277 research outputs found
Perceptions Of Secondary English Teachers On Using English Curriculum To Meet Social And Emotional Learning Goals
The purpose of this qualitative study was to explore secondary public school English Language Arts (ELA) teachers’ perceptions of implementing ELA curriculum as it may relate to social and emotional learning (SEL) goals. The problem explored was the rise of adolescents’ mental health concerns (CDC, 2019) and the role of secondary schools in attempting to address these concerns. The literature on this topic explored the mental health crisis for adolescents, the history and philosophy of SEL, and how secondary schools are integrating SEL, and how the ELA curriculum may be effective at meeting SEL goals. Six secondary public ELA teachers shared their perceptions through semi-structured interviews. Data from these interviews were coded and analyzed using a 5-step data analysis process developed by Creswell and Poth (2018). The analysis of the findings indicated that participants had an accurate understanding of the definition and goals of SEL. Participants offered multiple examples of strategies and lessons they used to meet SEL goals within their classroom routines and ELA curriculum and found that the ELA curriculum was a natural fit for meeting SEL goals. Additionally, participants believed that it was most effective for their adolescent students to address SEL without calling it SEL. This study is significant because research on adolescent mental health supported the idea that decreasing stigma by normalizing discussion of mental health can have beneficial outcomes for adolescent students. This research has implications for administrators, educators of all content areas, and secondary students
Letters from Wm. Chas. Roberts, J. B. Fisher, A. H. Throckmorton, Lucien Waggener, J. W. Logan, and A. B. Nelson
Letters of recommendation for O. W. Long
Tunable Blood Shunt for Neonates With Complex Congenital Heart Defects
Despite advancements in procedures and patient care, mortality rates for neonatal recipients of the Norwood procedure, a palliation for single ventricle congenital malformations, remain high due to the use of a fixed-diameter blood shunt. In this study, a new geometrically tunable blood shunt was investigated to address limitations of the current treatment paradigm (e.g., Modified Blalock-Taussig Shunt) by allowing for controlled modulation of blood flow through the shunt to accommodate physiological changes due to the patient’s growth. First, mathematical and computational cardiovascular models were established to investigate the hemodynamic requirements of growing neonatal patients with shunts and to inform design criteria for shunt diameter changes. Then, two stages of prototyping were performed to design, build and test responsive hydrogel systems that facilitate tuning of the shunt diameter by adjusting the hydrogel’s degree of crosslinking. We examined two mechanisms to drive crosslinking: infusion of chemical crosslinking agents and near-UV photoinitiation. The growth model showed that 15–18% increases in shunt diameter were required to accommodate growing patients’ increasing blood flow; similarly, the computational models demonstrated that blood flow magnitudes were in agreement with previous reports. These target levels of diameter increases were achieved experimentally with model hydrogel systems. We also verified that the photocrosslinkable hydrogel, composed of methacrylated dextran, was contact-nonhemolytic. These results demonstrate proof-of-concept feasibility and reflect the first steps in the development of this novel blood shunt. A tunable shunt design offers a new methodology to rebalance blood flow in this vulnerable patient population during growth and development
The Foot of Homo Naledi
Modern humans are characterized by a highly specialized foot that reflects our obligate bipedalism. Our understanding of hominin foot evolution is, although, hindered by a paucity of well-associated remains. Here we describe the foot of Homo naledi from Dinaledi Chamber, South Africa, using 107 pedal elements, including one nearly-complete adult foot. The H. naledi foot is predominantly modern human-like in morphology and inferred function, with an adducted hallux, an elongated tarsus, and derived ankle and calcaneocuboid joints. In combination, these features indicate a foot well adapted for striding bipedalism. However, the H. naledi foot differs from modern humans in having more curved proximal pedal phalanges, and features suggestive of a reduced medial longitudinal arch. Within the context of primitive features found elsewhere in the skeleton, these findings suggest a unique locomotor repertoire for H. naledi, thus providing further evidence of locomotor diversity within both the hominin clade and the genus Homo
The Foot of \u3cem\u3eHomo naledi\u3c/em\u3e
Modern humans are characterized by a highly specialized foot that reflects our obligate bipedalism. Our understanding of hominin foot evolution is, although, hindered by a paucity of well-associated remains. Here we describe the foot of Homo naledi from Dinaledi Chamber, South Africa, using 107 pedal elements, including one nearly-complete adult foot. The H. naledi foot is predominantly modern human-like in morphology and inferred function, with an adducted hallux, an elongated tarsus, and derived ankle and calcaneocuboid joints. In combination, these features indicate a foot well adapted for striding bipedalism. However, the H. naledi foot differs from modern humans in having more curved proximal pedal phalanges, and features suggestive of a reduced medial longitudinal arch. Within the context of primitive features found elsewhere in the skeleton, these findings suggest a unique locomotor repertoire for H. naledi, thus providing further evidence of locomotor diversity within both the hominin clade and the genus Homo
