420 research outputs found
Радиационно-химический синтез перфторированной полимерной мембраны с сульфокислотными группами
В результаті радіаційно-індукованої прищепної сополімеризації з водних розчинів двох мономерів — акрилової кислоти і натрієвої солі стиролсульфонату — на полімерну плівку з фторованого пропілену-етилену синтезована протонобмінна мембрана з сульфокислотними групами. Розглянуті основні експериментальні параметри, що впливають на процес прищепної сополімеризації.Sulfonic acid proton exchange membranes based on a poly(tetrafluoroethylene-co-hexafluoropropylene) film are synthesized through the graft copolymerization of sodium styrenesulfonate and acrylic acid monomers from binary monomer aqueous solutions. The effects of the main polymerization parameters on the degree of grafting are studied
On the Use of Covariate Supersets for Identification Conditions
The union of distinct covariate sets, or the superset, is often used in proofs for the identification or the statistical consistency of an estimator when multiple sources of bias are present. However, the use of a superset can obscure important nuances. Here, we provide two illustrative examples: one in the context of missing data on outcomes, and one in which the average causal effect is transported to another target population. As these examples demonstrate, the use of supersets may indicate a parameter is not identifiable when the parameter is indeed identified. Furthermore, a series of exchangeability conditions may lead to successively weaker conditions. Future work on approaches to address multiple biases can avoid these pitfalls by considering the more general case of nonoverlapping covariate sets
When Does Differential Outcome Misclassification Matter for Estimating Prevalence?
Background: When accounting for misclassification, investigators make assumptions about whether misclassification is "differential" or "nondifferential." Most guidance on differential misclassification considers settings where outcome misclassification varies across levels of exposure, or vice versa. Here, we examine when covariate-differential misclassification must be considered when estimating overall outcome prevalence. Methods: We generated datasets with outcome misclassification under five data generating mechanisms. In each, we estimated prevalence using estimators that (a) ignored misclassification, (b) assumed misclassification was nondifferential, and (c) allowed misclassification to vary across levels of a covariate. We compared bias and precision in estimated prevalence in the study sample and an external target population using different sources of validation data to account for misclassification. We illustrated use of each approach to estimate HIV prevalence using self-reported HIV status among people in East Africa cross-border areas. Results: The estimator that allowed misclassification to vary across levels of the covariate produced results with little bias for both populations in all scenarios but had higher variability when the validation study contained sparse strata. Estimators that assumed nondifferential misclassification produced results with little bias when the covariate distribution in the validation data matched the covariate distribution in the target population; otherwise estimates assuming nondifferential misclassification were biased. Conclusions: If validation data are a simple random sample from the target population, assuming nondifferential outcome misclassification will yield prevalence estimates with little bias regardless of whether misclassification varies across covariates. Otherwise, obtaining valid prevalence estimates requires incorporating covariates into the estimators used to account for misclassification
Strong-field terahertz-optical mixing in excitons
Driving a double-quantum-well excitonic intersubband resonance with a
terahertz (THz) electric field of frequency \omega_{THz} generated terahertz
optical sidebands \omega=\omega_{THz}+\omega_{NIR} on a weak NIR probe. At high
THz intensities, the intersubband dipole energy which coupled two excitons was
comparable to the THz photon energy. In this strong-field regime the sideband
intensity displayed a non-monotonic dependence on the THz field strength. The
oscillating refractive index which gives rise to the sidebands may be
understood by the formation of Floquet states, which oscillate with the same
periodicity as the driving THz field.Comment: 4 pages, 6 figure
Missing Outcome Data in Epidemiologic Studies
Missing data are pandemic and a central problem for epidemiology. Missing data reduce precision and can cause notable bias. There remain too few simple published examples detailing types of missing data and illustrating their possible impact on results. Here we take an example randomized trial that was not subject to missing data and induce missing data to illustrate 4 scenarios in which outcomes are 1) missing completely at random, 2) missing at random with positivity, 3) missing at random without positivity, and 4) missing not at random. We demonstrate that accounting for missing data is generally a better strategy than ignoring missing data, which unfortunately remains a standard approach in epidemiology
