Pengaruh Penyakit Ginjal Kronik Terhadap Disfungsi Ereksi Pria

: Chronic kidney disease is decreased in kidney function that persistent and irreversible. Chronic kidney disease can lead to problems in the erectile function of men because of disorders on some factors, that are the endocrine system, the vascular system, psychological factor, and neurogenic disorder. WHO estimated that there will be an increasing number of patients with chronic kidney disease by 41.4% between the years 1995-2025 in Indonesia. Research on erectile dysfunction in patients with chronic kidney disease has not been done yet in Indonesia, especially in Manado. The Aim of this research is to know the effect of chronic kidney disease to erectile dysfunction of men. The research design for this study is observasional descriptive. The number of samples obtained as many as 34 samples of patients with stage 5 chronic kidney disease, be found 18 people (52.95%) suffering from mild erectile dysfunction, 12 people (35.29%) suffering from mild-moderate erectile dysfunction, a man (2.94%) suffering from moderate erectile dysfunction, 2 people (5.88%) suffering from severe erectile dysfunction, and a man (2.94%) with no erectile dysfunction. The conclusion is patients with chronic kidney disease can lead to problems in the erectile function, because of influence from the above factors. Suggestion on this research is necessary to check blood testosterone levels and find more samples

SDG localisation and decentralised development aid: exploring opposing discourses and practices in Valencia's aid sector

The approval of the 2030 Agenda and the Sustainable Development Goals (SDGs) has generated intense debates in the aid sector at the global, national and subnational levels. A key question is whether they can address structural problems in development aid policies and practices, such as the lack of accountability and coherence, unequal power relations, or depoliticisation. It seems that this will depend on how the agenda is adopted in the various territories as well as on the different interests at play. We address this question by studying the case of the Valencian Autonomous region. This is the territory in Spain where institutions have been the most active in establishing the SDGs at the core of the political discourses. We follow a qualitative methodology based on semi-structured interviews with key respondents from the public, civil society and university sectors, participant observation, and the analysis of secondary information. Inspired by critical discourse analysis, we explore the varying and conflicting discourses regarding the potential of SDGs to address the problems of aid, and on the impacts that its adoption are producing. We illustrate that the introduction of SDGs in aid policies is a conflictive process modelled by the power dynamics

Mineralogy and genesis of the kihabe Zn-Pb-V prospect, Aha Hills, Northwest Botswana

The Kihabe Zn-Pb-V > (Cu-Ag-Ge) prospect is located at the boundary between Namibia and Botswana (Aha Hills, Ngamiland District) in a strongly deformed Proterozoic fold belt, corresponding to the NE extension of the Namibian Damara Orogen. The Kihabe prospect contains Zn-Pb resources of 14.4 million tonnes at 2.84% zinc equivalent, Ag resources of 3.3 million ounces, and notable V-Ge amounts, still not evaluated at a resource level. The ores are represented by a mixed sulfide–nonsulfide mineralization. Sulfide minerals consist mainly of sphalerite, galena and pyrite in a metamorphic quartzwacke. Among the nonsulfide assemblage, two styles of mineralization occur in the investigated samples: A first one, characterized by hydrothermal willemite and baileychlore, and a second one consisting of supergene smithsonite, cerussite, hemimorphite, Pb-phosphates, arsenates and vanadates. Willemite is present in two generations, which postdate sulfide emplacement and may also form at their expenses. These characteristics are similar to those observed in the willemite occurrences of the nearby Otavi Mountainland, which formed through hydrothermal processes, during the final stages of the Damara Orogeny. The formation of the Kihabe willemite is likely coeval. Baileychlore is characterized by textures indicating direct precipitation from solutions and dissolution–crystallization mechanisms. Both processes are typical of hydrothermal systems, thus suggesting a hydrothermal genesis for the Kihabe Zn-chlorite as well. Baileychlore could represent an alteration halo possibly associated either with the sulfide or with willemite mineralization. The other nonsulfide minerals, smithsonite, cerussite, various Pb-phosphates and vanadates, are clearly genetically associated with late phases of supergene alteration, which overprinted both the sulfide and the willemite-and baileychlore-bearing mineralizations. Supergene alteration probably occurred in this part of Botswana from the Late Cretaceous to the Miocene