The foot of Homo naledi
Modern humans are characterized by a highly specialized foot that reflects our obligate bipedalism. Our understanding of hominin foot evolution is, although, hindered by a paucity of well-associated remains. Here we describe the foot of Homo naledi from Dinaledi Chamber, South Africa, using 107 pedal elements, including one nearly-complete adult foot. The H. naledi foot is predominantly modern human-like in morphology and inferred function, with an adducted hallux, an elongated tarsus, and derived ankle and calcaneocuboid joints. In combination, these features indicate a foot well adapted for striding bipedalism. However, the H. naledi foot differs from modern humans in having more curved proximal pedal phalanges, and features suggestive of a reduced medial longitudinal arch. Within the context of primitive features found elsewhere in the skeleton, these findings suggest a unique locomotor repertoire for H. naledi, thus providing further evidence of locomotor diversity within both the hominin clade and the genus Homo
Difficulty in diagnosing the pathological nature of an acute fracture of the clavicle: a case report
Fractures of the clavicle comprise between 5% to10% of all fractures. Medial clavicular fractures are uncommon and are normally caused by high-energy trauma. A low impact mechanism of injury should raise suspicion of a pathological fracture, but this case report highlights the difficulty in diagnosing the pathological nature of an acute fracture of the clavicle. We describe a patient who presented with a medial clavicular fracture after a simple fall but the fracture was diagnosed as pathological in retrospect four months after the initial presentation. We would also like to emphasise that the medial clavicle is the most frequent site of pathological fractures of the clavicle, and the possibility of an underlying pathological condition should be considered whenever a patient with a medial clavicular fracture is encountered
The Cayman Crab Fly Revisited — Phylogeny and Biology of Drosophila endobranchia
BACKGROUND: The majority of all known drosophilid flies feed on microbes. The wide spread of microorganisms consequently mean that drosophilids also can be found on a broad range of substrates. One of the more peculiar types of habitat is shown by three species of flies that have colonized land crabs. In spite of their intriguing lifestyle, the crab flies have remained poorly studied. Perhaps the least investigated of the three crab flies is the Cayman Island endemic Drosophila endobranchia. Apart from its life cycle very little is known about this species, including its phylogenetic position, which has remained unresolved due to a cryptic set of characteristics. PRINCIPAL FINDINGS: Based on molecular data, corroborated by a re-analysis of the morphological make up, we have resolved the phylogenetic position of D. endobranchia and show that it somewhat surprisingly belongs to the large Neotropical repleta radiation, and should be considered as an aberrant member of the canalinea species group. Furthermore we also provide additional data on the behavior of these remarkable flies. CONCLUSION: Our findings reveal that the two Caribbean crab flies are not as distantly related as first thought, as both species are members of the derived repleta radiation. That this lineage has given rise to two species with the same odd type of breeding substrate is curious and prompts the question of what aspects of their shared ancestry has made these flies suitable for a life on (and inside) land crabs. Knowledge of the phylogenetic position of D. endobranchia will allow for comparative explorations and will aid in efforts aimed at understanding processes involved in drastic host shifts and extreme specialization
Tentacle probe sandwich assay in porous polymer monolith improves specificity, sensitivity and kinetics
Nucleic acid sandwich assays improve low-density array analysis through the
addition of a capture probe and a specific label, increasing specificity and
sensitivity. Here, we employ photo-initiated porous polymer monolith (PPM) as a
high-surface area substrate for sandwich assay analysis. PPMs are shown to
enhance extraction efficiency by 20-fold from 2 μl of
sample. We further compare the performance of labeled linear probes, quantum dot
labeled probes, molecular beacons (MBs) and tentacle probes (TPs). Each probe
technology was compared and contrasted with traditional hybridization methods
using labeled sample. All probes demonstrated similar sensitivity and greater
specificity than traditional hybridization techniques. MBs and TPs were able to
bypass a wash step due to their ‘on–off’
signaling mechanism. TPs demonstrated reaction kinetics 37.6 times faster than
MBs, resulting in the fastest assay time of 5 min. Our data further indicate TPs
had the most sensitive detection limit (<1 nM) as well
as the highest specificity (>1
× 104 improvement) among all tested probes
in these experiments. By matching the enhanced extraction efficiencies of PPM
with the selectivity of TPs, we have created a format for improved sandwich
assays
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