11 research outputs found
Germline Mutations in FAN1 Cause Hereditary Colorectal Cancer by Impairing DNA Repair
- Author
- Balbín Milagros
- Bellido Fernando
- Blanco Ignacio
- Blay Pilar
- Brunet Joan
- Caldés Trinidad
- Capellá Gabriel
- Durán Mercedes
- Garré Pilar
- Guinó Elisabet
- Iglesias Silvia
- Lastra Enrique
- Lázaro Conxi
- López-Doriga Adriana
- Mina Leonardo B.
- Moreno Victor
- Navarro Matilde
- Pineda Marta
- Pons Tirso
- Puente Xose S.
- Pujana Miguel Ángel
- Rueda Daniel
- Sanz-Pamplona Rebeca
- Seguí Nuria
- Soto José Luís
- Surrallés Jordi
- Sánchez-Heras Ana Beatriz
- Urioste Miguel
- Valdés-Mas Rafael
- Valencia Alfonso
- Valle Laura
- Vidal August
- Villanueva Alberto
- Publication venue
- Publication date
- 30/09/2015
- Field of study
Identification of genes associated with hereditary cancers facilitates management of patients with family histories of cancer. We performed exome sequencing of DNA from 3 individuals from a family with colorectal cancer who met the Amsterdam criteria for risk of hereditary nonpolyposis colorectal cancer. These individuals had mismatch repair-proficient tumors and each carried nonsense variant in the FANCD2/FANCI-associated nuclease 1 gene (FAN1), which encodes a nuclease involved in DNA inter-strand cross-link repair. We sequenced FAN1 in 176 additional families with histories of colorectal cancer and performed in vitro functional analyses of the mutant forms of FAN1 identified. We detected FAN1 mutations in approximately 3% of families who met the Amsterdam criteria and had mismatch repair-proficient cancers with no previously associated mutations. These findings link colorectal cancer predisposition to the Fanconi anemia DNA repair pathway, supporting the connection between genome integrity and cancer risk
Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults
- Author
- Abbas Rezaianzadeh
- Abdonas Tamosiunas
- Abdul Basit
- Abdul Hamid Zargar
- Abdullah Alkandari
- Abdullatif Husseini
- Abhijit Sen
- Abla M Sibai
- Abu Am Hanif
- Adela Chirita-Emandi
- Adelheid Weber
- Adetoyeje Y Oyeyemi
- Adewale L Oyeyemi
- Adolfo Rubinstein
- Adoubi Kassi Anicet
- Adroaldo Cesar Araujo Gaya
- Afshin Ostovar
- Agnes L Kadvan
- Agneta Sjöberg
- Agneta Yngve
- Agnès Le Port
- Agustinus Soemantri
- Agustín Perez-Londoño
- Ahmad A Zainuddin
- Ahmad Faudzi Yusoff
- Ahmad Reza Dorosty
- Ahmed A Madar
- Aida Pilav
- Aïcha Soumaré
- Akaninyene Otu
- Akihiro Yoshihara
- Akkumis Salhanova
- Akram Pourshams
- Ala'a Alkerwi
- Alain Morejon
- Alanna G da Silva
- Albertino Damasceno
- Alberto Barceló
- Alberto Palloni
- Albina A Fakhretdinova
- Alejandro Diaz
- Aleksander Giwercman
- Aleksandra Gomula
- Aleksandra Piwonska
- Alessandro Gialluisi
- Aletta E Schutte
- Alexander D Deev
- Alexandra M Cucu
- Alexandre C Pereira
- Alfonso Siani
- Alfonso Sousa-Poza
- Ali Ahmadi
- Ali Akbar Shayesteh
- Ali Esmaeili
- Ali Ghanbari
- Ali Reza Safarpour
- Alice Bonilla-Vargas
- Alicia Matijasevich
- Alina G Platonova
- Alina Kerimkulova
- Aline Meirhaeghe
- Aline P Batista
- Alireza Ansari-Moghaddam
- Alireza Khosravi
- Alireza Moslem
- Alireza Sadjadi
- Alisha N Wade
- Alison J Hayes
- Alison J Price
- Allan G Hill
- Allan Linneberg
- Almaz Sharman
- Altan Onat
- Aluisio Jd Barros
- Alun Evans
- Amalia De Curtis
- Amanda G Thrift
- Amanda J Cross
- Amaneh Shayanrad
- Ambady Ramachandran
- Amelia C Crampin
- Amina Barkat
- Amir Houshang Mehrparvar
- Amirabbas Momenan
- Ana Azevedo
- Ana B Crujeiras
- Ana Barradas-Pires
- Ana Carolina Mgn de Sá
- Ana D González-Alvarez
- Ana Henriques
- Ana I Rito
- Ana Jelaković
- Ana Maria B Menezes
- Ana P Ortiz
- Ana Paula C Cândido
- Anabela Mota-Pinto
- Anar Dushpanova
- Anastasia Markaki
- Anders Grøntved
- Andre L Guimaraes
- Andre P Kengne
- Andrea Gazzinelli
- Andrea Gualtieri
- Andrea Rodriguez-Martinez
- Andrea Rvr Horimoto
- Andrea Schneider
- Andrea Y Rodríguez
- Andrea Zentai
- Andreas Stang
- Andreia N Pizarro
- Andrew Kingston
- Andrew Reynolds
- Andrew Wong
- Andrzej Galbarczyk
- Andrzej Pająk
- Andrzej Więcek
- Anelise Reis Gaya
- Aneta Grajda
- Aneta Weres
- Anette Varbo
- Angel R Gonzalez
- Angela Chetrit
- Angela Döring
- Angela Spinelli
- Angelika Schaffrath Rosario
- Angelique Chan
- Angélica M Ochoa-Avilés
- Anie Marcil
- Anil Poudyal
- Anja L Madsen
- Anja Schienkiewitz
- Anna Bartosiewicz
- Anna Bugge
- Anna Fijalkowska
- Anna Jansson
- Anna V Alieva
- Annamari Lundqvist
- Anne A Bjerregaard
- Anne Chinnock
- Anne Juolevi
- Anne Taylor
- Anne Tjonneland
- Anneke Blokstra
- Annette J Dobson
- Annette Peters
- Annika Rosengren
- Anthony Kafatos
- Antonia Trichopoulou
- Antonio Bernabe-Ortiz
- Antonio Cabrera de León
- Antonio M Silva
- Antonio Mistretta
- Antonio Pedro Graça
- Antonio Prista
- Antonis Zampelas
- Antonisamy Belavendra
- Anu Mishra
- Anwar M Batieha
- Archie W Rayner
- Areti Triantafyllou
- Argyro Karakosta
- Ari Voutilainen
- Aristides M Machado-Rodrigues
- Arnaud Chiolero
- Aroor Bhagyalaxmi
- Arsalan Khaledifar
- Artur Mazur
- Arvind Pandey
- Arwa M Alshangiti
- Aryeh D Stein
- Asher Fawwad
- Attilio Rigotti
- Atul Trivedi
- Augustin F Beybey
- Augustine N Odili
- Augusto Di Castelnuovo
- Aung Soe Htet
- Ausra Petrauskiene
- Avula Laxmaiah
- Axel C Carlsson
- Aya Mostafa
- Ayman A Zayed
- Azaliia M Tuliakova
- Azhar Dyussupova
- Azim Nejatizadeh
- Azli Baharudin
- Åsa Ågren
- Badreya Al-Lahou
- Bagher Larijani
- Bahareh Kheiri
- Bahman Cheraghian
- Bakary Jallow
- Baltazar Nunes
- Barbara Heude
- Barbara Thorand
- Barry M Popkin
- Batyrbek Assembekov
- Beatriz D Schaan
- Bee Koon Poh
- Behrooz Hamzeh
- Bekbolat Zholdin
- Belgin Unal
- Belong Cho
- Ben Schöttker
- Benjamin Acosta-Cazares
- Benoit Salanave
- Benson M Kazembe
- Bente Sparboe-Nilsen
- Bernard Maire
- Bernardo L Horta
- Bernhard O Boehm
- Bert-Jan van den Born
- Bettina Bringolf-Isler
- Bharathi Viswanathan
- Bhawesh Koirala
- Bihungum Bista
- Bill Stavreski
- Bin Zhou
- Bing Zhang
- Birgit Linkohr
- Biruta Velika
- Blanca Sandra Ruiz-Betancourt
- Bo Werner
- Boban Mugoša
- Bogdan Wojtyniak
- Bojan Jelaković
- Bontha V Babu
- Boyd A Swinburn
- Börge Schmidt
- Branimir Leskošek
- Breige A McNulty
- Brian Oldenburg
- Brooklyn Fraser
- Bruna Gonçalves Cordeiro da Silva
- Buthaina M Alkhatib
- Børge G Nordestgaard
- Caleb Ochimana
- Calogero Saieva
- Calvin Ke
- Camilla T Damsgaard
- Carl Lachat
- Carla Menêses Hardman
- Carlo Maria Barbagallo
- Carlos A Aguilar-Salinas
- Carlos O Mendivil
- Carlos P Boissonnet
- Carmen Iñiguez
- Carolina B Tarqui-Mamani
- Caroline H Fall
- Caroline Ramos de Moura Silva
- Carsten O Schmidt
- Cassiano Ricardo Rech
- Catherine Kyobutungi
- Catterina Ferreccio
- Cecilia Björkelund
- Cecily Kelleher
- Cesar G Victora
- Cézane P Reuter
- Chandini Nekkantti
- Chao Qiang Jiang
- Charalambos A Hadjigeorgiou
- Charles Agyemang
- Charles K Mondo
- Charles Lunogelo
- Charles Sossa Jérome
- Charlie Lim
- Charlotte B Ottendahl
- Charmaine A Duante
- Charumathi Sabanayagam
- Chiara Donfrancesco
- Chien-An Sun
- Chien-Jen Chen
- Ching-Yu Cheng
- Chinh Nguyen Huu
- Chinwuba Ijoma
- Chongjian Wang
- Chris Cowell
- Christa L Lilly
- Christa Meisinger
- Christian Gieger
- Christina C Dahm
- Christina Howitt
- Christina Mavrogianni
- Christine Cameron
- Christophe Tzourio
- Christopher J Paciorek
- Chung T Nguyen
- Cihangir Erem
- Claes Ohlsson
- Clara Homs
- Claudia M Hormiga
- Cláudia S Minderico
- Clicerio González-Villalpando
- Clive Osmond
- Coimbatore Subramaniam Shanthirani
- Con Burns
- Constance Schultsz
- Constanta Huidumac Petrescu
- Cora L Craig
- Correia Júnior Marco Aurélio de Valois
- Cosmin R Cojocaru
- Cristina P Padez
- Crizian G Saar
- Cynthia M Pérez
- Cyrus Cooper
- Daan Kromhout
- Dalia Luksiene
- Damaskini Valvi
- Damian K Francis
- Dan Zhu
- Daniel Bia
- Daniel Fernández-Bergés
- Daniel Ferrante
- Daniel G Vasques
- Daniel Lemogoum
- Daniel Weghuber
- Daniela Galeone
- Daniela Kállayová
- Daniela Pierannunzio
- Daniela Rodrigues
- Daphne Lai
- Daphne Mirkopoulou
- David A Gonzalez-Chica
- David De Ridder
- David Faeh
- David Goltzman
- Davide Noto
- Davood Khalili
- Deborah C Malta
- Debra S Judge
- Deena Al Asfoor
- Deepak N Amarapurkar
- Delphine De Smedt
- Demetre Labadarios
- Denise Eldemire-Shearer
- Dermot O'Reilly
- Dénes Molnár
- Diana A Santos
- Diane T Meto
- Dianna J Magliano
- Dickman Gareta
- Diego Augusto Santos Silva
- Diego G Christofaro
- Diego Salmerón
- Diego Vanuzzo
- Dimitrios Papandreou
- Dimitrios Poulimeneas
- Dimitrios Trichopoulos
- Dirk De Bacquer
- Dirk Vanderschueren
- Dominique Cottel
- Dominique Hange
- Dong Zhao
- Dongfeng Gu
- Dora Romaguera
- Doris Stöckl
- Dorja Vocanec
- Doroteia A Höfelmann
- Dusko J Bjelica
- Dušan Grafnetter
- Duygu Islek
- Dwi Hapsari Tjandrarini
- E Shyong Tai
- Ebrahim Eftekhar
- Ebrahim Ghaderi
- Eduardo Capuano
- Eduardo Salazar Martinez
- Edward F Fottrell
- Edward Janus
- Edward W Gregg
- Edwige Landais
- Edyta Łuszczki
- Eero O Kajantie
- Efthymios Kapantais
- Eha Nurk
- Ei Ei K Nang
- Eiji Oda
- Ekaterina Chikova-Iscener
- Ekaterina Stoyanova
- Elaine Dennison
- Elaine M Murtagh
- Eldridge Ferrer
- Elena Anufrieva
- Elena Bogova
- Elena Pahomova
- Elena Sacchini
- Elena V Skoblina
- Eleonora d'Orsi
- Elias F Gudmundsson
- Elin Kolle
- Elin P Sørgjerd
- Elio Riboli
- Elisabete Ramos
- Elisabetta L Romeo
- Eliza Cinteza
- Eliza Markidou Ioannidou
- Ellina M Iakupova
- Elling Bere
- Ellis Owusu-Dabo
- Ellisiv B Mathiesen
- Elnaz Faramarzi
- Els Clays
- Else Karin Grøholt
- Elvis Oa Wambiya
- Elvynna Leong
- Elysée Claude Bika Lele
- Elzbieta Dziankowska-Zaborszczyk
- Eman Aly
- Emanuel Zitt
- Emanuela Gualdi-Russo
- Emanuela Pettenuzzo
- Emiel Hoogendijk
- Emily B Wong
- Emily Sonestedt
- Emma Ruiz Moreno
- Emmanuel Cohen
- Emmanuella Magriplis
- Eng Joo Tan
- Enguerran Macia
- Enisa Kujundzic
- Enrique Gutiérrez González
- Enzo Manzato
- Erfan Ghasemi
- Eric Monterrubio-Flores
- Erik J Timmermans
- Erik Lykke Mortensen
- Erkin Mirrakhimov
- Ertugrul Celikcan
- Eruke E Egbagbe
- Espen Bjertness
- Esteban Carmuega
- Esther Lopez-Garcia
- Esther M González-Gil
- Ethel Santacruz
- Eugène Sobngwi
- Eunice Ugel
- Eva Corpeleijn
- Eva Gerdts
- Eva Karaglani
- Eva Martos
- Evangelia Tzala
- Ewelina Czenczek-Lewandowska
- Éva Kovács
- Fabian Rohner
- Fabián Méndez
- Fabio Galvano
- Fadi J Charchar
- Fadia AlBuhairan
- Fangfang Chen
- Farahnaz Joukar
- Farhad Moradpour
- Farhad Pourfarzi
- Farhad Zamani
- Fariborz Mansour-Ghanaei
- Farid Najafi
- Farshad Farzadfar
- Farzad Hadaegh
- Fatai A Maruf
- Fatemeh Malekzadeh
- Fatima Zahra Laamiri
- Felicia Cañete
- Felipe F Casanueva
- Felipe V Cureau
- Felix Gutzwiller
- Felix K Assah
- Felix O Kaducu
- Felix P Phiri
- Fereidoun Azizi
- Fernanda Cunha Soares
- Fernando Rigo
- Fernando Rodríguez-Artalejo
- Félicité Tchibindat
- Fikru Tullu
- Flavio D Fuchs
- Flavio Nervi
- Flora Am Ukoli
- Flora Bacopoulou
- Florian Muca
- Francesco Branca
- Francesco Gianfagna
- Francesco Panza
- Francesco Pistelli
- Francis Delpeuch
- Francis Morey
- Francisco de Assis Guedes de Vasconcelos
- Francisco J Felix-Redondo
- François F Kaze
- Frank Claessens
- Frank J Rühli
- Frank Tanser
- Fred Michel Paccaud
- Fred Nuwaha
- Freda Pitakaka
- Frederic Gottrand
- Frederick C Wu
- Frøydis N Vik
- Furusawa Takuro
- G K Mini
- Gabriel M Leung
- Gabriele Eiben
- Gabriele Nagel
- Gabriella Gruden
- Gailute Bernotiene
- Galina Obreja
- Gareth Stratton
- Garry Jennings
- Garry R Brian
- Geetha R Menon
- Genc Burazeri
- Geofrey Musinguzi
- Georg Lappas
- Georg Posch
- George Ll Machado-Coelho
- George Moschonis
- George S Stergiou
- Georgia Vourli
- Georgina Gómez
- Gerald Jarnig
- Gerhard Sulo
- Gerson Ferrari
- Gert Bm Mensink
- Gilad Twig
- Gilda Estela Benitez Rolandi
- Giletta Matteo
- Giota Touloumi
- Giovanna Masala
- Giovanni de Gaetano
- Giovanni Veronesi
- Giovanni Viegi
- Giuseppe Grosso
- Gladys E Maestre
- Glen Gironella
- Godsent C Isiguzo
- Gonzalo Valdivia
- Goodarz Danaei
- Gowri Mahasampath
- Graziella Bruno
- Graziella D'Arrigo
- Grazyna Jasienska
- Gregor Jurak
- Gregor Starc
- Gregorio Varela-Moreiras
- Gretchen A Stevens
- Grethe S Tell
- Gry Schultz
- Grzegorz Sobek
- Guadalupe Echeverría
- Guadalupe Longo Abril
- Guang Ning
- Guanghui Dong
- Guansheng Ma
- Guillermo Frontera
- Guillermo Sequera
- Gul Ergor
- Gulmira Aitmurzaeva
- Gustavo Velasquez-Melendez
- Guy De Backer
- Guy Fagherazzi
- Günay Can
- Günther Fink
- Gwenaëlle Le Coroller
- Gyulli M Kazakbaeva
- Ha Tp Do
- Haakon E Meyer
- Habiba Ben Romdhane
- Haiquan Xu
- Hajer Aounallah-Skhiri
- Halima Al-Hinai
- Halyna Pavlyshyn
- Hamed Pouraram
- Hamid Hakimi
- Hamideh Sabbaghi
- Han Cg Kemper
- Hana Shimizu-Furusawa
- Hana Zamrazilová
- Hanan F Abdul Rahim
- Hanna K Tolonen
- Hanna Nalecz
- Hanno Ulmer
- Hannu Mt Uusitalo
- Hans Concin
- Hanspeter Stamm
- Harald Geiger
- Haroldo S Ferreira
- Harshpal S Sachdev
- Harunobu Nakamura
- Hassan Aguenaou
- Hazzaa M Al-Hazzaa
- Heba M Fouad
- Hedley K Quintana
- Heidi Klakk
- Helen Gonçalves
- Helena Krizan
- Helena Nogueira
- Helle-Mai Loit
- Helmut Schröder
- Heloísa Bettiol
- Henrike Galenkamp
- Henry Völzke
- Herculina S Kruger
- Herman Borghs
- Herman Schargrodsky
- Hermann Brenner
- Hermann Pohlabeln
- Hermine T Mopa
- Hélène Delisle
- Himanshu K Chaturvedi
- Hoang Van Minh
- Holger Theobald
- Hon-Yen Wu
- Hongsheng Bi
- Honor Bixby
- Hossein Poustchi
- Hsien-Ho Lin
- Huashuai Chen
- Huda M Al Hourani
- Hui Cai
- Huijun Wang
- Hung-Kwan So
- Husam F Alomirah
- Hyeon Chang Kim
- Hynek Pikhart
- Ian R Hambleton
- Ian Rouse
- Ida Maria Schmidt
- Idowu O Senbanjo
- Idris Guessous
- Igor Spiroski
- Ildar Fakhradiyev
- Ilona Nenko
- Ilpo Tapani Huhtaniemi
- Ilse Msl Khouw
- Imelda A Agdeppa
- Imperia Brajkovich
- Imran Ahmed
- Imre Janszky
- Ina S Santos
- Indah S Widyahening
- Indrapal I Meshram
- Inés Sánchez Rodríguez
- Inge Huybrechts
- Inger Ariansen
- Ingunn Holden Bergh
- Ioannis Pagkalos
- Ionela M Pascanu
- Iqbal Bata
- Iraj Mohebbi
- Iraj Nabipour
- Irene Gm van Valkengoed
- Irfan Nuhoğlu
- Irina Kovalskys
- Iris Pigeot
- Isabel O Oliveira
- Isabelle Herter-Aeberli
- Ishag Adam
- Isti I Fujiati
- Iulia Jurca Simina
- Iuliia A Rusakova
- Ivaila Y Ivanova-Pandourska
- Ivan Pećin
- Ivana Radic
- Iveta Pudule
- Ivo Rakovac
- Izet Bajramovic
- J Jaime Miranda
- Jaakko Mursu
- Jaakko Tuomilehto
- Jacek J Jóźwiak
- Jaco De Bacquer
- Jacqueline F Price
- Jacqueline Ramke
- Jakob Tarp
- Jakub Stokwiszewski
- Jalila El Ati
- James Bentham
- James E Bennett
- James P Wirth
- Jamila Abubakar Garba
- Jan A Staessen
- Jan-Walter De Neve
- Jana Klanova
- Jana Kratenova
- Jana Námešná
- Jane Dp Renner
- Janette Walton
- Janice L Lukrafka
- Janina Petkeviciene
- Janine Clarke
- Janne S Tolstrup
- Jannicke Igland
- Japhet Killewo
- Jardena J Puder
- Jari J Jokelainen
- Jaume Marrugat
- Javad Aghazadeh-Attari
- Javad Harooni
- Jawad A Al-Lawati
- Jean Claude N Mbanya
- Jean Dallongeville
- Jean Ferrieres
- Jean Woo
- Jean-Bernard Ruidavets
- Jean-Michel Gaspoz
- Jean-René M'Buyamba-Kabangu
- Jeannette Klimont
- Jeannette Lee
- Jelena Kos
- Jennifer L Baker
- Jennifer Servais
- Jenny M Kindblom
- Jeonghee Lee