Vanadium ore resources of the African continent: State of the Art

As part of the critical metals group, vanadium is an essential commodity for the low- and zero-CO2 energy generation, storage and transport. This contribution aims to carry out a review of the known vanadium ore sources and mineralizations located in Africa, which are highly diversified in their geological and mineralogical characteristics, and can be classified in: 1. Vanadiferous (titano)magnetite deposits; 2. Sandstone-hosted (U)-vanadium deposits; 3. Calcrete-hosted (U)-vanadium deposits; 4. Vanadate deposits; 5. Graphite-associated vanadium deposits; 6. Vanadium occurrences associated with laterite, bauxite, and phosphate ores. The economically most significant vanadium sources in Africa are associated with titanomagnetite layers in mafic–ultramafic layered magmatic intrusions (e.g., the Bushveld Complex in South Africa and the Great Dyke in Zimbabwe). Vanadium has been historically mined also in vanadate deposits deriving from the supergene alteration of Pb-Zn-Cu sulfide ores in Namibia and Zambia. Several areas in these countries, where potentially re-processable old tailings and slags have been accumulated, still have economic potential. Vanadium mineralizations are associated with graphite bodies in the Mozambique Metamorphic Belt. Vanadium is also enriched in uranium ores occurring in the Upper Paleozoic-Mesozoic Karoo continental sediments: typical examples are found in Botswana, South Africa, and Zimbabwe. Significant uranium-vanadium concentrations (where carnotite prevails) occur in relatively recent (Tertiary-Quaternary) calcrete duricrusts in paleo-fluviatile beds, which are widespread throughout the African continent. These derive from the weathering of U-(V)-fertile source rocks, which under favorable paleoclimatic conditions resulted in the vanadium precipitation in the critical zone. Variable vanadium amounts have been also recorded in iron ore deposits, phosphorites, and laterites, even though the phosphate deposits seem to have the most favorable characteristics for potentially economic vanadium concentrations. On the whole, South Africa holds the most significant vanadium ore resources globally. However, also many other African countries, where this metal could be profitably extracted as a by-product from other economic ores, will probably be at the forefront of vanadium production in the near future

Influence of genetic processes on geochemistry of fe-oxy-hydroxides in supergene Zn non-sulfide deposits

In supergene Zn non-sulfide deposits, the Fe-oxy-hydroxides (FeO/OH) are mainly concentrated in the residual zones (gossan) on top of the oxidized ore bodies, although they can also be found throughout the whole weathering profile coexisting with the primary and secondary ore assemblages. Fe-oxy-hydroxides are rarely pure as they form in systems where a wide range of metals, most of them of economic importance (e.g., Zn, Pb, Co, REE, Sc, Ga, Ge, V, etc.), freely circulate and can be “captured” under specific conditions. Although their occurrence can be widespread, and they have a potential to scavenge and accumulate critical metals, FeO/OH are considered gangue phases during the existing processing routes of Zn non-sulfide ores. Moreover, very little is known about the role of the deposit type on the geochemistry of FeO/OH formed in a specific association. Therefore, this paper provides a comprehensive assessment of the trace element footprint of FeO/OH from a number of Zn non-sulfide deposits, in order to define parameters controlling the metals’ enrichment process in the mineral phase. To achieve this, we selected FeO/OH-bearing mineralized samples from four supergene Zn non-sulfide ores in diverse settings, namely Hakkari (Turkey), Jabali (Yemen), Cristal (Peru) and Kabwe (Zambia). The petrography of FeO/OH was investigated by means of scanning electron microscope energy dispersive analysis (SEM-EDS), while the trace element composition was assessed using laser ablation-ICP-MS (LA-ICP-MS). Statistical analyses performed on LA-ICP-MS data defined several interelement associations, which can be ascribed to the different nature of the studied deposits, the dominant ore-formation process and subsequent evolution of the deposits and the environmental conditions under which FeO/OH phases were formed. Based on our results, the main new inferences are: (A) Zinc, Si, Pb, Ga and Ge enrichment in FeO/OH is favored in ores where the direct replacement of sulfides is the dominant process and/or where the pyrite is abundant (e.g., Cristal and Hakkari). (B) When the dissolution of the host-rock is a key process during the supergene ore formation (i.e., Jabali), the buffering toward basic pH of the solutions favors the uptake in FeO/OH of elements leached from the host carbonate rock (i.e., Mn), whilst restricting the uptake of elements derived from the dissolution of sulfides (i.e., Zn, Pb, Ga and Ge), as well as silica. (C) The input of exotic phases can produce significant enrichment in “unconventional” metals in FeO/OH (i.e., Cr and Co at Kabwe; Y at Cristal) depending on whether the optimal pH-Eh conditions are attained. (D) In the Kabwe deposit, FeO/OH records heterogeneous geochemical conditions within the system: where locally basic conditions prevailed during the alteration process, the V and U concentration in FeO/OH is favored; yet conversely, more acidic weathering produced Zn-and Si-bearing FeO/OH

