Recruitment of the Fouling Bivalve, Mytilopsis sallei (Recluz), on Metallic and Nonmetallic Surfaces at Visakhapatnam Harbor, India

In 1967, the dreissinid bivalve, Mytilopsis saUei (Recluz), was first noticed in Indian waters at the Southern Lighter Channel of Visakhapatnam harbor, Andhra Pradesh, India. It is believed that his species was introduced into the Indo-Pacific region from Central America via the Panama Canal and Fiji through ship foulin

A Robust Search Method Using Features To Determine Combined Keywords On Cloud Encrypted Data

Users are more comfortable trusting their sensitive information to the cloud as its security continues to improve. However, when there are several encrypted files, each with its own set of keywords for indexing, the storage overhead grows exponentially, and search efficiency suffers. Therefore, this work provides a technique for searching encrypted cloud data that makes use of features to match joint keywords (FMJK). Joint keywords are generated by randomly selecting a subset of the data owner's non-duplicated keywords choice among the documents' extracted keywords; together, these keywords form a keyword dictionary. Every combined keyword matches with a document's feature as well as a query keyword, making the former's result considered a dimension of a document's index with the latter's result considered a dimension about the query trapdoor. Its BM25 method is then utilized for arranging the top k results by the inner product between the document index and the trapdoor

The role of Brønsted and Lewis acidity in the green synthesis of homopropargyl alcohols over HZSM-5

Ahighly efficient and simple reaction under exceptionally mild conditions is shown for the synthesis of biologically and pharmaceutically active molecules of homopropargyl alcohol using HZSM-5 as the catalyst. Products analyzed by IR, 1H NMR, 13CNMRand GC-MS showed consistent yields of 98 % of the alcohol, even with respective recycles of the regenerated catalyst. The reaction was also carried out with selected mineral acids, acidic oxides and other acidic catalysts to compare reactivity and the influence of the type of acidity involved in the reaction. The results indicate that the presence of both Brønsted and Lewis acidity is beneficial for inducing a high rate of reaction when compared to systems having either predominantly Brønsted or Lewis acidity.Keywords: Homopropargyl, zeolites, HZSM-

The laminin–keratin link shields the nucleus from mechanical deformation and signalling

The mechanical properties of the extracellular matrix dictate tissue behaviour. In epithelial tissues, laminin is a very abundant extracellular matrix component and a key supporting element. Here we show that laminin hinders the mechanoresponses of breast epithelial cells by shielding the nucleus from mechanical deformation. Coating substrates with laminin-111—unlike fibronectin or collagen I—impairs cell response to substrate rigidity and YAP nuclear localization. Blocking the laminin-specific integrin ß4 increases nuclear YAP ratios in a rigidity-dependent manner without affecting the cell forces or focal adhesions. By combining mechanical perturbations and mathematical modelling, we show that ß4 integrins establish a mechanical linkage between the substrate and keratin cytoskeleton, which stiffens the network and shields the nucleus from actomyosin-mediated mechanical deformation. In turn, this affects the nuclear YAP mechanoresponses, chromatin methylation and cell invasion in three dimensions. Our results demonstrate a mechanism by which tissues can regulate their sensitivity to mechanical signals.We thank A. Farré and the other members of IMPETUX OPTICS, S.L., for their help and expertise in the design and implementation of the optical tweezers experiments; R. Sunyer for help and advice with the microprinting experiments; S. Usieto, A. Menéndez, N. Castro, M. Purciolas and W. Haaksma for providing technical support; L. Rosetti and S. Saloustros for providing data analysis tools; and J. de Rooij, A. L. Le Roux, L. Faure, A. Labernadie, R. Oria and J. Abenza, as well as all the members of the groups of P.R.-C. and X.T. for helpful discussion. Finally, we thank G. Wiche, A. Sonnenberg and N. Montserrat for providing plasmids, antibodies or cell lines used for this work. We acknowledge funding from the Spanish Ministry of Science and Innovation (PID2021-128635NB-I00 MCIN/AEI/10.13039/501100011033 and ‘ERDF-EU A way of making Europe’ to X.T., PID2019-110949GB-I00 to M.A. and PID2019-110298GB-I00 to P.R.-C.), the European Commission (H2020-FETPROACT-01-2016-731957), the European Research Council (Adv-883739 to X.T.; CoG-681434 to M.A.; StG- 851055 to A.E.-A.), the Generalitat de Catalunya (2017-SGR-1602 to X.T. and P.R.-C.; 2017-SGR-1278 to M.A. and P.S.) and European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement no. 797621 to M.G.-G. The prize ‘ICREA Academia’ for excellence in research to M.A. and P.R.-C., Fundació la Marató de TV3 (201936-30-31 and 201903-30-31-32), and ‘la Caixa’ Foundation (LCF/PR/HR20/52400004 and ID 100010434 under agreement LCF/PR/HR20/52400004). IBEC and CIMNE are recipients of a Severo Ochoa Award of Excellence from MINCIN. A.E.M.B. was supported by a Sir Henry Wellcome Fellowship (210887/Z/18/Z). A.E.-A. receives funding from the Francis Crick Institute, which receives its core funding from the Cancer Research UK (CC2214), the UK Medical Research Council (CC2214) and the Wellcome Trust (CC2214).Peer ReviewedPostprint (published version