- Jeongseon Kim
- Jeremy M Jacobs
- Jeroen de Bont
- Jerzy Chudek
- Jesus D Melgarejo
- Jesus Vioque
- Jesús Humberto Gómez Gómez
- Jesús Ibarluzea
- Jia Li Duan
- Jianfeng Wu
- Jiang He
- Jie Hao
- Jie Mi
- Jim I Mann
- Jin Soo Moon
- Jing Liu
- Jingli Gao
- Jitendra Jonnagaddala
- Joana Araújo
- Joana Carvalho
- Joanna Baran
- Joanne Katz
- Joany Mariño
- Joao Luiz Bastos
- Joaquin Barnoya
- João Breda
- João M Pedro
- Jochanan Stessman
- Jody C Miller
- Joel Gr Roy
- Johan G Eriksson
- Johan Sundström
- Johan Van der Heyden
- Johann Willeit
- Johanna A Otero
- Johanna Gunnlaugsdottir
- Johanna M Geleijnse
- Johannes Brug
- John Amoah
- John Tuitele
- Jolanda Hyska
- Jolanda Ma Boer
- Jolanta Slowikowska-Hilczer
- Jonathan E Shaw
- Jonathan Giovannelli
- Jordi Sunyer
- Jorge Bezerra
- Jorge Escobedo-de la Peña
- Jorge Mota
- Jorge Motta
- Jose G Boggia
- Jose Sánchez-Abanto
- Josep Redon
- Joseph Cacciottolo
- José A Casajús
- José Camolas
- José Eugenio Lozano
- José María Huerta
- José R Banegas
- Josipa Josipović
- Jost B Jonas
- Jostein Steene-Johannessen
- Jouko L Saramies
- Juan A Rivera
- Juan Francisco Miquel
- Juan J Cruz
- Juan P González-Rivas
- Judit A Repasy
- Judith Benedics
- Judith Simons
- Juel Jarani
- Juergen Breckenkamp
- Juha Auvinen
- Jukka T Salonen
- Julianne Williams
- Julie Aarestrup
- Julie Taylor
- Julio Zuñiga Cisneros
- Jun Hata
- Jun Ma
- Juraci A Cesar
- Jurate Klumbiene
- Jurate Medzioniene
- Jussi Kauhanen
- Justina Vaitkeviciute
- Justyna Godos
- Justyna Leszczak
- Justyna Wyszyńska
- Jutta Stieber
- Juvenal Soares Dias-da-Costa
- Júlio Mello
- Jürgen König
- Jyh Eiin Wong
- Jyrki K Virtanen
- Jytte Halkjær
- Jørgen Meisfjord
- K R Thankappan
- Kaare Christensen
- Kai-Uwe Saum
- Kairat Davletov
- Kairit Mikkel
- Kamarul Imran Musa
- Kamel Ajlouni
- Kaosar Afsana
- Karen Morgan
- Karen Sparrenberger
- Karen Webster-Kerr
- Kari Kuulasmaa
- Karien Stronks
- Karin De Ridder
- Karin Schindler
- Karina Mary de Paiva
- Karl J Lackner
- Karl-Heinz Herzig
- Karl-Heinz Jöckel
- Karolina Miłkowska
- Kaspar Staub
- Katarzyna Dereń
- Katharina Maruszczak
- Kathrin Wolf
- Katia Biasch
- Katia V Bloch
- Katja B Leth-Møller
- Katsuyasu Kouda
- Kazem Mohammad
- Kazi M Jamil
- Keiu Nelis
- Kelias P Msyamboza
- Kelly Samara Silva
- Kenisha Russell Jonsson
- Kenji Shibuya
- Kenneth James
- Kevin I Norton
- Khadichamo Boymatova
- Khairil Si-Ramlee
- Khanh Le Nguyen Bao
- Khem B Karki
- Khuong Quynh Long
- Kim F Michaelsen
- Kim Overvad
- Kirsten Mehlig
- Kishwar Azad
- Km Venkat Narayan
- Ko Ko Zaw
- Kodanda R Kanala
- Kodavanti Mallikharjuna Rao
- Koen Van Herck
- Konrad Jamrozik
- Konstantinos D Tambalis
- Konstantinos Gkiouras
- Kotsedi Daniel K Monyeki
- Kouamelan Doua
- Kremlin Wickramasinghe
- Krishna K Aryal
- Krista Fischer
- Kristine Allin
- Kristyna Zejglicova
- Kumiko Ohara
- Kurt Widhalm
- Kyungwon Oh
- Labros S Sidossis
- Lachmie Lall
- Lacramioara Brinduse
- Laetitia Huiart
- Laila El Ammari
- Lalka S Rangelova
- Lariane M Ono
- Larissa Pruner Marques
- Lars Ängquist
- Lars Bo Andersen
- Lars Jøran Kjerpeseth
- Lars Lind
- Lars Wichstrøm
- Laura A Rodríguez-Villamizar
- Laura Censi
- Laura Gutierrez
- Laura Lauria
- Laura Torres-Collado
- Laura-María Compañ-Gabucio
- Lauren Lissner
- Leandra Abarca-Gómez
- Leanne M Riley
- Lechaba Tshepo
- Leila B Moreira
- Leila Houti
- Lekhraj Rampal
- Lela Shengelia
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- Valter Barbosa Filho
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- Vayia Rarra
- Vedrana Sember
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- Veronica Mocanu
- Vesna Juresa
- Vesselka L Duleva
- Victor M Herrera
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- Vijaya Lingam
- Viktoria Anna Kovacs
- Viktoriya Furdela
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- Viviana Guajardo
- Viviane C Cardoso
- Vladimir Kutsenko
- Wafaie W Fawzi
- Wan Mohamad Wan Bebakar
- Wan Nazaimoon Wan Mohamud
- Wei Zheng
- Wei-Cheng Lo
- Wei-Yen Lim
- Weili Yan
- Wen-Harn Pan
- Wenbin Wei
- Wendy Van Lippevelde
- Wenhua Zhao
- Wichai Aekplakorn
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- Winsome R Parnell
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- Wojciech Drygas
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- Wolfgang Ahrens
- Wolfgang Kratzer
- Xenophon Theodoridis
- Xiangjun Wang
- Xiaoguang Yang
- Xiaotian Liu
- Ximena Berrios Carrasola
- Xinyi Gwee
- Xiu-Hua Guo
- Xu Lin
- Xu Ma
- Xueling Sim
- Xun Tang
- Ya Xing Wang
- Yadlapalli S Kusuma
- Yajaira Briceño
- Yang Yang
- Yanhui Dong
- Yanina Zocalo
- Yanitsa V Zhecheva
- Yannis Manios
- Yanping Li
- Yemane Berhane
- Yeunsook Rho
- Yeva Movsesyan
- Yi Song
- Yi Zeng
- Yih Chung Tham
- Yiling J Cheng
- Yin Guo
- Ying-Wei Wang
- Yingfeng Zheng
- Yn-Tz Sung
- Yong Tao
- Yonghua Hu
- Yosef Farzi
- Yoto Yotov
- Youcef Laid
- Young-Ho Khang
- Yousef Saleh Khader
- Yu-Ling Yu
- Yuan He
- Yufang Bi
- Yuki Fujita
- Yulia Balanova
- Yuliya V Solovieva
- Yuna He
- Yunjiang Yu
- Yury P Nikitin
- Yves Kameli
- Yves Martin-Prevel
- Yvonne T van der Schouw
- Zahra Mohammadi
- Zbigniew Gaciong
- Zbigniew Kulaga
- Zengchang Pang
- Zhamilya Battakova
- Zhamyila Usupova
- Zhanna Kalmatayeva
- Zhen-Yu Zhang
- Zhengming Chen
- Ziad A Abdeen
- Zivka Dika
- Zlatko Fras
- Zulfiqar A Bhutta
- Zulfiya Abdurrahmonova
- Zumin Shi
- Łukasz Kryst
- Publication venue
- Publication date
- 01/03/2024
- Field of study
Background Underweight and obesity are associated with adverse health outcomes throughout the life course. We
estimated the individual and combined prevalence of underweight or thinness and obesity, and their changes, from
1990 to 2022 for adults and school-aged children and adolescents in 200 countries and territories.
Methods We used data from 3663 population-based studies with 222 million participants that measured height and
weight in representative samples of the general population. We used a Bayesian hierarchical model to estimate
trends in the prevalence of different BMI categories, separately for adults (age ≥20 years) and school-aged children
and adolescents (age 5–19 years), from 1990 to 2022 for 200 countries and territories. For adults, we report the
individual and combined prevalence of underweight (BMI <18·5 kg/m2) and obesity (BMI ≥30 kg/m2). For schoolaged children and adolescents, we report thinness (BMI <2 SD below the median of the WHO growth reference)
and obesity (BMI >2 SD above the median).
Findings From 1990 to 2022, the combined prevalence of underweight and obesity in adults decreased in
11 countries (6%) for women and 17 (9%) for men with a posterior probability of at least 0·80 that the observed
changes were true decreases. The combined prevalence increased in 162 countries (81%) for women and
140 countries (70%) for men with a posterior probability of at least 0·80. In 2022, the combined prevalence of
underweight and obesity was highest in island nations in the Caribbean and Polynesia and Micronesia, and
countries in the Middle East and north Africa. Obesity prevalence was higher than underweight with posterior
probability of at least 0·80 in 177 countries (89%) for women and 145 (73%) for men in 2022, whereas the converse
was true in 16 countries (8%) for women, and 39 (20%) for men. From 1990 to 2022, the combined prevalence of
thinness and obesity decreased among girls in five countries (3%) and among boys in 15 countries (8%) with a
posterior probability of at least 0·80, and increased among girls in 140 countries (70%) and boys in 137 countries (69%)
with a posterior probability of at least 0·80. The countries with highest combined prevalence of thinness and
obesity in school-aged children and adolescents in 2022 were in Polynesia and Micronesia and the Caribbean for
both sexes, and Chile and Qatar for boys. Combined prevalence was also high in some countries in south Asia, such
as India and Pakistan, where thinness remained prevalent despite having declined. In 2022, obesity in school-aged
children and adolescents was more prevalent than thinness with a posterior probability of at least 0·80 among girls
in 133 countries (67%) and boys in 125 countries (63%), whereas the converse was true in 35 countries (18%) and
42 countries (21%), respectively. In almost all countries for both adults and school-aged children and adolescents,
the increases in double burden were driven by increases in obesity, and decreases in double burden by declining
underweight or thinness.
Interpretation The combined burden of underweight and obesity has increased in most countries, driven by an
increase in obesity, while underweight and thinness remain prevalent in south Asia and parts of Africa. A healthy
nutrition transition that enhances access to nutritious foods is needed to address the remaining burden of
underweight while curbing and reversing the increase in obesit
Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2/ERIC-PPCI): a single-blind randomised controlled trial.
- Author
- Aarøe Jens
- Abbass Hakam
- Abella-Ovalle Luis
- Adam Zul
- Agyemang Michael
- Ahlehof Ole
- Ahlehoff Ole
- Ahmad Yousif
- Al-Lamee Rasha
- Alberdi Lucía
- Aleti Shilpa
- Ali Danish
- Allen Kezia
- Alvares Wilson
- Alzuhairi Karam
- Amed Nadifa
- Anantharam Brijesh
- Andersen Grethe
- Andersen Henning Rud
- Anderson Michelle
- Andiapen Mervyn
- Andrews Michelle
- Ankersen Jens Peter
- Ansell Valerie
- Arango Amalia
- Armstrong Elissa
- Astarci Josenir
- Atkinson Emma
- Austin Rosalynn
- Avanzas Pablo
- Aziz Ahmed
- Azkhalil Mohammed
- Bales Emily
- Banerjee Prithwish
- Barclay Justin
- Barker Deborah
- Barker Joann
- Barmby David
- Bates Rachel
- Baucutt Karen
- Been Martin
- Beirnes Charmaine
- Bell Sheila
- Bennett Amy
- Bennett Lorraine
- Bernardo-Alba Pablo
- Berry Alan
- Berry Colin
- Besana Rissa
- Bhatre Gurbir
- Bhatti Rishma
- Bidle Amanda
- Bijsterveld Petra
- Bose Tuhina
- Boyle Georgina
- Brady Rebecca
- Braybrook Christine
- Breeze Jonathan
- Brennan Oliver
- Brett Sarah
- Brogan Richard
- Brown Janette
- Bucciarelli-Ducci Chiara
- Buchanan Louise
- Buelga-Díaz Covadonga
- Bueno Hector
- Bulluck Heerajnarain
- Burd Amanda
- Burnett Gillian
- Burtonwood Natalie
- Burunsuzoglu Senem
- Butler Robert
- Butler Robert
- Byrne Jean
- Bøtker Hans Erik
- Capel Robert
- Cappelen Helle
- Carruthers Gayle
- Carstensen Steen
- Castro Rafael
- Champney Felicity
- Chant Nicholas
- Charles Thabitha
- Chester Emma
- Chong Jun
- Christensen Erika Frischknecht
- Christiansen Evald Høj
- Christiansen Martin Kirk
- Christmas Natasha
- Chu Rebecca
- Chung Alan
- Cimas Teodorna
- Clapp Brian
- Clare Thomas
- Clarke Millie
- Clayton Tim
- Clifford Piers
- Cockayne Laura
- Colicchia Martina
- Collier Lucy
- Cooper Theresa
- Copas Andrew
- Copestick Jane
- Corps Ellie
- Corrigan Julie
- Cottam Victoria
- Cotton James
- Coward Paul
- Cox Emily
- Crause Jacolene
- Cruden Nick
- Cunliffe Denise
- Cunnington Michael
- Cuxton Josephine
- Dana Ali
- Dana Ali
- Darby Damaris
- Davies John
- Davies Justin
- Davies Nina
- de Cima Sara
- de la Hera Galarza Jesus Maria
- de la Roz Manuel
- De Mance Gianluigi
- De Sousa Phillipa
- Deen Zakhira
- del Valle Raquel
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- Denman Joanne
- Dias Priyanthi
- Dillon Angela
- Dimond Kirsty
- Din J.
- Dockerty Francesca
- Dodd Matthew
- Douglas James
- Douthwaite Rebecca
- Drew Martin
- Díaz-González Eloy
- East Clare
- Eaton Michelle
- Ellert Julia
- Elliott Rebecca
- Ellis Howard
- Elshiekh Dr Mohamed
- Elston Ruth
- Emery Lisa
- Engstrom Thomas
- Erntgaard Dennis
- Evans Richard
- Fahrai Gregor
- Farag Mohamed
- Fath-Orboubadi DR Fazin
- Fati Pene
- Fayed Hossam
- Fente Ana I.
- Fernandez Olga
- Fernández Elena
- Fernández-Carral Marcos Fernández-Carral
- Fernández-Gonzalo David
- Fernández-Mallo Francisco J.
- Finch Amanda
- Fleming Catherine
- Fofie Joyce
- Foundun Aboo
- Francis Rohin
- Francis Rohin
- Frank Emma
- Freeman Philip
- Freestone Beth
- Fuentes María D.
- Gale Joanne
- Gale Joanne
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- Gamma Reto
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- García-Alonso María
- García-Castro Alfonso
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- Germon Rachel
- Gibson Kirsty
- Giebner Matthias
- Gill Abby
- Gill Simrat
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- Given Rachel
- Glen James
- Goitia-Martín Javier
- Gomes Sara
- Gorog Diana
- Gorog Diana A
- Gowing Anne
- Gracey Jay
- Grech Ever
- Greenwood John
- Greenwood John P
- Gregory Sally
- Gregson Lisa
- Griffiths Huw
- Grosser Konrad
- Gue Ying
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- Gunn Julian
- Guyatt Samantha
- Hall Charlotte
- Hall Ian
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- Hansen Henrik Steen
- Hansen Knud Nørregård
- Hansen Poul Anders
- Hansen Troels Martin Hansen
- Harfield Scott
- Harkins Ruth
- Harland Charlotte
- Hartley Amy
- Hausenloy Derek J
- Haworth Peter
- Hayes Michelle
- Hedegaard Kim Witting
- Hedrera Segundo A.
- Helqvist Steffen
- Henderson Rob
- Hendry Cara
- Heppell Richard
- Hermosa Francisco J.
- Hernández Ernesto
- Hetherington Daniel
- Hetherington Simon
- Hildick-Smith David
- Hindle Julia
- Hjort Jakob
- Hoare Amy
- Hobson Alex
- Hodgson Adrian
- Hodierne Jeremy
- Hogrefe Kai
- Holloway Rachael
- Holmvang Lene
- Hoole Stephen
- Hopper Oliver
- Horler Stephanie
- Horner Victoria
- Horwood Carol
- Houghton Richard F
- Housley Kay
- Howe Serena
- Hudson Karen
- Hussein Jodie
- Hyndman Samantha
- Ibanez Borja
- Iglesias-Llaca Fernando
- Ilsley Mary
- Ingoldby Fiona
- Iqbal , Javid
- Iversen Allan
- Jack Pearse
- Jackson-Lawrence Karen
- Jakobsen Lars
- Jamal Zahra
- Jamieson-Leadbitter Caroline
- Jennison Alan
- Jensen Lisette Okkels
- Jensen Svend Eggert
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- Jones Sophie
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- Joyce Joan
- Junker Anders
- Jørgensen Erik
- Kaeng Lee
- Kaltoft Anne
- Kanji Rahim
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- Kaur-Babooa Priya
- Kaus Henning
- Keate Kirstie
- Kelbæk Henning
- Kelly Julie
- Kelsall Nicci
- Kempel John
- Kennard Sarah
- Khan Arif
- Kharbanda Rajesh
- Kharbanda Rajesh K
- Khawaja Muhammed Zeeshan
- Knight Rosemary
- Knighton Abigail
- Kobson Barbara
- Kodoth Vivek
- Kolakaluri Laurel
- Koothoor Raiji
- Korsgaard Mette Tidemand
- Kotecha Tushar
- Krishnamoorthy Suresh
- Krishnamurthy Arvindra
- Kristensen Steen Dalby
- Laca Sonia I.
- Lakeman Nicki
- Langrish Jeremy
- Lasica Ratko
- Lassen Jens Flensted
- Laurence Julia
- Lazar Nicoleta
- Leathers Chris
- Lee Dr Kaeng
- Lee Kelvin
- Lee Sandra
- Lenzi Valentina
- Leonard Gerry
- Lippert Freddy K
- Llorente-Álvarez Susana
- Lloyd Steph
- Loder Chris
- Longbottom Colin
- Longman Kristel
- Lozano Iñigo
- Lucking Andrew
- Ludman Andrew
- Lønborg Jacob T
- Maart Clint
- Mackenzie Ailie
- Mackie Sarah
- Madsen Morten
- Maeng Michael
- Malik Iqbal
- Marber Michael
- Mark Bettina Løjmand
- Markham-Jones Helene
- Martin Katherine
- Martinez-González Eugenio
- Martins Joe
- Martínez-Bastida Ginés
- Martínez-Fernández César M.
