A Distributed Game-Theoretic Solution for Power Management in the Uplink of Cell-Free Systems

This paper investigates cell-free massive multiple input multiple output systems with a particular focus on uplink power allocation. In these systems, uplink power control is highly non-trivial, since a single user terminal is associated with multiple intended receiving base stations. In addition, in cell-free systems, distributed power control schemes that address the inherent spectral and energy efficiency targets are desirable. By utilizing tools from game theory, we formulate our proposal as a noncooperative game, and using the best-response dynamics, we obtain a distributed power control mechanism. To ensure that this power control game converges to a Nash equilibrium, we apply the theory of potential games. Differently from existing gamebased schemes, interestingly, our proposed potential function has a scalar parameter that controls the power usage of the users. Numerical results confirm that the proposed approach improves the use of the energy stored in the battery of user terminals and balances between spectral and energy efficiency.Comment: Accepted at IEEE Globecom 202

Efficient Battery Usage in Wireless-Powered Cell-Free Systems with Self-Energy Recycling

This paper investigates wireless-powered cell-free systems, in which the users send their uplink data signal while simultaneously harvesting energy from network nodes and user terminals - including the transmitting user terminal itself - by performing self-energy recycling. In this rather general setting, a closed-form lower bound of the amount of harvested energy and the achieved signal-to-interference-plus-noise ratio expressions are derived. Then, to improve the energy efficiency, we formulate the problem of minimizing the users' battery energy usage while satisfying minimum data rate requirements. Due to the non-convexity of the problem, a novel alternating optimization algorithm is proposed, and its proof of convergence is provided. Finally, numerical results show that the proposed method is more efficient than a state-of-art algorithm in terms of battery energy usage and outage rate.Comment: Accepted as a correspondance at IEEE TV

Mixed Coherent and Non-Coherent Transmission for Multi-CPU Cell-Free Systems

Existing works on cell-free systems consider either coherent or non-coherent downlink data transmission and a network deployment with a single central processing unit (CPU). While it is known that coherent transmission outperforms noncoherent transmission when assuming unlimited fronthaul links, the former requires a perfect timing synchronization, which is practically not viable over a large network. Furthermore, relying on a single CPU for geographically large cell-free networks is not scalable. Thus, to realize the expected gains of cellfree systems in practice, alternative transmission strategies for realistic multi-CPU cell-free systems are required. Therefore, this paper proposes a novel downlink data transmission scheme that combines and generalizes the existing coherent and non-coherent transmissions. The proposed transmission scheme, named mixed transmission, works based on the realistic assumption that only the access points (APs) controlled by a same CPU are synchronized, and thus transmit in a coherent fashion, while APs from different CPUs require no synchronism and transmit in a non-coherent manner. We also propose extensions of existing clustering algorithms for multi-CPU cell-free systems with mixed transmission. Simulation results show that the combination of the proposed clustering algorithms with mixed transmission have the potential to perform close to the ideal coherent transmission.Comment: Submitted for possible publication in IEEE conferenc

Oral sucrosomial iron is as effective as intravenous ferric carboxy‐maltose in treating anemia in patients with ulcerative colitis

Anemia is a frequent complication of ulcerative colitis, and is frequently caused by iron deficiency. Oral iron supplementation displays high rates of gastrointestinal adverse effects. However, the formulation of sucrosomial iron (SI) has shown higher tolerability. We performed a prospective study to compare the effectiveness and tolerability of oral SI and intravenous ferric carboxy‐maltose (FCM) in patients with ulcerative colitis in remission and mild‐to‐moderate anemia. Patients were randomized 1:1 to receive 60 mg/day for 8 weeks and then 30 mg/day for 4 weeks of oral SI or intravenous 1000 mg of FCM at baseline. Hemoglobin and serum levels of iron and ferritin were assessed after 4, 8, and 12 weeks from baseline. Hemoglobin and serum iron increased in both groups after 4 weeks of therapy, and remained stable during follow up, without significant treatment or treatment‐by‐time interactions (p = 0.25 and p = 0.46 for hemoglobin, respectively; p = 0.25 and p = 0.26 for iron, respectively). Serum ferritin did not increase over time during SI supplementation, while it increased in patients treated with FCM (treatment effect, p = 0.0004; treatment‐bytime interaction effect, p = 0.0002). Overall, this study showed that SI and FCM displayed similar effectiveness and tolerability for treatment of mild‐to‐moderate anemia in patients with ulcerative colitis under remission

Evolution of the cosmic ray anisotropy above 10^{14} eV

The amplitude and phase of the cosmic ray anisotropy are well established experimentally between 10^{11} eV and 10^{14} eV. The study of their evolution into the energy region 10^{14}-10^{16} eV can provide a significant tool for the understanding of the steepening ("knee") of the primary spectrum. In this letter we extend the EAS-TOP measurement performed at E_0 around 10^{14} eV, to higher energies by using the full data set (8 years of data taking). Results derived at about 10^{14} and 4x10^{14} eV are compared and discussed. Hints of increasing amplitude and change of phase above 10^{14} eV are reported. The significance of the observation for the understanding of cosmic ray propagation is discussed.Comment: 4 pages, 3 figures, accepted for publication on ApJ Letter

Searching for prompt signatures of nearby core-collapse supernovae by a joint analysis of neutrino and gravitational-wave data

