Prospects for strangeness measurement in ALICE

The study of strangeness production at LHC will bring significant information on the bulk chemical properties, its dynamics and the hadronisation mechanisms involved at these energies. The ALICE experiment will measure strange particles from topology (secondary vertices) and from resonance decays over a wide range in transverse momentum and shed light on this new QCD regime. These motivations will be presented as well as the identification performance of ALICE for strange hadrons.Comment: 12 pages, 11 figures Proceedings of the Workshop on Relativistic Nuclear Physics (WRNP) 2007, Kiev, Ukraine Conference Info: http://wrnp2007.bitp.kiev.ua/ Submitted to "Physics of Atomic Nuclei

Bulk matter physics and its future at the Large Hadron Collider

Measurements at low transverse momentum will be performed at the LHC for studying particle production mechanisms in $pp$ and heavy-ion collisions. Some of the experimental capabilities for bulk matter physics are presented, focusing on tracking elements and particle identification. In order to anticipate the study of baryon production for both colliding systems at multi-TeV energies, measurements for identified species and recent model extrapolations are discussed. Several mechanisms are expected to compete for hadro-production in the low momentum region. For this reason, experimental observables that could be used for investigating multi-parton interactions and help understanding the "underlying event" content in the first $pp$ collisions at the LHC are also mentioned.Comment: 6 pages, 7 figures. To appear in the proceedings of Hot Quarks 2008, Estes Park, Colorado, 18-23 August 200

Etude des politiques relatives aux stratégies de gestion de la chimiorésistance dans le cadre de la lutte contre la trypanosomose en Afrique de l'Ouest: cas du Mali

Discussion sur l’etude des politiques relatives aux stratégies de gestion de la chimiorésistance dans le cadre de la lutte contre la trypanosomose en Afrique de l’Ouest, Mali. Le projet a pour objectif d’assurer l’efficacité des trypanocides comme une composante effective des strategies intégrées et améliorées de contrôle de Ia trypanosomose animale dans Ia region ouest-africaine. Pour atteindre cet objectif, des organisations nationales de recherche et de developpement, des institutions internationales et régionales de recherche, et des universités allemandes travaillent en partenariat afin de développer aux niveaux local et regional des strategies de reduction de risque de Ia chimiorésistance. L’accent est mis principalement sur l‘information et des supports techniques aux paysans, aux prestataires de service en sante animale, aux vétérinaires professionnels et aux décideurs politiques. Les informations et supports techniques ont pour but de promouvoir Ia lutte intégrée et l’utilisation rationnelle des trypanocides afin de réduire les risques a long terme de Ia chimiorésistance sans compromettre Ia capacité des éleveurs a pouvoir protéger leurs animaux contre les effets néfastes de la trypanosomose animale. Le projet est réalisé au Burkina Faso, au Mali et en Guinée par l’lnstitut International de Recherche sur l’Elevage (lLRl) en collaboration avec d’autres organisations. Des approaches de solutions sont alors proposees de maniere a apporter une solution durable au phenomene de la chimioresistance

Strange prospects for LHC energies

Strange quark and hadron production will be studied at the Large Hadron Collider (LHC) energies in order to explore the properties of both pp and heavy-ion collisions. The ALICE experiment will be specifically efficient in the strange sector with the identification of baryons and mesons over a wide range of transverse momentum. Dedicated measurements are proposed for investigating chemical equilibration and bulk properties. Strange particles can also help to probe kinematical regions where hard processes and pQCD dominate. We try to anticipate here several ALICE analyses to be performed as the first Pb--Pb and pp data will be available.Comment: 5 pages, 2 figures. To appear in the proceedings of Hot Quarks 2006, Villasimius, Italy, 15-20 May 200

Ontology-driven development of web services to support district energy applications

Current urban and district energy management systems lack a common semantic referential for effectively interrelating intelligent sensing, data models and energy models with visualization, analysis and decision support tools. This paper describes the structure, as well as the rationale that led to this structure, of an ontology that captures the real-world concepts of a district energy system, such as a district heating and cooling system. This ontology (called eedistrict ontology) is intended to support knowledge provision that can play the role of an intermediate layer between high-level energy management software applications and local monitoring and control software components. In order to achieve that goal, the authors propose to encapsulate queries to the ontology in a scalable web service, which will facilitate the development of interfaces for third-party applications. Considering the size of the ee-district ontology once populated with data from a specific district case study, this could prove to be a repetitive and time-consuming task for the software developer. This paper therefore assesses the feasibility of ontology-driven automation of web service development that is to be a core element in the deployment of heterogeneous district-wide energy management software

The STAR Silicon Strip Detector (SSD)

The STAR Silicon Strip Detector (SSD) completes the three layers of the Silicon Vertex Tracker (SVT) to make an inner tracking system located inside the Time Projection Chamber (TPC). This additional fourth layer provides two dimensional hit position and energy loss measurements for charged particles, improving the extrapolation of TPC tracks through SVT hits. To match the high multiplicity of central Au+Au collisions at RHIC the double sided silicon strip technology was chosen which makes the SSD a half million channels detector. Dedicated electronics have been designed for both readout and control. Also a novel technique of bonding, the Tape Automated Bonding (TAB), was used to fullfill the large number of bounds to be done. All aspects of the SSD are shortly described here and test performances of produced detection modules as well as simulated results on hit reconstruction are given.Comment: 11 pages, 8 figures, 1 tabl