- Martínez-Pérez Polácido J.
- Martínez-Valle Marta
- Massey Ian
- Mathur Anthony
- Matic Dragan
- Mcarthy Rachel
- McCormick Louise
- McFarlane-Henry Eleanor
- McGregor Andrew
- McLeod Jane
- McSkeane Anna
- Meade Tom
- Meadows Deborah
- Medina-Cameán Ana B.
- Mehmedbegovic Zlatko
- Merrick Angela
- Metherell Stella
- Middle Janet
- Milasinovic Dejan
- Milgate Sarah
- Mohiddin Saidi
- Mojela Idah
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- Moore Roger
- More Ranjit
- More Ranjit
- Moreby Berni
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- Morris Steve
- Morís César
- Mota Paula
- Mudd Alexandra
- Munir Shahzad
- Muriel-Velasco Ana
- Musa Anntoniette
- Musselwhite Janine
- Møller Ulla Kristine
- Nair Sunil
- Naves María C.
- Neal Debbie
- Nelthorpe Faye
- Neubauer Stephen
- Newman Hannah
- Nicholas Jennifer M
- Nicholson Anne
- Nicholson Susan
- Nonide Marta
- Norfolk Derek
- O'Connor John
- O'Donnell Joshua
- O'Kane Peter
- O'Neill James
- Oakes Trevor
- Ocampo Madelaine
- Odedra Toral
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- Oliver Victoria
- Oommen Anu
- Orr Sarah
- Paddy Loveth
- Padrón Remigio
- Panicker Abeesh Sadasiva
- Parsons Georgina
- Pascual Isaac
- Pascual Susana
- Patale Sheetal
- Pavlidis Antonis
- Pedersen Danny Mejsner
- Pedersen Frants
- Pedersen Karin Møller
- Pedersen Knud Erik
- Pedley Lauren
- Pejic Marijana
- Peláez María C.
- Pemberton Chris
- Pengelley Clare
- Penney Lucy
- Pepper Stacey
- Perara Divaka
- Perkins Alexander
- Phillips Hannah
- Phuyal Urmila
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- Polokova Karin
- Polwarth Gary
- Pomar-Amillo Ángeles
- Pozo-López Mónica
- Prendergast Bernard
- prentice Scott
- Preston Stephen
- Prodanovic Maja
- Prossora Mary
- Pulikal George
- Quintana Rosa B.
- Radford Elizabeth
- Radosavljevic-Radovanovic Mina
- Radovanovic Nebojsa
- Rai Amrit
- Raju Prashanth
- Rakhit Roby
- Rakhit Roby D
- Ramlall Manish
- Ramos Angelo
- Ratcliffe Amanda
- Raungaard Bent
- Ravkilde Jan
- Redington Andrew
- Redman Emily
- Redwood Simon
- Redwood Simon
- Reed Helen
- Reeve Christy
- Relph Chris
- Richardson James
- Riches Joanne
- Riddervold Ingunn Skogstad
- Riedel Ella
- Roberts Josh
- Robertson Steven
- Rodil-Díaz Juan A.
- Rondán Juan
- Ross David
- Roy Liby
- Roza César L.
- Rozado José
- Ryan Tony
- Ryding Alisdair
- Ryding Alisdair D
- Saclot Louie
- Samaniego Beatriz
- Sanchez-Vidal Ruth
- Sandhu Kully
- Sarti Charlotte
- Saunamäki Kari
- Saunders Heidi
- Savic Lidija
- Schmidt Michael R
- Schumacher Natasha
- Scott Kerry
- Sebastian Deepa
- Sebastian Deepti
- Segovia Eduardo
- Sevillano Annaliza
- Shaw Caroline
- Shelton Rhidian
- Shepherd Lucy
- Sherwood Martin
- Sidgwick Sian
- Simpson Holly
- Skipper Nicola
- Skov Charlotte Schmidt
- Smallwood Andrew
- Smee Joanna
- Smit Angelique
- Smith Bethany
- Smith Clare
- Smith Ian
- Smith Jan
- Smith Megan
- Smith Trevor
- Snow Tom
- Solieri Ashley
- Somers Kathryn
- Spence Sharon
- Spickett Helen
- Spinthakis Nicholas
- Stables Rod
- Staines Jocasta
- Stankovic Goran
- Stimson Leah
- Storey Robert F.
- Strike Philip
- Subotic Ida
- Suttling Anne
- Suárez Alfonso
- Suárez-Coto Raquel
- Suárez-Noriega Raquel
- Sørensen Henrik Toft
- Sørensen Rikke
- Tapp Luke
- Tawiah Cecilia
- Taylor Rebecca
- Terkelsen Christian Juhl
- Thambi Sunil
- Theodorou Nana
- Thim Troels
- Thomas Isobel
- Thompson Rebecca
- Thornborough Lauren
- Thornton Emma
- Thuesen Leif
- Thygesen Kristian
- Tilsted Hans Henrik
- Tipping Aoife
- Tomlinson Lucy
- Tomlinson Sharon
- Topic Dragan
- Tresguerres Jose M.
- Turner Charlotte
- Turner Jenny
- Turney Sharon
- Upton Robert
- Uscumlic Ana
- Van Dyck Laura
- Varma Madhusudhan
- Varma Madhusudhan
- Veerapen Jessry
- Vega-Fernández José L.
- Vegas-Valle Jose M.
- Veien Karsten
- Venugopal Vinod
- Vertue Mark
- Victor Saji
- Villadsen Anton Boel
- Villanueva María J.
- Villar-Fernández Lara
- Vinagrero María S.
- Viribay Fernando M.
- Vlad Ionela
- von Weitzel-Mudersbach Paul
- Vukcevic Vladan
- Vázquez-Suárez María
- Waddington Natalia
- Wain Jill
- Waitrak Paulina
- Waldron Molly
- Wallace Lauren
- Walshe Siobhan
- Walvin Tom
- Warner Karen
- Watkins Richard
- Watkinson Oliver
- Weatherlley Louise
- Webb Ian
- Webb Ian
- Wells Nicki
- Westwood Mark
- Wheeldon Nigel
- Whitehead Helena
- Whiteside Charlene
- Wilkinson Conor
- Wilson Karen
- Wittrock Daniel
- Wolyrum Mathias
- Woods Sarah
- Wragg Christopher
- Yellon Derek M
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2019
- Field of study
BACKGROUND: Remote ischaemic conditioning with transient ischaemia and reperfusion applied to the arm has been shown to reduce myocardial infarct size in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI). We investigated whether remote ischaemic conditioning could reduce the incidence of cardiac death and hospitalisation for heart failure at 12 months. METHODS: We did an international investigator-initiated, prospective, single-blind, randomised controlled trial (CONDI-2/ERIC-PPCI) at 33 centres across the UK, Denmark, Spain, and Serbia. Patients (age >18 years) with suspected STEMI and who were eligible for PPCI were randomly allocated (1:1, stratified by centre with a permuted block method) to receive standard treatment (including a sham simulated remote ischaemic conditioning intervention at UK sites only) or remote ischaemic conditioning treatment (intermittent ischaemia and reperfusion applied to the arm through four cycles of 5-min inflation and 5-min deflation of an automated cuff device) before PPCI. Investigators responsible for data collection and outcome assessment were masked to treatment allocation. The primary combined endpoint was cardiac death or hospitalisation for heart failure at 12 months in the intention-to-treat population. This trial is registered with ClinicalTrials.gov (NCT02342522) and is completed. FINDINGS: Between Nov 6, 2013, and March 31, 2018, 5401 patients were randomly allocated to either the control group (n=2701) or the remote ischaemic conditioning group (n=2700). After exclusion of patients upon hospital arrival or loss to follow-up, 2569 patients in the control group and 2546 in the intervention group were included in the intention-to-treat analysis. At 12 months post-PPCI, the Kaplan-Meier-estimated frequencies of cardiac death or hospitalisation for heart failure (the primary endpoint) were 220 (8·6%) patients in the control group and 239 (9·4%) in the remote ischaemic conditioning group (hazard ratio 1·10 [95% CI 0·91-1·32], p=0·32 for intervention versus control). No important unexpected adverse events or side effects of remote ischaemic conditioning were observed. INTERPRETATION: Remote ischaemic conditioning does not improve clinical outcomes (cardiac death or hospitalisation for heart failure) at 12 months in patients with STEMI undergoing PPCI. FUNDING: British Heart Foundation, University College London Hospitals/University College London Biomedical Research Centre, Danish Innovation Foundation, Novo Nordisk Foundation, TrygFonden
Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study
- Author
- A. Mohammed Kalakwa
- A. Nemer Ayoub
- Abantanga Francis A.
- Abatli Safa' Jamal
- Abbas Wisam
- Abbo Olivier
- Abdelbaqi Reem
- Abdelhady Dina Sobhy
- Abdelhafez Mohammad Omar Mohammad
- Abdelhamid Sultan S.
- Abdelmaksoud Sherif
- Abdelmoumen Roua
- Abdelmutalib Fakereldeen
- Abdul-Mumin Alhassan
- Abduljawad Fatima Mousa
- Abdullah Fizan
- Abdullah Mohd Yusof bin
- Abdulraheem Nurudeen
- Abdulrahman Alaa
- Abdulsalam Moruf Adekunle
- Abdunomonovich Dekhkonboev Avazjon
- Aboelela Ahmed
- Abouheba Mohamed
- Abrahamsson Kate
- Abrunhosa Matias Marcia
- Abu-Nejmah Fawzi
- Abuajaila Abdulsalam
- Abuattaya Adham Ashraf
- Abubakar Auwal M
- Abueideh Ahmad
- Abuhayyeh Husam Aldean
- Abuhlega Ma'aly A.
- Abukhalaf Sadi
- Abumunshar Ali Abdelhay
- Acuna Gaston
- Adams Stephen
- Adamu Sani
- Adanan Mohd Fitri Shukri bin Mohamed
- Adawi Ihda
- Adawi Samer
- Adawy Ahmad
- Ade-Ajayi Niyi
- Adegboyega Rilwan
- Ademuyiwa Adesoji
- Adesanya Opeoluwa
- Adhiwidjaja Cathline Freya
- Adofo-Ansong Nana
- Agboola Titiloye Hannah
- Agelebe Efeturi
- Aguilar Aguilar Faye
- Aguilar Gargurevich Prince Pamela
- Aguirre-Lopez Pastor
- Agulham Miguel Angelo
- Ahmad Hira
- Ahmad Zahidah Adlynee Haji
- Ahmed Hazem
- Ahmed Mahmoud Abdelfattah
- Ajai Olalekan Temitope
- Ajao Emmanuel Akinlabi
- Ajiboye Olalekan S.
- Ajrami Yara
- Ajwa Ahmad Elian Abu
- Akan M. Eren
- Akhbari Melika
- Akhter Nadeem
- Akova Fatih
- Al-Attar Hala M.
- Al-Halbouni Layana
- Al-Mamun Abdullah
- Al-Mayoof Ali Farooq
- Al-Momani Hashem M.
- Al-Mouakeh Ahmad
- Al-Rayyes Maisara
- Al-saleem Hasan Subhi Hasan Abu
- Al-Salhi Ashraf Ayman
- Al-Shwaikh Samar H.
- Al-Slaibi Ibrahim
- Al-Taher Raed Nael
- Al-Taher Raed Nael
- Al-Tammam Hiba
- Alakaloko Felix
- Alamrain Abdulwhhab Ayman Abu
- Alanguia Chipana Cathy Lee
- Alattas Khalid
- Alberto Carlos
- Albozidi Aya
- Alcántara Elvyn
- ALDIRAWI MOHAMMED A. M.
- Alebbini Mohanad Mutasem
- Alfoghi Mabroka
- Algabri Hayder Nadhim Obaid
- Alglaib Mohammed Meftah
- Alhamid Ahmad
- Alhamid Aos
- Alhassan Priscilla
- Ali Hassan
- Ali Karim Osamy
- Ali Liza
- Ali Mansour
- Alijla Sharif
- Alijla Sharif S.
- Aliwisat Ahmad Hasan
- Aljaboo Hajir
- Aljadidi Wesal Omar F. Saied
- Aljarad Ziad
- Alkareem Raghad mohammad abdu
- Almada Suad Ahmed
- Almadhoun Walaa
- Almasri Murad
- Almeida Aguiar Arthur
- Almeida Giovana
- Almengar Inas
- Almohamady Hisham
- Almosaibli Mohammad
- Almusleh Tasneem Fathi Hasan
- Alnaeri Ali
- Alnahhal Khaled
- Alonso Verónica
- Alosta Hasan Mustafa
- Alqarajeh Firas
- Alqor Mohammad Omar Ibrahim
- Alsaadi Nijmeh Nasser
- Alsaggaf Ameen
- Alsaied Amer
- Alser Mohammed
- Alser Osaid H.
- Alshaikhkhalil Haya Abdulnasser Ali
- Alshehri Abdullah
- Altaweel Ahmed
- Altın Merve
- Altokhais Tariq
- Altomi Mohamed
- Alturki Fahad
- Alvarado Zelada Jackelyne
- Alves Dutra da Silva Érika
- Alwadia Soha Marwan Salem
- Alwaggaa Nouriyah Ali
- Alzamari Ainaa Ata Mohammad
- Alzate Gallego Edgar
- Alzeer Asmahan Mohammad Suliman
- Alzerei Sulaiman T.
- Alzraikat Sayel H.
- Alzubair Afnan
- Alzughayyar Tareq Z.
- Amad Mohamed
- Amado Fernando
- Amaechi Chukwubinyelum
- Amah Christopher Chim
- Amarin Justin Z.
- Amarin Marzouq
- Ambriz-González Gabriela
- Ameh Emmanuel
- Amjad Muhammad Bin
- Amoabin Afua Amoabin
- Anatole Nzanzu
- Anatole Nzanzu Kipata
- Anaya Dominguez Marlene
- Anaya Firas
- Andrade Jerhy
- Andreussi Lorna
- Anicama Elias Rocio
- Annajjar Mohammad hasan
- Anntinea Jessmine
- Antunes Amanda
- Antunez-Mora Alexandra
- Anyomih Theophilus Teddy Kojo
- Anzelewicz Stefan
- Apaza Leon Jose Luis
- Appeadu-Mensah William
- Arabiat Esraa
- Arafa Mohamed Ahmed
- Arafat Hasan
- Aragão Liliana
- Arancibia Gutiérrez Elsa
- Aranda Sánchez Cristian Irela
- Arar Ahmad Samih
- Arauco Jenny
- Arbab Hana
- Arboleda Jenny
- Aremo Anuoluwapo
- Arnadóttir Helena
- Arnaud Alexis P
- Arnold Marion
- Arnoletto Lucia Beatriz
- Arrmali Saddam
- Arrmalli Lina Ali
- Arshad Muhammad
- Arthur Felicity
- Arul Suren
- Ashour Dina Ayman
- Ashour Yara shareef
- Aslan Yakup
- Aspirot Ann
- Assi Ahmadfateh
- Assi Muath Abdelrahem Fuad
- Astudillo Miguel
- Atatri Yazid yousef mahmoud
- Atta Ahmed
- Attia Alaa Mobarak
- Avile Romina
- Avolio Luigi
- Awad Hadeel
- Aydin Emrah
- Aykut Merve
- Ayque Rosas Fernando
- Aziz Dayang Anita Abdul
- Ba'baa' Basheer
- Badr Helmy
- Baertschiger Reto
- Bagbio Dominic
- Bah Abdoulie
- Bai Qiang
- Bai Yu Zuo
- Baistrocchi Valentina
- Bakar Ainal Huda Abu
- Baker Wisam
- Ballouhey Quentin
- Balousha Abrar ghassan
- Bamanga Ahmed
- Baniowda Muath A. M.
- Bao Xiaozhou
- Barauskas Vidmantas
- Barbosa Patricia Reis
- Baseggio Natalia
- Bashir Fatma
- Bashir Muhammad Kashif
- Bassan Gonçalves Paulo César
- Bataineh Ziad A.
- Batal Mohammad Mohannad
- Bazozi Hana Milad
- Beasley Spencer
- Becker Karin
- Belmino Gadelha Aluísio Augusto
- Benaskeur Yousra-Imane
- Beres Alana
- Berková Klára
- Bernaus Marianela
- Berrocal Anaya Waldo
- Berzanskis Mindaugas
- Beshtawi Doha mustafa saleh
- Beşir Ahmet
- Bianchin Ezequiel
- Bibas Fatma
- Biber Elna
- Bischoff Cristiano
- Bismarck Sylvester von
- Blain Otilia Eva
- Blanc Thomas
- Blazquez-Gomez Eva
- Bobadilla Morales Lucina
- Bode Christopher
- Bonnard Arnaud
- Boonthai Ampaipan
- Borbonet Daniel
- Bouhadiba Nordeen
- Bowder Alex
- Bracho Blanchet Eduardo
- Bradshaw Kate
- Bragagnini Paolo
- Brahmamdam Pavan
- Bravo Mauro Nicolas
- Bright Benedict Paul
- Brito Quevedo Luz Mery
- Broch Aline
- Brolin Santis Isolan Paola Maria
- Brunero Marco
- Bruxel Carla Luisa
- Bsisu Isam
- Bucaram Elena
- Bueno Mazzuca Rafael
- Bueno Motter Sarah
- Bujarimin Ahmad Shafiee bin
- Bulnes Mendizabal David
- Burks Stephen S.
- Burns Kate
- Butler Marilyn
- Bvulani Bruce
- C. Nwosu David
- Caamal Lorenzo Juvencio
- Calancea Calin
- Calderon Moore Antonio
- Calderón Arancibia José Alfredo
- Calistus Nwachukwu
- Cama Jitoko
- Camamra Kajali
- Cameron Fraser
- Camp Lauren
- Canözer Ali
- Caouette-Laberge Louise
- Cardenas Alva Loreley Raquel
- Cardenas Ruiz Velasco Juan Jose
- Carrasco Ana Lucia
- Carrasco-Ortega Cesar
- Carrillo Isabel
- Casado Francis Tanise
- Casal Beloy Isabel
- Caseb Paloma
- Casquero Victor
- Castañeda Espinosa Sergio
- Castaño Avila Daniela
- Castedo Camacho Fabiola Ruth
- Cavaiuolo Silvia
- Cañapataña Sahuanay Veronica Raquel
- Cepeda Rodrigo
- Cesur İlknur Banlı
- Chan Jonathan
- Chang Jeremy
- Charras Maria Delia
- Chaudary Ali Raza
- Chaudhry Muhammad Amjad
- Chauhan Nirav
- Chavez Galvez Patricia
- Chen Lulu
- Chen Rui
- Cheung Maija
- Chipalavela Rossana Francisco
- Chiriboga Elena
- Chitiavi Soita Wycliffe
- Chitnis Milind
- Cho Seok Hyeon
- Choo Candy SC
- Chukwu Isaac
- Chukwuemeka Anyanwu Lofty-John
- Chung Jae Hee
- Cletus Cyril
- Coghill Griffin
- Collins Nwokoro
- Colombo de Holanda Felipe
- Contreras Carla Sofia
- Coon John
- Cordonnier Annelien
- Cornelli Fabio
- Cornwall Hannah
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- Tamaddun Hafatin Fairos bt
- Tang Weibing
- Tanimola Adebayo Gbenga
- Tanming Patchareeporn
- Tanny Sharman Tan
- Tantush Sara Abobaker
- Tarabishi Ahmad Sankari
- Tarek Ahmed
- Tarmohamed Murad
- Tarniba Sara Ali
- Tarrado Xavier
- Tasker David
- Teague Warwick
- Telles Leila
- Temilade Bolarinwa Bolanle
- Teo Rufinah
- Teran Araceli
- Terzic Sabina
- Testoni Daniela
- Thaiwatcharamas Kanokrat
- Thiessen Jesh
- Thomas Amy Hughes
- Thomas Gordon
- Thomas Mark C
- Thompson Hannah
- Till Holger
- Tillig Bernd
- Tinoco Guzmán Nestor Julien
- Tobor Szymon
- Toczewski Krystian
- Tom Alan
- Toplicic Djordje
- Toral Eliana
- Torres Miranda Cesar
- Torres Picón Cintya Maria de Jesus
- Torres-Canchala Laura
- Toselli Luzia
- Touabti Souhem
- Toufik Iaiche Achour
- Tovar Gutierrez Natalia
- Trainba Sara
- Trigoso Mori Fernando
- Trindade Deyl Rafael
- Trojanová Barbora
- Trypens Agata
- Tumi Mohamed
- Tuyishime Eugene
- Türkyılmaz Canan
- Türkyılmaz Zafer
- Ubhi Harmony
- Ugwu Jideofor O
- Ugwunne Chuka A
- Ulasi Ikechukwu
- Ullrich Sarah
- Vacek Jonathan
- Vaitkiene Agota
- Valencia Santiago
- Valeria Pelussi
- Valerio-Vazquez Rafael
- Vanis Nedim
- Vaquila Justo
- Varela Maria Florencia
- Vasquez Matos Juan Pedro
- Vatta Fabrizio
- Vega Centen Stephany
- Velaña Junior
- Vellusamy V Muthualhagi M
- Venant Ntakarutimana
- Venkatraman Soundappan Sannappa
- Verdeata Roxana
- Verduga Ivan
- Verduga Leonardo
- Vergara Carolina
- Verkauskas Gilvydas
- Veronica Sofficci
- Vervoort Dominique
- Vianney Butoyi Jean Marie
- Vida Lucian
- Vidal Cristian R. Zalles
- Vierboom Liam
- Villalba Villalba Araceli
- Villegas Silva Raúl
- Vinskaite Asta
- Vos Corné de
- Vosoughi Armin
- Wafa Tamer
- Walker Gregor
- Wang Jinhu
- Wang Peng
- Waseem Basma
- Weeratunga Naveen
- Weiszewsk Alicja
- Wen Gang
- Werneck Raposo Juliana
- Wester Tomas
- Wijekoon Naveen
- Wilke Alexandra
- Williams Isabelle
- Williams Omolara
- Williams Regan
- Win Win Sabai Phyu
- Wishah Bisan D. M.
