Observations of SN2011fe with INTEGRAL

SN2011fe was detected by the Palomar Transient Factory on August 24th 2011 in M101 few hours after the explosion. From the early spectra it was immediately realized that it was a Type Ia supernova thus making this event the brightest one discovered in the last twenty years. In this paper the observations performed with the instruments on board of INTEGRAL (SPI, IBIS/ISGRI, JEM-X and OMC) before and after the maximum of the optical light as well as the interpretation in terms of the existing models of $\gamma$--ray emission from such kind of supernovae are reported. All INTEGRAL high-energy have only been able to provide upper limits to the expected emission due to the decay of $^{56}$Ni. These bounds allow to reject explosions involving a massive white dwarf in the sub--Chandrasekhar scenario. On the other hand, the optical light curve obtained with the OMC camera suggests that the event was produced by a delayed detonation of a CO white dwarf that produced $\sim 0.5$ M$\odot$ of $^{56}$Ni. In this particular case, INTEGRAL would have only been able to detect the early $\gamma$--ray emission if the supernova had occurred at a distance of 2 -3 Mpc, although the brightest event could be visible up to distances larger by a factor two.Comment: Proceedings of "An INTEGRAL view of the high-energy sky (the first 10 years)" the 9th INTEGRAL Workshop, October 15-19, 2012, Paris, France, in Proceedings of Science (INTEGRAL 2012), Eds. A. Goldwurm, F. Lebrun and C. Winkler, http://pos.sissa.it/cgi-bin/reader/conf.cgi?confid=176, id number PoS (INTEGRAL 2012) 103 (2013

Observation of SN2011fe with INTEGRAL. I. Pre--maximum phase

SN2011fe was detected by the Palomar Transient Factory on August 24th 2011 in M101 a few hours after the explosion. From the early optical spectra it was immediately realized that it was a Type Ia supernova thus making this event the brightest one discovered in the last twenty years. The distance of the event offered the rare opportunity to perform a detailed observation with the instruments on board of INTEGRAL to detect the gamma-ray emission expected from the decay chains of $^{56}$Ni. The observations were performed in two runs, one before and around the optical maximum, aimed to detect the early emission from the decay of $^{56}$Ni and another after this maximum aimed to detect the emission of $^{56}$Co. The observations performed with the instruments on board of INTEGRAL (SPI, IBIS/ISGRI, JEMX and OMC) have been analyzed and compared with the existing models of gamma-ray emission from such kind of supernovae. In this paper, the analysis of the gamma-ray emission has been restricted to the first epoch. Both, SPI and IBIS/ISGRI, only provide upper-limits to the expected emission due to the decay of $^{56}$Ni. These upper-limits on the gamma-ray flux are of 7.1 $\times$ 10$^{-5}$ ph/s/cm$^2$ for the 158 keV line and of 2.3 $\times$ 10$^{-4}$ ph/s/cm$^2$ for the 812 keV line. These bounds allow to reject at the $2\sigma$ level explosions involving a massive white dwarf, $\sim 1$ M$\odot$ in the sub--Chandrasekhar scenario and specifically all models that would have substantial amounts of radioactive $^{56}$Ni in the outer layers of the exploding star responsible of the SN2011fe event. The optical light curve obtained with the OMC camera also suggests that SN2011fe was the outcome of the explosion, possibly a delayed detonation although other models are possible, of a CO white dwarf that synthesized $\sim 0.55$ M$_\odot$ of $^{56}$Ni. For this specific model.Comment: Accepted for publication in A&A. 10 pages, 10 figure

FNDC5 is produced in the stomach and associated to body composition

The fibronectin type III domain-containing protein 5 (FNDC5) discovered in 2002 has recently gained attention due to its potential role in protecting against obesity. In rat, no data exist regarding FNDC5 production and regulation in the stomach. The aim of the present work was to determine the expression of FNDC5 in the rat stomach and its potential regulation by body composition. The present data shows FNDC5 gene expression in the gastric mucosa. Immunohistochemical studies found FNDC5 immunopositivity in chief cells of gastric tissue. By the use of three different antibodies FNDC5 was found expressed in gastric mucosa and secreted by the stomach. The rate of gastric FNDC5 secretion parallels the circulating levels of FNDC5. The body fat mass increase after intervention with high fat diet coincided with a decrease in the secretion of FNDC5 from the stomach and a diminution in the FNDC5 circulating levels. In summary, the present data shows, for the first time, the expression of FNDC5 in the stomach of rats and its regulation by body composition, suggesting a potential role of gastric FNDC5 in energy homeostasishis work has been supported by grants from Instituto de Salud Carlos III (PI1202021 and PI15/01272) cofounded by FEDER, Xunta de Galicia (10 PXIB 918 273PR) and Fundación Mutua Madrileña. SB-F is funded by Xunta de Galicia and Universidade de Santiago de Compostela, CF by IDIS (Instituto de Investigación Sanitaria de Santiago de Compostela), CC by Ciber obn and OA-M is funded by the ISCIII/SERGAS thought a research contract “Sara Borrell” (CD14/00091). MP is funded by ISCIII/SERGAS through a research contract “Miguel Servet II”. LMS is a SERGAS-I3SNS researcher. Centro de Investigacion Biomedica en Red Fisiopatología de la Obesidad y Nutrición (CIBERobn) is a iniciative of the Instituto de Salud Carlos III (ISCIII) of Spain which is supported by FEDER fundsS

