Gervaise Blier to M. James Meredith (12 October 1962)

https://egrove.olemiss.edu/mercorr_pro/2147/thumbnail.jp

Extending WorldMap to Make It Easier for Humanists and Others to Find, Use, and Publish Geospatial Information

WorldMap is being developed by the Center for Geographic Analysis at Harvard University as an open source and open access online platform for visualizing and sharing spatial data. It has attracted considerable use since released in July of 2011. We propose making improvements to WorldMap which will transform it from mapping portal to geospatial node on the web. We will develop a new data catalog to expose WorldMap contents for interactive use in systems outside WorldMap. We will gather map metadata from map servers around the world to add to this catalog, eventually maintaining a complete index of map services. To improve search in a metadata-weak map services environment we will add the capability to search by time; develop a mechanism for exposing feature level text to layer search; and use rankings, usage statistics and internal links to weight search results. We will also enable users to create temporal gazetteers and contribute them to a common crowd-sourced gazetteer

Alien Registration- Blier, Rose D. (Dover-Foxcroft, Piscataquis County)

https://digitalmaine.com/alien_docs/10521/thumbnail.jp

The noradrenergic symptom cluster: clinical expression and neuropharmacology

Signs and symptoms of depression can be linked to one or more monoaminergic systems, specifically the norepinephrine (NE), the dopamine (DA), and the serotonin (5-HT) systems. In particular, the modulation of energy, vigilance, and arousal can be directly linked to the NE system. There is, however, a great deal of overlap in the modulation of the symptoms of depression between these monoaminergic systems. There are considerable reciprocal interactions between the NE, DA, and the 5-HT systems. When using a selective serotonin reuptake inhibitor (SSRI), for example, 5-HT transmission is enhanced, but at the same time there is a dampening of the activity of NE and DA neurons through inhibitory 5-HT2A and 5-HT2C receptors, respectively. This could explain the residual symptoms of fatigue, lack of energy, and anhedonia, often seen after patients present an overall positive response to a SSRI. Using a dual 5-HT and NE reuptake inhibitor (SNRI), such as milnacipran, would result in an additional increase in NE activity. Futhermore, inhibiting NE reuptake increases DA availability in the frontal cortex since DA is mainly cleared by the NE transporters in several brain regions. A risk inherent in increased NE activity is that of provoking anxiety. This is avoided however by the attenuation of the phasic reactivity of the firing of NE neurons through prolonged administration of SSRI and SNRI

Effects of temperature on in vitro sediment reworking processes by a gallery biodiffusor, the polychaete Neanthes virens

Temperature-induced variations in bioturbation could affect sediment mixing processes in the marine benthic environment. In this study, sediment reworking by Neanthes virens (Sars), a widely distributed polychaete in muddy sand communities of northern temperate latitudes, was studied under different temperature conditions representing winter (1°C), spring and fall (6°C), summer(13°C), and tide pool (18°C) temperatures in the lower St. Lawrence Estuary, Québec, Canada. Sediment reworking was quantified using inert fluorescent particles (luminophores) deposited at the sediment surface. Based on the 1-D luminophore distributions obtained after 5 and 30 d, the use of the specific ‘gallery-biodiffusor’ model allowed us to quantify both biodiffusion (Db) and biotransport (Vb) due to the organisms. Our results showed temperature effects on sediment transport. The lowest biotransport and biodiffusion coefficients were measured at 1 and 6°C and did not change with time. The highest biodiffusion occurred at 13°C for both sampling periods. At 18°C, biodiffusion was intermediate while biotransport was maximal. Differences between the 13°C biodiffusive transport and the other temperatures increased with time. Low transport values at 1 and 6°C suggest that a quiescent stage exists for this species at these temperatures, with sediment mixing occurring mostly during burrow construction. On the other hand, sediment mixing resulted from both the burrow construction and maintenance phases at higher temperatures (13 and 18°C)

A representation-learning approach for insurance pricing with images

Unstructured data are a promising new source of information that insurance companies may use to understand their risk portfolio better and improve the customer experience. However, these novel data sources are difficult to incorporate into existing ratemaking frameworks due to the size and format of the unstructured data. In this paper, we propose a framework to use street view imagery within a generalized linear model. To do so, we use representation learning to extract an embedding vector containing useful information from the image. This embedding is dense and low-dimensional, making it appropriate to use within existing ratemaking models. We find that there is useful information included in street view imagery to predict the frequency of claims for certain types of perils. This model can be used as-is in a ratemaking framework but also opens the door to future empirical research on attempting to extract the causal effect from images that lead to increased or decreased predicted claim frequencies. Throughout, we discuss the practical difficulties (technical and social) of using this type of data for insurance pricing

The longest-lived metazoan, Arctica islandica, exhibits high mitochondrial H2O2 removal capacities

A greater capacity of endogenous matrix antioxidants has recently been hypothesized to characterize mitochondria of long-lived species, curbing bursts of reactive oxygen species (ROS) generated in this organelle. Evidence for this has been obtained from studies comparing the long-lived naked mole rat to laboratory mice. We tested this hypothesis by comparing the longest-lived metazoan, the marine bivalve Arctica islandica (MLSP=507 y), with shorter-lived and evolutionarily related species. We used a recently developed fluorescent technique to assess mantle and gill tissue mitochondria’s capacity to consume hydrogen peroxide (H2O2) in multiple physiological states ex vivo. Depending on the type of respiratory substrate provided, mitochondria of Arctica islandica could consume between 3-14 times more H2O2 than shorter-lived species. These findings support the contention that a greater capacity for the elimination of ROS characterizes long-lived species, a novel property of mitochondria thus far demonstrated in two key biogerontological models from distant evolutionary lineages