- Wishah Nidal
- Wissanji Hussein
- Wolak Przemyslaw
- Wolny Agnieszka
- Wong Janice
- Wong Marilyn
- Wright Naomi Jane
- Wu Guowei
- Wyrzykowski Dariusz
- Xiaodong Guo
- Xie Hua
- Yacoub Mina A.
- Yaghi Bashar
- Yaghi Dua Hasan
- Yalcinkaya Ali
- Yang Hee-Beom
- Yanis Ahmad H.
- Yanowsky Reyes Guillermo
- Yao Yang
- Yapo Benjamin
- Yarza Fernández Jessica
- Yeniay Aslı Öztürk
- Yola Mariya Mukhtar
- Yong Feng
- Youn Joong Kee
- Yousuf Hina
- Yu Mengnan
- Yu Raisa
- Yuen Quah Soong
- Yuldashev Rustam Z.
- Yunus Aayenah
- Za'nouneh Faris J. Abu
- Zaghlol Louay Y.
- Zahari Dato' Dr Zakaria bin
- Zain Mostafa
- Zaman Azrina SK
- Zanellato Josiane Bernartt
- Zarwawi Ahmad Zulhisyam bin
- Zea-Salazar Luis Enrique
- Zeinelabdeen Ali
- Zhao Xiaoxia
- Zhu Jianming
- Zhu Libin
- Zidan Mazen
- Zivanovic Dragoljub
- Zottis Barcelos Fabricio
- Zreeg Dafer abdulhakim . S.
- Zurikat Rajai O.
- Zvizdic Nada
- Zvizdic Zlatan
- Çekiç Bahanur
- Çelik Müge
- Özçelik Zerrin
- Şeref Kıvanç
- Šafus Antonín
- Škvařil Jan
- Štichhauer Radek
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
Summary
Background Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally.
Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies
have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of
the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income
countries globally, and identified factors associated with mortality.
Methods We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to
hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis,
exomphalos, anorectal malformation, and Hirschsprung’s disease. Recruitment was of consecutive patients for a
minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical
status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary
intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause,
in-hospital mortality for all conditions combined and each condition individually, stratified by country income status.
We did a complete case analysis.
Findings We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital
diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal
malformation, and 517 with Hirschsprung’s disease) from 264 hospitals (89 in high-income countries, 166 in middleincome
countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male.
Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3).
Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income
countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups).
Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in lowincome
countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries;
p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients
combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11],
p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20
[1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention
(ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety
checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed
(ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of
parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65
[0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality.
Interpretation Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between lowincome,
middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will
be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger
than 5 years by 2030
CONOCIMIENTOS EN SALUD SEXUAL Y REPRODUCTIVA EN ESTUDIANTES DE UNA INSTITUCIÓN EDUCATIVA DE CALI COLOMBIA-2020-2021
- Author
- Publication venue
- Revista Edu-Física
- Publication date
- 09/02/2022
- Field of study
Introduction: Knowledge of sexual and reproductive rights worldwide has allowed adolescents to widely recognize them. Unintended pregnancy at an early age, school dropouts and sexually transmitted diseases (STDs) are serious consequences derived from the lack of knowledge on the subject.
Objective: To determine the impact of an educational intervention on sexual and reproductive health in adolescents from a secondary education institution, Cali, Colombia 2021.
Materials and methods: a quasi-experimental study was carried out measuring the before and after an educational intervention in 60 adolescents from a secondary education institution, in the city of Cali. A survey validated by expert judgment was used as a measurement instrument.
Results: during the study, the knowledge before and after an educational intervention of 60 adolescents was evaluated, finding that 82% had already started sexual relations, 40% were unaware of their rights in sexual and reproductive health, 25% denied using a method of contraception and 12% have had an STD; With the educational intervention, the level of knowledge improved in 100% of the adolescents.
Conclusions: Inadequate knowledge about contraception, early initiation of sexual relations without prior orientation, specific weaknesses regarding sexually transmitted diseases were identified in 60% of adolescents. At the end of the intervention, a significant increase in the level of knowledge in adolescents was achievedIntroducción: El conocimiento de los derechos sexuales y reproductivos a nivel mundial, han permitido que los adolescentes los reconozcan ampliamente. El embarazo no planeado a temprana edad, la deserción escolar y las enfermedades de transmisión sexual (ETS) son consecuencias graves derivadas de la falta de conocimiento sobre el tema.
Objetivo: Determinar el impacto de una intervención educativa sobre salud sexual y reproductiva en adolescentes de una institución de educación media, Cali, Colombia 2021.
Materiales y métodos: se realizó un estudio cuasi experimental midiendo el antes y después de una intervención educativa en 60 adolescentes de una institución de educación media, en la ciudad de Cali. Como instrumento de medición se utilizó una encuesta validada por juicio de expertos.
Resultados: durante el estudio se evaluaron los conocimientos pre y post a una intervención educativa a 60 adolescentes, encontrando que el 82% ya inicio relaciones sexuales, 40% desconocían sus derechos en salud sexual y reproductiva, 25% niega utilizar un método de anticoncepción y 12% ha tenido una ETS; con la intervención educativa, el nivel de conocimientos mejoro en 100% de los adolescentes.
Conclusiones: Se identificó en 60% de los adolescentes conocimientos inadecuados sobre anticoncepción, inicio temprano de relaciones sexuales sin orientación previa, debilidades específicas sobre enfermedades de transmisión sexual. Al concluir la intervención se logró un aumento significativo del nivel de conocimiento en los adolescentes
 
The role of centre and country factors on process and outcome indicators in critically ill patients with hospital-acquired bloodstream infections
- Author
- Aalinezhad Fatemeh
- Abdulwahed Eman
- Abed-Maillard S.
- Abello Anton
- Abidi Khalid
- Abillama Fayez
- Abousnina Fathi A.
- Abu-Sayf Natalia
- Acevedo José Oscar
- Adekola Oyebola O.
- Adeola Fowotade
- Agalar Canan
- Aguilar Candy Garcia
- Ahmadi Fatemeh
- Ahmed Abdullah Khudhur
- Ahmed Samiul
- Akdogan Ozlem
- Akova Murat
- Akova Murat
- Aksoy Firdevs
- Aktas Sabahat Cagan
- Akyol Ahmet
- Al-Jadaan Mohammad
- Aldhalia Amer
- Alfandari Serge
- Ali Fadi
- Ali Saedah
- AliAli Almajdoub Mohammed
- Aljabbary Ahmed
- Almekhlafi Ghaleb A.
- Almiqlash Bushray
- Almiroudi Mariota Panagiota
- Alsisi Adel
- Altin Nilgün
- Altintas Neriman Defne
- Alves Madalena
- Amerigo Joaquin Amador
- Amiri Fereshteh
- Amro Sarah
- Anderzhanova Anastasia
- Angell Hollie
- Antcliffe David
- Antrolikar Supriya
- Aparicio Christelle
- Apichatbutr Yutthana
- Aqeelah Ahmed
- Arbelot Charlotte
- Argaud Laurent
- Arias Mario
- Arias Sonia Sousa
- Armestar Fernando
- Arnillas Maria Pilar Gracia
- Artigas Ricard Mellado
- Arvaniti Kostoula
- Arvaniti Kostoula
- Asiyanbi Gabriel
- Aslan Abdullah Tarik
- Aslan Abdullah Tarık
- Athanasa Zoi
- Atobe Kaori
- Attokaran Antony George
- Attwood Ben
- Auchabie Johann
- Awad Ahmed K.
- Awad Maher
- Ayestaran J. Ignacio
- Azman Abd. Hamid
- Åkerlund Joyce
- Babashev Baurzhan
- Baby Sailaja K.
- Badre Gaëtan
- Baghbanian Reza
- Baig Nadia
- Baikady R. Rao
- Bajaj Manan
- Bakr Lubna
- Banach Dorota
- Barbier François
- Barbier François
- Baronia Arvind
- Barsoum Mina
- Bassetti Matteo
- Bassetti Matteo
- Batirel Ayse
- Battaglini Denise
- Baudry Thomas
- Baumer Tom
- Bayindir Yasar
- Baykam Nurcan
- Bazhykayeva Yelena
- Belkhadir Z.
- Bellina Davide
- Belman Daniel
- Belskiy Vladislav
- Bermudez Rosana Munoz
- Beuzelin M.
- Bhadange Neeraj
- Bilir Yeliz
- Bilkhayr Hala
- Biradar Vishwanath
- Bisanti Alessandra
- Biston Patrick
- Black E.
- Blasco-Navalpotro Miguel Angel
- Bloos Frank
- Bojko Jozef
- Borsi Seyed Hamid
- Bortolotti Perrine
- Bose Payel
- Botelho Isabel
- Bouaziz Mounir
- Bouhuwaish Ahmad
- Boukatta Brahim
- Bourenne Jérémy
- Bourgeois Marc
- Bracht Hendrik
- Brajkovic Ana Vujaklija
- Brewster David
- Broda Hanna
- Bruel Cédric
- Bubenek-Turconi Serban
- Buetti Niccolò
- Buetti Niccolò
- Buimsaedah Ahmad
- Burma Yaroslava
- C. Kampolis null
- Cakmak Rumeysa
- Carelli Simone
- Cartoze Nuno
- Casares Vanessa
- Castanera Jérémy
- Castillo Roberto Alejandro
- Catalan Beatriz
- Centeno Pablo
- Cerman Jaroslav
- Ceyhun Solakoğlu
- Chaaban Mohammad Karam
- Chandran Jagadish
- Chantziara Vasiliki
- Chatzis Marinos
- Chen Xiaomei
- Chiewroongroj Supattra
- Chikungwa Moses
- Chou Nai-Kuan
- Chukina Maria
- Cia Cong-Tat
- Cobb Katherine
- Cobilinschi Cristian
- Cole Stephen
- Conway Morris Andrew
- Cortegiani Andrea
- Cortegiani Andrea
- Costa Vasco
- Cotoia Antonella
- Coupez Elisabeth
- Covotta Marco
- Cowton Amanda
- Cunha Rui Pedro
- Custovic Aida
- Çolak Onur
- Çolak Sait
- da Costa Tito
- Dabiri Gholamreza
- Dahyot-Fizelier Claire
- Daroui Ivan
- Datta Avijatri
- Davalos-Alvarez Adrian
- De Bus Liesbet
- De Bus Liesbet
- de Figueiredo António Manuel Pereira
- De Geer Lina
- De La Rica Alejandro Suarez
- De Pascale Gennaro
- De Schryver Nicolas
- De Waele Elisabeth
- De Waele Jan
- De Waele Jan J.
- Demeret Sophie
- Demiray Emine Kubra Dindar
- Dendane Pr Tarek
- Denys Wouter
- Desalu Ibironke
- Dessap Pr Armand Mekonted
- Di Gravio Valentina
- Di Guardo Andrea
- Diab Adei
- Dimopoulos Pr Georges
- Djanikian Flora
- Dolan Rachael
- Dominguez-Cherit Jose G.
- Dsilva Carol
- Duarte Tiago
- Dubler Simon
- Duburcq Thibault
- Dulac Thierry
- Duprey Matthieu
- Dwivedi Jyotsna
- D’herbon Vall
- Edin Alicia
- Efthymiou Anna
- Elbadawy Merihan A.
- Elbahnasawy Mohamed
- Elbuzidi Abdurahaman
- Elhadi Muhammed
- Elhadidy Amr
- Elmandouh Omar
- Elrabi Omar
- Elsayed Ahmed
- Ercole Ari
- Erdoğan Cem
- Eremenko Aleksandr
- Eroglu Ahmet
- Eroglu Ege
- Erol Çiğdem
- Ersoy Yasemin
- Ersoz Gulden
- Escudier Etienne
- Espina Lorena Forcelledo
- Evik Guliz
- Fares Aya
- Fartoukh Muriel
- Faulkner Maria
- Fernández Rubén
- Ferrer Ricard
- Fildisis Georgios
- Filipescu Daniela Carmen
- Filipovic-Grcic Ina
- Finnis Mackenzie
- Fiorelli Silvia
- Flores Matias
- Fong Kean Khang
- Foucrier Arnaud
- Fourie Cheryl
- Francois Guy
- Franke Uwe
- Fujitani Shigeki
- Furman Mikhail
- Gaigolnik Denis
- Gainnier Marc
- Gallego Alberto Orejas
- Gamra Marwa
- Garcon Pierre
- Geng Nan
- Georgopoulou Maria
- Ghannam A.
- Ghosh Pralay
- Giacobbe Daniele
- Giacobbe Daniele Roberto
- Goh Ken Junyang
- Goh Qing Yuan
- Goksu Senay
- Gomà Gemma
- Gottschalk Antje
- Goyal Shraddha
- Graham Clive
- Gratarola Angelo
- Grigoras Ioana
- Grintescu Ioana Marina
- Gritsan Alexey
- Gritsan Alexey
- Guesdon Charlotte
- Guimarães Nádia
- Gundogan Kursat
- Gurjar Mohan
- Gurjar Mohan
- Guzeldag Seda
- Gürbüz Yunus
- Hachimi Abdelhamid
- Haentjens Lionel
- Haibo Qiu
- Hall Daniel
- Hamid Hytham K. S.
- Haney Michael
- Harara Belal
- Hasan Hayat Ben
- Hasan M. Shahnaz
- Hasan Rabab Shaban Ben
- Hasan Rajib
- Hashimoto Satoru
- Hayashi Yoshiro
- Hdada Aisha Khaled
- Hemead Hanan M.
- Henin Pierre
- Hermosillo Mariana
- Hernandez Aaron Mark
- Herrera Mara Ocotlan Gonzalez
- Hewer Tayne
- Hoheisen Sandra
- Hollevoet Isabelle
- Homaidan Ahmed Gaber Sadik
- Hosokawa Koji
- Houfi Ashraf El
- Housni Brahim
- Hssain Ali Ait
- Hu Chungfang
- Hu Ting-Yu
- Huang Min
- Hugill Keith
- Humphreys Miss Sally K.
- Huq Shihan Mahmud Redwanul
- Husain A.
- Iasonidou Cristina
- Ibrahim Rebecca
- Idowu Olusola
- Iliescu C. C.
- Imzi Nadia
- Ippolito Mariachiara
- Islam Mohammad Motiul
- Jackson Matthew
- Jain Nikhilesh
- Jakob Stephan
- Jamaluddin Muhamad Fadhil Hadi
- Janny Sylvie
- Jaramillo C’havala
- Javaherforoosh Fatemeh
- Jayyab Mustafa Abu
- Jeon Kyeongman
- Jhanji S.
- Jobran Rania
- Johnson Aimee
- Kagan Ilya
- Kaimakamis Evangelos
- Kalem Ayşe Kaya
- Kalfon Pierre
- Kaligozhin Zhannur
- Kanjaa Nabil
- Kannan Santhana
- Karaali Ridvan
- Karaiskos Ilias
- Karar Ali Adil Ali
- Karic Edin
- Karmakar Saurabh
- Karumai Toshiyuki
- Kashipazha Davood
- Kato Hideaki
- Kayaaslan Bircan
- Kayaaslan Bircan
- Keegan Allison
- Kent Melanie
- Khade Reena
- Kiani Arash
- Kipnis Eric
- Klouche Kada
- Kocagoz Sesin
- Kogkopoulos Evangelos
- Koksal Iftihar
- Komorowska Irmina Kaptur
- Kothari Nikhil
- Kotkowska Anna
- Kouroulas Pr Vasilios
- Koutsoukou Vasiliki
- Kovacevic Pedja
- Krystopchuk Andriy
- Ku Shih-Chi
- Kuo Li-Kuo
- Kuriyama Akira
- Kurt Ibrahim
- Kusoglu Hulya
- Kutsogiannis Demetrios J.
- Kwa Andrea Lay Hoon
- Lance Marcus
- Larcher Romaric
- Lasic Hrvoje
- Laupland Kevin
- Layos Nathalie
- Le Guennec Loïc
- Le Meur Anthony
- Le Souhaitier Mathieu
- Leal Jesús Nicolás Pantoja
- Ledo Sara
- Ledtischke Anne
- Lee Sang-Min
- Lefrant Jean-Yves
- Lennard James
- Leone Marc
- Leone Pr Marc
- Lepper Philippe
- Leroy Olivier
- Levin Phillip
- Li Andrew Yunkai
- Lie Sui An
- Liew Mun Thing
- Lim Jia Yan
- Lim Sung Yoon
- Ling Lowell
- Lipman Jeffrey
- Litton Edward
- Lodi Giovanni
- Loftus S.
- Lomeli-Teran Manuel
- Longbottom Rebecca
- Lopez Patricia Mabel
- Louis Guillaume
- Lungu Olguta
- Luo Jili
- Macfie Caroline
- Magomedov Marat
- Mahmoodpoor Ata
- Makino Jun
- Malliotakis Polychronis
- Marchalot A.
- Marcu Alexandra
- Margetts Ben
- Marmanidou Kyriaki
- Marouli Diamantina
- Marques Ana Josefina Pinheiro
- Marsden Nicholas
- Martin-Loeches Ignacio
- Martinez Maria
- Maseda Emilio
- Masjedi Mansoor
- Massri Alexandre
- Matei Mariana Kristina
- Mateu Philippe
- Matsuyoshi Takeo
- Mazlan Mohd Zulfakar
- Mc Cree Melanie
- McCoshen Lorena
- Mcguigan Peter
- Mckee Rachel
- Mehraban Zahra
- Mehtap Selcuk
- Meleshkina Yulia
- Mendes António Carvalho
- Mer Mervyn
- Merenkov Yevgeniy
- Mesland Jean-Baptiste
- Metz Carlos
- Meyer Jason
- Mikstacki Adam
- Mingmin Chen
- Mira Jean-Paul
- Mirabella Michele
- Mishima Yuka
- Misra Krushna Chandra
- Misset Benoît
- Moldovan Leora
- Molinos Elena
- Mon Tomas
- Montefiore Pablo
- Montini Luca Maria
- Montravers Philippe
- Montravers Pr P.
- Montrucchio Giorgia
- Montrucchio Giorgia
- Moorthi Dhakshina
- Morris Andrew Conway
- Morris Andrew Conway
- Morvillo Lic Natalia
- Mostafa Tarek
- Mouhssine Doumiri
- Moura José Pedro
- Mugazov Miras
- Mukherjee Sudipta
- Mulhi Randeep
- Muzaffar Syed Nabeel
- N. Zappela null
- Nadeem Rashid
- Nafees Khalid Mahmood Khan
- Nagashima Michio
- Ng Kangqi
- Ng Louis Xiang Long
- Ng Shin Yi
- Nica Alexandru
- Nikolaou Charikleia
- Nikolic Mario
- Nissar Shaikh
- Noel Cindérella
- Noor Zuraini Md
- Novo Mariana
- Nowakowski Tomasz
- Nuccetelli Yanina
- null null
- Nunes Cristina
- Ñamendys-Silva Silvio A.
