60 research outputs found
Glutamine Acts as a Neuroprotectant against DNA Damage, Beta-Amyloid and H2O2-Induced Stress
- Author
- A Lee
- A Martinez-Hernandez
- AJ Rivett
- AP Lin
- BP Best
- BT Lamb
- C Brasse-Lagnel
- CD Smith
- D Boyd-Kimball
- D Eisenberg
- D Gunnersen
- DA Butterfield
- DM Savarese
- E Pham
- ER Stadtman
- G Burbaeva
- H Tumani
- Hyoung-gon Lee
- J Albrecht
- J Busser
- J Haberle
- J Zou
- JD Cahoy
- JD Rabinowitz
- Jianmin Chen
- K Herrup
- Karl Herrup
- KS Kuhn
- L Li
- MM Vilenchik
- N Hattori
- NH Varvel
- P Nicklin
- PG Antuono
- R Gorovits
- RC Davis
- RM Berg
- SP Fernandes
- SR Robinson
- SR Robinson
- T Eid
- T Sakiyama
- V Gorbunova
- V Visalli
- Y He
- Y Yang
- Z Feng
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2011
- Field of study
Glutamine is the most abundant free amino acid in the human blood stream and is ‘conditionally essential’ to cells. Its intracellular levels are regulated both by the uptake of extracellular glutamine via specific transport systems and by its intracellular synthesis by glutamine synthetase (GS). Adding to the regulatory complexity, when extracellular glutamine is reduced GS protein levels rise. Unfortunately, this excess GS can be maladaptive. GS overexpression is neurotoxic especially if the cells are in a low-glutamine medium. Similarly, in low glutamine, the levels of multiple stress response proteins are reduced rendering cells hypersensitive to H2O2, zinc salts and DNA damage. These altered responses may have particular relevance to neurodegenerative diseases of aging. GS activity and glutamine levels are lower in the Alzheimer's disease (AD) brain, and a fraction of AD hippocampal neurons have dramatically increased GS levels compared with control subjects. We validated the importance of these observations by showing that raising glutamine levels in the medium protects cultured neuronal cells against the amyloid peptide, Aβ. Further, a 10-day course of dietary glutamine supplementation reduced inflammation-induced neuronal cell cycle activation, tau phosphorylation and ATM-activation in two different mouse models of familial AD while raising the levels of two synaptic proteins, VAMP2 and synaptophysin. Together, our observations suggest that healthy neuronal cells require both intracellular and extracellular glutamine, and that the neuroprotective effects of glutamine supplementation may prove beneficial in the treatment of AD
Understanding and eliminating iron interference in colorimetric nitrate and nitrite analysis
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Sexual assault resistance education for university women: study protocol for a randomized controlled trial (SARE trial)
- Author
- A Simpson
- AH Eagly
- B Fisher
- BP Marx
- C Grady
- C Pacifici
- CA Gidycz
- CA Gidycz
- CA Gidycz
- Canadian Panel on Violence Against Women
- Charlene Y Senn
- CY Senn
- CY Senn
- CY Senn
- DA Dillman
- DL Lang
- DL Payne
- DM Saunders
- EA Yeater
- EA Yeater
- EM Ozer
- EO Laumann
- G Cowan
- G Cowan
- GM Wingood
- H Johnson
- H Lorraine Radtke
- HH Cleveland
- I Sochting
- Ian R Newby-Clark
- J Hanmer
- J McCaw
- J Norris
- JC Weitlauf
- JD Foubert
- JVP Check
- K Bachar
- K Hanson Breitenbecher
- KA Hanson
- KA Lonsway
- KA Lonsway
- Karen L Hobden
- KC Basile
- KF Balsam
- KH Breitenbecher
- KH Breitenbecher
- L Greaves
- LA Anderson
- LM Orchowski
- M Beres
- M Kimble
- M Testa
- M Testa
- MD Gray
- Misha Eliasziw
- MP Koss
- MP Koss
- MP Koss
- MP Koss
- MP Koss
- MP Koss
- MP Koss
- MP Koss
- MT Gordon
- N Dickert
- N Gavey
- N Gavey
- N Gavey
- ND Brener
- ND Brener
- P Tjaden
- PA Schewe
- Paula C Barata
- PB Bart
- PD Rozee
- PS Nurius
