An NMR-based nanostructure switch for quantum logic

We propose a nanostructure switch based on nuclear magnetic resonance (NMR) which offers reliable quantum gate operation, an essential ingredient for building a quantum computer. The nuclear resonance is controlled by the magic number transitions of a few-electron quantum dot in an external magnetic field.Comment: 4 pages, 2 separate PostScript figures. Minor changes included. One reference adde

Deciphering the Link between Doubly Uniparental Inheritance of mtDNA and Sex Determination in Bivalves: Clues from Comparative Transcriptomics

Bivalves exhibit an astonishing diversity of sexual systems and sex-determining mechanisms. They can be gonochoric, hermaphroditic or androgenetic, with both genetic and environmental factors known to determine or influence sex. One unique sex-determining system involving the mitochondrial genome has also been hypothesized to exist in bivalves with doubly uniparental inheritance (DUI) of mtDNA. However, the link between DUI and sex determination remains obscure. In this study, we performed a comparative gonad transcriptomics analysis for two DUI-possessing freshwater mussel species to better understand the mechanisms underlying sex determination and DUI in these bivalves. We used a BLAST reciprocal analysis to identify orthologs between Venustaconcha ellipsiformis and Utterbackia peninsularis and compared our results with previously published sex-specific bivalve transcriptomes to identify conserved sex-determining genes. We also compared our data with other DUI species to identify candidate genes possibly involved in the regulation of DUI. A total of 3c12,000 orthologous relationships were found, with 2,583 genes differentially expressed in both species. Among these genes, key sex-determining factors previously reported in vertebrates and in bivalves (e.g., Sry, Dmrt1, Foxl2) were identified, suggesting that some steps of the sex-determination pathway may be deeply conserved in metazoans. Our results also support the hypothesis that a modified ubiquitination mechanism could be responsible for the retention of the paternal mtDNA in male bivalves, and revealed that DNA methylation could also be involved in the regulation of DUI. Globally, our results suggest that sets of genes associated with sex determination and DUI are similar in distantly-related DUI species

DOE transporation programs - computerized techniques

One of the major thrusts of the transportation programs at the Oak Ridge National Laboratory has been the development of a number of computerized transportation programs and data bases. The U.S. Department of Energy (DOE) is supporting these efforts through the Transportation Technology Center at Sandia National Laboratories and the Tranportation Operations and Traffic Management (TOTM) organization at DOE Headquarters. Initially this project was centered upon research activities. However, since these tools provide traffic managers and key personnel involved in preshipment planning with a unique resource for ensuring that the movement of radioactive materials can be properly accomplished, additional interest and support is coming from the operational side of DOE. The major accomplishments include the development of two routing models (one for rail shipments and the other for highway shipments), an emergency response assistance program, and two data bases containing pertinent legislative and regulatory information. This paper discusses the mose recent advances in, and additions to, these computerized techniques and provides examples of how they are used

Specific pathway abundances in the neonatal calf faecal microbiome are associated with susceptibility to Cryptosporidium parvum infection: a metagenomic analysis.

Cryptosporidium parvum is the main cause of calf scour worldwide. With limited therapeutic options and research compared to other Apicomplexa, it is important to understand the parasites' biology and interactions with the host and microbiome in order to develop novel strategies against this infection. The age-dependent nature of symptomatic cryptosporidiosis suggests a link to the undeveloped immune response, the immature intestinal epithelium, and its associated microbiota. This led us to hypothesise that specific features of the early life microbiome could predict calf susceptibility to C. parvum infection. In this study, a single faecal swab sample was collected from each calf within the first week of life in a cohort of 346 animals. All 346 calves were subsequently monitored for clinical signs of cryptosporidiosis, and calves that developed diarrhoea were tested for Rotavirus, Coronavirus, E. coli F5 (K99) and C. parvum by lateral flow test (LFT). A retrospective case–control approach was taken whereby a subset of healthy calves (Control group; n = 33) and calves that went on to develop clinical signs of infectious diarrhoea and test positive for C. parvum infection via LFT (Cryptosporidium-positive group; n = 32) were selected from this cohort, five of which were excluded due to low DNA quality. A metagenomic analysis was conducted on the faecal microbiomes of the control group (n = 30) and the Cryptosporidium-positive group (n = 30) prior to infection, to determine features predictive of cryptosporidiosis. Taxonomic analysis showed no significant differences in alpha diversity, beta diversity, and taxa relative abundance between controls and Cryptosporidium-positive groups. Analysis of functional potential showed pathways related to isoprenoid precursor, haem and purine biosynthesis were significantly higher in abundance in calves that later tested positive for C. parvum (q ≤ 0.25). These pathways are either absent or streamlined in the C. parvum parasites. Though the de novo production of isoprenoid precursors, haem and purines are absent, C. parvum has been shown to encode enzymes that catalyse the downstream reactions of these pathway metabolites, indicating that C. parvum may scavenge those products from an external source. The host has previously been put forward as the source of essential metabolites, but our study suggests that C. parvum may also be able to harness specific metabolic pathways of the microbiota in order to survive and replicate. This finding is important as components of these microbial pathways could be exploited as potential therapeutic targets for the prevention or mitigation of cryptosporidiosis in bovine neonates

An observation of spin-valve effects in a semiconductor field effect transistor: a novel spintronic device