- Oikonomou Marina
- Oladimeji Motunrayo
- Olatosi John
- Omori Koichiro
- Ong Caroline Yu Ming
- Opdenacker Godelive
- Osman Nermin
- Ouhadian Maryam
- Ozair Ahmad
- Ozgen Cansu
- Ozturk Barcin
- Pagani Jl
- Pahuja Madhumati
- Paiva José Artur
- Paiva José-Artur
- Palermo Anna Maria
- Papageorgiou Eirini
- Papanikolaou M.
- Papathanakos A. /Pr Georgios
- Papoti Sofia
- Parcell Benjamin J.
- Park Seung Yong
- Park Sunghoon
- Pascoalinho Dulce
- Pasieka Bastian
- Paskalis Harry
- Patel Jamie
- Patel Mayur
- Patrier Juliette
- Paulet Rémi
- Peichota Mariusz
- Peije Li
- Pelagalli Lorella
- Pelosi Paolo
- Pereira Énio
- Pereira Tiago
- Perez-Nieto Orlando R.
- Perrigault Pierre-François
- Persec Jasminka
- Petros Sirak
- Pheng Lee See
- Philippart François
- Pietraszek-Grzywaczewska Iwona
- Pinto Ana Rios
- Pollock Hamish
- Popescu Mihai
- Porcile Elisa
- Póvoa Pedro
- Prazak Josef
- Predoi Cornelia Elena
- Prieto Emilio Garcia
- Psallida Vasiliki
- Qian Chuanyun
- Qin Bingyu
- Qiu Haibo
- Quah Jessica Lishan
- Queiró Joana
- Quesada María Dolores
- Rabbani Raihan
- Rabbani Raihan
- Radonic Radovan
- Raguer Laura
- Rahman Hamizah Bt Abdul
- Raj Ashok
- Ramanan Mahesh
- Rashid Nurhikmahtul Aqilah Haji Abd
- Rashidi Mahboobeh
- Rathod Darshana
- Razazi Keyvan
- Regli Adrian
- Renaud Paul Jean
- Renta Foteini
- Renuka M. K.
- Retselas Ioannis
- Reyes Luis Felipe
- Rigler Merav
- Rinka Hiroshi
- Ritzema Jenny
- Rizzo Anna Chiara
- Rocca Ricard Ferrer
- Rocca Ricard Ferrer
- Rocco Monica
- Roger Claire
- Roig Regina
- Rojo Roceld
- Romanou Vasiliki
- Romero-Gonzalez Juan P.
- Roshdy Ashraf
- Rosman Jérémy
- Routledge Matthew
- Rubina Noor Ahmedi
- Ruckly Stephane
- Ruckly Stéphane
- Ruppe Etienne
- Saber Ahmed
- Sabetian Golnar
- Saidahmed Elfayadh
- Saito Hiroki
- Sakagianni Aikaterini
- Sakan Sanja
- Sakkalis Anastasios
- Sales Gabriele
- Salgado Dra Maria
- Sallam Hend
- Saltoglu Nese
- Samdani Pratit
- Sanderson Amanda
- Sanousi Bashir El
- Santos Emilio Diaz
- Saracoglu Kemal Tolga
- Sari Ali
- Sarode Vineet
- Sarshad Hakimeh
- Sarton Benjamine
- Savaie Mohsen
- Saxena Manoj
- Sánchez-Hurtado Luis
- Schlevenin Maria Grazia
- Schmidt Karsten
- Seddiki Pr Rachid
- Segura Matías
- Sellami Pr Walid
- Serck Nicolas
- Serghini Issam
- Setti Nour
- Sharma Ankur
- Sharma Priya
- Shekhar Saurav
- Sheshala Kaladhar
- Shigemitsu Hidenobu
- Siami Shidasp
- Siddiqui Suhail Sarwar
- Silva Stein
- Singer Pierre
- Singh Ritu
- Sjovall Fredrik
- Sligl Wendy
- Sligl Wendy
- Sligl Wendy
- Smith Tim
- Smonig Roland
- Smyrniotis Dimitrios
- Soar Natalie
- Sokhan Anton
- Soltan Marina
- Soltani Farhad
- Soulountsi Vasiliki
- Souweine Bertrand
- Spahic Dzana
- Sridharan Dhadappa Damodar
- Sudhirchandra Shah
- Sulaiman Helmi
- Sungurtekin Hulya
- Svensson Carl Johan
- Szakmany Tamas
- Szczesniak Anna
- Tabah Alexis
- Tabah Alexis
- Tabatabaei Seyed Mohammad Nasirodin
- Taher Ahmed Sa
- Tajvidi Ramin
- Takaki Shunsuke
- Talan Leyla
- Tamowicz Barbara
- Tatham Kate
- Tejeda-Huezo Brigitte
- Telli Murat
- Temirov Talgat
- Templeton Maie
- Teresa Ana
- Theodorou Vasiliki
- Thomas-Rueddel Daniel
- Thompson Patricia
- Thyrault Martial
- Tilley Rebecca E.
- Timsit Jean-François
- Timsit Jean-François
- Timuroglu Arif
- Tinaslanidis George
- Tizard Kate
- Tomas Ernesto Deloya
- Tomescu Dana
- Tong Lee Kok
- Torlinski Tomasz
- Torre Valentina Della
- Tran Marc
- Tribulev Maksim
- Tunay Burcu
- Turki Olfa
- Tyler Steven
- Ubeda Alejandro
- Udy Andrew
- Ugwu Euphemia Mgbosoro
- Vaidyanathan R.
- Valeanu C. C. IliescuLiana
- Valeanu Liana
- Vanderhaeghen Sofie F. M.
- Vargas Joel
- Vasileiou Maria
- Vera Paula
- Vidal Gabriela
- Viderman Dmitriy
- Villafuerte Missael Vladimir Espinoza
- Vistovskaya Natala
- Visvalingam Sheshendrasurian
- Voiriot Guillaume
- Wajdi Maazouzi Ahmed
- Walczak-Wieteska Paulina
- Walid Haji Adi Muhamad Ibnu
- Walsham James
- Wang Hao
- Wang Jinfeng
- Wang Ruilan
- Wang Yan
- Wasowska Dominika
- Weeda. Elizabeth
- Wei-Hua Lu
- Weifeng Xie
- Weiss Emmanuel
- Wempe Carola
- Wittebole Xavier
- Wong Siong Ling Danny
- Wongsurakiat Phunsup
- Wusi Qiu
- Xie Jianfeng
- Xu Lei
- Yakubu Saidu Yusuf
- Yamasaki Masaki
- Yan Jing
- Yap Timothy
- Ye Jilu
- Ye Ling
- Yeh Tony Yu-Chang
- Yilmaz Mesut
- Yin Chengfen
- Yin Yongjie
- Ymbetzhanov Yerlan
- Yonan Aimee
- Yoshida Hideki
- Younes Oujidi
- Young Meredith
- Zaki Ahmed
- Zand Farid
- Zargar Mohammad Amin
- Zeggwagh Pr Amine Ali
- Zhang Min
- Zhao Juan
- Zhao Peng
- Zhen Wang
- Zhou Suming
- Zlojutro Biljana
- Zormpa Artemis
- Zubareva Nadezhda
- Zuccaro Francesco
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Purpose: The primary objective of this study was to evaluate the associations between centre/country-based factors and two important process and outcome indicators in patients with hospital-acquired bloodstream infections (HABSI). Methods: We used data on HABSI from the prospective EUROBACT-2 study to evaluate the associations between centre/country factors on a process or an outcome indicator: adequacy of antimicrobial therapy within the first 24 h or 28-day mortality, respectively. Mixed logistical models with clustering by centre identified factors associated with both indicators. Results: Two thousand two hundred nine patients from two hundred one intensive care units (ICUs) were included in forty-seven countries. Overall, 51% (n = 1128) of patients received an adequate antimicrobial therapy and the 28-day mortality was 38% (n = 839). The availability of therapeutic drug monitoring (TDM) for aminoglycosides everyday [odds ratio (OR) 1.48, 95% confidence interval (CI) 1.03-2.14] or within a few hours (OR 1.79, 95% CI 1.34-2.38), surveillance cultures for multidrug-resistant organism carriage performed weekly (OR 1.45, 95% CI 1.09-1.93), and increasing Human Development Index (HDI) values were associated with adequate antimicrobial therapy. The presence of intermediate care beds (OR 0.63, 95% CI 0.47-0.84), TDM for aminoglycoside available everyday (OR 0.66, 95% CI 0.44-1.00) or within a few hours (OR 0.51, 95% CI 0.37-0.70), 24/7 consultation of clinical pharmacists (OR 0.67, 95% CI 0.47-0.95), percentage of vancomycin-resistant enterococci (VRE) between 10% and 25% in the ICU (OR 1.67, 95% CI 1.00-2.80), and decreasing HDI values were associated with 28-day mortality. Conclusion: Centre/country factors should be targeted for future interventions to improve management strategies and outcome of HABSI in ICU patients
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- Author
- Ababneh Hazim
- Abad-Motos Ane
- Abbas Ferial Mohamed Ali
- Abbo Olivier
- Abbott Tom
- Abbott Tom
- Abdelkabir Mohammed
- Abdelkhalek Mohamed
- Abdoun Meriem
- Abdur-Rahman Lukman
- Abdur-Rahman Lukman
- Abebe Metasebia
- Aboazamazem Hajir
- Abou Chaar Mohamad K.
- Abou Chaar Mohamad K.
- Abouelnagah Galal
- Abozied Hesham
- Abu Salhiyeh Ala A.
- Abu-Ismail Luai
- Abu-Mehsen Marah
- Abuawad Carla
- Abukhalaf Sadi A.
- Abuleil Amro
- Ackermann Travis
- Acquah Daniel Kwesi
- Adam Mohammed Elmujtba Adam Essa
- Adamina Michel
- Adamina Michel
- Ademuyiwa Adesoji
- Adesanya Opeoluwa
- Adisa Adewale
- Adisa Adewale
- Afolabi Akinwale
- Agarwal Arnav
- Agarwal Gaurav
- Agarwal Ketan
- Agastra Ervis
- Agastra Ervis
- Agbadebo Mouhamed
- Agbonrofo Peter
- Aguilera-Arevalo Maria-Lorena
- Aguilera-Arevalo Maria-Lorena
- Ahmad Amer
- Ahmad Siddique
- Ahmadi Navid
- Ahmed Waheed-Ul-Rahman
- Aigner Felix
- Aiken Taylor
- Akhavizadegan Hamed
- Akhbari Melika
- Akililu Yemisirach Bizuneh
- Akinmade Akinola
- Al Ameer Ahmed
- Al Ameer Ahmed
- Al Amri Abdulrahman
- Al Balushi Zainab
- Al Islam Ben Jouira Rayet
- Al Maadany Faraj
- Al-Manaseer Balqees Mahmoud
- Al-Naggar Hamza
- Al-Naggar Hamza
- Al-Raimi Ibrahim
- Al-Sabbagh Yusra
- Al-Shehari Mohammed
- Aladawi Omar
- Alajalen Amer
- Alalawi Yousef
- AlAmeer Ehab
- Alameer Ehab
- Alansari Arowa Hassan Abdulrahman
- Alawami Mohammed
- Alawneh Yazan
- Alayan Mohammed
- Albared Sara Maa
- Albertsmeier Markus
- Albertsmeier Markus
- Alderazi Amer
- Aldlyami Ehab
- Aldressi Wafa
- Alecci Anna
- Alexander Philip
- AlFakhri Abdullah
- Alharthi Mohammed
- Alhassoun Turki
- Alhefdhi Amal
- Alkadeeki Ghadah
- Alkaseek Akram
- Alkhatib Ahmad
- Allemand Carola
- Almabayev Ydyrys
- Almeida-Reis Rui
- Almiqlash Bushray
- Almoguera Jorge
- Almugaddami Ayman
- Almulhim Abddulrahman Saleh
- Alnachoukati Omar
- Alnahr Hareth
- Alonso Jesús Aarón Martínez
- Alonso Manuel Diez
- Alonso Nestor Fabian Pedraza
- Alqudah Majdi Ali
- Alrayes Bourhan
- Alsaadi Hayder
- Alsaadi Hayder
- Alser Osaid
- Alshaar Muhammad
- Alshahrani Mushabab
- Alshareef Khayriyah
- Alshehri Ameen
- Alshryda Sattar
- Alshryda Sattar
- Alsibai Sareyah
- Alsunna Zaid
- Altaf Humera Naz
- Althumairi Azah
- Althumairi Azah
- Althumairi Azah
- Alvarado Carlos Eduardo Otiniano
- Alyami Mohammad
- Alzahrani Abdulrahman
- Alzaidi Turki M.
- Alzate Juan Pablo
- Alzerwi Nasser
- Amisi Nicolas
- Amnaina Mohamed
- Amor María Sol Crespi
- André Benoît
- Angeles Martina Aida
- Anwer Mariyah
- Anyanwu Lofty-John
- Aouabed Nesrine
- Aqeelah Ahmed
- Aqil Sabra
- Arancibia José Alfredo Calderón
- Arango Maria Clara Mendoza
- Arbane Gill
- Argus Leah
- Arias Claudia
- Arnalsteen Laurent
- Arnaud Alexis P.
- Arnaud Alexis P.
- Asif Muhammad
- Assefa Melatework
- Atnafu Bahru
- Aulerio Giuliana D.
- Aurora
- Awad Selmy
- Ayasra Faris
- Ayasra Faris
- Ayoub Abdu
- Ayub Bushra
- Ayub Khurram
- Azevedo José
- Azevedo José
- Azevedo Pedro
- Aziz Aliya
- Azzam Ahmed Y.
- Bacalbasa Nicolae
- Badareesh L.
- Badenes Rafael
- Badiani Sarit
- Baig Mariam
- Bains Lovenish
- Baiocchi Glauco
- Baiocchi Glauco
- Baiocchi Glauco
- Bajaj Ankur
- Balanta-Melo Julián
- Balasubramanya Supriya
- Bali Oussama
- Baliarsing Lipika
- Ball Alasdair
- Ballouhey Quentin
- Ban Vin Shen
- Bankhead-Kendall Brittany
- Bankhead-Kendall Brittany
- Barillas Sabrina
- Barker John
- Barros Aldo Vieira
- Basnayake Oshan
- Bastet Joaquin
- Basu Somprakas
- Bateman Antony
- Bath Michael
- Batista Sylvia
- Bauset Juan Carlos Catalá
- Bayo Heura Llaquet
- Baía Catarina
- Behzadi Abdollah
- Bekele Kebebe
- Bele Uros
- Bele Uros
- Bellver Pedro Palazon
- Ben Amer Anass
- Benallel Nassim
- Benson Ruth
- Berber Norberto
- Bergeat Damien
- Bergkvist David Julià
- Bernal-Sprekelsen Juan Carlos
- Berndtson Allison
- Bertrand Marta
- Bescós Coro
- Bezabih Yoseph Solomon
- Bhanderi Shivam
- Bhangu Aneel
- Bhangu Aneel
- Bhat Dhananjaya
- Bhatti Abu Bakar Hafeez
- Bhende Vishal
- Bhutiani Neal
- Bianco Agustín
- Biccard Bruce
- Blanco-Colino Ruth
- Blanco-Colino Ruth
- Blanco-Colino Ruth
- Blasco Laura Sánchez
- Boccalatte Luis
- Boccalatte Luis
- Boccalatte Luis
- Boira Mar Achalandabaso
- Boisson Matthieu
- Bolatbekova Raikhan
- Bolger Jarlath
- Bollano Enton
- Bonci Eduard-Alexandru
- Bonci Eduard-Alexandru
- Borda-Luque Giuliano
- Boretto Jorge G.
- Borges Filipe Castro
- Bork Ulrich
- Borowski David W.
- Botero Marcela Velez
- Bouaoud Souad
- Bouche Pierre-Alban
- Bouchenak Kamel
- Boucher Sophie
- Boudou Rocio
- Bouhuwaish Ahmad
- Brandariz Rodrigo
- Branquinho Rita
- Brar Amanpreet
- Brar Amanpreet
- Bravo Ana Maria Minaya
- Bravo Ana Maria Minaya
- Breen Kerry
- Brennan Caitlin
- Brien Stephen O.
- Bright Tim
- Brown Wendy
- Brunaud Laurent
- Brunner Stefan M.
- Buarque Igor Lima
- Bucyibaruta Georges
- Bukhari Syed Imran
- Buljubasich Martin
- Burchakchi Arturo
- Burgan Dania
- Busnelli Virginia Cano
- Buttaro Martin
- Butyrskii Aleksandr
- Bwala Kefas
- Bywater Edward P.
- C Ricci
- Caiado André
- Caicedo Lina
- Cal Fernando Bonilla
- Callcut Rachael
- Calvache Albaro José Nieto
- Calvache Jose Andres
- Calvache Jose Andres
- Calvache Jose Andres
- Calzaretta Laura Gisela Alvarez
- Campana Juan Pablo
- Campos Heloisa Galvão do Amaral
- Capitaine Daniel
- Cappeliez Serge
- Cardoso Paulo
- Carmichael Heather
- Carminatti Tomas
- Carrera Jacqueline
- Carreras-Castañer Anna
- Caruana Edward
- Cereghini Julian
- Cerovac Anis
- Cerovac Anis
- Chadi Sami
- Chakrabortee Sohini
- Chan Matthew
- Chandrasinghe Pramodh
- Chapatwala Reema
- Charbonneau Helene
- Charles Shane
- Chaudhary Muhammad Hamid
- Chaudhry Daoud
- Chaudhry Daoud
- Chaudhry Navneet Kumar
- Chauhan Govind Singh
- Chebaro Alexandre
- Chew Min Hoe
- Chin Theresa
- Chinyowa Simbarashe
- Chiuyari Jose Rios
- Choong Peter
- Chowdappa Raghunandan Gorantlu
- Chowdhury Sharfuddin
- Christensen Peter
- Chuan Alwin
- Chwat Carina
- Chwat Carina
- Clancy Cillian
- Coimbra Felipe José Fernandez
- Coleman Julia
- Colmenares Yahaira Tatiana Carpio
- Colás-Ruiz Enrique
- Connelly Tara
- Connor Clare O.
- Coonar Aman
- Corbett Harriet
- Corella Fernando
- Corripio-Sanchez Ramon
- Costa Luciana Cidade
- Costas-Chavarri Ainhoa
- Costea Radu
- Cotta Estefanía
- Cox Daniel
- Cox Daniel
- Creavin Ben
- Croattini Roberto Sebastián
- Croghan Stefanie M.
- Crétolle Célia
- Cukier Moises
- Cukier Moises
- Cullinane Carolyn
- Cunha Miguel F.
- Cunha Miguel F.
- Dajti Irida
- Dajti Irida
- Dajti Irida
- Daoud Hassan
- Das Rishi
- Davies-Jones Gareth
- Davis Niall
- Dawson Amanda Caroline
- Dawson Amanda Caroline
- Dawson Brett E.
- Dbeis Rachel
- De Andrés-Asenjo Beatriz
- De Cortazar Unai Garcia
- de Dieu Haragirimana Jean
- de León Laura Román García
- De Simone Belinda
- Dean Benjamin
- Degefa Eyueal
- Del Pilar Paucar Urbina Arazzelly
- Delibegovic Samir
- Delisau-Puig Olga
- Dell Angela
- Demetrashvili Zaza
- Demetrashvili Zaza
- Demetriades Andreas K.
- Derilo Habtamu
- Desai Anant
- Deus Ana Cláudia
- Dharap Satish
- Dhondt Bert
- Dhufera Hailu
- Di Martino Marcello
- Di Saverio Salomone
- Di Vincenzo Marcela
- Diaz-Couselo Fernando
- Diehl Thomas
- Dimofte Mihail-Gabriel
- DiNome Maggie
- Djahida Bahraoui
- Doerner Johannes
- Domenech Julio
- Donlon Noel
- Drake Frederick
- Drake Thomas
- Drasovean Radu
- Duarte Amalia Barrios
- Duarte Carolina Lugo
- Dube Surya Kumar
- Duchalais Emilie
- Dudi-Venkata Nagendra
- Duran Irani
- Duric Natalie
- Duro Agustin
- Dwaga Sumayya Essayah
- Dziakova Jana
- Déserts Marc Danguy des
- Díaz-Feijoo Berta
- Earley Helen
- Eberbach Helge
- Edwards John
- Edwards John
- Efetov Sergey
- Efetov Sergey
- Egoroff Natasha
- Eiras Miguel Angel Freiria
- Ekenze Sebastian
- El Helw Amin
- El Kafsi Jihène
- El-Boghdadly Kariem
- El-Boghdadly Kariem
- El-Hussuna Alaa
- Elhadi Muhammed
- Elhadi Muhammed
- Elhajdawe Fras
- Elliott Brodie
- Ellojli Ibrahim
- Elwahab Sami Abd
- Emerson Hannah
- Emile Sameh
- Emile Sameh
- Enjuto Diego
- Escartin Jorge
- Escudero Damián García
- Escudero Mario I.
