Electromechanical and Dynamic Characterization of In-House-Fabricated Amplified Piezo Actuator

A diamond-shaped amplified piezo actuator (APA) fabricated using six multilayered piezo stacks with maximum displacement of 173 μm at 175V and the amplification factor of 4.3. The dynamic characterization of the actuator was carried out at different frequencies (100 Hz–1 kHz) and at different AC voltages (20V–40V). The actuator response over this frequency range was found neat, without attenuation of the signal. Numerical modeling of multilayered stack actuator was carried out using empirical equations, and the electromechanical analysis was carried out using ABAQUS software. The block force of the APA was 81 N, calculated by electromechanical analysis. This is similar to that calculated by dynamic characterization method

The nature of the continuum limit in strongly coupled quenched QED

We review the results of large scale simulations of noncompact quenched $QED$ which use spectrum and Equation of State calculations to determine the theory's phase diagram, critical indices, and continuum limit. The resulting anomalous dimensions are in good agreement with Schwinger-Dyson solutions of the ladder graphs of conventional $QED$ and they satisfy the hyperscaling relations expected of a relativistic renormalizable field theory. The spectroscopy results satisfy the constraints of the Goldstone mechanism and PCAC, and may be indicative of Technicolor versions of the Standard Model which are strongly coupled at short distances.Comment: (talk given at the XXVI ICHEP, Dallas, TX, Aug 6-12 92), 6 pp., ILL-(TH)-92-#2

Changes over time in socioeconomic inequalities in breast and rectal cancer survival in England and Wales during a 32-year period (1973-2004): the potential role of health care.

BACKGROUND: Socioeconomic inequalities in cancer survival are well documented but they vary for different cancers and over time. Reasons for these differences are poorly understood. PATIENTS AND METHODS: For England and Wales, we examined trends in socioeconomic survival inequalities for breast cancer in women and rectal cancer in men during the 32-year period 1973-2004. We used a theoretical framework based on Victora's 'inverse equity' law, under which survival inequalities could change with the advent of successive new treatments, of varying effectiveness, which are disseminated with different speed among patients of different socioeconomic groups. We estimated 5-year relative survival for patients of different deprivation quintiles and examined trends in survival inequalities in light of major treatment innovations. RESULTS: Inequalities in breast cancer survival (921,611 cases) narrowed steadily during the study (from -10% to -6%). In contrast, inequalities in rectal cancer survival (187,104 cases) widened overall (form -5% to -11%) with fluctuating periods of narrowing inequality. CONCLUSIONS: Trends in socioeconomic differences in tumour or patient factors are unlikely explanations of observed changes over time in survival inequalities. The sequential introduction into clinical practice of new treatments of progressively smaller incremental benefit may partly explain the reduction in inequality in breast cancer survival

Real-time monitoring of proton exchange membrane fuel cell stack failure

Uneven pressure drops in a 75-cell 9.5-kWe proton exchange membrane fuel cell stack with a U-shaped flow configuration have been shown to cause localised flooding. Condensed water then leads to localised cell heating, resulting in reduced membrane durability. Upon purging of the anode manifold, the resulting mechanical strain on the membrane can lead to the formation of a pin-hole/membrane crack and a rapid decrease in open circuit voltage due to gas crossover. This failure has the potential to cascade to neighbouring cells due to the bipolar plate coupling and the current density heterogeneities arising from the pin-hole/membrane crack. Reintroduction of hydrogen after failure results in cell voltage loss propagating from the pin-hole/membrane crack location due to reactant crossover from the anode to the cathode, given that the anode pressure is higher than the cathode pressure. Through these observations, it is recommended that purging is avoided when the onset of flooding is observed to prevent irreparable damage to the stack

The structural sensitivity of open shear flows calculated with a local stability analysis

The structural sensitivity shows where an instability of a fluid flow is most sensitive to changes in internal feedback mechanisms. It is formed from the overlap of the flow's direct and adjoint global modes. These global modes are usually calculated with 2D or 3D global stability analyses, which can be very computationally expensive. For weakly non-parallel flows the direct global mode can also be calculated with a local stability analysis, which is orders of magnitude cheaper. In this theoretical paper we show that, if the direct global mode has been calculated with a local analysis, then the adjoint global mode follows at little extra cost. We also show that the maximum of the structural sensitivity is the location at which the local k+ and k- branches have the same imaginary value. Finally, we use the local analysis to derive the structural sensitivity of two flows: a confined co-flow wake at Re = 400, for which it works very well, and the flow behind a cylinder at Re = 50, for which it works reasonably well. As expected, we find that the local analysis becomes less accurate when the flow becomes less parallel.This is the preprint version of the manuscript as submitted to the journal. The final version will be published by Elsevier

Inherent bounds on forecast accuracy due to observation uncertainty caused by temporal sampling

© Copyright 2015 American Meteorological Society (AMS).Author Affiliations: MARION P. MITTERMAIER (Numerical Modelling, Weather Science, Met Office, Exeter, United Kingdom). DAVID B. STEPHENSON (Exeter Climate Systems, Department of Mathematics and Computer Science, Exeter University, Exeter, United Kingdom)Synoptic observations are often treated as error-free representations of the true state of the real world. For example, when observations are used to verify numerical weather prediction (NWP) forecasts, forecast-observation differences (the total error) are often entirely attributed to forecast inaccuracy. Such simplification is no longer justifiable for short-lead forecasts made with increasingly accurate higher-resolution models. For example, at least 25% of t + 6 h individual Met Office site-specific (postprocessed) temperature forecasts now typically have total errors of less than 0.2 K, which are comparable to typical instrument measurement errors of around 0.1 K. In addition to instrument errors, uncertainty is introduced by measurements not being taken concurrently with the forecasts. For example, synoptic temperature observations in the United Kingdom are typically taken 10 min before the hour, whereas forecasts are generally extracted as instantaneous values on the hour. This study develops a simple yet robust statistical modeling procedure for assessing how serially correlated subhourly variations limit the forecast accuracy that can be achieved. The methodology is demonstrated by application to synoptic temperature observations sampled every minute at several locations around the United Kingdom. Results show that subhourly variations lead to sizeable forecast errors of 0.16-0.44 K for observations taken 10 min before the forecast issue time. The magnitude of this error depends on spatial location and the annual cycle, with the greater errors occurring in the warmer seasons and at inland sites. This important source of uncertainty consists of a bias due to the diurnal cycle, plus irreducible uncertainty due to unpredictable subhourly variations that fundamentally limit forecast accuracy.NCAR-DT