- PS Nurius
- PS Nurius
- RJA Little
- RS Kimball
- S Chaiken
- SAS Institute Inc
- SE Ullman
- SE Ullman
- SE Ullman
- SE Ullman
- SE Ullman
- SM Burn
- T Day
- T Lemmens
- TL Messman-Moore
- VL Banyard
- VL Banyard
- Wilfreda E Thurston
- Women Against Rape
- WS Dekeseredy
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Climate Change, Coral Reef Ecosystems, and Management Options for Marine Protected Areas
- Author
- A Bakun
- A Baldwin
- A Friedlander
- A Hastings
- A Shepherd
- AA Rosenberg
- AC Baker
- AE Douglas
- AL Perry
- AL Shanks
- Alan M. Friedlander
- B Cicin-Sain
- B Dickson
- B Michaelidis
- BI McNeil
- Billy D. Causey
- BJ Peterson
- BP Kinlan
- Brian D. Keller
- BS Halpern
- C Cabanes
- C Langdon
- C Mora
- C Wilkinson
- CB Munn
- CB Paris
- CD Harvell
- CD Harvell
- CDG Harley
- CG Soto
- CH Greene
- Christa M. Woodley
- CL Sabine
- CM Roberts
- CM Roberts
- CM Roberts
- CM Roberts
- CM Roberts
- CM Roberts
- CM Roberts
- CR Wilkinson
- CR Wilkinson
- CR Wilkinson
- CR Wilkinson
- D Harvell
- D Lirman
- D Pauly
- D Pauly
- D Scavia
- Daniel F. Gleason
- DB Snyder
- DE Burkepile
- DL Albritton
- DL Breitburg
- DM Baltz
- DR Bellwood
- DR Bellwood
- DR Bellwood
- DR Robertson
- DW Freshwater
- E McLeod
- E Rignot
- ED McCoy
- EE Sotka
- EF Pane
- Elizabeth McLeod
- EN Edinger
- ET Game
- F Micheli
- GA Burton Jr
- GE Davis
- GM Ruiz
- GP Jones
- GP Jones
- GR Walther
- GW Allison
- GW Allison
- H Galbraith
- HK Lotze
- HV Boyett
- HV McGregor
- I Mosquera
- I Nagelkerken
- J Engel
- JA Bohnsack
- JA Estes
- JA Kleypas
- JA Kleypas
- JA McGowan
- JA Sobel
- JBC Jackson
- JC Ogden
- JC Orr
- JE Johnson
- JF Bruno
- JG Hiddink
- JK Reaser
- JL Chen
- JM Coe
- JM Pandolfi
- JM Pandolfi
- JM Roberts
- JM Roessig
- JM West
- Johanna E. Johnson
- JP Barry
- JP McCarty
- JT Carlton
- JT Carlton
- JT Tilmant
- JW McManus
- JW Porter
- JW Porter
- K Caldeira
- K Engie
- K Kim
- KD Hyrenbach
- KE Fabricius
- KH Mann
- KK Yates
- KP Boessenkool
- KRT Whelan
- KT Frank
- L Burke
- L Burke
- L Cho
- L Fernandes
- L Kaufman
- LB Crowder
- LB Crowder
- LD Mydlarz
- LH Gunderson
- LR Gerber
- LS Mills
- M Beger
- M Khamer
- M Nyström
- M Ruckelshaus
- MA Hixon
- MA Snyder
- MD Behrens
- ME Kimball
- MH Carr
- MH Ledlie
- MJ Kaiser
- MJ McPhaden
- MP Lesser
- MP Marchetti
- MV Moore
- NAJ Graham
- National Marine Fisheries Service (NMFS)
- National Research Council (NRC)
- NJ Mantua
- NK Dulvy
- NL Bindoff
- NN Rabalais
- NRC
- O Hoegh-Guldberg
- O Hoegh-Guldberg
- O Hoegh-Guldberg
- P Hallock
- P Marshall
- P Marshall
- PA Fields
- PAR Hockey
- PB Moyle
- PE Whitfield
- Pew Oceans Commission (POC)
- PF Sale
- PJ Mumby
- PJ Mumby
- PK Dayton
- R Berkelmans
- R Condrey
- R Curry
- R Curry
- R Law
- RA Feely
- RB Aronson
- RE Bell
- Rikki Grober-Dunsmore
- RJ Nicholls
- RJ Orth
- RJT Klein
- RK Cowen
- RK Cowen
- Robert S. Steneck
- RR Stewart
- RR Warner
- RS Steneck
- RS Steneck
- RS Steneck
- RS Steneck
- RV Salm
- RW Grigg
- S Airamé
- S Philip
- S Wells
- SA Levin
- SA Murawski
- Satie Airamé
- SD Donner
- SD Donner
- SE Edge
- SE Edge
- SE Swearer
- SF Thrush
- SJ McNaughton
- SR Carpenter
- SR Palumbi
- SR Palumbi
- SR Palumbi
- SR Palumbi
- SR Palumbi
- SR Palumbi
- SR Thorrold
- Steven L. Miller
- SV Smith
- T Done
- TA Gardner
- TA Gardner
- The Royal Society (TRS)
- TJ Done
- TP Hughes
- TP Hughes
- TR McClanahan
- US Department of Commerce (USDOC)
- WF Precht
- WK Fitt
- WP Sousa
- Y Sadovy
- Y Shirayama
- Publication venue
- Springer-Verlag
- Publication date
- 01/01/2009
- Field of study