- Eskander Antoine
- Espin-Basany Eloy
- Espino Pablo Calvo
- Espinosa-Bravo Martin
- Esquivel Carlos
- Estruch Nuria Montferrer
- Etchill Eric
- Evans Jonathan
- Evelyn Nissi
- Ezanno Anne-Cecile
- Fahadullah Muhammad
- Fahmy Mohamed
- Fakhradiyev Ildar
- Fakhradiyev Ildar
- Farfus Anthony
- Farik Shebani
- Farooq Umer
- Faulkner Gemma
- Faustin Ntirenganya
- Fernandez Juan Delgado
- Fernandez Laura Gomez
- Fernandez Maria Sol
- Fernández Fátima Sánchez
- Fernández-López Antonio-José
- Ferrer Antonio Perez
- Ferry Jenny
- Figari Marcelo
- Figueroa Rodrigo
- Figueroa-Casanova Rafael
- Filipce Venko
- Filipescu Daniela
- Fiore Marco
- Fisseha Tigist
- Flamey Nicolas
- Fleming Christina
- Flexman Alana
- Fluegen Georg
- Flumignan Ronald
- Ford Samuel
- Forero-Torres Alexander
- Forneris Agustin Albani
- Fotopoulou Christina
- Fowler Alexander
- Fraidenraij Uriel
- Fredon Fabien
- Fuentes Marta Alcaraz
- Fuentes Tyare
- Fujimoto Yuki
- Futaba Kaori
- Gagnier Joel
- Gahwagi Milad
- Gallegos Diego
- Gallino Esteban Sebastian
- Gallo Gaetano
- Ganly Ian
- Garcia Manuel
- Garcia-Adamez Jorge
- García Lucia Diego
- García Pablo Martín
- García-Mansilla Agustín Maria
- García-Montoya Oscar-Julián
- Gaujoux Sebastien
- Gauna Guillermo Hernandez
- Gempt Jens
- Georgiades Fanourios
- Gerchunoff José Ignacio
- Ghani Muhammad Owais Abdul
- Ghazal Ahmad
- Ghazwani Salman
- Ghodke Rahul
- Ghosh Dhruva
- Ghosh Dhruva
- Ghosh Indranil
- Ghozy Sherief
- Ghunaim Mohammed
- Gialamas Eleftherios
- Gialamas Eleftherios
- Gigena Cecilia
- Gil-Sala Daniel
- Ginghina Octav
- Giorgakis Emmanouil
- Girard Edouard
- Girard Noémie
- Gishanthan Shanthamoorthy
- Gjata Arben
- Gjyli Kostandin
- Glasbey James C.
- Glasbey James C.
- Glass Nina
- Glowka Tim R.
- Gohar Muhammad
- Golet Marta Roldón
- Gomes Gustavo Mendonça Ataíde
- Gomez Jose Tomas Castell
- Gomez-Fernandez Hugo
- Gomez-Rosado Juan-Carlos
- Gonzalez Diana Samantha
- Gonzalez Marcos
- Gonzalez Matias Ignacio
- Gonzalez Santiago Valderrabano
- González Javier Serrano
- González-Gimeno Maria Jose
- González-Suárez Susana
- Goransky Jeremias
- Gosain Ankush
- Gourlay Ralph
- Gousias Konstantinos
- Gouvas Nikolaos
- Gouvas Nikolaos
- Grama Florin
- Grassano Bianca
- Greenhalgh Michael
- Griffiths Ewen
- Gronchi Alessandro
- Groot Gary
- Gross Jefferson
- Guillen Jose Ramon Oliver
- Gujjuri Rohan R.
- Gujjuri Rohan R.
- Gulla Aiste
- Gunawansa Nalaka
- Gupta Anand
- Gupta Rahul
- Gurumeta Alfredo Abad
- Gut Anna Eleonora
- Gómez Mercedes Estaire
- Ha Jeong
- Habumuremyi Sosthene
- Hadzibegovic Ana Danic
- Haidar Hanan
- Haider Fayza
- Haif Assia
- Hailu Samuel
- Hailu Samuel
- Hakami Ibrahim
- Hamad Faten Reyad Bani
- Hamdun Intisar Hisham Said
- Hameed Zeeshan
- Hammed Ali
- Hammond John
- Haran Cheyaanthan
- Hardie John
- Harper Luke
- Harrison Ewen M.
- Harrison Ewen M.
- Hashimoto Daisuke
- Hassan Ramy A.
- Hecker Andreas
- Henein Christin
- Heredia Fernando
- Heriot Alexander
- Hervieux Erik
- Herzberg Jonas
- Higuera Felipe
- Hilmi Ahmed
- Hirji Sameer
- Hirschburger Markus
- Hodgson Russell
- Holc Fernando
- Hollington Paul
- Hollyman Marianne
- Horch Raymund E.
- Horisberger Karoline
- Hossain Kamral
- Huang Abel
- Husain Shatha
- Hutchinson Peter
- Hyman Gabriella Yael
- Höhn Philipp
- Iascano Fernando Martinez
- Ikele Hilary
- Imanishimwe Alphonsine
- Incorvia Joseph
- Incorvia Joseph
- Infante Antonio Rodriguez
- Ingabire Jc Allen
- Ionescu Sebastian
- Isaac Otolia
- Isik Arda
- Isik Arda
- Iskander Othman
- Jain Kavitha
- Jain Ritu
- Jamal Aiman
- Jamal Mohammad
- James Harelimana Grace
- Jauregui Esteban Gabriel
- Javadpour Mohsen
- Javed Saad
- Javed Saad
- Jaworska Natalia
- Jayarajah Umesh
- Jayarajah Umesh
- Jeandel Clement
- Jenkinson Michael
- Jimaale Elmi Ahmed Mohamed
- Jimenez Raul
- Jimenez Virginia
- Jiménez Pablo Mijahil Avilés
- Jiménez Pablo Mijahil Avilés
- Jin-Young Jang
- Jira Moa
- Jisry Ghassan
- Jlassi Haithem
- Johnson David
- Jones Conor S.
- Jonker Pascal
- Jouffret Lionel
- Júnior Samuel Aguiar
- Kaafarani Haytham
- Kaafarani Haytham
- Kaafarani Haytham
- Kabir Syed Mohammad Umar
- Kabweru Wilberforce M.
- Kache Stephen
- Kacimi Salah Eddine Oussama
- Kaidarova Dilyara
- Kaiser Julia Christina
- Kakeeto Andrew
- Kaman Lileswar
- Kamarajah Sivesh K.
- Kamarajah Sivesh K.
- Kamphues Carsten
- Kandevani Naser Yousefzadeh
- Kannan Ravi
- Karout Lina
- Karthigeyan Madhivanan
- Kassir Radwan
- Kauppila Joonas H.
- Kauppila Joonas H.
- Kaups-Fresno Krista
- Kavalakat Alfie
- Keatley James M.
- Kembuan Gabriele
- Keppler Alexander M.
- Keppler Lena
- Kerawala Asad Ali
- Kerawala Cyrus
- Kerpaci Jola
- Khadidja Kouidri
- Khalifa Houda
- Khalil Kareem S.
- Khamees Almu'atasim
- Khan Tabassum
- Khatri Chetan
- Kherani Safeena
- Khokhar Muhammad Imran
- Khosravi Mohammad
- Khosravi Mohammad Hossein
- Kieser David
- King Jasmin
- Kirov Mikhail
- Kiweewa Ronald
- Klat Jaroslav
- Knight Stephen Richard
- Kochetkov Viktor
- Koh Cherry
- Koh Frederick
- Koh Frederick
- Kolias Angelos
- Komen Niels
- Konate Ibrahima
- Konrads Christian
- Kopetskyi Slava
- Kopjar Tomislav
- Kornblith Lucy
- Kowalski Luiz Paulo
- Košir Jurij Aleš
- Košir Jurij Aleš
- Kpangon Cyrille
- Kronberger Irmgard
- Kronberger Irmgard Elisabeth
- Kroon Hidde M.
- Kruijff Schelto
- Kudsk-Iversen Søren
- Kulimbet Mukhtar
- Kulkarni Amruta
- Kumar Aruna
- Kumar Ashwani
- Kundra Rakesh
- Kuroda Naoto
- Kwan Tsun Yu
- Königsrainer Alfred
- la Medina Antonio Ramos-De
- Laban Simon
- Lakkis Zaher
- Lakpriya Sathya
- Lalmi Ismahene
- Lalín Agustina Florencia Castro
- Lami Mariam
- Landaluce-Olavarria Aitor
- Larrañaga Juan
- Latif Haider
- Lau Lorena Fuentes Rivera
- Laudani Veronica
- Laudani Veronica
- Laura Saura García
- Lavanya Kannaiyan R.
- Lawal Taiwo Akeem
- Lawani Ismaïl
- Lawani Ismaïl
- Lawday Samuel
- Le Bian Alban Zarzavadjian
- Lederhuber Hans
- Lekuya Hervé Monka
- Lekuya Hervé Monka
- Lekuya Hervé Monka
- Leung Elaine
- Leventoğlu Sezai
- Leventoğlu Sezai
- Lewis-Lloyd Christopher
- Lewis-Lloyd Christopher
- Li Elizabeth
- Li Elizabeth
- Lidder Surjit
- Lincango-Naranjo Eddy
- Lincango-Naranjo Eddy
- Lindert Judith
- Linz Valerie Catherine
- Litvin Andrey
- Litvin Andrey
- Liveris Anna
- Liyo Juan
- Llano Lionel
- Lo Terence
- Loaloa Mohamed Reda
- Lobos Pablo
- Lohsiriwat Varut
- Losada Manuel
- Lott Natalie
- Lou Wenhui
- Lowey Megan
- Lozada Jorge Centeno
- Löffler Markus W.
- Lucchini Sergio Martin
- Lucchini Sergio Martin
- Lueckel Stephanie
- Lugones Ignacio
- Lule Herman
- Lule Herman
- Lule Herman
- Luna Joaquin
- Luzzi Emilia
- López Anna Sánchez
- López Cristina Barrena
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- Perez Rivera Carlos J.
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- Steinkamp Pieter
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- Varghese Chris
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- Vaysse Charlotte
- Velasco Jorge Caño
- Velasquez Enrique Jose Ruiz
- Venkatappa Sunil Kumar
- Venn Mary L.
- Verhaeghe Romain
- Verhaeghe Romain
- Vidal Rafael Perez
- Vidya Raghavan
- Vijayakumar Vijayakumar M.
- Villanueva Julio
- Vimalakanthan Thanusan
- Vita Diana Crego
- Vivancos Patricia Caja
- Viveiros Octavio
- Vives Inmaculada
- Vives Josep Maria Muñoz
- Vo Uyen Giao
- von Pusch Silke
- Vrapi Enxhi
- Vázquez Irene Ortega
- Wafi Omar
- Wagner Arthur
- Waissbluth Sofia
- Waqar Shahzad Hussain
- Watson David
- Watson Eleanor
- Watters David
- Weeraddana Prabuth Dulanjan
- Wells Cameron
- Welter Stefan
- Wettstein Dániel
- Wickramasinghe Dakshitha
- Wickramasinghe Dakshitha
- Wiegering Armin
- Wijeysundera Duminda
- Williams Emmanuel
- Williams Omolara
- Williams Omolara
- Wilson Michael
- Wolf Sebastian
- Wolfer Susanne
- Wong Enoch
- Wright Deborah
- Wright Deborah
- Wright Naomi
- Wuraola Funmilola
- Wuraola Funmilola
- Xaviour Okedi Francis
- Xu William
- Yadev I.
- Yagoub Ghozlan
- Yaqoob Eesha
- Yaqoob Hassan Nawaz
- Yasin Seid Mohammed
- Yazbek Guilherme
- Yebes Alvaro
- Yeung Justin
- Yip Sebastian Shu
- Youssef Mina
- Zabaleta Jon
- Zahid Imdad Ahmad
- Zanoni Gerardo
- Zapardiel Ignacio
- Zapata Carlos Shiraishi
- Zarnescu Narcis Octavian
- Zarour Ahmad
- Zarour Ahmad
- Zarour Ahmad
- Zarratea Celeste Soledad
- Zegarra Sergio
- Zequi Stenio C.
- Zezular Damaris Idara Anabel
- Zhou Xuanyu
- Zhussupov Baurzhan
- Zijaj Lorena
- Zimmelman Natalie
- Zmora Oded
- Zmora Oded
- Zohra Belabbes Fatima
- Publication venue
- HAL CCSD
- Publication date
- 01/11/2021
- Field of study
We aimed to determine the impact of pre-operative isolation on postoperative pulmonary complications after elective surgery during the global SARS-CoV-2 pandemic. We performed an international prospective cohort study including patients undergoing elective surgery in October 2020. Isolation was defined as the period before surgery during which patients did not leave their house or receive visitors from outside their household. The primary outcome was postoperative pulmonary complications, adjusted in multivariable models for measured confounders. Pre-defined sub-group analyses were performed for the primary outcome. A total of 96,454 patients from 114 countries were included and overall, 26,948 (27.9%) patients isolated before surgery. Postoperative pulmonary complications were recorded in 1947 (2.0%) patients of which 227 (11.7%) were associated with SARS-CoV-2 infection. Patients who isolated pre-operatively were older, had more respiratory comorbidities and were more commonly from areas of high SARS-CoV-2 incidence and high-income countries. Although the overall rates of postoperative pulmonary complications were similar in those that isolated and those that did not (2.1% vs 2.0%, respectively), isolation was associated with higher rates of postoperative pulmonary complications after adjustment (adjusted OR 1.20, 95%CI 1.05–1.36, p = 0.005). Sensitivity analyses revealed no further differences when patients were categorised by: pre-operative testing; use of COVID-19-free pathways; or community SARS-CoV-2 prevalence. The rate of postoperative pulmonary complications increased with periods of isolation longer than 3 days, with an OR (95%CI) at 4–7 days or ≥ 8 days of 1.25 (1.04–1.48), p = 0.015 and 1.31 (1.11–1.55), p = 0.001, respectively. Isolation before elective surgery might be associated with a small but clinically important increased risk of postoperative pulmonary complications. Longer periods of isolation showed no reduction in the risk of postoperative pulmonary complications. These findings have significant implications for global provision of elective surgical care. We aimed to determine the impact of pre-operative isolation on postoperative pulmonary complications after elective surgery during the global SARS-CoV-2 pandemic. We performed an international prospective cohort study including patients undergoing elective surgery in October 2020. Isolation was defined as the period before surgery during which patients did not leave their house or receive visitors from outside their household. The primary outcome was postoperative pulmonary complications, adjusted in multivariable models for measured confounders. Pre-defined sub-group analyses were performed for the primary outcome. A total of 96,454 patients from 114 countries were included and overall, 26,948 (27.9%) patients isolated before surgery. Postoperative pulmonary complications were recorded in 1947 (2.0%) patients of which 227 (11.7%) were associated with SARS-CoV-2 infection. Patients who isolated pre-operatively were older, had more respiratory comorbidities and were more commonly from areas of high SARS-CoV-2 incidence and high-income countries. Although the overall rates of postoperative pulmonary complications were similar in those that isolated and those that did not (2.1% vs 2.0%, respectively), isolation was associated with higher rates of postoperative pulmonary complications after adjustment (adjusted OR 1.20, 95%CI 1.05–1.36, p = 0.005). Sensitivity analyses revealed no further differences when patients were categorised by: pre-operative testing; use of COVID-19-free pathways; or community SARS-CoV-2 prevalence. The rate of postoperative pulmonary complications increased with periods of isolation longer than 3 days, with an OR (95%CI) at 4–7 days or ≥ 8 days of 1.25 (1.04–1.48), p = 0.015 and 1.31 (1.11–1.55), p = 0.001, respectively. Isolation before elective surgery might be associated with a small but clinically important increased risk of postoperative pulmonary complications. Longer periods of isolation showed no reduction in the risk of postoperative pulmonary complications. These findings have significant implications for global provision of elective surgical care
Global variation in postoperative mortality and complications after cancer surgery: a multicentre, prospective cohort study in 82 countries
- Author
- A Yacoub Mina
- A. Adam Mohammed
- A. Nassar Mahmoud
- A.Nemer Ayoob
- Aahlin Eirik Kjus
- Ab Rahim Mohd Fadliyazid
- Abad Gurumeta Alfredo
- Abad-Motos Ane
- Abang Jamari Dyg Zahratul Hamrak
- Abantanga Francis
- Abarca Sol
- Abazid Eias
- Abbas Abbas
- Abbas Khalid
- Abbas Mohammad Monir
- Abbasy Jibran
- Abbosh Ali
- Abd Karim Muhammad Fairuz Shah
- Abd Wahab Haidar Hadri
- Abd Barook
- Abdalei Abdulwahab
- Abdalla Ahmed Elkamel Ahmed
- Abdallah Aya
- AbdAllah Mostafa Salim Mohamed
- Abdel Malik Abu Baker
- Abdelhady Mousa Heba
- Abdelhady Samar
- Abdelhakim Ahmed
- Abdelkader Muhammad
- Abdelkawy Shaza
- Abdelkhalek Mohamed
- Abdellatif Esraa
- Abdelmaksoud Tawakel Noura
- Abdelmohsen Naglaa
- Abdelmotaleb Ibrahem
- Abdelrazek Aly
- Abdelsalam Israa
- Abdelshakour Mahmoud
- Abdelwahed Ahmed Mohamed
- Abdou Abdulrahman Osama
- Abdou Alrawy
- Abdou Hossam
- Abdul Aziz Mohamed Rezal
- Abdul Aziz Nora
- Abdulgawad Almogy Mariam
- Abdulla Mazin A.
- Abdullah Muhammad Tariq
- Abdullahi Lawal
- Abdullayev Seymur
- Abed Saeed
- Abelló David
- Abiola Olajide
- Abo mahadi Asmaa'
- Abo-khammash Areej
- Abou Chaar Mohamad K.
- Abou El.soud Moustafa Ramadan
- Abouelsoad Nervana
- Abraham Joyner
- Abreu da Silva Alberto
- Abu Ahammala Ayman B.
- Abu Al Amrain Mahmoud
- Abu Al-saleem Hasan
- Abu Alamrain Abdulwhhab
- Abu Alqumboz Amjad
- Abu Ataya Ahmed
- Abu hallalah Muad fathi khalleefah
- Abu Jamie Najlaa
- Abu Jayyab Israa
- Abu shua'ib Rana
- Abu Zainah Baraa
- Abu-Nimeh Samar
- Abu-Rous Mohammed R.
- Abu-srour Abrar
- Abuelhatal Hasan
- Abuelqomboz Ayham
- Abuhilal Baseel
- Abuhlaiga Ma'aly
- Abujamra Saleh
- Abukhalaf Sadi A.
- Abusalem Lana
- AbuSirrees Mahmoud
- Acevedo Veronica
- Acharya Rajgopal
- Achkasov Sergey
- Acosta Eric
- Adamo Karin
- Adamou Harissou
- Adams Jamie
- Adams Lawrence
- Adawi Samer
- Adebanjo Ademola
- Adel Marina
- Adel Sawsan
- Ademuyiwa Adesoji
- Ademuyiwa Adesoji
- Adenuga Adedire
- Aderounmu Adewale
- Adesanya Opeoluwa
- Adesina Alaba
- Adesunkanmi Abdul-Rashid
- Adeyeye Ademola
- Adidharma Peter
- Adisa Adewale O
- Adnan Nour
- Afifi Amr Abdelghani
- Afifi Eman
- Afolayan Michael Olatunji
- Afzal Asma
- Agarwal Arnav
- Agarwal Raksheeth
- Agbakwuru Augustine
- Agbeko Anita Eseenam
- Aguilar Martinez Maria Del Mar
- Aguilera Maria Lorena
- Aguilera-Arevalo Maria-Lorena
- Ahlqvist Sandra
- Ahmad Izzuddin Ahmad Imran
- Ahmad Kasim
- Ahmad Sarwat
- Ahmed Ahmedgaber
- Ahmed Hazem Abdelkarem
- Ahmed Mariam
- Ahmed Nabila
- Ahmed Zahra
- Ainoa Eppu
- Aithie Joanna M S
- Ajani Costanza
- Ajao Akinlabi
- Ajiboye Anthony
- Ajmera Ankit
- Akande Oluwatosin
- Akaydin Elif
- Akbaba Ata Cem
- Akbar Sana Amir
- Akeel Nouf
- Akeem Aderogba Adeleke
- Akin Alp
- Akinkuolie Akinbolaji
- Akisheva Aygulya
- Akitikori Mabel Temisanren
- Akrida Ioanna
- Aktas Melik Kagan
- Al basos Iyad
- Al Farsi Maryam
- Al Nassrallah Majdi
- Al Sagheir Eman
- Al Saqqa Sara
- Al Saqqa Sara
- Al-Allaf Omar
- Al-Busaidi Ibrahim S.
