: Chronic kidney disease is decreased in kidney function that persistent and irreversible. Chronic kidney disease can lead to problems in the erectile function of men because of disorders on some factors, that are the endocrine system, the vascular system, psychological factor, and neurogenic disorder. WHO estimated that there will be an increasing number of patients with chronic kidney disease by 41.4% between the years 1995-2025 in Indonesia. Research on erectile dysfunction in patients with chronic kidney disease has not been done yet in Indonesia, especially in Manado. The Aim of this research is to know the effect of chronic kidney disease to erectile dysfunction of men. The research design for this study is observasional descriptive. The number of samples obtained as many as 34 samples of patients with stage 5 chronic kidney disease, be found 18 people (52.95%) suffering from mild erectile dysfunction, 12 people (35.29%) suffering from mild-moderate erectile dysfunction, a man (2.94%) suffering from moderate erectile dysfunction, 2 people (5.88%) suffering from severe erectile dysfunction, and a man (2.94%) with no erectile dysfunction. The conclusion is patients with chronic kidney disease can lead to problems in the erectile function, because of influence from the above factors. Suggestion on this research is necessary to check blood testosterone levels and find more samples