On sectional and bisectional curvature of the H

Let M be an H-umbilical submanifold of an almost Hermitian manifold M˜. Some relations expressing the difference of bisectional and of sectional curvatures of M˜ and of M are obtained. The geometric notion of related bases for a pair of oriented planes permits to write the second members in a completely geometrical form. When the planes are not orthogonal, more simple formulas are obtained. The paper ends with a remark, concerning the vector field JH, and some special cases

Extreme nonlinear electrodynamics in metamaterials with very small linear dielectric permittivity

We consider a sub-wavelength periodic layered medium whose slabs are filled by arbitrary linear metamaterials and standard nonlinear Kerr media and we show that the homogenized medium behaves as a Kerr medium whose parameters can assume values not available in standard materials. Exploiting such a parameter availability, we focus on the situation where the linear relative dielectric permittivity is very small thus allowing the observation of the extreme nonlinear regime where the nonlinear polarization is comparable with or even greater than the linear part of the overall dielectric response. The behavior of the electromagnetic field in the extreme nonlinear regime is very peculiar and characterized by novel features as, for example, the transverse power flow reversing. In order to probe the novel regime, we consider a class of fields (transverse magnetic nonlinear guided waves) admitting full analytical description and we show that these waves are allowed to propagate even in media with $\epsilon0$ since the nonlinear polarization produces a positive overall effective permittivity. The considered nonlinear waves exhibit, in addition to the mentioned features, a number of interesting properties like hyper-focusing induced by the phase difference between the field components.Comment: 12 pages, 7 figure

Sex-related differences and chronobiology of ST-elevation myocardial infarction: findings from a single hub center in Italy

Objective: Type I acute myocardial infarction (AMI) is a life-threatening condition. Time of event and rescue procedures, and sex-specific differences may play a crucial role. We aimed to investigate chronobiological patterns and sex-specific differences in a cohort of AMI patients referred to a single hub center in Italy. Patients and methods: We considered all patients consecutively admitted for AMI (STEMI) to the Hospital of the Heart, in Massa, Tuscany (a region of Italy), between 2006 to 2018, who underwent interventional procedures. Sex, age, time of hospital admission, outcome (discharged alive/deceased), main comorbidities, and time between symptom onset and emergency medical service (EMS) activation, were analyzed. Chronobiologic analysis was applied according to hour of day, month, and season of the year. Results: Overall 2,522 patients (mean age 64.6±13.1 years, 73% males) were considered. In-hospital death (IHM) occurred in 96 subjects (3.8%). At univariate analysis, deceased subjects were more likely to be female, older, with longer wait for EMS activation and with interventional procedures during night-time. The multivariate analysis identified female sex, age, history of ischemic heart disease, and night-time interventional procedure as independently associated factors to IHM. Chronobiologic analysis showed a pattern with a main morning peak for total sample, males, and females (p=0.00027; p=0.0006); p=0.0121, respectively). Events showed a higher peak in summer, with no differences by sex, but IHM was higher in winter. Females showed a higher delay for EMS activation, compared to males (p<0.001), but with no effects on prognosis. On the contrary, males with a delay showed higher mortality. Conclusions: Great effort should be spent to reduce patient-related delays in interventional procedures, being this issue crucial in both sexes

X-ray and Radio Interactions in the Cores of Cooling Flow Clusters

We present high resolution ROSAT x-ray and radio observations of three cooling flow clusters containing steep spectrum radio sources at their cores. All three systems exhibit strong signs of interaction between the radio plasma and the hot intracluster medium. Two clusters, A133 and A2626, show enhanced x-ray emission spatially coincident with the radio source whereas the third cluster, A2052, exhibits a large region of x-ray excess surrounding much of the radio source. Using 3-D numerical simulations, we show that a perturbed jet propagating through a cooling flow atmosphere can give rise to amorphous radio morphologies, particularly in the case where the jet was ``turned off'' and allowed to age passively. In addition, the simulated x-ray surface brightness produced both excesses and deficits as seen observationally.Comment: 25 pages, 10 figures, accepted for publication in A

TRAIL Dependent Fratricidal Killing of gp120 Primed Hepatocytes by HCV Core Expressing Hepatocytes

The mechanism by which HIV and HCV cooperatively accelerate hepatocyte damage is not clearly understood; however, each virus affects the TRAIL: TRAIL- receptor system. We, therefore, questioned whether the independent effects of HCV and HIV combine to synergistically result in TRAIL dependent hepatocyte killing. We describe that Huh7 hepatocytes treated with HIV gp120 results in both increase TRAIL-R2 expression and an acquired sensitivity to TRAIL mediated killing. Moreover HCV infection and HCV core expression alone in Huh7 cells upregulates TRAIL. Co-incubation of HIV gp120 primed hepatocytes with HCV core expressing hepatocytes results in the selective death of the HIV gp120 primed hepatocytes that is selectively blocked by TRAIL–R2-Fc fusion protein. Liver biopsies from HIV mono-infected patients have increased TRAIL-R2; biopsies from HCV infected patients have increased TRAIL, while co-infected liver biopsies have increased PARP cleavage within hepatocytes indicating enhanced apoptosis. These findings suggest a pathogenic model to understand why HIV/HCV co-infection accelerates liver injury