- Al-Dhufri Ali
- Al-Himyari Hamza S.
- Al-Masri Mahmoud
- Al-Najjar Hani
- Al-Sabbagh Yusra
- Al-Shwaikh Samar
- Al-Slaibi Ibrahim
- Al-Taher Raed
- Al-Tammam Hiba
- Alabuzidi Aya
- Alagha Othman
- Alammarin Mohammad
- Alapatt John
- Alasttal Mohammed
- Alatise Olusegun Isaac
- Albaggar Marwa
- Albahnasawi Moath A.
- Albati Naif
- Alberga Anna
- Alberts Justin
- AlBsoul Ahmad
- Albsoul Nader
- Alcorta Rodrigo
- Alejandre Villalobos Cristina
- Alemdag Gökçe nur
- Alexander Philip
- Alfarra Nada
- Alfitory Asma
- Alhabil Belal
- Alhaj Ahmad
- Alherz Mohammad
- Alhimyar Maryam
- Ali Ahmad Syed Mustafa
- Ali SANI Samuel
- Ali Amr
- Ali Asmaa
- Ali Mahmoud
- Ali Shabina
- Alimi Marjan
- Aliosin Oleg
- Aliyu Halima
- Aljaafreh Almoutuz
- Aljaber Dana
- Aljaberi Loay
- Aljanfi Asma
- Aljiffry Murad
- Aljohmani Lylas
- Alkhaledi Ahmad
- Alkhatib Ala'a Aldeen
- Alkhatib Haya
- Alkhatib Mo'min
- Allen Ingabire J.C.
- Almasri Murad
- Almeida Braga Sara
- Almeida Filipe
- Almigheerbi Alabas
- Almoqayyad Abdelrahman
- Almuzghi Fakhruddin
- Alnoury Mostafa
- Alonso Batanero Ester
- Alqadi Mohammad
- Alsaid Bayan
- Alsalameh Barah
- Alsallaq Osama
- Alser Osaid
- Alshaar Muhammad
- Alsharef Tagwa
- Alsharqawi Nourah
- Alswerki Mohammad
- Altaf Amna
- Altaf Rabiya
- AlTaweel Mohammed
- Althini Abdulmunem Ahmed Mustafa
- Altibi Ahmed M.
- Altinel Yuksel
- Altiner Saygin
- Altomare Donato Francesco
- Altumei Zohoor
- Alvarez Rivera Alvaro Eduardo
- Alvarez-Cano Alethia
- Alves do Canto Brum Homero
- Alves Daniela Macedo
- Alves Magda
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- Zahran Diaaaldin
- Zakaria Andee Dzulkarnaen
- Zakaria Mai
- Zakaria Omar
- Zakaria Zaidi
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- Zammit Matthew
- Zanini Nicola
- Zara Vlu Jean
- Zara Vlu Jean
- Zarti Heba
- Zarzycki Piotr
- Zattoni Davide
- Zavala Gabriela
- Zawahrah Hassan
- Zeiton Asaid
- Zeko Amanda
- Zeng Zhi
- Zeromskas Paulius
- Zhang Geoffrey
- Zhivkov Evgeni
- Zid Esraa
- Zidan Ahmed Mohy
- Zielasek Christian
- Zilinskas Justas
- Zimmermann Bernd
- Ziprin Paul
- Zizzo Maurizio
- Zografos George
- Zoikas Athanasios
- Zorrilla Matilla Laura Patricia
- Zoulamoglou Menelaos
- Zreeg Dafer
- Zub-Pokrowiecka Anna
- Zubiaurre Vanessa
- Zuhdy Mohammed
- Zuikyte Diana
- Zuloaga Fernandez del Valle Carlos Jose
- Zulu Stanley
- Ângelo Miguel
- Älgå Andreas
- Çolak Elif
- Ümarik Toomas
- Šatkauskas Mindaugas
- Škimelyte Monika
- Šlenfuktas Vygintas
- Šuman Oliver
- Žatecký Jan
- Žumbakys Žygimantas
- Župan Domagoj
- Publication venue
- 'Elsevier BV'
- Publication date
- 30/01/2021
- Field of study
© 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 licenseBackground: 80% of individuals with cancer will require a surgical procedure, yet little comparative data exist on early outcomes in low-income and middle-income countries (LMICs). We compared postoperative outcomes in breast, colorectal, and gastric cancer surgery in hospitals worldwide, focusing on the effect of disease stage and complications on postoperative mortality. Methods: This was a multicentre, international prospective cohort study of consecutive adult patients undergoing surgery for primary breast, colorectal, or gastric cancer requiring a skin incision done under general or neuraxial anaesthesia. The primary outcome was death or major complication within 30 days of surgery. Multilevel logistic regression determined relationships within three-level nested models of patients within hospitals and countries. Hospital-level infrastructure effects were explored with three-way mediation analyses. This study was registered with ClinicalTrials.gov, NCT03471494. Findings: Between April 1, 2018, and Jan 31, 2019, we enrolled 15 958 patients from 428 hospitals in 82 countries (high income 9106 patients, 31 countries; upper-middle income 2721 patients, 23 countries; or lower-middle income 4131 patients, 28 countries). Patients in LMICs presented with more advanced disease compared with patients in high-income countries. 30-day mortality was higher for gastric cancer in low-income or lower-middle-income countries (adjusted odds ratio 3·72, 95% CI 1·70–8·16) and for colorectal cancer in low-income or lower-middle-income countries (4·59, 2·39–8·80) and upper-middle-income countries (2·06, 1·11–3·83). No difference in 30-day mortality was seen in breast cancer. The proportion of patients who died after a major complication was greatest in low-income or lower-middle-income countries (6·15, 3·26–11·59) and upper-middle-income countries (3·89, 2·08–7·29). Postoperative death after complications was partly explained by patient factors (60%) and partly by hospital or country (40%). The absence of consistently available postoperative care facilities was associated with seven to 10 more deaths per 100 major complications in LMICs. Cancer stage alone explained little of the early variation in mortality or postoperative complications. Interpretation: Higher levels of mortality after cancer surgery in LMICs was not fully explained by later presentation of disease. The capacity to rescue patients from surgical complications is a tangible opportunity for meaningful intervention. Early death after cancer surgery might be reduced by policies focusing on strengthening perioperative care systems to detect and intervene in common complications. Funding: National Institute for Health Research Global Health Research Unit
Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study
- Author
- A Yacoub Mina
- A. Adam Mohammed
- A. Nassar Mahmoud
- A.Nemer Ayoob
- Aahlin Eirik Kjus
- Ab Rahim Mohd Fadliyazid
- Abad Gurumeta Alfredo
- Abad-Motos Ane
- Abang Jamari Dyg Zahratul Hamrak
- Abantanga Francis
- Abarca Sol
- Abazid Eias
- Abbas Abbas
- Abbas Khalid
- Abbas Mohammad Monir
- Abbasy Jibran
- Abbosh Ali
- Abd Karim Muhammad Fairuz Shah
- Abd Wahab Haidar Hadri
- Abd Barook
- Abdalei Abdulwahab
- Abdalla Ahmed Elkamel Ahmed
- Abdallah Aya
- AbdAllah Mostafa Salim Mohamed
- Abdel Malik Abu Baker
- Abdelhady Mousa Heba
- Abdelhady Samar
- Abdelhakim Ahmed
- Abdelkader Muhammad
- Abdelkawy Shaza
- Abdelkhalek Mohamed
- Abdellatif Esraa
- Abdelmaksoud Tawakel Noura
- Abdelmohsen Naglaa
- Abdelmotaleb Ibrahem
- Abdelrazek Aly
- Abdelsalam Israa
- Abdelshakour Mahmoud
- Abdelwahed Ahmed Mohamed
- Abdou Abdulrahman Osama
- Abdou Alrawy
- Abdou Hossam
- Abdul Aziz Mohamed Rezal
- Abdul Aziz Nora
- Abdulgawad Almogy Mariam
- Abdulla Mazin A.
- Abdullah Muhammad Tariq
- Abdullahi Lawal
- Abdullayev Seymur
- Abed Saeed
- Abelló David
- Abiola Olajide
- Abo mahadi Asmaa'
- Abo-khammash Areej
- Abou Chaar Mohamad K.
- Abou El.soud Moustafa Ramadan
- Abouelsoad Nervana
- Abraham Joyner
- Abreu da Silva Alberto
- Abu Ahammala Ayman B.
- Abu Al Amrain Mahmoud
- Abu Al-saleem Hasan
- Abu Alamrain Abdulwhhab
- Abu Alqumboz Amjad
- Abu Ataya Ahmed
- Abu hallalah Muad fathi khalleefah
- Abu Jamie Najlaa
- Abu Jayyab Israa
- Abu shua'ib Rana
- Abu Zainah Baraa
- Abu-Nimeh Samar
- Abu-Rous Mohammed R.
- Abu-srour Abrar
- Abuelhatal Hasan
- Abuelqomboz Ayham
- Abuhilal Baseel
- Abuhlaiga Ma'aly
- Abujamra Saleh
- Abukhalaf Sadi A.
- Abusalem Lana
- AbuSirrees Mahmoud
- Acevedo Veronica
- Acharya Rajgopal
- Achkasov Sergey
- Acosta Eric
- Adamo Karin
- Adamou Harissou
- Adams Jamie
- Adams Lawrence
- Adawi Samer
- Adebanjo Ademola
- Adel Marina
- Adel Sawsan
- Ademuyiwa Adesoji
- Ademuyiwa Adesoji O
- Adenuga Adedire
- Aderounmu Adewale
- Adesanya Opeoluwa
- Adesina Alaba
- Adesunkanmi Abdul-Rashid
- Adeyeye Ademola
- Adidharma Peter
- Adisa Adewale
- Adisa Adewale O
- Adnan Nour
- Afifi Amr Abdelghani
- Afifi Eman
- Afolayan Michael Olatunji
- Afzal Asma
- Agarwal Arnav
- Agarwal Raksheeth
- Agbakwuru Augustine
- Agbeko Anita Eseenam
- Aguilar Martinez Maria Del Mar
- Aguilera Maria Lorena
- Aguilera-Arevalo Maria-Lorena
- Ahlqvist Sandra
- Ahmad Izzuddin Ahmad Imran
- Ahmad Kasim
- Ahmad Sarwat
- Ahmed Ahmedgaber
- Ahmed Hazem Abdelkarem
- Ahmed Mariam
- Ahmed Nabila
- Ahmed Zahra
- Ainoa Eppu
- Aithie Joanna M S
- Ajani Costanza
- Ajao Akinlabi
- Ajiboye Anthony
- Ajmera Ankit
- Akande Oluwatosin
- Akaydin Elif
- Akbaba Ata Cem
- Akbar Sana Amir
- Akeel Nouf
- Akeem Aderogba Adeleke
- Akin Alp
- Akinkuolie Akinbolaji
- Akisheva Aygulya
- Akitikori Mabel Temisanren
- Akrida Ioanna
- Aktas Melik Kagan
- Al basos Iyad
- Al Farsi Maryam
- Al Nassrallah Majdi
- Al Sagheir Eman
- Al Saqqa Sara
- Al Saqqa Sara
- Al-Allaf Omar
- Al-Busaidi Ibrahim S.
- Al-Dhufri Ali
- Al-Himyari Hamza S.
- Al-Masri Mahmoud
- Al-Najjar Hani
- Al-Sabbagh Yusra
- Al-Shwaikh Samar
- Al-Slaibi Ibrahim
- Al-Taher Raed
- Al-Tammam Hiba
- Alabuzidi Aya
- Alagha Othman
- Alammarin Mohammad
- Alapatt John
- Alasttal Mohammed
- Alatise Olusegun Isaac
- Albaggar Marwa
- Albahnasawi Moath A.
- Albati Naif
- Alberga Anna
- Alberts Justin
- AlBsoul Ahmad
- Albsoul Nader
- Alcorta Rodrigo
- Alejandre Villalobos Cristina
- Alemdağ Gökçe nur
- Alexander Philip
- Alfarra Nada
- Alfitory Asma
- Alhabil Belal
- Alhaj Ahmad
- Alherz Mohammad
- Alhimyar Maryam
- Ali Ahmad Syed Mustafa
- Ali SANI Samuel
- Ali Amr
- Ali Asmaa
- Ali Mahmoud
- Ali Shabina
- Alimi Marjan
- Aliosin Oleg
- Aliyu Halima
- Aljaafreh Almoutuz
- Aljaber Dana
- Aljaberi Loay
- Aljanfi Asma
- Aljiffry Murad
- Aljohmani Lylas
- Alkhaledi Ahmad
- Alkhatib Ala'a Aldeen
- Alkhatib Haya
- Alkhatib Mo'min
- Allen Ingabire J.C.
- Almasri Murad
- Almeida Braga Sara
- Almeida Filipe
- Almigheerbi Alabas
- Almoqayyad Abdelrahman
- Almuzghi Fakhruddin
- Alnoury Mostafa
- Alonso Batanero Ester
- Alqadi Mohammad
- Alsaid Bayan
- Alsalameh Barah
- Alsallaq Osama
- Alser Osaid
- Alshaar Muhammad
- Alsharef Tagwa
- Alsharqawi Nourah
- Alswerki Mohammad
- Altaf Amna
- Altaf Rabiya
- AlTaweel Mohammed
- Althini Abdulmunem Ahmed Mustafa
- Altibi Ahmed M.
- Altinel Yuksel
- Altiner Saygin
- Altomare Donato Francesco
- Altumei Zohoor
- Alvarez Rivera Alvaro Eduardo
- Alvarez-Cano Alethia
- Alves do Canto Brum Homero
- Alves Daniela Macedo
- Alves Magda
- Alvi Abdul
- Alwaheidi Malak
- Alwali Abdallah
- Alwerfally AbdulMawlay
- Alwhaidi Noor
- Alyafi Amr
- Alzabti Fatima
- Alzahaf Ahmed
- AlZohour Mohammad
- Amadou Magagi Ibrahim
- Amandito Radhian
- Amarin Justin Z.
- Amaro Margarida
- Ambrazevicius Marijus
- Amendola Alfonso
- Amin Leila
- Amine Souadka
- Amjad Talal
- Amorim Edgar
- Amro Adham
- Anandan Premkumar
- Anas khalifa Rawda
- Anastasio Lorenzo
- Andersson Yvette
- Andreotti Dario
- Andrew David
- André Benoît
- Ang Sue Ean
- Angel Miguel
- Anggita Gultom Phebe
- Annapureddy Naga
- Anokhin Evgeny
- Ansaloni Luca
- Ansarei Dhirar
- Ansari Abdul Basit
- Antaky Marco
- Anthony Natasha
- Anthoulakis Christos
- Antonopoulou Maria Ioanna
- Anwar Mohamed
- Anwer Abdul Wahid
- Anyanwu Chikamuche
- Anyanwu Lofty-John
- Anyanwu Mercy Chinemerem
- Anyomih Theophilus Teddy Kojo
- Appukuttan Akhila
- Aquilino Fabrizio
- Archibald Jess
- Arciénega Yañez María del pilar
- Argentou Maria-Ioanna
- Argudo Nuria
- Argyriou Eleftherios Orestis
- Arias Madrid Natalia
- Aribi Sarra
- Arifin Ghafur Rasyid
- Arizpe Daniel
- Arnaud Alexis P
- Arora Bharti
- Arora Deeksha
- Arowolo Olukayode
- Arrangoiz Rodrigo
- Arslan Ekin
- Artigau Eva
- Ashfaq Ahsan
- Ashour Dina
- Ashour Firas
- Ashoushan Hana
- Ashraf Ahmed
- Ashraf Alaa
- Asif Ashar
- Asnel Dorisme
- Asok Anjitha
- Assa Rawan
- Assalhi Mohamed
- Asta Martina
- Asti Emanuele Luigi Giuseppe
- Atakul Onur
- Atallah Khalid
- Atanasov Boyko
- Atawneh Mohammad
- Athamneh Sarah
- Ather Muaaz
- Athisayaraj Thomas
- Atkociunas Aivaras
- Attia Mohamed
- Au Angela
- Awad Israa
- Awadallah Haneen
- Awaji Kholoud
- Awesat Eman
- Awolowo Ajibola
- Ayandipo Omobolaji
- Ayash Mohammad
- Ayau Fernanda
- Ayesh Kholoud
- Ayman El-sawy Esraa
- Ayoub Rami
- Aytac Erman
- Ayub Bushra
- Ayub Saima
- Ayyad Rawan
- Azevedo José
- Azodo Ijeoma
- Azzubia Joma
- B L Ashika
- Ba Mouhamadou Bachir
- Babaa Basheer
- Babirye Lilian
- Bacic Ivan
- Badr Esraa Tarek
- Badr Helmy
- Badran Abdul
- Badwe Rajendra
- Bafford Andrea Chao M.D.
- Baggaley Caitlin
- Bahroun Sumayyah Ghayth
- Baiao José Miguel
- Baiocchi Daniella
- Bairos Menezes Maria
- Baiu Ioana
- Bajilan Mohammad
- Bajomo Oreoluwa
- Bake Jacques
- Baki Bahadir Emre
- Bakoleas Panagiotis
- Balaawi Reem
- Balalis Dimitrios
- Balata Mohamed
- Balkarov Artem
- Ballouhey Quentin
- Balogun Olanrewaju
- Baloyiannis Ioannis
- Baltaci Ege
- Bamaca Ixcajoc Elvis Benjamin
- Banaz Tuba
- Banda Bitiel
- Banglani Muntaha
- Bani Hani Farah
- Bani hani Mohammad
- Bani hani Zeina
- Baniowda Muath
- Banks Alexander
- Bannister Sharon
- Baranyai Zsolt
- Barati Nastaran
- Barbosa Camacho Francisco José
- Barbosa José
- Bardos David
- Barendegere Venerand
- Barghuthi Lutfi
- Barhoush Ola
- Barnes Nicole
- Baronio Gianluca
- Barreda Zelaya Lilian Elizabeth
- Barrera López Francisco Javier
- Barsic Neven
- Barter Charlotte
- Bartosiak Katarzyna
- Basarab Maksym
- Basso Stefano Maria Massimiliano.