Design of a five-axis ultra-precision micro-milling machine—UltraMill. Part 2: Integrated dynamic modelling, design optimisation and analysis

Using computer models to predict the dynamic performance of ultra-precision machine tools can help manufacturers to substantially reduce the lead time and cost of developing new machines. However, the use of electronic drives on such machines is becoming widespread, the machine dynamic performance depending not only on the mechanical structure and components but also on the control system and electronic drives. Bench-top ultra-precision machine tools are highly desirable for the micro-manufacturing of high-accuracy micro-mechanical components. However, the development is still at the nascent stage and hence lacks standardised guidelines. Part 2 of this two-part paper proposes an integrated approach, which permits analysis and optimisation of the entire machine dynamic performance at the early design stage. Based on the proposed approach, the modelling and simulation process of a novel five-axis bench-top ultra-precision micro-milling machine tool—UltraMill—is presented. The modelling and simulation cover the dynamics of the machine structure, the moving components, the control system and the machining process and are used to predict the entire machine performance of two typical configurations

Automated tractography in patients with temporal lobe epilepsy using TRActs Constrained by UnderLying Anatomy (TRACULA)

Purpose A detailed understanding of white matter tract alterations in patients with temporal lobe epilepsy (TLE) is important as it may provide useful information for likely side of seizure onset, cognitive impairment and postoperative prognosis. However, most diffusion-tensor imaging (DTI) studies have relied on manual reconstruction of tract bundles, despite the recent development of automated techniques. In the present study, we used an automated white matter tractography analysis approach to quantify temporal lobe white matter tract alterations in TLE and determine the relationships between tract alterations, the extent of hippocampal atrophy and the chronicity and severity of the disorder. Methods We acquired preoperative T1-weighted and DTI data in 64 patients with well-characterized TLE, with imaging and histopathological evidence of hippocampal sclerosis. Identical acquisitions were collected for 44 age- and sex-matched healthy controls. We employed automatic probabilistic tractography DTI analysis using TRActs Constrained by UnderLying Anatomy (TRACULA) available in context of Freesurfer software for the reconstruction of major temporal lobe tract bundles. We determined the factors influencing probabilistic tract reconstruction and investigated alterations of DTI scalar metrics along white matter tracts with respect to hippocampal volume, which was automatically estimated using Freesurfer's morphometric pipelines. We also explored the relationships between white matter tract alterations and duration of epilepsy, age of onset of epilepsy and seizure burden (defined as a function of seizure frequency and duration of epilepsy). Results Whole-tract diffusion characteristics of patients with TLE differed according to side of epilepsy and were significantly different between patients and controls. Waypoint comparisons along each tract revealed that patients had significantly altered tissue characteristics of the ipsilateral inferior-longitudinal, uncinate fasciculus, superior longitudinal fasciculus and cingulum relative to controls. Changes were more widespread (ipsilaterally and contralaterally) in patients with left TLE while patients with right TLE showed changes that remained spatially confined in ipsilateral tract regions. We found no relationship between DTI alterations and volume of the epileptogenic hippocampus. DTI alterations of anterior ipsilateral uncinate and inferior-longitudinal fasciculus correlated with duration of epilepsy (over and above effects of age) and age at onset of epilepsy. Seizure burden correlated with tissue characteristics of the uncinate fasciculus. Conclusion This study shows that TRACULA permits the detection of alterations of DTI tract scalar metrics in patients with TLE. It also provides the opportunity to explore relationships with structural volume measurements and clinical variables along white matter tracts. Our data suggests that the anterior temporal lobe portions of the uncinate and inferior-longitudinal fasciculus may be particularly vulnerable to pathological alterations in patients with TLE. These alterations are unrelated to the extent of hippocampal atrophy (and therefore potentially mediated by independent mechanisms) but influenced by chronicity and severity of the disorder

In vivo precision of the GE Lunar iDXA for the measurement of visceral adipose tissue in adults: the influence of body mass index.

CoreScan is a new software for the GE Lunar iDXA, which provides a quantification of visceral adipose tissue (VAT). The objective of this study was to determine the in vivo precision of CoreScan for the measurement of VAT mass in a heterogeneous group of adults. Forty-five adults (aged 34.6 (8.6) years), ranging widely in body mass index (BMI 26.0 (5.2)  kg/m(2); 16.7-42.4 kg/m(2)), received two consecutive total body scans with repositioning. The sample was divided into two subgroups based on BMI, normal-weight and overweight/obese, for precision analyses. Subgroup analyses revealed that precision errors (RMSSD:%CV; root mean square standard deviation:% coefficient of variation) for VAT mass were 20.9 g:17.0% in the normal-weight group and 43.7 g:5.4% in overweight/obese groups. Our findings indicate that precision for DXA-VAT mass measurements increases with BMI, but caution should be used with %CV-derived precision error in normal BMI subjects.European Journal of Clinical Nutrition advance online publication, 15 October 2014; doi:10.1038/ejcn.2014.213