Marine protected areas (MPAs) provide place-based management of marine ecosystems through various degrees and types of protective actions. Habitats such as coral reefs are especially susceptible to degradation resulting from climate change, as evidenced by mass bleaching events over the past two decades. Marine ecosystems are being altered by direct effects of climate change including ocean warming, ocean acidification, rising sea level, changing circulation patterns, increasing severity of storms, and changing freshwater influxes. As impacts of climate change strengthen they may exacerbate effects of existing stressors and require new or modified management approaches; MPA networks are generally accepted as an improvement over individual MPAs to address multiple threats to the marine environment. While MPA networks are considered a potentially effective management approach for conserving marine biodiversity, they should be established in conjunction with other management strategies, such as fisheries regulations and reductions of nutrients and other forms of land-based pollution. Information about interactions between climate change and more “traditional” stressors is limited. MPA managers are faced with high levels of uncertainty about likely outcomes of management actions because climate change impacts have strong interactions with existing stressors, such as land-based sources of pollution, overfishing and destructive fishing practices, invasive species, and diseases. Management options include ameliorating existing stressors, protecting potentially resilient areas, developing networks of MPAs, and integrating climate change into MPA planning, management, and evaluation
Search for gravitational waves from Scorpius X-1 in the second Advanced LIGO observing run with an improved hidden Markov model
- Author
- Abbott Bp
- Abbott R
- Abbott Td
- Abraham S
- Acernese F
- Ackley K
- Adams C
- Adhikari Rx
- Adya Vb
- Affeldt C
- Agathos M
- Agatsuma K
- Aggarwal N
- Aguiar Od
- Aiello L
- Ain A
- Ajith P
- Allen G
- Allocca A
- Aloy Ma
- Altin Pa
- Amato A
- Anand S
- Ananyeva A
- Anderson Sb
- Anderson Wg
- Angelova Sv
- Antier S
- Appert S
- Arai K
- Araya Mc
- Areeda Js
- Arene M
- Arnaud N
- Aronson Sm
- Ascenzi S
- Ashton G
- Aston Sm
- Astone P
- Aubin F
- Aufmuth P
- AultONeal K
- Austin C
- Avendano V
- Avila-Alvarez A
- Babak S
- Bacon P
- Badaracco F
- Bader Mkm
- Bae S
- Baird J
- Baker Pt
- Baldaccini F
- Ballardin G
- Ballmer Sw
- Bals A
- Banagiri S
- Barayoga Jc
- Barbieri C
- Barclay Se
- Barish Bc
- Barker D
- Barkett K
- Barnum S
- Barone F
- Barr B
- Barsotti L
- Barsuglia M
- Barta D
- Bartlett J
- Bartos I
- Bassiri R
- Basti A
- Bawaj M
- Bayley Jc
- Bazzan M
- Becsy B
- Bejger M
- Belahcene I
- Bell As
- Beniwal D
- Benjamin Mg
- Berger Bk
- Bergmann G
- Bernuzzi S
- Berry Cpl
- Bersanetti D
- Bertolini A
- Betzwieser J
- Bhandare R
- Bidler J
- Biggs E
- Bilenko Ia
- Bilgili Sa
- Billingsley G
- Birney R
- Birnholtz O
- Biscans S
- Bischi M
- Biscoveanu S
- Bisht A
- Bitossi M
- Bizouard Ma
- Blackburn Jk
- Blackman J
- Blair Cd
- Blair Dg
- Blair Rm
- Bloemen S
- Bobba F
- Bode N
- Boer M
- Boetzel Y
- Bogaert G
- Bondu F
- Bonnand R
- Booker P
- Boom Ba
- Bork R
- Boschi V
- Bose S
- Bossilkov V
- Bosveld J
- Bouffanais Y
- Bozzi A
- Bradaschia C
- Brady Pr
- Bramley A
- Branchesi M
- Brau Je
- Breschi M
- Briant T
- Briggs Jh
- Brighenti F
- Brillet A
- Brinkmann M
- Brockill P
- Brooks Af
- Brooks J
- Brown Dd
- Brunett S
- Buikema A
- Bulik T
- Bulten Hj
- Buonanno A
- Buskulic D
- Bustillo Jc
- Buy C
- Byer Rl
- Cabero M
- Cadonati L
- Cagnoli G
- Cahillane C
- Callister Ta
- Calloni E
- Camp Jb
- Campbell Wa
- Cannon Kc
- Cao H
- Cao J
- Carapella G
- Carbognani F
- Caride S
- Carney Mf
- Carullo G
- Casentini C
