158 research outputs found
Bridging the science–policy gap in the climate migration field. KNOMAD policy brief 22.
While the scientific understanding of climate migration is advancing, major gaps prevail in addressing the related humanitarian and socio-economic challenges. Drawing from recent research, this Policy Brief discusses key challenges and presents recommendations for enhancing the science-policy interface to more effectively tackle the complexities of climate-related movements of people. The outlined suggestions aim to foster inclusive representation, improve the accuracy of assessments, leverage public data sources, and broaden the scope of research and policy initiatives
Recommended from our members
Improving the evidence base: A methodological review of the quantitative climate migration literature
The question whether and how climatic factors influence human migration has gained both academic and public interest in the past years. Based on two meta-analyses, this paper systematically reviews the quantitative empirical literature on climate-related migration from a methodological perspective. In total, information from 127 original micro- and macro-level studies is analyzed to assess how different concepts, research designs, and analytical methods shape our understanding of climate migration. We provide an overview of common methodological approaches and present evidence on their potential implications for the estimation of climatic impacts. We identify five key challenges, which relate to the i) measurement of migration and ii) climatic events, iii) the integration and aggregation of data, iv) the identification of causal relationships, and v) the exploration of contextual influences and mechanisms. Advances in research and modelling are discussed together with best practice cases to provide guidance to researchers studying the climate-migration nexus. We recommend for future empirical studies to employ approaches that are of relevance for and reflect local contexts, ensuring high levels of comparability and transparency
Gezocht: andere methoden en nieuwe partners: landschapsecologie en WLO
De landschapsecologie is inmiddels een gevestigde wetenschap. Toch gaan de biodiversiteit en de kwaliteit van het landschap in Nederland en Vlaanderen nog steeds achteruit. Kunnen we rnet ons vakgebied dan niet meer positieve invloed hebben op landschapsveranderingen? En als we menen van wel hoe dan? Op die vragen gaat dit artikel i
Prediction of residual pipeline resource taking into account the operation loading conditions
An effective energy approach to the evaluation of the residual service life of a pipe of oil pipeline containing a crack on its inner surface for the two-frequency loading mode of biaxial tensioncompression has been proposed. The two-frequency variations of pressure in the pipe are caused by the turbulence of the flow of oil (highfrequency), opening and closing of the gate valves, and the shutdowns of the pumps (low frequency).Предложен эффективный энергетический подход к оценке остаточного эксплуатационного ресурса нефтепровода с трещиной на внутренней поверхности трубы, подвергаемой двухчастотному биаксиальному нагружению растяжением-сжатием. Двухчастотный режим изменения давления в трубопроводе обусловлен турбулентностью потока нефти (высокочастотная составляющая), открыванием и закрыванием задвижек, а так же отключением нефтенасосов (низкочастотная составляющая)
Der Umzug der Menschheit: Die transformative Kraft der Städte
Die Wucht der derzeitigen Urbanisierungsdynamik und ihre Auswirkungen sind so groß, dass sich weltweit Städte, Stadtgesellschaften, Regierungen und Internationale Organisationen diesem Trend stellen müssen. Ein „Weiter so wie bisher“, würde ohne gestaltende Urbanisierungspolitik zu einer nicht-nachhaltigen Welt-Städte-Gesellschaft führen. Nur wenn Städte und Stadtgesellschaften ausreichend handlungsfähig werden, können sie ihre Kraft für eine nachhaltige Entwicklung entfalten: In den Städten wird sich entscheiden, ob die Große Transformation zur Nachhaltigkeit gelingt. In diesem Buch werden die Erfolgsbedingungen dafür diskutiert
Humanity on the move: Unlocking the transformative power of cities
The momentum of urbanization and its impacts are so massive that we must face up to this trend. In view of the existing cognitive, technical, economic and institutional path dependencies, a policy of business as usual – i.e. an unstructured, quasi-automatic urbanization – would lead to a non-sustainable ‘world cities society’. Only if cities and urban societies are sufficiently empowered can they make use of the opportunities for sustainability and successfully follow the urban transformation pathways. The success or failure of the Great Transformation will be decided in the cities. The WBGU discusses the relevant conditions for the success of this transformation in this report
Expression of MuRF1 or MuRF2 is essential for the induction of skeletal muscle atrophy and dysfunction in a murine pulmonary hypertension model
Background
Pulmonary hypertension leads to right ventricular heart failure and ultimately to cardiac cachexia. Cardiac cachexia induces skeletal muscles atrophy and contractile dysfunction. MAFbx and MuRF1 are two key proteins that have been implicated in chronic muscle atrophy of several wasting states.
Methods
Monocrotaline (MCT) was injected over eight weeks into mice to establish pulmonary hypertension as a murine model for cardiac cachexia. The effects on skeletal muscle atrophy, myofiber force, and selected muscle proteins were evaluated in wild-type (WT), MuRF1, and MuRF2-KO mice by determining muscle weights, in vitro muscle force and enzyme activities in soleus and tibialis anterior (TA) muscle.
Results
In WT, MCT treatment induced wasting of soleus and TA mass, loss of myofiber force, and depletion of citrate synthase (CS), creatine kinase (CK), and malate dehydrogenase (MDH) (all key metabolic enzymes). This suggests that the murine MCT model is useful to mimic peripheral myopathies as found in human cardiac cachexia. In MuRF1 and MuRF2-KO mice, soleus and TA muscles were protected from atrophy, contractile dysfunction, while metabolic enzymes were not lowered in MuRF1 or MuRF2-KO mice. Furthermore, MuRF2 expression was lower in MuRF1KO mice when compared to C57BL/6 mice.
Conclusions
In addition to MuRF1, inactivation of MuRF2 also provides a potent protection from peripheral myopathy in cardiac cachexia. The protection of metabolic enzymes in both MuRF1KO and MuRF2KO mice as well as the dependence of MuRF2 expression on MuRF1 suggests intimate relationships between MuRF1 and MuRF2 during muscle atrophy signaling
Evidence for Shared Cognitive Processing of Pitch in Music and Language
Language and music epitomize the complex representational and computational capacities of the human mind. Strikingly similar in their structural and expressive features, a longstanding question is whether the perceptual and cognitive mechanisms underlying these abilities are shared or distinct – either from each other or from other mental processes. One prominent feature shared between language and music is signal encoding using pitch, conveying pragmatics and semantics in language and melody in music. We investigated how pitch processing is shared between language and music by measuring consistency in individual differences in pitch perception across language, music, and three control conditions intended to assess basic sensory and domain-general cognitive processes. Individuals’ pitch perception abilities in language and music were most strongly related, even after accounting for performance in all control conditions. These results provide behavioral evidence, based on patterns of individual differences, that is consistent with the hypothesis that cognitive mechanisms for pitch processing may be shared between language and music.National Science Foundation (U.S.). Graduate Research Fellowship ProgramEunice Kennedy Shriver National Institute of Child Health and Human Development (U.S.) (Grant 5K99HD057522
- …