Synaptic Plasticity and Spike Synchronisation in Neuronal Networks

This work was possible by partial financial support from the following Brazilian government agencies: CNPq (154705/2016-0, 311467/2014-8), CAPES, Fundacao Araucaria, and Sao Paulo Research Foundation (processes FAPESP 2011/19296-1, 2015/07311-7, 2016/16148-5, 2016/23398-8, 2015/50122-0). Research supported by grant 2015/50122-0 Sao Paulo Research Foundation (FAPESP) and DFG-IRTG 1740/2.Peer reviewedPostprin

Spike-burst chimera states in an adaptive exponential integrate-and-fire neuronal network

We wish to acknowledge the support from Fundação Araucária, CNPq (Grant No. 150701/2018-7), CAPES, and FAPESP (Grant Nos. 2015/07311-7, 2018/03211-6, and 2017/18977-1).Peer reviewedPublisher PD

Effects of drug resistance in the tumour-immune system with chemotherapy treatment

Acknowledgement This study was possible by partial financial support from the following Brazilian government agencies: Fundaao Araucaria, National Council for Scientific and Technological Development, Coordination for the Improvement of Higher Education Personnel, and Sao Paulo Research Foundation (2015/07311-7, 2017/18977- 1, 2018/03211-6, 2020/04624-2)Peer reviewedPostprin

Genomics and epidemiology for gastric adenocarcinomas (GE4GAC): a Brazilian initiative to study gastric cancer

Abstract Gastric cancer (GC) is the fifth most common type of cancer worldwide with high incidences in Asia, Central, and South American countries. This patchy distribution means that GC studies are neglected by large research centers from developed countries. The need for further understanding of this complex disease, including the local importance of epidemiological factors and the rich ancestral admixture found in Brazil, stimulated the implementation of the GE4GAC project. GE4GAC aims to embrace epidemiological, clinical, molecular and microbiological data from Brazilian controls and patients with malignant and pre-malignant gastric disease. In this letter, we summarize the main goals of the project, including subject and sample accrual and current findings

A conservation roadmap for the subterranean biome

The 15th UN Convention on Biological Diversity (CBD) (COP15) will be held in Kunming, China in October 2021. Historically, CBDs and other multilateral treaties have either alluded to or entirely overlooked the subterranean biome. A multilateral effort to robustly examine, monitor, and incorporate the subterranean biome into future conservation targets will enable the CBD to further improve the ecological effectiveness of protected areas by including groundwater resources, subterranean ecosystem services, and the profoundly endemic subsurface biodiversity. To this end, we proffer a conservation roadmap that embodies five conceptual areas: (1) science gaps and data management needs; (2) anthropogenic stressors; (3) socioeconomic analysis and conflict resolution; (4) environmental education; and (5) national policies and multilateral agreements.Peer reviewe

Biology of human hair: Know your hair to control it

Hair can be engineered at different levels—its structure and surface—through modification of its constituent molecules, in particular proteins, but also the hair follicle (HF) can be genetically altered, in particular with the advent of siRNA-based applications. General aspects of hair biology are reviewed, as well as the most recent contributions to understanding hair pigmentation and the regulation of hair development. Focus will also be placed on the techniques developed specifically for delivering compounds of varying chemical nature to the HF, indicating methods for genetic/biochemical modulation of HF components for the treatment of hair diseases. Finally, hair fiber structure and chemical characteristics will be discussed as targets for keratin surface functionalization

I Diretrizes do Grupo de Estudos em Cardiogeriatria da Sociedade Brasileira de Cardiologia

O idoso apresenta características próprias na manifestação das doenças, na resposta à terapêutica e no efeito colateral dos medicamentos. Constitui um grupo de maior risco para o aparecimento das doenças degenerativas, em geral, e cardiovasculares, em particular, além de apresentar maior número de comorbidades