- Castro Jmg
- Caudill S
- Cavaglia M
- Cavalier F
- Cavalieri R
- Cella G
- Cerda-Duran P
- Cesarini E
- Chaibi O
- Chakravarti K
- Chamberlin Sj
- Chan M
- Chao S
- Charlton P
- Chase Ea
- Chassande-Mottin E
- Chatterjee D
- Chaturvedi M
- Cheeseboro Bd
- Chen Hy
- Chen X
- Chen Y
- Cheng Hp
- Cheong Ck
- Chia Hy
- Chiadini F
- Chincarini A
- Chiummo A
- Cho G
- Cho Hs
- Cho M
- Christensen N
- Chu Q
- Chua S
- Chung Kw
- Chung S
- Ciani G
- Cieslar M
- Ciobanu Aa
- Ciolfi R
- Cipriano F
- Cirone A
- Clara F
- Clark Ja
- Clearwater P
- Cleva F
- Coccia E
- Cohadon Pf
- Cohen D
- Colleoni M
- Collette Cg
- Collins C
- Colpi M
- Cominsky Lr
- Constancio M
- Conti L
- Cooper Sj
- Corban P
- Corbitt Tr
- Cordero-Carrion I
- Corezzi S
- Corley Kr
- Cornish N
- Corre D
- Corsi A
- Cortese S
- Costa Ca
- Costa Cfd
- Cotesta R
- Coughlin Mw
- Coughlin Sb
- Coulon Jp
- Countryman St
- Couvares P
- Covas Pb
- Cowan Ee
- Coward Dm
- Cowart Mj
- Coyne Dc
- Coyne R
- Creighton Jde
- Creighton Td
- Cripe J
- Croquette M
- Crowder Sg
- Cullen Tj
- Cumming A
- Cunningham L
- Cuoco E
- D'Angelo B
- D'Antonio S
- Dal Canton T
- Dalya G
- Danilishin Sl
- Danzmann K
- Dasgupta A
- Datrier Leh
- Dattilo V
- Dave I
- Davier M
- Davis D
- Daw Ej
- De Laurentis M
- De Pietri R
- De Rosa R
- De Rossi C
- de Varona O
- DeBra D
- Deenadayalan M
- Degallaix J
- Del Pozzo W
- Deleglise S
- DeMarchi Lm
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- Dent T
- DeSalvo R
- Dhurandhar S
- Di Fiore L
- Di Giorgio C
- Di Giovanni F
- Di Giovanni M
- Di Girolamo T
- Di Lieto A
- Di Pace S
- Di Palma I
- Di Renzo F
- Diaz Jc
- Diaz Mc
- Dietrich T
- DiFronzo C
- Ding B
- Divakarla Ak
- Dmitriev A
- Doctor Z
- Donovan F
- Dooley Kl
- Doravari S
- Dorrington I
- Downes Tp
- Drago M
- Driggers Jc
- Du Z
- Ducoin Jg
- Dupej P
- Durante O
- Dwyer Se
- Easter Pj
- Eddolls G
- Edo Tb
- Effler A
- Ehrens P
- Eichholz J
- Eikenberry Ss
- Eisenmann M
- Eisenstein Ra
- Errico L
- Essick Rc
- Estelles H
- Estevez D
- Etienne Zb
- Etzel T
- Evans M
- Evans Tm
- Fafone V
- Fairhurst S
- Fan X
- Farinon S
- Farr B
- Farr Wm
- Fauchon-Jones Ej
- Favata M
- Fays M
- Fazio M
- Fee C
- Feicht J
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- Feng F
- Fernandez-Galiana A
- Ferrante I
- Ferreira Ec
- Ferreira Ta
- Fidecaro F
- Fiori I
- Fiorucci D
- Fishbach M
- Fisher Rp
- Fishner Jm
- Fittipaldi R
- Fitz-Axen M
- Fiumara V
- Flaminio R
- Fletcher M
- Floden E
- Flynn E
- Fong H
- Font Ja
- Forsyth Pwf
- Fournier Jd
- Frasca S
- Frasconi F
- Frei Z
- Freise A
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- Fritschel P
- Frolov Vv
- Fronze G
- Fulda P
- Fyffe M
- Gabbard Ha
- Gadre Bu
- Gaebel Sm
- Gair Jr
- Gammaitoni L
- Gaonkar Sg
- Garcia-Quiros C
- Garufi F
- Gateley B
- Gaudio S
- Gaur G
- Gayathri V
- Gemme G
- Genin E
- Gennai A
- George D
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- Gergely L
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- Giacomazzo B
- Giaime Ja
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- Gibson Dr
- Gill K
- Glover L
- Gniesmer J
- Godwin P
- Goetz E
- Goetz R
- Goncharov B
- Gonzalez G
- Gopakumar A
- Gossan Se
- Gosselin M
- Gouaty R
- Grace B
- Grado A
- Granata M
- Grant A
- Gras S
- Grassia P
- Gray C
- Gray R
- Greco G
- Green Ac
- Green R
- Gretarsson Em
- Grimaldi A
- Grimm Sj
- Groot P
- Grote H
- Grunewald S
- Gruning P
- Guidi Gm
- Gulati Hk
- Guo Y
- Gupta A
- Gupta A
- Gupta P
- Gustafson Ek
- Gustafson R
- Haegel L
- Halim O
- Hall Br
- Hall Ed
- Hamilton Ez
- Hammond G
- Haney M
- Hanke Mm
- Hanks J
- Hanna C
- Hannuksela Oa
- Hansen Tj
- Hanson J
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- Haris K