- Bastiaenen Vivian
- Batashki Ilia
- Bath Michael
- Beattie Miriam
- Bedada Alemayehu Ginbo
- Belais Fanny
- Belal qadomi Asef
- Belev Nikolay
- Belli Andrea
- Beltrán de Heredia Juan
- Belvedere Angela
- Ben Dallah Najah
- Ben Saoud Abdulsalam Ali
- Bengur Fuat Baris
- Benkabbou Amine
- Benke Marton
- Benyaiche Chaymae
- Bergeat Damien
- Bernstein Mitchell
- Beshtawi Doha
- Besli Sevval
- Beuran Mircea
- Bhandare Manish
- Bhangu Aneel
- Bhatti Muhammad Iqbal
- Bianchini Stefania
- Bianco Francesco
- Bibas Fatma
- Biccard Bruce M
- Bielosludtsev Oleksii
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- Haji Reema
- Hajjaj Ahmed N K
- Hall Timothy
- Hamdan Hamdan
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- Tawalbeh Ra'fat
- Tawalbeh Tamara
- Tayar Serkan
- Tayler Viki
- Teasdale Ella
- Teh Jen
- Tejeda Garrido Jorge Carlos Guillermo
- Tennakoon Athula
- Tepe Mustafa Deniz
- Teppo Sandra
- Ter Alvin Zubin
- Teras Jyri
- Tereshchenko Maksym
- Tew Yong Yong
- Thakkar Purvi
- Thalgaspitiya Sujeewa Priyantha Bandara
- Tharanath Kavya
- Tharwat Hoda
- Theodoropoulos Charalampos
- Theodorou Dimitrios
- Theodosopoulos Theodosios
- Theofanis George
- Thomas Hannah
- Thomas Jimmy Scott
- Thomas-Jones Iolo
- Thompson Amari
- Thompson Joanna
- Thorell Anders
- Tin Moe Moe
- Tinton Nicolas
- Tiong Ing Ching
- Titan Ashley
- Tlhomelang Omphile
- Todorov George
- Tojal André
- Tol Isabel
- Tomas Kadir
- Tomazic Ales
- Tomé Miguel
- Tondo Matteo
- Tonini Valeria
- Torre Ana
- Torrent Jansà Laia
- Toscano Pacheco Andrea
- Toussaint Arnaud
- Townson Adam
- Trabulsi Nora
- Trenba Sarah
- Triantafyllou Tania
- Tribedi Thomas
- Troche Pesqueira Noemí
- Troche José Manuel
- Troilo Francesca
- Trompetto Mario
- Tropeano Francesca Paola
- Trostchansky Ivan
- Truan Nuria
- Trugeda-Carrera Maria Soledad
- Trujillo Díaz Jeancarlos
- Trullenque Juan Ramon
- Trunčíková Vendula
- Truong Anthony
- Truszkiewicz Katarzyna
- Tryliskyy Yegor
- Tsandiraki Justin
- Tsimpoukelis Antonios
- Tucker Sally
- Tulley Joshua
- Turati Luca
- Turri Giulia
- Turunen Antti
- Turunen Arto
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- Tuynman Jurriaan
- Tyselskiy Volodimir
- Tzovaras George
- Tüfek Ozan yavuz
- Türkyilmaz Serdar
- Ubartas Nerijus
- Ubiali Paolo
- Ugoletti Lara
- Ugolini Giampaolo
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- Umenze Franklin
- Umoke Ifeanyi
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- Urbieta Aitor
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- Usai Antonella
- Usta Arif
- Utrilla Fornals Alejandra
- Uwakunda Carine
- Uy Gemma Leonora
- Uysal Muhammed
- V Sushmita
- Valente da Costa Ana
- Valle Aranda Yener Cristyell
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- van Berge Henegouwen Mark I.
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- van Praag Elise Maria
- van Schilt Kaz
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- Warden Claire
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- Willemin Melissa
- Williams Christopher Yee Khang
- Wills Vanessa
- Wilson Karim
- Wilson Michael
- Wimmer Kerstin
- Windsor John
- Wineberg Devorah
- Winiarski Marek
- Winoto Hadi
- Winter Beatty Jasmine
- Winter Des
- Wisal Maham
- Wisselink Daan
- Wogensen Fredrik
- Wondoh Paul M.
- Wong Florence
- Wong Hsu Ven
- Wong Jane J
- Wong Jeremy
- Wong Lai Fen
- Wong Michael Pak-Kai
- Wong Sui-Weng
- Wong Tsz Lun Ernest
- Wood Lauren
- Woon-Shoo-Tong Xiao-Ming Sarah
- Wren Sherry
- Wuraola Funmilola
- Xanthopoulou Georgia
- Yabut Kenneth
- Yacoub Aseel
- Yaghi Nadine
- Yaghi Yasmine
- Yahia Mohamed Ali Mohamed
- Yakushkina Al'ona
- Yalçinkaya Ali
- Yang P Zichu
- Yanikoğlu Erkan
- Yanni Fady
- Yates Charlotte
- Ye Geoffrey
- Yeen Chin Leow
- Yemez Kürşat
- Yenidünya Nilüfer
- Yenli Edwin
- Yeo Jeremy
- Yeoh Andrea
- Yepez Raul
- Yeşilsancak Merve
- Yildirim Reyyan
- Yildiz Alp
- Yilmaz Duygu
- Yip Ching Wan
- Ylatoma Díaz Edgar Alcides
- Yong Shun Qi
- Yoong Andrel
- Yorke Joseph
- Yotsov Tsanko
- You Lucia
- Younes Eman
- Younes Maha
- Yousry Basant
- Yozgatli Tahir Koray
- Yu Kristin
- Yue Sum Yu Pansy
- Yunes Asmaa
- Yusuf Baasil
- Yüksel Osman
- Zabiyaka Mikhail
- Zachariah Sanoop Koshy
- Zafar Syed Nabeel
- Zaffaroni Gloria
- Zahra Baryab
- Zahran Diaaaldin
- Zakaria Andee Dzulkarnaen
- Zakaria Mai
- Zakaria Omar
- Zakaria Zaidi
- Zambrana Campos Vanesa
- Zammit Matthew
- Zanini Nicola
- Zara Vlu Jean
- Zarti Heba
- Zarzycki Piotr
- Zattoni Davide
- Zavala Gabriela
- Zawahrah Hassan
- Zeiton Asaid
- Zeko Amanda
- Zeng Zhi
- Zeromskas Paulius
- Zhang Geoffrey
- Zhivkov Evgeni
- Zid Esraa
- Zidan Ahmed Mohy
- Zielasek Christian
- Zilinskas Justas
- Zimmermann Bernd
- Ziprin Paul
- Zizzo Maurizio
- Zografos George
- Zoikas Athanasios
- Zorrilla Matilla Laura Patricia
- Zoulamoglou Menelaos
- Zreeg Dafer
- Zub-Pokrowiecka Anna
- Zubiaurre Vanessa
- Zuhdy Mohammed
- Zuikyte Diana
- Zuloaga Fernandez del Valle Carlos Jose
- Zulu Stanley
- Ângelo Miguel
- Älgå Andreas
- Çolak Elif
- Ümarik Toomas
- Čepuliené Daiva
- Şahin Can
- Šatkauskas Mindaugas
- Škimelytè Monika
- Šlenfuktas Vygintas
- Šuman Oliver
- Žatecký Jan
- Žumbakys Žygimantas
- Župan Domagoj
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/07/2022
- Field of study
© 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licenseBackground: Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between hospital infrastructure, resource availability, and processes on early outcomes after cancer surgery worldwide. Methods: A multimethods analysis was performed as part of the GlobalSurg 3 study—a multicentre, international, prospective cohort study of patients who had surgery for breast, colorectal, or gastric cancer. The primary outcomes were 30-day mortality and 30-day major complication rates. Potentially beneficial hospital facilities were identified by variable selection to select those associated with 30-day mortality. Adjusted outcomes were determined using generalised estimating equations to account for patient characteristics and country-income group, with population stratification by hospital. Findings: Between April 1, 2018, and April 23, 2019, facility-level data were collected for 9685 patients across 238 hospitals in 66 countries (91 hospitals in 20 high-income countries; 57 hospitals in 19 upper-middle-income countries; and 90 hospitals in 27 low-income to lower-middle-income countries). The availability of five hospital facilities was inversely associated with mortality: ultrasound, CT scanner, critical care unit, opioid analgesia, and oncologist. After adjustment for case-mix and country income group, hospitals with three or fewer of these facilities (62 hospitals, 1294 patients) had higher mortality compared with those with four or five (adjusted odds ratio [OR] 3·85 [95% CI 2·58–5·75]; p<0·0001), with excess mortality predominantly explained by a limited capacity to rescue following the development of major complications (63·0% vs 82·7%; OR 0·35 [0·23–0·53]; p<0·0001). Across LMICs, improvements in hospital facilities would prevent one to three deaths for every 100 patients undergoing surgery for cancer. Interpretation: Hospitals with higher levels of infrastructure and resources have better outcomes after cancer surgery, independent of country income. Without urgent strengthening of hospital infrastructure and resources, the reductions in cancer-associated mortality associated with improved access will not be realised. Funding: National Institute for Health and Care Research
Geoeconomic variations in epidemiology, ventilation management, and outcomes in invasively ventilated intensive care unit patients without acute respiratory distress syndrome: a pooled analysis of four observational studies
- Author
- Aage Christiansen
- Aaradhana Adhikari
- Aaron Venti
- Aayesha Qadeer
- Abdellatif Benslama
- Abigail Beane
- Abu Hena Mostafa Kamal
- Abul Faiz
- Adam B Schlichting
- Adam Bell Bell
- Adenilton M R Ampinelli
- Aditya Uppalapati
- Adrian Donnelly
- Adriana M Fernandez
- Adrien Robine
- Aftab Akhtar
- Agreta Gecaj-Gashi
- Ahmed Farooq
- Ahmed S Al Jabbary
- Ahmet Dilek
- Ahmet Sukru Denker
- Ai Y Hang
- Aiman Tulaimat
- Akihiro Takaba
- Akinori Uchiyama
- Akira Hirata
- Akm Shamsul Alam
- Akut Aytulun
- Alain Combes
- Alain M Dive
- Alain Mercat
- Alain U Alisasis
- Alan Zazu
- Alastair Rose
- Alberto Deicas
- Alec A Tallet Alfonso
- Alejandro A Saez
- Alejandro Ebeid
- Alejandro G Castro
- Alejandro R Bruhn
- Alek Kumar
- Alessandro Bacuzzi
- Alessandro Protti
- Alessia Mattei
- Alex Mcleod
- Alex Morton
- Alexandra Ceniceros-Barros
- Alexandra J Williams
- Alexandra Marcu
- Alexandra Siqueira Colombo
- Alexandre Biasi Cavalcanti
- Alexandre Biasi Cavalcanti
- Alexandre Chan
- Alexandre Demoule
- Alexandre Guilherme Ribeiro de Carvalho
- Alexandre Molin
- Alexandre Molin
- Alexey I Gritsan
- Alfons Arizmendi
- Aline Ascoli
- Alison Ghosh
- Alistair Nichol
- Alistair Roy Roy
- Alma Cani
- Alvaro Ramirez-Gutierrez
- Amadeu Martinez
- Amanda Cowton
- Amanda Krstevski
- Amanda Maria R R de Oliveira
- Amanda Skinner
- Amanda Whileman
- Amine Ali Zeggwagh
- Amine Ali Zeggwagh
- Amy McInerney
- Ana Carolina P Antônio
- Ana Carolina Peçanha
- Ana G França
- Ana M Araujo
- Ana M Pellicer
- Anais Briquet
- Anand Dongre
- Anatole Harrois
- Anders Aneman
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- Andre Japiassu
- Andre Luiz Baptiston Nunes
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- Andre Vercueil
- Andrea Coppadoro
- Andrea Cortegiani
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- Andrea Lombardo
- Andrea N Cracchiolo
- Andrea Tinnirello
- Andreas Barratt-Due
- Andreas W Reske
- Andrej Sribar
- Andrew Bentley
- Andrew Corner
- Andrew Ferguson
- Andrew J Burtenshaw
- Andrey A Gazenkampf
- André Peretti Torelly
- Angela Delsing
- Angela Pinder
- Aniko D Frigyik
- Anil Hormis
- Anil P Hormis
- Anitha Shenoy
- Anna Hunt
- Anna Oscarsson Tibblin
- Anna Rossi
- Anna T Dowling
- Anna Walker
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- Anne Adolfsson
- Anne B Guttormsen
- Annop Piriyapatsom
- Antero do Vale Fernandes
- Antoine Pronovost
- Antonino Giarratano
- Antonio Artigas
- Antonio Braschi
- Antonio Carlos Nogueira
- Antonio G Jimenez
- Antonio Jorge Pereira
- Antonio L Ruiz-Aguilar
- Antonio P Nassar Jr
- Antonio Paulo Nassar Junior
- António M Alvarez
- António M Messias
- Aogan C O'Muircheartaigh
- Areef Ahsan
- Areej Javeed
- Ariel Chena
- Arnaud Follin
- Arshad Taqi
- Arvind K Baronia
- Ary Serpa Neto
- Ashley Schomer
- Ashok S Raj
- Asisclo J Villagomez
- Asisclo Villagomez
- Asma Ben Souissi
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- Asoka Gunaratne
- Atta Ur Rehman
- Aurelia M Martinho
- Aylin Seven
- Bao H Zhu
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- Barry Dixon
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- Basak Ceyda Meco
- Batoul Khoundabi
- Beatriz C Tan
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- Ben Creagh-Brown
- Bernard Goubaux
- Bernhard Holzgraefe
- Bhagyesh Shah
- Bhuvana Krishna
- Bimal Kudavidanage
- Bin Li
- Bingyu Qin
- Bojan Jovanovic
- Boris G Villamagua
- Brenno Cardoso Gomes
- Brigit L Roberts
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- Bruno Franco Mazza
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- Colette Seasman
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- Colin K Grissom
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- Cora Lavigne Moreira
- Corcoles G Virgilio
- Corinne Leemann-Refondini
- Cristiane Ritter
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- Cristina M Cox
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- Cédric Daubin
- Daisuke Niimi
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- Dalton de Souza Barros
- Damien Roux
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- Daniela Albiero
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- Daniele M Combaux
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- Dawn Trodd
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- Deborah M Inskip
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- Denise Griffin
- Dharshinie Dorasamy
- Diego Pastor Marcos
- Dimitrios Matamis
- Dina Gomaa
- Dina Gomaa
- Dina Ismail
- Dk Maizatul Aiman B Pg Hj Ismail
- Donald A Irvine
- Donall O'Croinin
- Donatella Mestria
- Dora Mannarino
- Dorel Sandesc
- Dorothy M Breen
- Dorothée Carpentier
- Dulce M Dector
- Dyanne Moysés Dalcomune
- Dácil Parrilla Toribio
- Ed Bajwa
- Eddy Fan
- Edel A Meaney
- Edgardo E Tabhan
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- Edison Moraes
- Eduardo Beck
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- Eimhin S Dunne
- Eizo Watanabe
- Elaine Ferreira
- Eldar Søreide
- Electra E Stamou
- Elena Frati
- Elena Gallego Curto
- Elena Perez Losada
- Eleni K Mouloudi
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- Eliana Bernadete Caser
- Eliane Bernadete Caser
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- Eliezer Silva
- Elisa Estenssoro
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- Elisabetta Pecci
- Elise P Sauvadet
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- Elton Afonso Lopes
- Emanuel Cirstea
- Emilio M Osman
- Emma L Willett
- Emre Erbabacan
- Enrique A Piacentini
- Enrique Cereijo
- Eoin Young
- Erika E Borotto
- Erin Nishikawa
- Erna Alberts
- Esther Bermejo Lopez
- Esther Diaz-Rodriguez
- Ettore R Vascotto
- Eva O Nagy
- Evangelos Kalaitzis
- Evelin Drociunas Pacheco
- Evgeny Grigoriev
- Evren Senturk
- Ewan C Goligher
- Fa C Zhou
- Fabien Grelon
- Fabienne D Simonis
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- Fahd Amir
- Fan Zhang
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- Farooq Brohi
- Farshad Heidari
- Fatma Ulger
- Fayez M Kheir
- Feda Kahveci
- Federico Gordo
- Fekri Abroug
- Felipe A Aliaga
- Felipe Dal-Pizzol
- Felipe Saddy
- Felipe T Martinez
- Ferdinando Raimondi
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- Fernando Borges Rodriguez
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- Fernando José da Silva Ramos
- Fernando Rios
- Ferran Roche-Campo
- Filipa M Barros
- Finn H Andersen
- Flavia A Loiacono
- Flavia Ribeiro Machado
- Francesco L Santoli
- Francesco Mojoli
- Francesco Raponi
- Francis Schneider
- Francisca G Cazorla-Barranquero
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- Francisco Javier Flores Mejia
- Francisco P Huerta
- Francisco Soriano
- Francois Beloncle
- Frank Stansil
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- Frank Van Haren
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- Fredrik Schiöler
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- Fumihito Ito
- Fábio Poianas Giannini
- Gabriel Démpaire
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- Gabrielle C Hanlon
- Gaetan Béduneau
- Galen Henderson
- Garcia M Elisabet
- Gareth P Sellors
- Gary H Mills
- Gautier Buzancais
- Gayle Clifford
- Ged Dempsey
- Gemma Rialp
- Gerard Curley
- Ghaleb Almekhlafi
- Ghanem M Mustafa
- Ghassan Kamel
- Giacomo Bellani
- Giacomo Monti
- Gianluca Zani
- Giannis A Zacharas
- Gilda Cinnella
- Giorgio A Iotti
- Giovana Colozza Mecatti
- Giovanna Occhipinti
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- Giulia Crapelli
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- Guillermo Bugedo
- Guillermo M Albaiceta
- Gulay Eren
- Gustavo A Plotnikow
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- Gustavo Pittini
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- Veronica Villar
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- Vesna Bumbasirevic
- Vicente Cés de Souza Dantas
- Vijayanand Palaniswamy
- Vincenzo Pota
- Vincenzo Russotto
- Vincenzo Schiavone
- Viratch Tangsujaritvijit
- Virginie Lemiale
- Visanthi Pinto
- Vivek Kakar
- Vladimir Cerny
- Vlasta Klaric
- Wahid Altaf
- Wajdi Maazouzi
- Wei H Zhu
- Wei Wang
- Weihua Lu
- Wenkui Yu
- Wenwen Li
- Werner Schmid
- William Stigler
- Xavier Wittebole
- Xian Y Zhao
- Xiao B Huang
- Xiao L Li
- Xiaoming Luo
- Xing Y Zhang
- Xinyu Li
- Y A Hasitha Dilhani
- Ya Q Wu
- Yaasen Arabi
- Yan Gao
- Yaseen M Arabi
- Yasuaki Ogino
- Yavuz Orak
- Yen Lam Minh
- Yi Han
- Yimin Li
- Yonghao Xu
- Yoshihiro Yamaji
- Yoshinobu Kameyama
- Youssef Haddad
- Youzhong An
- Yozo Kashiwa
- Yu D Di
- Yuan N Gao
- Yuan Y Li
- Yuanhua Lu
- Yves D Jarquin-Badiola
- Zerrin Demirtürk
- Zhe Zhai
- Zheng L Ye
- Zhenyang He
- Zhou Li-Xin
- Álvaro Réa-Neto
- Ángela Algaba
- Ángela González-Salamanca
- Çiler Zincircioglu
- Érica Aranha Suzumura
- Ênio Rego
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
Background: Geoeconomic variations in epidemiology, the practice of ventilation, and outcome in invasively ventilated intensive care unit (ICU) patients without acute respiratory distress syndrome (ARDS) remain unexplored. In this analysis we aim to address these gaps using individual patient data of four large observational studies.
Methods: In this pooled analysis we harmonised individual patient data from the ERICC, LUNG SAFE, PRoVENT, and PRoVENT-iMiC prospective observational studies, which were conducted from June, 2011, to December, 2018, in 534 ICUs in 54 countries. We used the 2016 World Bank classification to define two geoeconomic regions: middle-income countries (MICs) and high-income countries (HICs). ARDS was defined according to the Berlin criteria. Descriptive statistics were used to compare patients in MICs versus HICs. The primary outcome was the use of low tidal volume ventilation (LTVV) for the first 3 days of mechanical ventilation. Secondary outcomes were key ventilation parameters (tidal volume size, positive end-expiratory pressure, fraction of inspired oxygen, peak pressure, plateau pressure, driving pressure, and respiratory rate), patient characteristics, the risk for and actual development of acute respiratory distress syndrome after the first day of ventilation, duration of ventilation, ICU length of stay, and ICU mortality.
Findings: Of the 7608 patients included in the original studies, this analysis included 3852 patients without ARDS, of whom 2345 were from MICs and 1507 were from HICs. Patients in MICs were younger, shorter and with a slightly lower body-mass index, more often had diabetes and active cancer, but less often chronic obstructive pulmonary disease and heart failure than patients from HICs. Sequential organ failure assessment scores were similar in MICs and HICs. Use of LTVV in MICs and HICs was comparable (42·4% vs 44·2%; absolute difference -1·69 [-9·58 to 6·11] p=0·67; data available in 3174 [82%] of 3852 patients). The median applied positive end expiratory pressure was lower in MICs than in HICs (5 [IQR 5-8] vs 6 [5-8] cm H2O; p=0·0011). ICU mortality was higher in MICs than in HICs (30·5% vs 19·9%; p=0·0004; adjusted effect 16·41% [95% CI 9·52-23·52]; p<0·0001) and was inversely associated with gross domestic product (adjusted odds ratio for a US$10 000 increase per capita 0·80 [95% CI 0·75-0·86]; p<0·0001).
Interpretation: Despite similar disease severity and ventilation management, ICU mortality in patients without ARDS is higher in MICs than in HICs, with a strong association with country-level economic status