single yeast-like cells and multicellular filaments. This morphogenetic process has long been considered as a key fungal virulence factor. Here, we identify the evolutionarily conserved Set3/Hos2 histone deacetylase complex (Set3C) as a crucial repressor of the yeast-to-filament transition. Cells lacking core components of the Set3C are able to maintain all developmental phases, but are hypersusceptible to filamentation-inducing signals, because of a hyperactive cAMP/Protein Kinase A signaling pathway. Strikingly, Set3C-mediated control of filamentation is required for virulence in vivo, since set3Δ/Δ cells display strongly attenuated virulence in a mouse model of systemic infection. Importantly, the inhibition of histone deacetylase activity by trichostatin A exclusively phenocopies the absence of a functional Set3C, but not of any other histone deacetylase gene. Hence, our work supports a paradigm for manipulating morphogenesis in C. albicans through alternative antifungal therapeutic strategies