We present the first spintronic semiconductor field effect transistor. The injector and collector contacts of this device were made from magnetic permalloy thin films with different coercive fields so that they could be magnetized either parallel or antiparallel to each other in different applied magnetic fields. The conducting medium was a two dimensional electron gas (2DEG) formed in an AlSb/InAs quantum well. Data from this device suggest that its resistance is controlled by two different types of spin-valve effect: the first occurring at the ferromagnet-2DEG interfaces; and the second occuring in direct propagation between contacts.Comment: 4 pages, 2 figure

The β3-integrin endothelial adhesome regulates microtubule-dependent cell migration

Integrin β3 is seen as a key anti-angiogenic target for cancer treatment due to its expression on neovasculature, but the role it plays in the process is complex; whether it is pro- or anti-angiogenic depends on the context in which it is expressed. To understand precisely β3's role in regulating integrin adhesion complexes in endothelial cells, we characterised, by mass spectrometry, the β3-dependent adhesome. We show that depletion of β3-integrin in this cell type leads to changes in microtubule behaviour that control cell migration. β3-integrin regulates microtubule stability in endothelial cells through Rcc2/Anxa2-driven control of active Rac1 localisation. Our findings reveal that angiogenic processes, both in vitro and in vivo, are more sensitive to microtubule targeting agents when β3-integrin levels are reduced

The Contribution of Outdoor Fine Particulate Matter to Indoor Air Quality in Bangkok Metropolitan Region, Thailand – Are Indoor Dwellers Safe?

Objective: This study aimed to analyze the relationship between indoor and outdoor fine particulate matter (PM2.5) concentrations and to characterize factors that may contribute to domestic PM2.5 concentrations, including smoking, printer/copier, and cooking activities. Methods: We measured the ambient and indoor PM2.5 concentrations from 7 sampling sites in Bangkok Metropolitan and vicinity area, Thailand by using PM2.5 concentrations sensor (SN-GCHA1, Panasonic Photo & Lighting Co., Ltd). Real-time PM2.5 concentrations, temperature, and relative humidity (RH) measurements were recorded hourly for two consecutive days during February 20th to March 2nd, 2018. We collected real-time indoor and outdoor PM2.5 mass concentrations at the same time. Factors influencing domestic PM2.5 production in the indoor environment were recorded. Results: The mean indoor PM2.5 concentrations from each site ranged from 20.05-45.85 μg/m3 and the mean outdoor PM2.5 concentrations ranged from 9.42-56.56 μg/m3. The ambient and indoor PM2.5 mass concentrations curves tended to fluctuate in a similar trend. There was a significantly positive correlation between the average ambient and the average indoor PM2.5 mass concentrations in all studied places. The correlation coefficient (r) varied from 0.6 to 0.833. Five from seven sites demonstrated a strong correlation (r ≥ 0.7), whereas, two from seven sites demonstrated a moderate correlation (0.5 ≤ r < 0.7). The average indoor/ambient PM2.5 concentration ratio from each place ranged from 0.37 to 3.57. Conclusion: The indoor PM2.5 concentrations are correlated with the ambient PM2.5 concentrations. The concentrations of PM2.5 in most sampling sites were higher than the recommended threshold. Hence, indoor dwellers are still at risk for health impacts from PM2.5. Besides public management of the ambient PM2.5, the interventions dealing with the indoor PM2.5 should be promoted concurrently

Quantum entanglement and information processing via excitons in optically-driven quantum dots

We show how optically-driven coupled quantum dots can be used to prepare maximally entangled Bell and Greenberger-Horne-Zeilinger states. Manipulation of the strength and duration of the selective light-pulses needed for producing these highly entangled states provides us with crucial elements for the processing of solid-state based quantum information. Theoretical predictions suggest that several hundred single quantum bit rotations and Controlled-Not gates could be performed before decoherence of the excitonic states takes place.Comment: 3 separate PostScript Figures + 7 pages. Typos corrected. Minor changes added. This updated version is to appear in PR

EXPLORING THE ROLE OF OSPREYS IN EDUCATION

Recent research in childhood education has demonstrated that experiences in nature are important in shaping early environmental consciousness (Hinds and Sparks 2008, Hussar and Horvath 2011, Cheng and Monroe 2012) and ultimately the expression of pro-environmental attitudes and behaviors during adulthood (Wells and Lekies 2006, Chawla and Cushing 2007, Collado et al. 2013). Increasingly, those experiences happen via written and electronic media (e.g., textbooks, computer screens) or in very anthropogenic environments (e.g., in parks and zoos) and less through direct contact with nature, a concept Louv (2005) referred to as ‘‘nature deficit disorder.’’ Even in schools where environmental education is prioritized, the extent of access to outdoor classroom activities or experiential learning opportunities can limit the degree to which children can observe, explore, and directly experience the natural world (Hudson 2001, Louv 2005, Ernst 2009). Interestingly, the same information technologies that might serve to limit contact with nature also have the potential to enhance and encourage interest and concern for the natural world (Blewitt 2011, Pearson et al. 2011). We believe this is an important paradox that warrants much further exploration and evaluation within educational and scientific communities

The T2K ND280 Off-Axis Pi-Zero Detector

The Pi-Zero detector (P{\O}D) is one of the subdetectors that makes up the off-axis near detector for the Tokai-to-Kamioka (T2K) long baseline neutrino experiment. The primary goal for the P{\O}D is to measure the relevant cross sections for neutrino interactions that generate pi-zero's, especially the cross section for neutral current pi-zero interactions, which are one of the dominant sources of background to the electron neutrino appearance signal in T2K. The P{\O}D is composed of layers of plastic scintillator alternating with water bags and brass sheets or lead sheets and is one of the first detectors to use Multi-Pixel Photon Counters (MPPCs) on a large scale.Comment: 17 pages, submitted to NIM