Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Early Childhood Development Programs in the Capital Region (Edmonton & Area): Outcome Evaluation Report

Under the Early Childhood Development (ECD) Initiative, the Planning Committee identified the following categories of programs which would receive ECD funding: Home Visitation; Head Start; Child Care; Multicultural Family Connections; Child and Family Resource Centres; Leduc County Family and Community Support Services; and Strathcona County Family and Community Services. This report presents information related to Child and Family Resource Centres, Multicultural Family Connections, and Family and Community Services (Leduc County Family and Community Support Services, and Strathcona County Family and Community Services). Separate reports have been prepared which contain evaluation of findings for Home Visitation,1 Head Start,2 and Child Care

Evaluation of Capital Region Home Visitation Network: Outcome Evaluation Report, 2001-2004

The purpose of this report is to present selected findings regarding program activities and outputs, and a more detailed analysis of the impact of the Home Visitation program at a system level based on outcomes measures. The findings in this report are drawn from the comprehensive evaluation of the Capital Region Home Visitation Network. More specifically, this report has two major objectives as follows: 1. To present an analysis of descriptive information about the clients in all the sites in the Capital Region Home Visitation Network including the following: • program activities: contacts, goal summaries, and community referrals; and • program outputs: client profiles, client intake, demographic characteristics, and risk assessments. 2. To present an analysis of program outcomes based on: • outcomes data collected from a core set of outcomes measurement tools, aggregated and summarized regionally; • a survey of clients’ experiences and views of the Home Visitation program; • involvement with Child Welfare services; and • utilization of health care services