Illustration of 2 Fusion Designs and Estimators
"Fusion" study designs combine data from different sources to answer questions that could not be answered (as well) by subsets of the data. Studies that augment main study data with validation data, as in measurement-error correction studies or generalizability studies, are examples of fusion designs. Fusion estimators, here solutions to stacked estimating functions, produce consistent answers to identified research questions using data from fusion designs. In this paper, we describe a pair of examples of fusion designs and estimators, one where we generalize a proportion to a target population and one where we correct measurement error in a proportion. For each case, we present an example motivated by human immunodeficiency virus research and summarize results from simulation studies. Simulations demonstrate that the fusion estimators provide approximately unbiased results with appropriate 95% confidence interval coverage. Fusion estimators can be used to appropriately combine data in answering important questions that benefit from multiple sources of information
Spin Exciton in quantum dot with spin orbit coupling in high magnetic field
Coulomb interactions of few () electrons confined in a disk shaped
quantum dot, with a large magnetic field applied in the z-direction
(orthogonal to the dot), produce a fully spin polarized ground state. We
numerically study the splitting of the levels corresponding to the multiplet of
total spin (each labeled by a different total angular momentum )
in presence of an electric field parallel to , coupled to by a
Rashba term. We find that the first excited state is a spin exciton with a
reversed spin at the origin. This is reminiscent of the Quantum Hall
Ferromagnet at filling one which has the skyrmion-like state as its first
excited state. The spin exciton level can be tuned with the electric field and
infrared radiation can provide energy and angular momentum to excite it.Comment: 9 pages, 9 figures. submitted to Phys.Rev.
Negatively Charged Excitons and Photoluminescence in Asymmetric Quantum Well
We study photoluminescence (PL) of charged excitons () in narrow
asymmetric quantum wells in high magnetic fields B. The binding of all
states strongly depends on the separation of electron and hole layers.
The most sensitive is the ``bright'' singlet, whose binding energy decreases
quickly with increasing even at relatively small B. As a result, the
value of B at which the singlet--triplet crossing occurs in the spectrum
also depends on and decreases from 35 T in a symmetric 10 nm GaAs well
to 16 T for nm. Since the critical values of at which
different states unbind are surprisingly small compared to the well
width, the observation of strongly bound states in an experimental PL
spectrum implies virtually no layer displacement in the sample. This casts
doubt on the interpretation of PL spectra of heterojunctions in terms of
recombination
TLD1433 photosensitizer inhibits conjunctival melanoma cells in zebrafish ectopic and orthotopic tumour models
The ruthenium-based photosensitizer (PS) TLD1433 has completed a phase I clinical trial for photodynamic therapy (PDT) treatment of bladder cancer. Here, we investigated a possible repurposing of this drug for treatment of conjunctival melanoma (CM). CM is a rare but often deadly ocular cancer. The efficacy of TLD1433 was tested on several cell lines from CM (CRMM1, CRMM2 and CM2005), uveal melanoma (OMM1, OMM2.5, MEL270), epidermoid carcinoma (A431) and cutaneous melanoma (A375). Using 15 min green light irradiation (21mW/cm(2), 19 J.cm(-2), 520 nm), the highest phototherapeutic index (PI) was reached in CM cells, with cell death occurring via apoptosis and necrosis. The therapeutic potential of TLD1433 was hence further validated in zebrafish ectopic and newly-developed orthotopic CM models. Fluorescent CRMM1 and CRMM2 cells were injected into the circulation of zebrafish (ectopic model) or behind the eye (orthotopic model) and 24 h later, the engrafted embryos were treated with the maximally-tolerated dose of TLD1433. The drug was administrated in three ways, either by (i) incubating the fish in drug-containing water (WA), or (ii) injecting the drug intravenously into the fish (IV), or (iii) injecting the drug retro-orbitally (RO) into the fish. Optimally, four consecutive PDT treatments were performed on engrafted embryos using 60 min drug-to-light intervals and 90 min green light irradiation (21 mW/cm(2), 114 J.cm(-2), 520 nm). This PDT protocol was not toxic to the fish. In the ectopic tumour model, both systemic administration by IV injection and RO injection of TLD1433 significantly inhibited growth of engrafted CRMM1 and CRMM2 cells. However, in the orthotopic model, tumour growth was only attenuated by localized RO injection of TLD1433. These data unequivocally prove that the zebrafish provides a fast vertebrate cancer model that can be used to test the administration regimen, host toxicity and anti-cancer efficacy of PDT drugs against CM. Based on our results, we suggest repurposing of TLD1433 for treatment of incurable CM and further testing in alternative pre-clinical models.Animal science
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