The Richardson's Law in Large-Eddy Simulations of Boundary Layer flows

Relative dispersion in a neutrally stratified planetary boundary layer (PBL) is investigated by means of Large-Eddy Simulations (LES). Despite the small extension of the inertial range of scales in the simulated PBL, our Lagrangian statistics turns out to be compatible with the Richardson $t^3$ law for the average of square particle separation. This emerges from the application of nonstandard methods of analysis through which a precise measure of the Richardson constant was also possible. Its values is estimated as $C_2\sim 0.5$ in close agreement with recent experiments and three-dimensional direct numerical simulations.Comment: 15 LaTex pages, 4 PS figure

Management and efficacy of intensified insulin therapy starting in outpatients

Diabetic patients under multiple injection insulin therapy (i.e., intensified insulin therapy, IIT) usually start this treatment during hospitalization. We report here on the logistics, efficacy, and safety of IIT, started in outpatients. Over 8 months, 52 type I and type II diabetics were followed up whose insulin regimens consecutively had been changed from conventional therapy to IIT. Two different IIT strategies were compared: free mixtures of regular and intermediate (12 hrs)-acting insulin versus the basal and prandial insulin treatment with preprandial injections of regular insulin, and ultralente (24 hrs-acting) or intermediate insulin for the basal demand. After 8 months HbA1 levels had decreased from 10.6%±2.4% to 8.0%±1.3% (means±SD). There was no difference between the two regimens with respect to metabolic control; but type II patients maintained the lowered HbA1 levels better than type I patients. Only two patients were hospitalized during the follow-up time because of severe hypoglycemia. An increase of body weight due to the diet liberalization during IIT became a problem in one-third of the patients. Our results suggest that outpatient initiation of IIT is safe and efficacious with respect to near-normoglycemic control. Weight control may become a problem in IIT patients

An ISOCAM survey through gravitationally lensing galaxy clusters. III. New results from mid-infrared observations of th e cluster Abell 2219

The massive cluster of galaxies Abell 2219 (z = 0.228) was observed at 14.3 $\mu$m with the Infrared Space Observatory and results were published by Barvainis et al. (1999). These observations have been reanalyzed using a method specifically designed for the detection of faint sources that had been applied to other clusters. Five new sources were detected and the resulting cumulative total of ten sources all have optical counterparts. The mid-infrared sources are identified with three cluster members, three foreground galaxies, an Extremely Red Object, a star and two galaxies of unknown redshift. The spectral energy distributions (SEDs) of the galaxies are fit with models from a selection, using the program GRASIL. Best-fits are obtained, in general, with models of galaxies with ongoing star formation. For three cluster members the infrared luminosities derived from the model SEDs are between ~5.7x10^10 Lsun and 1.4x10^11 Lsun, corresponding to infrared star formation rates between 10 and 24 Msun yr^-1. The two cluster galaxies that have optical classifications are in the Butcher-Oemler region of the color-magnitude diagramme. The three foreground galaxies have infrared luminosities between 1.5x10^10 Lsun and 9.4x10^10 Lsun yielding infrared star formation rates between 3 and 16 Msun yr^-1. Two of the foreground galaxies are located in two foreground galaxy enhancements (Boschin et al. 2004). Including Abell 2219, six distant clusters of galaxies have been mapped with ISOCAM and luminous infrared galaxies (LIRGs) have been found in three of them. The presence of LIRGs in Abell 2219 strengthens the association between luminous infrared galaxies in clusters and recent or ongoing cluster merger activity.Comment: 8 pages, 4 figures, A&A accepted, full paper with high-resolution figures available at http://bermuda.ucd.ie/~dcoia/papers/. Reference adde

Diffuse light and building history of the galaxy cluster Abell 2667

We have searched for diffuse intracluster light in the galaxy cluster Abell 2667 (z=0.233) from HST images in three filters. We have applied to these images an iterative multi-scale wavelet analysis and reconstruction technique, which allows to subtract stars and galaxies from the original images. We detect a zone of diffuse emission south west of the cluster center (DS1), and a second faint object (ComDif), within DS1. Another diffuse source (DS2) may be detected, at lower confidence level, north east of the center. These sources of diffuse light contribute to 10-15% of the total visible light in the cluster. Whether they are independent entities or are part of the very elliptical external envelope of the central galaxy remains unclear. VLT VIMOS integral field spectroscopy reveals a faint continuum at the positions of DS1 and ComDif but do not allow to compute a redshift. A hierarchical substructure detection method reveals the presence of several galaxy pairs and groups defining a similar direction as the one drawn by the DS1-central galaxy-DS2 axis. The analysis of archive XMM-Newton and Chandra observations shows X-ray emission elongated in the same direction. The X-ray temperature map shows the presence of a cool core, a broad cool zone stretching from north to south and hotter regions towards the north east, south west and north west. This possibly suggests shock fronts along these directions produced by infalling material. These various data are consistent with a picture in which diffuse sources are concentrations of tidal debris and harassed matter expelled from infalling galaxies by tidal stripping and undergoing an accretion process onto the central cluster galaxy; as such, they are expected to be found along the main infall directions.Comment: Accepted for publication in Astronomy and Astrophysic