1,367 research outputs found
Comparison of plantain plantlets propagated in temporary immersion bioreactors and gelled medium during in vitro growth and acclimatization
The current work compared the physiological characteristics of plantain (Musa AAB) plantlets micropropagated in
temporary immersion bioreactors (TIB) and on a gelled medium (GM). The plantlets were evaluated during in vitro
growth (in the shoot elongation phase) and at the end of ex vitro acclimatization. TIB improved rooting and gave rise to
longer shoots and higher dry mass. Respiration rate was the highest at the beginning of shoot elongation in both the TIB
and GM plantlets. Photosynthetic rate in TIB was significantly higher than in GM from the midpoint of acclimatization,
whereas a pyruvate kinase (PK) activity was lower. Starch accumulation was ca. two fold higher in corms than in leaves
and always higher in the TIB than GM plantlets. The higher expression of genes coding for carbon metabolism enzymes
PK and phosphoenolpyruvate carboxylase (PEPC) in TIB than in PM indicates a more important role of an autotrophic
metabolism in the TIB plantlets when compared to the GM ones. The accumulated reserves were used during the first
days of acclimatization leading to the higher survival rates and to the better plant quality of the TIB plantlet
Comparative Antioxidant, Antiproliferative and Apoptotic Effects of Ilex laurina and Ilex paraguariensis on Colon Cancer Cells
Purpose: To determine and compare the antioxidant, antiproliferative and apoptotic effects of leaf infusions of Ilex laurina and Ilex paraguariensis in colon cancer cells.Methods: Antioxidant activity was determined by ORAC (Oxygen Radical Absorbance Capacity) and FRAP (Ferric Reducing Antioxidant Power). Cytotoxic and antiproliferative effects were analyzed using MTT ((3-(4, 5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide) and sulfhorodamine-B respectively. Cell death and apoptosis of human colon adenocarcinoma cells SW480 and their metastatic-derived SW620 cells, were analyzed by flow cytometry using propidium iodide and Annexin-V.Results: Although their flavonoid levels were similar, I. laurina infusion contained 2.2 and 4.4 times higher amounts of total phenolic and caffeoyl derivatives, respectively, than I. paraguariensis. FRAP and ORAC values for I. laurina infusion were 1.6 and 2.0 more active than I. paraguariensis. Both plant infusions inhibited viability and cell growth of SW480 and SW620 cells. These results may be associated to cell cycle-arrest and apoptosis because of the comparable increase of hypodiploid and annexin-V positive colon cancer cells.Conclusion: These data highlight the antioxidant and promising anticancer activities of I. laurina and Ilex paraguariensis.Keywords: Ilex laurina, Ilex paraguariensis, Antioxidant, Antiproliferative, Apoptosis, Colon cance
Heavy-light decay topologies as a new strategy to discover a heavy gluon
We study the collider phenomenology of the lightest Kaluza-Klein excitation
of the gluon, G*, in theories with a warped extra dimension. We do so by means
of a two-site effective lagrangian which includes only the lowest-lying spin-1
and spin-1/2 resonances. We point out the importance of the decays of G* to one
SM plus one heavy fermion, that were overlooked in the previous literature. It
turns out that, when kinematically allowed, such heavy-light decays are
powerful channels for discovering the G*. In particular, we present a
parton-level Montecarlo analysis of the final state Wtb that follows from the
decay of G* to one SM top or bottom quark plus its heavy partner. We find that
at \sqrt{s} = 7 TeV and with 10 fb^{-1} of integrated luminosity, the LHC can
discover a KK gluon with mass in the range M_{G*} = (1.8 - 2.2) TeV if its
coupling to a pair of light quarks is g_{G*qqbar} = (0.2-0.5) g_3. The same
process is also competitive for the discovery of the top and bottom partners as
well. We find, for example, that the LHC at \sqrt{s} = 7 TeV can discover a 1
TeV KK bottom quark with an integrated luminosity of (5.3 - 0.61) fb^{-1} for
g_{G*qqbar} = (0.2-0.5) g_3.Comment: 36 pages, 13 figures. v2: a few typos corrected, comments added,
version published in JHE
A Standardised Procedure for Evaluating Creative Systems: Computational Creativity Evaluation Based on What it is to be Creative
Computational creativity is a flourishing research area, with a variety of creative systems being produced and developed. Creativity evaluation has not kept pace with system development with an evident lack of systematic evaluation of the creativity of these systems in the literature. This is partially due to difficulties in defining what it means for a computer to be creative; indeed, there is no consensus on this for human creativity, let alone its computational equivalent. This paper proposes a Standardised Procedure for Evaluating Creative Systems (SPECS). SPECS is a three-step process: stating what it means for a particular computational system to be creative, deriving and performing tests based on these statements. To assist this process, the paper offers a collection of key components of creativity, identified empirically from discussions of human and computational creativity. Using this approach, the SPECS methodology is demonstrated through a comparative case study evaluating computational creativity systems that improvise music
A Triple Protostar System Formed via Fragmentation of a Gravitationally Unstable Disk
Binary and multiple star systems are a frequent outcome of the star formation
process, and as a result, almost half of all sun-like stars have at least one
companion star. Theoretical studies indicate that there are two main pathways
that can operate concurrently to form binary/multiple star systems: large scale
fragmentation of turbulent gas cores and filaments or smaller scale
fragmentation of a massive protostellar disk due to gravitational instability.