- Harms J
- Harry Gm
- Harry Iw
- Hasskew Rk
- Haster Cj
- Haughian K
- Hayes Fj
- Healy J
- Heidmann A
- Heintze Mc
- Heitmann H
- Hellman F
- Hello P
- Hemming G
- Hendry M
- Heng Is
- Hennig J
- Hernandez Im
- Heurs M
- Hild S
- Hinderer T
- Hochheim S
- Hofman D
- Holgado Am
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- Holt K
- Holz De
- Hopkins P
- Horst C
- Hough J
- Howell Ej
- Hoy Cg
- Huang Y
- Hubner Mt
- Huerta Ea
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- Hughey B
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- Ingram C
- Inta R
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- Iyer Br
- Jacqmin T
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- Jariwala D
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- Kalogera V
- Kamai B
- Kandhasamy S
- Kang G
- Kanner Jb
- Kapadia Sj
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- Kashyap R
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- Katsanevas S
- Katsavounidis E
- Katzman W
- Kaufer S
- Kawabe K
- Keerthana Nv
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- Khalili Fy
- Khan I
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- Khazanov Ea
- Khetan N
- Khursheed M
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- Kim C
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- Kleybolte L
- Klika Jh
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- Kozak Db
- Kramer C
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- Krolak A
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- Kuehn G
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- Lasky Pd
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- Lazzarini A
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- Lousto Co
- Lovelace G
- Lower Me
- Luck H
- Lumaca D
- Lundgren Ap
- Lynch R
- Ma Y
- Macas R
- Macfoy S
- MacInnis M
- Macleod Dm
- Macquet A
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- Magee Rm
- Majorana E
- Maksimovic I
- Malik A
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- Mandic V
- Mangano V
- Mansell Gl
- Manske M
- Mantovani M
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- Marchesoni F
- Marion F
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- Markakis C
- Markosyan As
- Markowitz A
- Maros E
- Marquina A
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- Mukherjee A
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- Zimmerman Ab
- Zucker Me
- Zweizig J
- Publication venue
- College Park, MD : American Physical Society
- Publication date
- 01/01/2019
- Field of study
We present results from a semicoherent search for continuous gravitational waves from the low-mass x-ray binary Scorpius X-1, using a hidden Markov model (HMM) to track spin wandering. This search improves on previous HMM-based searches of LIGO data by using an improved frequency domain matched filter, the J-statistic, and by analyzing data from Advanced LIGO's second observing run. In the frequency range searched, from 60 to 650 Hz, we find no evidence of gravitational radiation. At 194.6 Hz, the most sensitive search frequency, we report an upper limit on gravitational wave strain (at 95% confidence) of h095%=3.47×10-25 when marginalizing over source inclination angle. This is the most sensitive search for Scorpius X-1, to date, that is specifically designed to be robust in the presence of spin wandering. © 2019 American Physical Society
Search for gravitational waves from Scorpius X-1 in the second Advanced LIGO observing run with an improved hidden Markov model
- Author
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- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2019
