Biogenesis of Pro-senescent Microparticles by Endothelial Colony Forming Cells from Premature Neonates is driven by SIRT1-Dependent Epigenetic Regulation of MKK6.

Senescent cells may exert detrimental effect on microenvironment through the secretion of soluble factors and the release of extracellular vesicles, such as microparticles, key actors in ageing and cardiovascular diseases. We previously reported that sirtuin-1 (SIRT1) deficiency drives accelerated senescence and dysfunction of endothelial colony-forming cells (ECFC) in PT neonates. Because preterm birth (PT) increases the risk for cardiovascular diseases during neonatal period as well as at adulthood, we hypothesized that SIRT1 deficiency could control the biogenesis of microparticles as part of a senescence-associated secretory phenotype (SASP) of PT-ECFC and investigated the related molecular mechanisms. Compared to control ECFC, PT-ECFC displayed a SASP associated with increased release of endothelial microparticles (EMP), mediating a paracrine induction of senescence in naïve endothelial cells. SIRT1 level inversely correlated with EMP release and drives PT-ECFC vesiculation. Global transcriptomic analysis revealed changes in stress response pathways, specifically the MAPK pathway. We delineate a new epigenetic mechanism by which SIRT1 deficiency regulates MKK6/p38 <sup>MAPK</sup> /Hsp27 pathway to promote EMP biogenesis in senescent ECFC. These findings deepen our understanding of the role of ECFC senescence in the disruption of endothelial homeostasis and provide potential new targets towards the control of cardiovascular risk in individuals born preterm

Os dividendos como estratégia de investimentos em ações

Na Teoria de Finanças, o papel dos dividendos nas cotações é um tema controverso, uma vez que há diferentes teorias que abordam sua relevância para o valor das ações e, em conseqüência, para a riqueza dos acionistas. Além disso, as descobertas empíricas que originaram a Hipótese de Mercado Eficiente de Capitais (HME) não apenas contradizem a Análise Técnica, mas também impõem um desafio à declarada habilidade superior da Análise Fundamentalista em gerar retornos superiores, com base em fatores ou variáveis contábeis, financeiros e econômicos, tais como o dividend yield (retorno em dividendos). A fim de se verificar a relação entre dividend yields e as taxas de retornos das ações, bem como a viabilidade de uma estratégia baseada em dividend yields históricos de "bater" o mercado, foram construídas, mensalmente, durante o período que vai do Plano Real em julho de 1994 a dezembro de 1999, três diferentes carteiras (alto, baixo e zero). Seus riscos, retornos e indicadores de desempenho ajustados ao risco foram calculados e comparados entre si e com seu paradigma (benchmark), o Índice da Bolsa de Valores de São Paulo - Ibovespa. A evidência empírica é incapaz de sugerir que as ações de altos dividend yield tendem a possuir maiores ou menores taxas de retorno do que as ações de baixo ou zero yield. Ademais, as evidências sugerem que não é possível demonstrar, usando o método empírico aplicado, uma clara associação entre dividend yield e taxas de retorno das ações.In Finance Theory, the role of dividends in stock prices is a controversial issue, considering the different theories that exist on their relevance for stock value and, consequently, for shareholders' wealth. Furthermore, empirical findings that have originated the Efficient Market Hypothesis (EMH) not only contradict Technical Analysis, but also pose a challenge to the Fundamental Analysis' supposedly superior ability to generate higher returns based on accounting, financial and economic factors or variables such as the dividend yield. In order to assess the relationship between dividend yields and stocks returns as well as the viability of a strategy based on historic dividend yield to "beat" the market, with reference to the period from the beginning of the Real Plan in July 1994 until December 1999, three different yield portfolios (high, low and zero) were formed on a monthly basis.Their risks, returns and risk-adjusted portfolio performance measurements were calculated, and then compared both among themselves and to the benchmark (São Paulo Stock Exchange Index - Ibovespa). Empirical evidence is unable to suggest either that stocks with a high dividend yield tend to have higher or lower returns than those with a low or zero yield. Moreover, the evidences suggest that, using the applied empirical method, no clear association between dividend yield and stock returns can be demonstrated

Psalmus XLIX quinque vocibus, cum symph. // Deus deorum, Locutus est (manuscrit autographe)

Titre uniforme : Bachelier, Louis (1702-1782). Compositeur. [Deus Deorum, locutus est. Solistes (4), choeur, à 5 voix orchestre (Psaume 49). Mi majeur]Titre propre pris au départ. - Sig. du compositeur à la fin du ms. : "à Clermont le 8 janvier 1749 // Bachelier". - Voix : Sol 2, Ut 3, Ut 4, Fa 3. - Choeur : Sol 2, Ut 3, Ut 4, Fa 3, Fa 4. - Orchestre : Sol 2 (2), Ut 4, Fa 4 (2). - Mentions d'instrumentation sous la musique : hautbois, trompette, bassons. - Au départ d'une autre main : "n° 37". - RaturesPrésentation musicale : [Partition]Incipit : Deus Deorum, locutus estAppartient à l’ensemble documentaire : RISM1Appartient à l’ensemble documentaire : RISMMs

Calcul des probabilités. Tome I / par Louis Bachelier,...

Contient une table des matièresAvec mode text