Professional attitudes to sex offenders: implications for multiagency and collaborative working

Recent years have seen the development and implementation of a range of multi-disciplinary and partnership approaches to managing risk in known sex offenders, involving collaboration between justice and human services agencies. Potential barriers to the development of effective multidisciplinary practices arise when participating professionals hold different attitudes about those they are responsible for managing. This paper examines differences in attitudes towards sex offenders in two professional groups – police officers and allied health workers. The results suggest that police officers tend to hold more negative views than those who deliver treatment and support services. They are more likely to believe that offenders cannot change their behaviour and should be subject to more punitive sanctions. These findings are discussed in relation to judgements of both risk and dangerousness and associated decisions about the appropriate management of sex offenders in multi-agency and multi-disciplinary working forums

Adding Diversity to a Diruthenium Biscyclopentadienyl Scaffold via Alkyne Incorporation: Synthesis and Biological Studies

We report the synthesis and the assessment of the anticancer potential of two series of diruthenium biscyclopentadienyl carbonyl complexes. Novel dimetallacyclopentenone compounds (2-4) were obtained (45-92% yields) from the thermal reaction(PhCCPh exchange) of [Ru2Cp2(CO)(& mu;-CO){& mu;-& eta;(1):& eta;(3)-C(Ph)C(Ph)C(O)}], 1, with alkynes HCCR [R = C5H4FeCp (Fc),3-C6H4(Asp), 2-naphthyl; Cp = & eta;(5)-C5H5, Asp = OC(O)-2-C6H4C(O)Me]. Protonation of 1-3 by HBF4 afforded the corresponding & mu;-alkenyl derivatives 5-7, in 40-86% yields. All productswere characterized by IR and NMR spectroscopy; moreover, cyclic voltammetry(1, 2, 5, 7) andsingle-crystal X-ray diffraction (5, 7)analyses were performed on representative compounds. Complexes 5-7 revealed a cytotoxic activity comparableto that of cisplatin in A549 (lung adenocarcinoma), SW480 (colon adenocarcinoma),and ovarian (A2780) cancer cell lines, and 2, 5, 6, and 7 overcame cisplatin resistancein A2780cis cells. Complexes 2, 5, and 7 (but not the aspirin derivative 6) inducedan increase in intracellular ROS levels. Otherwise, 6 strongly stabilizes and elongates natural DNA (from calf thymus,CT-DNA), suggesting a possible intercalation binding mode, whereas 5 is less effective in binding CT-DNA, and 7 isineffective. This trend is reversed concerning RNA, and in particular, 7 is able to bind poly(rA)poly(rU) showing selectivity forthis nucleic acid. Complexes 5-7 caninteract with the albumin protein with a thermodynamic signature dominatedby hydrophobic interactions. Overall, we show that organometallicspecies based on the Ru2Cp2(CO)( x ) scaffold (x = 2, 3) are activeagainst cancer cells, with different incorporated fragments influencingthe interactions with nucleic acids and the production of ROS