La autonomía universitaria

Fil: Tomasini, Mabel B. Universidad de Buenos Aires. Facultad de Derecho. Buenos Aires, ArgentinaI. - Introducción. II.-La autonomía universitaria como aspiración o ideal. III. -Sentido jurídico de la expresión Autonomía universitaria. 1 -Autonomía y autarquía. 2.-Régimen legal de la Universidad. 3.-Autonomía o autarquía universitaria a través de nuestra dinámica legislativa. IV. -La autonomía universitaria como producto de una delegación legislativa. l. - Delegación legislativa. 2.- Constitucionalidad o inconstitucionalidad de la delegación legislativa en materia universitaria. V. -Contralor administrativo sobre la Universidad. VI. -Designación de profesore

On the effect of human mobility to the design of metropolitan mobile opportunistic networks of sensors

This is the author accepted manuscriptWe live in a world where demand for monitoring natural and artificial phenomena is growing. The practical importance of Sensor Networks is continuously increasing in our society due to their broad applicability to tasks such as traffic and air-pollution monitoring, forest-fire detection, agriculture, and battlefield communication. Furthermore, we have seen the emergence of sensor technology being integrated in everyday objects such as cars, traffic lights, bicycles, phones, and even being attached to living beings such as dolphins, trees, and humans. The consequence of this widespread use of sensors is that new sensor network infrastructures may be built out of static (e.g., traffic lights) and mobile nodes (e.g., mobile phones, cars). The use of smart devices carried by people in sensor network infrastructures creates a new paradigm we refer to as Social Networks of Sensors (SNoS). This kind of opportunistic network may be fruitful and economically advantageous where the connectivity, the performance, of the scalability provided by cellular networks fail to provide an adequate quality of service. This paper delves into the issue of understanding the impact of human mobility patterns to the performance of sensor network infrastructures with respect to four different metrics, namely: detection time, report time, data delivery rate, and network coverage area ratio. Moreover, we evaluate the impact of several other mobility patterns (in addition to human mobility) to the performance of these sensor networks on the four metrics above. Finally, we propose possible improvements to the design of sensor network infrastructures

Biosensors in occupational safety and health management: A narrative review

A sensor is a device used to gather information registered by some biological, physical or chemical change, and then convert the information into a measurable signal. The first biosensor prototype was conceived more than a century ago, in 1906, but a properly defined biosensor was only developed later in 1956. Some of them have reached the commercial stage and are routinely used in environmental and agricultural applications, and especially, in clinical laboratory and industrial analysis, mostly because it is an economical, simple and efficient instrument for the in situ detection of the bioavailability of a broad range of environmental pollutants. We propose a narrative review, that found 32 papers and aims to discuss the possible uses of biosensors, focusing on their use in the area of occupational safety and health (OSH)

Chromatographic Methods Applied to the Characterization of Bio-Oil from the Pyrolysis of Agro-Industrial Biomasses

Biomass conversion into solid, liquid and gaseous products by pyrolytic technology is one of the most promising alternative to convert the biomass into useful products and energy. The total characterization of the products from the pyrolysis of biomass is one of the great challenges in this field, mainly due to their molecular complexity. Pyrolysis is a process that causes degradation of biomass in a non‐oxidative atmosphere, at relatively high temperatures, producing a solid residue rich in carbon and mineral matter, gases and bio‐oil. The yield and properties of the products depend on the nature of the biomass and the type of the pyrolysis process (type of reactor, temperature, gas flow, catalyst). Due to the high molecular complexity of bio‐oil, many different technical had been developed to their complete characterization. This chapter describes the principles of the techniques and main application of chromatographic methods (GC, LC, GC × GC, LC × LC, Nano‐LC) in the analysis of bio‐oils derived from thermo‐degradation of biomasses. Especial attention is carried out to two‐dimensional techniques that represent the state of the art in terms of separation, sensibility, selectivity and velocity of data acquisition for characterization of complex organic mixtures. For proper use of bio‐oil in the chemical industry, it is essential the identification and unambiguous determination of its major constituents. Only then, it is possible to propose a recovery route of some of these components for the development of an industry dedicated to a bio‐refinery. For this, chromatographic methods, especially GC × GC/MS, are fundamental because they allow analysis with high sensitivity and accuracy in identifying each constituent of the bio‐oil