Catalytic Valorisation of Biomass-Derived Levulinic Acid to Biofuel Additive γ-Valerolactone: Influence of Copper Loading on Silica Support

γ-valerolactone (GVL) is a crucial chemical feedstock used in the production of fuel additives, renewable fuels, and fine chemicals alternative to petroleum-based solvents and chemicals, supporting the transition to sustainable energy solutions. It is promptly acquired by hydrogenating levulinic acid (LA) in a gaseous or liquid phase with a homogeneous or heterogeneous catalyst using a variety of recognized catalytic processes. Herein, this work focuses on the use of silica-supported copper (Cu/SiO2) catalysts for the gas-phase hydrogenation of LA to GVL under mild reaction conditions. The study analyzes how copper loading can affect the catalytic activity of the Cu/SiO2, while the flow rate of LA, time-on-stream, reaction temperature, and LA concentration affect the catalytic efficiency. The SiO2 support’s various Cu loadings are crucial for adjusting the catalytic hydrogenation activity. One of the studied catalysts, a 5 wt% Cu/SiO2 catalyst, demonstrated ~81% GVL selectivity with ~78% LA conversion and demonstrated stability for ~8 h while operating at atmospheric pressure and temperature (265 °C) and 0.5 mL/h of LA flow rate. The ability to activate hydrogen, high amount of acidic sites, and surface area were all discovered to be advantageous for increased GVL selectivity.This work was supported by Qatar University through a National Capacity Building Program grant (NCBP) [QUCP-CAM-20/23-463]. Statements made herein are solely the responsibility of the authors.Scopu

Computational approaches for modeling human intestinal absorption and permeability

Human intestinal absorption (HIA) is an important roadblock in the formulation of new drug substances. Computational models are needed for the rapid estimation of this property. The measurements are determined via in vivo experiments or in vitro permeability studies. We present several computational models that are able to predict the absorption of drugs by the human intestine and the permeability through human Caco-2 cells. The training and prediction sets were derived from literature sources and carefully examined to eliminate compounds that are actively transported. We compare our results to models derived by other methods and find that the statistical quality is similar. We believe that models derived from both sources of experimental data would provide greater consistency in predictions. The performance of several QSPR models that we investigated to predict outside the training set for either experimental property clearly indicates that caution should be exercised while applying any of the models for quantitative predictions. However, we are able to show that the qualitative predictions can be obtained with close to a 70% success rate

Reference evapotranspiration in the irrigated perimeters of the state of Sergipe

O conhecimento da evapotranspiração de referência (ETo) é essencial no manejo de irrigação de culturas agrícolas em todo o mundo. Neste trabalho se utilizaram dados meteorológicos diários de evaporação do tanque "Classe A", temperaturas máximas e mínimas, insolação, velocidade do vento a 2 m de altura e umidade relativa do ar, referentes ao período de 1989 a 1993, coletados em quatro perímetros irrigados do Estado de Sergipe, para estimativa da ETo com base nos métodos do Tanque Classe "A", Radiação Solar, Hargreaves & Samani, Linacre e Penman-Monteith (FAO/56). Comparam-se os valores diários da ETo para a região estudada, através dos quais, quando comparados com o modelo de Penman-Monteith (FAO/56) se obtiveram os melhores desempenhos com os métodos que utilizam a radiação solar como dado de entrada no modelo. O método do Tanque Classe "A" não apresentou desempenho satisfatório em nenhum perímetro irrigado estudado. _________________________________________________________________________________________ ABSTRACT: The knowledge of reference evapotranspiration (ETo) is essential for the irrigation scheduling of crops throughout the world. This work used daily meteorological data of Class A pan evaporation, maximum and minimum air temperatures, insolation, wind speed at 2 m above surface and relative humidity from 1989 to 1993 for four irrigated perimeters of Sergipe. These data were used for estimating ETo based on the following methods: Class A pan evaporation, Solar Radiation, Hargreaves & Samani, Linacre and Penman-Monteith (FAO/56). The daily values of ETo were compared to those obtained by FAO Penman-Monteith method in order to choose the best method of estimating ETo for the region. The best performance was obtained for those models which used the solar radiation as the data input. The Class A pan evaporation method did not show favorable performance in any irrigated perimeter