- Field of study
We present results from a semicoherent search for continuous gravitational waves from the low-mass x-ray binary Scorpius X-1, using a hidden Markov model (HMM) to track spin wandering. This search improves on previous HMM-based searches of LIGO data by using an improved frequency domain matched filter, the J-statistic, and by analyzing data from Advanced LIGO’s second observing run. In the frequency range searched, from 60 to 650 Hz, we find no evidence of gravitational radiation. At 194.6 Hz, the most sensitive search frequency, we report an upper limit on gravitational wave strain (at 95% confidence) of h95%0=3.47×10−25 when marginalizing over source inclination angle. This is the most sensitive search for Scorpius X-1, to date, that is specifically designed to be robust in the presence of spin wandering
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
- Author
- Abdel-Aziz AK
- Abdelfatah S
- Abdellatif M
- Abdoli A
- Abel S
- Abeliovich H
- Abildgaard MH
- Abudu YP
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- Adamopoulos IE
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- Adolph TE
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- Agrewala JN
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- Yi C
- Yi-Ren Hong C-WH
- Yin X-M
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- Zanella I
- Zang QS
- Zanivan S
- Zappavigna S
- Zaragoza P
- Zarbalis KS
- Zarebkohan A
- Zarrouk A
- Zeitlin SO
- Zeng J
- Zeng J-D
- Zhan L
- Zhang B
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- Zhang KYB
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- Zhang X
- Zhang X
- Zhang X
- Zhang X
- Zhang X-W
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- Zhang Y
- Zhang Y
- Zhang Y
- Zhang Y
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- Zhang Y-D
- Zhang Y-Y
- Zhang Z
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- Zheng G
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- Zheng L
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- Zheng X-L
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- Zheng Z-G
- Zhivotovsky B
- Zhong Q
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- Zhou R
- Zhou X-J
- Zhou Y
- Zhou Y
- Zhou Y
- Zhou Z
- Zhou Z-Y
- Zhu B
- Zhu C
- Zhu G-Q
- Zhu H
- Zhu H
- Zhu H
- Zhu W-G
- Zhu Y
- Zhu Y
- Zhuang H
- Zhuang X
- Zientara-Rytter K
- Zimmermann CM
- Ziviani E
- Zoladek T
- Zong W-X
- Zorov DB
- Zorzano A
- Zou W
- Zou Z
- Zou Z
- Zuryn S
- Zwerschke W
- Álvarez ÉMC
- Ávalos Y
- Önal G
- Üstün S
- Čolić M
- Đokić J
- Žerovnik E
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
Coronary fractional flow reserve measurements of a stenosed side branch: a computational study investigating the influence of the bifurcation angle
- Author
- A Medina
- A Santamarina
- AG Giessen van der
- AG Giessen van der
- Antonius F. W. van der Steen
- B Bruyne De
- BK Koo
- BP Kimball
- C Chiastra
- C Godino
- C Pagiatakis
- Claudio Chiastra
- D Gallo
- D Gallo
- D Zhang
- F Mallinger
- FJH Gijsen
- Francesco Iannaccone
- Frank J. H. Gijsen
- G Finet
- G Liu
- GS Kassab
- IV Pivkin
- J Frattolin
- Joanna J. Wykrzykowska
- Jolanda J. Wentzel
- JTC Schrauwen
- K Canneyt Van
- KL Gould
- L Mauri
- M Echavarría-Pinto
- M Malvè
- M Malvè
- Maik J. Grundeken
- Matthieu De Beule
- MF Gross
- MF Gross
- MI Papafaklis
- MJ Kern
- N Vorobtsova
- NHJ Pijls
- P Barlis
- P Mortier
- PAL Tonino
- PAL Tonino
- Patrick Segers
- Patrick W. Serruys
- PK Siogkas
- S Beier
- S Tu
- S-J Kang
- S-L Chen
- SE Lee
- SIS Pinto
- SJ Sherwin
- T Iwami
- TP Hoef van de
- TP Hoef van de
- TP Hoef van de
- U Morbiducci
- U Morbiducci
- U Morbiducci
- U Morbiducci