Complex mosaic structural variations in human fetal brains

Somatic mosaicism, manifesting as single nucleotide variants (SNVs), mobile element insertions and structural changes in the DNA, is a common phenomenon in human brain cells, with potential functional consequences. Using a clonal approach, we previously detected 200-400 mosaic SNVs per cell in three human fetal brains (15 to 21 weeks post-conception). However, structural variation in the human fetal brain has not yet been investigated. Here, we discover and validate four mosaic structural variants (SVs) in the same brains and resolve their precise breakpoints. The SVs were of kilobase scale and complex, consisting of deletion(s) and rearranged genomic fragments, which sometimes originated from different chromosomes. Sequences at the breakpoints of these rearrangements had microhomologies, suggesting their origin from replication errors. One SV was found in two clones and we timed its origin to ~14 weeks post-conception. No large scale mosaic copy number variants (CNVs) were detectable in normal fetal human brains, suggesting that previously reported megabase-scale CNVs in neurons arise at later stages of development. By reanalysis of public single nuclei data from adult brain neurons, we detected an extra-chromosomal circular DNA event. Our study reveals the existence of mosaic SVs in the developing human brain, likely arising from cell proliferation during mid-neurogenesis. Although relatively rare compared to SNVs, and present in ~10% neurons, SVs in developing human brain affect a comparable number of bases in the genome (~6,200 vs ~4,000 bps), implying that they may have similar functional consequences

New Insights into the Genetic Regulation of Homologue Disjunction in Mammalian Oocytes

Mammalian oocytes execute a unique meiotic programme involving 2 arrest stages and an unusually protracted preamble to chromosome segregation during the first meiotic division (meiosis I). How mammalian oocytes successfully navigate their exceptional meiotic journey has long been a question of immense interest. Understanding the minutiae of female mammalian meiosis I is not merely of academic interest as 80–90% of human aneuploidy is the consequence of errors arising at this particular stage of oocyte maturation, a stage with a peculiar vulnerability to aging. Recent evidence indicates that oocytes employ many of the same cast of proteins during meiosis I as somatic cells do during mitosis, often to execute similar tasks, but intriguingly, occasionally delegate them to unexpected and unprecedented roles. This is epitomised by the master cell-cycle regulon, the anaphase-promoting complex or cyclosome (APC/C), acting in concert with a critical APC/C-targeted surveillance mechanism, the spindle assembly checkpoint (SAC). Together, the APC/C and the SAC are among the most influential entities overseeing the fidelity of cell-cycle progression and the precision of chromosome segregation. Here I review the current status of pivotal elements underpinning homologue disjunction in mammalian oocytes including spindle assembly, critical biochemical anaphase-initiating events, APC/C activity and SAC signalling along with contemporary findings relevant to progressive oocyte SAC dysfunction as a model for age-related human aneuploidy

Treatment of loco-regional recurrence of nasopharyngeal carcinoma in a non-endemic area: oncologic outcomes, morbidity, and proposal of a prognostic nomogram

Introduction: The study assessed outcomes and toxicities of different treatment modalities for local and/or regional recurrent nasopharyngeal carcinoma (NPC) in a non-endemic area. Methods: Patients treated with curative intent for recurrent NPC with salvage surgery, photon-based radiotherapy, proton therapy (PT), with or without chemotherapy, at different Italian referral centers between 1998 and 2020 were included. Adverse events and complications were classified according to the Common Terminology Criteria for Adverse Events. Characteristics of the patients, tumors, treatments, and complications are presented along with uni- and multivariate analysis of prognostic factors. A survival predictive nomogram is also provided. Results: A total of 140 patients treated from 1998 to 2020 were retrospectively assessed. Cases with lower age, comorbidity rate, stage, and shorter disease-free interval (DFI) preferentially underwent endoscopic surgery. More advanced cases underwent re-irradiation, fairly distributed between photon-based radiotherapy and PT. Age and DFI were independent factors influencing overall survival. No independent prognostic effect of treatment modality was observed. No significant difference in the morbidity profile of treatments was observed, with 40% of patients experiencing at least one adverse event classified as G3 or higher. Conclusion: Recurrent NPC in a non-endemic area has dissimilar aspects compared to its endemic counterpart, suggesting the need for further studies that can guide the choice of the best treatment modality

Prospects and Bottlenecks of Reciprocal Partnerships Between the Private and Humanitarian Sectors in Cash Transfer Programming for Humanitarian Response

As an alternative to commodity-based programming (in-kind aid), Cash Transfer Programming is attracting both humanitarian organizations' and institutional donors' attention. Unlike in-kind aid, Cash Transfer Programming transfers purchasing power directly to beneficiaries in the form of currency or vouchers for them to obtain goods and/or services directly from the local market. In distributing currency to beneficiaries, the private sector, especially financial service providers, plays a prominent role, due to the humanitarian sector's limited relevant resources. The present work unveils challenges for the private and humanitarian sectors, which hinder implementing Cash Transfer Programming. Based on primary and secondary qualitative data, the paper presents the main characteristics and the mechanisms of Cash Transfer Programming to explore how the private sector is involved with Cash Transfer Programming. Then, this study presents bottlenecks of reciprocal relationships between financial service providers and humanitarian organizations in Cash Transfer Programming