Identification of circulating miRNA profiles that distinguish malignant pleural mesothelioma from lung adenocarcinoma

Accurate diagnosis of malignant pleura mesothelioma (MPM) is challenging. Differential diagnosis of MPM versus lung adenocarcinoma (AD) is particularly difficult, yet clinically important since the two neoplasias call for different treatment approaches. Circulating miRNA-profiling to identify miRNAs that can be used to distinguish MPM from AD has not been reported. We conducted a wide screening study of miRNA profiles in serum pools of MPM patients (N = 11), AD patients (N = 36), and healthy subjects (N = 45) to identify non-invasive biomarkers for differential diagnosis of MPM and AD, using deep sequencing. Sequencing detected up to 300 known miRNAs and up to 25 novel miRNAs species in the serum samples. Among known miRNAs, 7 were upregulated in MPM and 12 were upregulated in AD compared to healthy controls. Of these, eight were distinctive for AD and three were unique for MPM. Direct comparison of the miRNA profiles for MPM and AD revealed differences in miRNA levels that could be useful for differential diagnosis. No differentially expressed novel miRNAs were found. Further bioinformatics analysis indicated that three upregulated miRNAs in MPM are associated with the p38 pathway. There are unique alterations in serum miRNAs in MPM and AD compared to healthy controls, as well as differences between MPM and AD profiles. Differing miRNA levels between MPM and AD may be useful for differential diagnosis. A potential association to p38 pathway of three upregulated miRNAs in MPM was revealed

Highlights from the Pierre Auger Observatory

The Pierre Auger Observatory is the world's largest cosmic ray observatory. Our current exposure reaches nearly 40,000 km$^2$ str and provides us with an unprecedented quality data set. The performance and stability of the detectors and their enhancements are described. Data analyses have led to a number of major breakthroughs. Among these we discuss the energy spectrum and the searches for large-scale anisotropies. We present analyses of our X$_{max}$ data and show how it can be interpreted in terms of mass composition. We also describe some new analyses that extract mass sensitive parameters from the 100% duty cycle SD data. A coherent interpretation of all these recent results opens new directions. The consequences regarding the cosmic ray composition and the properties of UHECR sources are briefly discussed.Comment: 9 pages, 12 figures, talk given at the 33rd International Cosmic Ray Conference, Rio de Janeiro 201

EO-ALERT: A Novel Architecture for the Next Generation of Earth Observation Satellites Supporting Rapid Civil Alerts

Satellite Earth Observation (EO) data is ubiquitously used in many applications, providing basic services to society, such as environment monitoring, emergency management and civilian security. Due to the increasing request of EO products by the market, the classical EO data chain generates a severe bottleneck problem, further exacerbated in constellations. A huge amount of EO raw data generated on-board the satellite must be transferred to ground, slowing down the EO product availability, increasing latency, and hampering the growth of applications in accordance with the increased user demand. This paper provides an overview of the results achieved by the EO-ALERT project (http://eo-alert-h2020.eu/), an H2020 European Union research activity led by DEIMOS Space. EO-ALERT proposes the definition and development of the next-generation EO data processing chain, based on a novel flight segment architecture that moves optimised key EO data processing elements from the ground segment to on-board the satellite, with the aim of delivering the EO products to the end user with very low latency (quasi-real-time). EO-ALERT achieves, globally, latencies below five minutes for EO products delivery, reaching latencies below 1 minute in some scenarios. The proposed architecture solves the above challenges through a combination of innovations in the on-board elements of the data chain and the communications. Namely, the architecture introduces innovative technological solutions, including on-board reconfigurable data handling, on-board image generation and processing for the generation of alerts (EO products) using Artificial Intelligence (AI), on-board data compression and encryption using AI, high-speed on-board avionics, and reconfigurable high data rate communication links to ground, including a separate chain for alerts with minimum latency and global coverage. The paper presents the proposed architecture, its performance and hardware, considering two different user scenarios; ship detection and extreme weather observation/nowcasting. The results show that, when implemented using COTS components and available communication links, the proposed architecture can deliver alerts to ground with latency lower than five minutes, for both SAR and Optical missions, demonstrating the viability of the EOALERT concept and architecture. The paper also discusses the implementation on an avionics test bench for testing the architecture with real EO data, with the aim of demonstrating that it can meet the requirements of the considered scenarios in terms of detection performance and provides technologies at a high TRL (4-5). When proven, this will open unprecedented opportunities for the exploitation of civil EO products, especially in latency sensitive scenarios, such as disaster management