- Y Onuma
- Y Shi
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Valorisation of Biowastes for the Production of Green Materials Using Chemical Methods
- Author
- A Altschul
- A Baiano
- A Basile
- A Crozier
- A Filly
- A Ghosh
- A Kubátová
- A O’Sullivan
- A Radich
- A Srivastava
- A Steinbuchel
- A Waglay
- AA Rosatella
- AAM Daifullah
- AB Trenwith
- AE Gerbase
- AJ Poole
- AM Liaquat
- AMJ Kootstra
- AS Bakhtiari
- AS Franca
- AS Marriott
- AS Matharu
- AS Pepper
- AS Pepper
- AS Pepper
- AS Yalcin
- AYZ Zhang
- B Bozan
- B Dyson
- B Kamm
- B Koubala
- B Narasimhamoorthy
- B Pérez-Vich
- BB Koubala
- BP Tissot
- BR Thakur
- BW Diers
- C Attaphong
- C Delhomme
- C Ding
- C Ding
- C Haşimoğlu
- C Marisa
- C McGlade
- C Rakopoulos
- C Rhodes
- C Spalatelu
- C-T Hsieh
- CJ Campbell
- Commission E-E
- CS Lin
- D Kalaiyezhini
- D Kimball
- D Pečar
- D Ratna
- DC Zimmerman
- DF McMillen
- DW Armstrong
- DY Kim
- E Ha
- E Johnson
- E Madsen
- E Reverchon
- E-Y Hwang
- EMS Machado
- F Altuna
- F Bakkali
- F Cherubini
- F Giuffrida
- F Leifa
- F Ma
- FDCA
- FL Jin
- FR Marín
- G Bounous
- G Dugo
- G Dwivedi
- G Kars
- G Lercker
- G Mothes
- G Pardo
- GA Lullo Di
- GK Pal
- GM Cooper
- GM Coppola
- GM Haider
- GO Regester
- GO Regester
- GPAG Pousa
- GW Smithers
- GZ Papageorgiou
- H Bagherian
- H Lee
- H Mellouk
- H Mhemdi
- H Wilcke
- HB Lofland
- HL Parker
- HM Mobarak
- HW Gardner
- HW-S Chan
- I Agirrezabal-Telleria
- I Backlund
- I Bechthold
- I Hamerton
- I Safarik
- IM Rodrigues
- J Crivello
- J Dodson
- J Friedrich
- J Harholt
- J Hermansson
- J Hu
- J Mena-Durán Cinthia
- J Salimon
- J Zhao
- J-J Lay
- JA Barnett
- JA Robertson
- JC Colmenares
- JG Zeikus
- JH Clark
- JH Gans
- JM del Valle
- JM Encinar
- JM Melillo
- JM Naranjo
- JP Wauquier
- JR Dodson
- JR Dodson
- K Alekkett
- K Chojnacka
- K McCormick
- KB Clark
- KD Tipton
- L Fabian
- L Limousy
- L McCusker
- L Velasco
- LA Pfaltzgraff
- LD Do
- LF Bauman
- LJ Pennington
- LM Mesquita
- M Abdullah
- M Akiyama
- M Boruah
- M Farnfield
- M Friedman
- M Galià
- M Jimenez-Carmona
- M Kratchanova
- M Kratchanova
- M Kuk
- M Mascal
- M Mascal
- M Mascal
- M Ojeda
- M Pinelo
- M Stemmelen
- MA Fazal
- MA Ferhat
- MA Maleque
- MA Silva
- MA Tony
- MB Zemel
- MG Plaza
- MH Ibrahim
- MJ Kamlet
- MJ Thornton
- ML Fishman
- MZ Ozel
- MZ Ozel
- MZ Özel
- N Kondamudi
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- N Vivek
- NA Owen
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- NS Caetano
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- P de Almeida
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- SJ Blanksby
- SJ Park
- SJ Park
- SN Naik
- T Baitiang
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- T Searchinger
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- TH Kwan
- TIJ Dugmore
- TJ Farmer
- TM Attard
- TM Attard
- TM Attard
- TM Attard
- TS Anirudhan
- TW Findley
- TY Filippova
- V Alt
- V Budarin
- V Budarin
- V Budarin
- V Bártová
- V Calvino-Casilda
- V Kachrimanidou
- VL Budarin
- VL Budarin
- VV Bokade
- VV Goud
- VV Goud
- VV Goud
- W Bergthaller
- W-J Yen
- WR Schmitz
- X Guo
- X Yang
- X Yu
- Y Lin
- Y Lu
- Y Wang
- Y-P Liu
- Y-Q Fu
- YY Linko
- Z Zhang
- Z Zhang
- Z Zhang
- Z Zhang
- ZS Petrović
- ZS Petrović
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/04/2017
- Field of study