Tendances de la tuberculose pulmonaire bactériologiquement confirmée et issues thérapeutiques en République Démocratique du Congo : 2007-2017: Trends of bacteriologically confirmed pulmonary tuberculosis and treatment outcomes in Democratic Republic of the Congo: 2007-2017

Context and objective. DR Congo ranks among high burden countries for tuberculosis. However, the real incidence of the disease is unknown. The study aimed to describe the trends in the estimated incidence of the bacteriologically confirmed pulmonary TB and therapeutic outcomes of patients. Methods. A retrospective analysis of data from TB patients recorded during the period of 2007 to 2017 through all the country. Linear regtression model and z-score helped to assess the year to year variations in notification rate and treatment outcomes. Results. A total of 884,458 patients were enrolled including 820,858 new patients (NP TP+) and 63,600 with a previous TB treatment. The increase reached 28.95% during this decade. The annual average inrease was of 2, 41% +/- 3, and 28 % for NP TP+ and of 5, 7% +/-0.26 for default patients. Treatment outcome assessment included 848,163 patients among them, 789, 716 NP TP+ and 58,447 with a previous TB treatment. The success rate was 88% in the former group, of 70% in those with relapse, 64.3% in patients with failure and 67.8% in the group of ancient defaulters. A total of 70,515 (8.3%) patients remained smear positive. Conclusion. The study shows an increase in the incidence of reported TP+ patients with a treatment outcome reaching the WHO’s expectations. However the high proportion of smear positive patients suggests a high risk of further acquired TB resistance. Contexte et objectifs. La République Démocratique du Congo compte parmi les pays à lourd fardeau pour la tuberculose (TB), l’incidence réelle de la maladie n’est pas formellement connue. La présente étude vise à décrire les tendances de l’incidence notifiée des patients atteints de tuberculose pulmonaire bactériologiquement confirmée (TP+) et leurs issues thérapeutiques. Méthodes. Cette étude documentaire, analyse les données des patients diagnostiqués et traités pour tuberculose de 2007 à 2017 en RDC. L’incidence notifiée des patients TP+, le taux d’accroissement annuel, les issues thérapeutiques ont été recherchés. Les variations du nombre de patients sont exprimées par les proportions. Les tendances sont présentées à travers les courbes de régression linéaire. Les issues thérapeutiques sont comparées à l’aide du z-score avec un seuil significatif de p˂ 0,05. Résultats. Au total 884 458 patients TP+ ont été rapportés, dont 820 858 nouveaux patients (NP TP+) et 63 600 déjà traités. Le taux d’accroissement au cours de cette décade était de 28,95%, soit de 66099 en 2007 à 93767 en 2017 pour les NP TP+. L’augmentation annuelle moyenne était de 2,41% +/- 3,28 pour les NP TP+ et de 5,7% +/- 0,26 par an pour les rechutes. La notification des échecs de traitement initial et repris après abandon de traitement ont une tendance à la baisse. L’évaluation thérapeutique de tous les cas cumulés a concerné 848 163 patients dont 789 716 NP TP+ et 58447 en retraitement. Le succès thérapeutique était de 88,0 % pour les NP TP+ et 70,0 % pour les rechutes, de 64,3 % pour les échecs et de 67,8% pour les repris en traitement après abandon. En somme 70 515 (8,3%) patients ont gardé des expectorations positives. Conclusion. Cette étude montre une tendance à la hausse de notification des cas incidents dont l’issue de traitement répond aux standards de l’OMS. En outre, un nombre des personnes demeurent porteurs de germes persistants précurseurs d’une TB pharmacorésistante acquise

Leadership Department Newsletter - June 2015

https://digitalcommons.andrews.edu/ldn-2015/1004/thumbnail.jp

16p11.2 Locus modulates response to satiety before the onset of obesity

Background: The 600 kb BP4-BP5 copy number variants (CNVs) at the 16p11.2 locus have been associated with a range of neurodevelopmental conditions including autism spectrum disorders and schizophrenia. The number of genomic copies in this region is inversely correlated with body mass index (BMI): the deletion is associated with a highly penetrant form of obesity (present in 50% of carriers by the age of 7 years and in 70% of adults), and the duplication with being underweight. Mechanisms underlying this energy imbalance remain unknown. Objective: This study aims to investigate eating behavior, cognitive traits and their relationships with BMI in carriers of 16p11.2 CNVs. Methods: We assessed individuals carrying a 16p11.2 deletion or duplication and their intrafamilial controls using food-related behavior questionnaires and cognitive measures. We also compared these carriers with cohorts of individuals presenting with obesity, binge eating disorder or bulimia. Results: Response to satiety is gene dosage-dependent in pediatric CNV carriers. Altered satiety response is present in young deletion carriers before the onset of obesity. It remains altered in adolescent carriers and correlates with obesity. Adult deletion carriers exhibit eating behavior similar to that seen in a cohort of obesity without eating disorders such as bulimia or binge eating. None of the cognitive measures are associated with eating behavior or BMI. Conclusions: These findings suggest that abnormal satiety response is a strong contributor to the energy imbalance in 16p11.2 CNV carriers, and, akin to other genetic forms of obesity, altered satiety responsiveness in children precedes the increase in BMI observed later in adolescence