We discuss the science motivations and prospects for a joint analysis of gravitational-wave (GW) and low-energy neutrino data to search for prompt signals from nearby supernovae (SNe). Both gravitational-wave and low-energy neutrinos are expected to be produced in the innermost region of a core-collapse supernova, and a search for coincident signals would probe the processes which power a supernova explosion. It is estimated that the current generation of neutrino and gravitational-wave detectors would be sensitive to Galactic core-collapse supernovae, and would also be able to detect electromagnetically dark SNe. A joint GW-neutrino search would enable improvements to searches by way of lower detection thresholds, larger distance range, better live-time coverage by a network of GW and neutrino detectors, and increased significance of candidate detections. A close collaboration between the GW and neutrino communities for such a search will thus go far toward realizing a much sought-after astrophysics goal of detecting the next nearby supernova.Comment: 10 pages, 3 figures. To appear in Class. Quantum Gra

Propagation of Muons and Taus at High Energies

The photonuclear contribution to charged lepton energy loss has been re-evaluated taking into account HERA results on real and virtual photon interactions with nucleons. With large $Q^2$ processes incorporated, the average muon range in rock for muon energies of $10^9$ GeV is reduced by only 5% as compared with the standard treatment. We have calculated the tau energy loss for energies up to $10^9$ GeV taking into consideration the decay of the tau. A Monte Carlo evaluation of tau survival probability and range show that at energies below $10^7-10^8$ GeV, depending on the material, only tau decays are important. At higher energies the tau energy losses are significant, reducing the survival probability of the tau. We show that the average range for tau is shorter than its decay length and reduce to 17 km in water for an incident tau energy of $10^9$ GeV, as compared with its decay length of 49 km at that energy. In iron, the average tau range is 4.7 km for the same incident energy.Comment: 25 pages including 8 figure

HPV sensitizes OPSCC cells to cisplatin-induced apoptosis by inhibiting autophagy through E7-mediated degradation of AMBRA1

Oropharyngeal squamous cell carcinoma (OPSCC) is an increasing world health problem with a more favorable prognosis for patients with human papillomavirus (HPV)-positive tumors compared to those with HPV-negative OPSCC. How HPV confers a less aggressive phenotype, however, remains undefined. We demonstrated that HPV-positive OPSCC cells display reduced macroautophagy/autophagy activity, mediated by the ability of HPV-E7 to interact with AMBRA1, to compete with its binding to BECN1 and to trigger its calpain-dependent degradation. Moreover, we have shown that AMBRA1 downregulation and pharmacological inhibition of autophagy sensitized HPV-negative OPSCC cells to the cytotoxic effects of cisplatin. Importantly, semi-quantitative immunohistochemical analysis in primary OPSCCs confirmed that AMBRA1 expression is reduced in HPV-positive compared to HPV-negative tumors. Collectively, these data identify AMBRA1 as a key target of HPV to impair autophagy and propose the targeting of autophagy as a viable therapeutic strategy to improve treatment response of HPV-negative OPSCC. Abbreviations: AMBRA1: autophagy and beclin 1 regulator 1; CDDP: cisplatin (CDDP); FFPE: formalin-fixed paraffin-embedded (FFPE); HNC: head and neck cancers (HNC); HPV: human papillomavirus (HPV); hrHPV: high risk human papillomavirus (hrHPV); OCSCC: oral cavity squamous carcinomas (OCSSC); OPSCC: oropharyngeal squamous cell carcinoma (OPSCC); OS: overall survival (OS); qPCR: quantitative polymerase chain reaction; RB1: RB transcriptional corepressor 1; ROC: receiver operating characteristic curve (ROC)

Measurement of the cosmic ray hadron spectrum up to 30 TeV at mountain altitude: the primary proton spectrum

The flux of cosmic ray hadrons at the atmospheric depth of 820 g/cm^2 has been measured by means of the EAS-TOP hadron calorimeter (Campo Imperatore, National Gran Sasso Laboratories, 2005 m a.s.l.). The hadron spectrum is well described by a single power law : S(E_h) = (2.25 +- 0.21 +- 0.34(sys)) 10^(-7)(E_h/1000)^(-2.79 +- 0.05) m^(-2) s^(-1) sr^(-1) GeV^(-1) over the energy range 30 GeV-30 TeV. The procedure and the accuracy of the measurement are discussed. The primary proton spectrum is derived from the data by using the CORSIKA/QGSJET code to compute the local hadron flux as a function of the primary proton spectrum and to calculate and subtract the heavy nuclei contribution (basing on direct measurements). Over a wide energy range E_0 = 0.5-50 TeV its best fit is given by a single power law : S(E_0) = (9.8 +- 1.1 +- 1.6(sys)) 10^(-5) (E_0/1000)^(-2.80 +- 0.06) m^(-2) s^(-1) sr^(-1) GeV^(-1). The validity of the CORSIKA/QGSJET code for such application has been checked using the EAS-TOP and KASCADE experimental data by reproducing the ratio of the measured hadron fluxes at the two experimental depths (820 and 1030 g/cm^2 respectively) at better than 10% in the considered energy range.Comment: 16 pages, 9 figures, accepted for publication in Astroparticle Physic

On Possibilities of Studying of Supernova Neutrinos at BAKSAN

We consider the possibilities of studying a supernova collapse neutrino burst at Baksan Neutrino Observatory (Institute for Nuclear Research, Russian Academy of Sciences) using the prposed 5-kt target-mass liquid scintillation spectrometer. Attention is given to the influence of mixing angle ${\theta}_{13}$ on the expected rates and spectra of neutrino events