With crude oil reserves dwindling, the hunt for a sustainable alternative feedstock for fuels and materials for our society continues to expand. The biorefinery concept has enjoyed both a surge in popularity and also vocal opposition to the idea of diverting food-grade land and crops for this purpose. The idea of using the inevitable wastes arising from biomass processing, particularly farming and food production, is, therefore, gaining more attention as the feedstock for the biorefinery. For the three main components of biomass—carbohydrates, lipids, and proteins—there are long-established processes for using some of these by-products. However, the recent advances in chemical technologies are expanding both the feedstocks available for processing and the products that be obtained. Herein, this review presents some of the more recent developments in processing these molecules for green materials, as well as case studies that bring these technologies and materials together into final products for applied usage
First Measurement of the Hubble Constant from a Dark Standard Siren using the Dark Energy Survey Galaxies and the LIGO/Virgo Binary-Black-hole Merger GW170814
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- Verkindt D
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- Vicere A
- Viets AD
- Vine DJ
- Vinet J-Y
- Vitale S
- Vivanco FH
- Vo T
- Vocca H
- Vorvick C
- Vyatchanin SP
- Wade AR
- Wade LE
- Wade M
- Walet R
- Walker AR
- Walker M
- Wallace L
- Walsh S
- Wang G
- Wang H
- Wang JZ
- Wang WH
- Wang YF
- Ward RL
- Warden ZA
- Warner J
- Was M
- Watchi J
- Weaver B
- Wechsler R
- Wei L-W
- Weinert M
- Weinstein AJ
- Weiss R
- Wellmann F
- Wen L
- Wessel EK
- Wessels P
- Wester W
- Westhouse JW
- Wette K
- Whelan JT
- Whiting BF
- Whittle C
- Wilken DM
- Williams D
- Williams PKG
- Williamson AR
- Willis JL
- Willke B
- Wimmer MH
- Winkler W
- Wipf CC
- Wittel H
- Woan G
- Woehler J
- Wofford JK
- Worden J
- Wright JL
- Wu DS
- Wysocki DM
- Xiao L
- Yamamoto H
- Yancey CC
- Yang L
- Yap MJ
- Yazback M
- Yeeles DW
- Yu H
- Yu H
- Yuen SHR
- Yvert M
- Zadrozny AK
- Zanolin M
- Zelenova T
- Zendri J-P
- Zertuche LM
- Zevin M
- Zhang J
- Zhang L
- Zhang T
- Zhao C
- Zhou M
- Zhou Z
- Zhu XJ
- Zimmerman A
- Zucker ME
- Zuntz J
- Zweizig J
- Publication venue
- IOP PUBLISHING LTD
- Publication date
- 01/05/2019
- Field of study
We present a multi-messenger measurement of the Hubble constant H 0 using the binary–black-hole merger GW170814 as a standard siren, combined with a photometric redshift catalog from the Dark Energy Survey (DES). The luminosity distance is obtained from the gravitational wave signal detected by the Laser Interferometer Gravitational-Wave Observatory (LIGO)/Virgo Collaboration (LVC) on 2017 August 14, and the redshift information is provided by the DES Year 3 data. Black hole mergers such as GW170814 are expected to lack bright electromagnetic emission to uniquely identify their host galaxies and build an object-by-object Hubble diagram. However, they are suitable for a statistical measurement, provided that a galaxy catalog of adequate depth and redshift completion is available. Here we present the first Hubble parameter measurement using a black hole merger. Our analysis results in H0=75−32+40kms−1Mpc−1, which is consistent with both SN Ia and cosmic microwave background measurements of the Hubble constant. The quoted 68% credible region comprises 60% of the uniform prior range [20, 140] km s−1 Mpc−1, and it depends on the assumed prior range. If we take a broader prior of [10, 220] km s−1 Mpc−1, we find {H}_{0 {78}_{-24}^{+96}\,\mathrm{km}\,{{\rm{s}}}^{-1}\,{\mathrm{Mpc}}^{-1} (57% of the prior range). Although a weak constraint on the Hubble constant from a single event is expected using the dark siren method, a multifold increase in the LVC event rate is anticipated in the coming years and combinations of many sirens will lead to improved constraints on H 0
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