Observational evidence for turbulent fragmentation on scales of 1000~AU has
recently emerged. Previous evidence for disk fragmentation was limited to
inferences based on the separations of more-evolved pre-main sequence and
protostellar multiple systems. The triple protostar system L1448 IRS3B is an
ideal candidate to search for evidence of disk fragmentation. L1448 IRS3B is in
an early phase of the star formation process, likely less than 150,000 years in
age, and all protostars in the system are separated by 200~AU. Here we
report observations of dust and molecular gas emission that reveal a disk with
spiral structure surrounding the three protostars. Two protostars near the
center of the disk are separated by 61 AU, and a tertiary protostar is
coincident with a spiral arm in the outer disk at a 183 AU separation. The
inferred mass of the central pair of protostellar objects is 1 M,
while the disk surrounding the three protostars has a total mass of 0.30
M_{\sun}. The tertiary protostar itself has a minimum mass of 0.085
M. We demonstrate that the disk around L1448 IRS3B appears susceptible
to disk fragmentation at radii between 150~AU and 320~AU, overlapping with the
location of the tertiary protostar. This is consistent with models for a
protostellar disk that has recently undergone gravitational instability,
spawning one or two companion stars.Comment: Published in Nature on Oct. 27th. 24 pages, 8 figure
Reducing Constraints in a Higher Dimensional Extension of the Randall and Sundrum Model
In order to investigate the phenomenological implications of warped spaces in
more than five dimensions, we consider a dimensional extension to
the Randall and Sundrum model in which the space is warped with respect to a
single direction by the presence of an anisotropic bulk cosmological constant.
The Einstein equations are solved, giving rise to a range of possible spaces in
which the additional spaces are warped. Here we consider models in
which the gauge fields are free to propagate into such spaces. After carrying
out the Kaluza Klein (KK) decomposition of such fields it is found that the KK
mass spectrum changes significantly depending on how the additional
dimensions are warped. We proceed to compute the lower bound on the KK mass
scale from electroweak observables for models with a bulk
gauge symmetry and models with a bulk gauge
symmetry. It is found that in both cases the most favourable bounds are
approximately TeV, corresponding to a mass of the first gauge
boson excitation of about 4-6 TeV. Hence additional warped dimensions offer a
new way of reducing the constraints on the KK scale.Comment: 27 pages, 15 figures, v3: Additional comments in sections 1, 2 and 4.
New appendix added. Five additional figures. References adde
Theory of Multidimensional Solitons
We review a number of topics germane to higher-dimensional solitons in
Bose-Einstein condensates. For dark solitons, we discuss dark band and planar
solitons; ring dark solitons and spherical shell solitons; solitary waves in
restricted geometries; vortex rings and rarefaction pulses; and multi-component
Bose-Einstein condensates. For bright solitons, we discuss instability,
stability, and metastability; bright soliton engineering, including pulsed atom
lasers; solitons in a thermal bath; soliton-soliton interactions; and bright
ring solitons and quantum vortices. A thorough reference list is included.Comment: review paper, to appear as Chapter 5a in "Emergent Nonlinear
Phenomena in Bose-Einstein Condensates: Theory and Experiment," edited by P.
G. Kevrekidis, D. J. Frantzeskakis, and R. Carretero-Gonzalez
(Springer-Verlag
Accreting Protoplanets in the LkCa 15 Transition Disk
Exoplanet detections have revolutionized astronomy, offering new insights
into solar system architecture and planet demographics. While nearly 1900
exoplanets have now been discovered and confirmed, none are still in the
process of formation. Transition discs, protoplanetary disks with inner
clearings best explained by the influence of accreting planets, are natural
laboratories for the study of planet formation. Some transition discs show
evidence for the presence of young planets in the form of disc asymmetries or
infrared sources detected within their clearings, as in the case of LkCa 15.
Attempts to observe directly signatures of accretion onto protoplanets have
hitherto proven unsuccessful. Here we report adaptive optics observations of
LkCa 15 that probe within the disc clearing. With accurate source positions
over multiple epochs spanning 2009 - 2015, we infer the presence of multiple
companions on Keplerian orbits. We directly detect H{\alpha} emission from the
innermost companion, LkCa 15 b, evincing hot (~10,000 K) gas falling deep into
the potential well of an accreting protoplanet.Comment: 35 pages, 3 figures, 1 table, 9 extended data item
Psychological interventions in asthma
Asthma is a multifactorial chronic respiratory disease characterised by recurrent episodes of airway obstruction. The current management of asthma focuses principally on pharmacological treatments, which have a strong evidence base underlying their use. However, in clinical practice, poor symptom control remains a common problem for patients with asthma. Living with asthma has been linked with psychological co-morbidity including anxiety, depression, panic attacks and behavioural factors such as poor adherence and suboptimal self-management. Psychological disorders have a higher-than-expected prevalence in patients with difficult-to-control asthma. As psychological considerations play an important role in the management of people with asthma, it is not surprising that many psychological therapies have been applied in the management of asthma. There are case reports which support their use as an adjunct to pharmacological therapy in selected individuals, and in some clinical trials, benefit is demonstrated, but the evidence is not consistent. When findings are quantitatively synthesised in meta-analyses, no firm conclusions are able to be drawn and no guidelines recommend psychological interventions. These inconsistencies in findings may in part be due to poor study design, the combining of results of studies using different interventions and the diversity of ways patient benefit is assessed. Despite this weak evidence base, the rationale for psychological therapies is plausible, and this therapeutic modality is appealing to both patients and their clinicians as an adjunct to conventional pharmacological treatments. What are urgently required are rigorous evaluations of psychological therapies in asthma, on a par to the quality of pharmaceutical trials. From this evidence base, we can then determine which interventions are beneficial for our patients with asthma management and more specifically which psychological therapy is best suited for each patient
Adipocyte-specific protein tyrosine phosphatase 1B deletion increases lipogenesis, adipocyte cell size and is a minor regulator of glucose homeostasis
Peer reviewedPublisher PD
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