3,235 research outputs found

    All work and no pay: consequences of unpaid work experience in the creative industries

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    This research note evaluates the benefits and pitfalls of unpaid work as an entry route into employment in the creative industries and investigates the consequences of this practice for those who already work in the sector. Based on a qualitative study of perspectives of stakeholders in unpaid work, this article argues that the social capital thesis, often used as a rationale for unpaid work, inadequately explains the practice of unpaid work experience, primarily because it does not take cognisance of the consequences of this practice for other people working in the sector. The study also highlights methodological issues that need to be considered in the future. As well as the importance of a plurality of stakeholder perspectives, the study emphasizes the need to consider the perspectives of those who are excluded from unpaid work and those who are potentially displaced by it

    Dilepton distributions at backward rapidities

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    The dilepton production at backward rapidities in pAupAu and pppp collisions at RHIC and LHC energies is investigated in the dipole approach. The results are shown through the nuclear modification ratio RpAR_{pA} considering transverse momentum and rapidity spectra. The dilepton modification ratio presents interesting behavior at the backward rapidities when compared with the already known forward ones, since it is related with the large xx kinematical region that is being probed. The rapidity dependence of the nuclear modification ratio in the dilepton production is strongly dependent on the Bjorken xx behavior of the nuclear structure function ratio RF2=F2A/F2pR_{F_{2}}=F_{2}^{A}/F_{2}^{p}. The RpAR_{pA} transverse momentum dependence at backward rapidities is modified due to the large xx nuclear effects: at RHIC energies, for instance, the ratio RpAR_{pA} is reduced as pTp_T increases, presenting an opposite behavior when compared with the forward one. It implies that the dilepton production at backward rapidities should carry information of the nuclear effects at large Bjorken xx, as well as that it is useful to investigate the pTp_T dependence of the observables in this kinematical regime.Comment: 15 pages, 6 figures. Version published in the Phys. Rev.

    Optical followup of galaxy clusters detected by the South Pole Telescope

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    The South Pole Telescope (SPT) is a 10 meter telescope operating at mm wavelengths. It has recently completed a three-band survey covering 2500 sq. degrees. One of the survey's main goals is to detect galaxy clusters using Sunyaev-Zeldovich effect and use these clusters for a variety of cosmological and astrophysical studies such as the dark energy equation of state, the primordial non-gaussianity and the evolution of galaxy populations. Since 2005, we have been engaged in a comprehensive optical and near-infrared followup program (at wavelengths between 0.4 and 5 {\mu}m) to image high-significance SPT clusters, to measure their photometric redshifts, and to estimate the contamination rate of the candidate lists. These clusters are then used for various cosmological and astrophysical studies.Comment: For TAUP 2011 proceeding

    Higher order eigenpair perturbations

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    Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/76914/1/AIAA-11149-583.pd

    An alternative pathway for membrane protein biogenesis at the endoplasmic reticulum.

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    From Europe PMC via Jisc Publications RouterHistory: epub 2021-07-01, ppub 2021-07-01Publication status: PublishedFunder: Ball State University (Ball State); Grant(s): Provost Startup AwardFunder: Wellcome Trust; Grant(s): 204957/Z/16/ZFunder: NIGMS NIH HHS; Grant(s): R15 GM116032The heterotrimeric Sec61 complex is a major site for the biogenesis of transmembrane proteins (TMPs), accepting nascent TMP precursors that are targeted to the endoplasmic reticulum (ER) by the signal recognition particle (SRP). Unlike most single-spanning membrane proteins, the integration of type III TMPs is completely resistant to small molecule inhibitors of the Sec61 translocon. Using siRNA-mediated depletion of specific ER components, in combination with the potent Sec61 inhibitor ipomoeassin F (Ipom-F), we show that type III TMPs utilise a distinct pathway for membrane integration at the ER. Hence, following SRP-mediated delivery to the ER, type III TMPs can uniquely access the membrane insertase activity of the ER membrane complex (EMC) via a mechanism that is facilitated by the Sec61 translocon. This alternative EMC-mediated insertion pathway allows type III TMPs to bypass the Ipom-F-mediated blockade of membrane integration that is seen with obligate Sec61 clients
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