Resistance to carbapenems in non-typhoidal Salmonella enterica serovars from humans, animals and food

Non-typhoidal serovars of Salmonella enterica (NTS) are a leading cause of food-borne disease in animals and humans worldwide. Like other zoonotic bacteria, NTS have the potential to act as reservoirs and vehicles for the transmission of antimicrobial drug resistance in different settings. Of particular concern is the resistance to critical “last resort” antimicrobials, such as carbapenems. In contrast to other Enterobacteriaceae (e.g., Klebsiella pneumoniae, Escherichia coli, and Enterobacter, which are major nosocomial pathogens affecting debilitated and immunocompromised patients), carbapenem resistance is still very rare in NTS. Nevertheless, it has already been detected in isolates recovered from humans, companion animals, livestock, wild animals, and food. Five carbapenemases with major clinical importance—namely KPC (Klebsiella pneumoniae carbapenemase) (class A), IMP (imipenemase), NDM (New Delhi metallo-β-lactamase), VIM (Verona integron-encoded metallo-β-lactamase) (class B), and OXA-48 (oxacillinase, class D)—have been reported in NTS. Carbapenem resistance due to the production of extended spectrum- or AmpC β-lactamases combined with porin loss has also been detected in NTS. Horizontal gene transfer of carbapenemase-encoding genes (which are frequently located on self-transferable plasmids), together with co- and cross-selective adaptations, could have been involved in the development of carbapenem resistance by NTS. Once acquired by a zoonotic bacterium, resistance can be transmitted from humans to animals and from animals to humans through the food chain. Continuous surveillance of resistance to these “last resort” antibiotics is required to establish possible links between reservoirs and to limit the bidirectional transfer of the encoding genes between S. enterica and other commensal or pathogenic bacteria

Effects of H2O, CO2, and N2 Air Contaminants on Critical Airside Strain Rates for Extinction of Hydrogen-Air Counterflow Diffusion Flames

Coaxial tubular opposed jet burners (OJB) were used to form dish shaped counterflow diffusion flames (CFDF), centered by opposing laminar jets of H2, N2 and both clean and contaminated air (O2/N2 mixtures) in an argon bath at 1 atm. Jet velocities for flame extinction and restoration limits are shown versus wide ranges of contaminant and O2 concentrations in the air jet, and also input H2 concentration. Blowoff, a sudden breaking of CFDF to a stable ring shape, occurs in highly stretched stagnation flows and is generally believed to measure kinetically limited flame reactivity. Restore, a sudden restoration of central flame, is a relatively new phenomenon which exhibits a H2 dependent hysteresis from Blowoff. For 25 percent O2 air mixtures, mole for mole replacement of 25 percent N2 contaminant by steam increased U(air) or flame strength at Blowoff by about 5 percent. This result is consistent with laminar burning velocity results from analogous substitution of steam for N2 in a premixed stoichiometric H2-O2-N2 (or steam) flame, shown by Koroll and Mulpuru to promote a 10 percent increase in experimental and calculated laminar burning velocity, due to enhanced third body efficiency of water in: H + O2 + M yields HO2 + M. When the OJB results were compared with Liu and MacFarlane's experimental laminar burning velocity of premixed stoichiometric H2 + air + steam, a crossover occurred, i.e., steam enhanced OJB flame strength at extinction relative to laminar burning velocity

Nuclear shape dependence of Gamow-Teller distributions in neutron-deficient Pb isotopes

We study Gamow-Teller strength distributions in the neutron-deficient even isotopes (184-194)Pb in a search for signatures of deformation. The microscopic formalism used is based on a deformed quasiparticle random phase approximation (QRPA) approach, which involves a self-consistent quasiparticle deformed Skyrme Hartree-Fock (HF) basis and residual spin-isospin forces in both the particle-hole and particle-particle channels. By analyzing the sensitivity of the Gamow-Teller strength distributions to the various ingredients in the formalism, we conclude that the beta-decay of these isotopes could be a useful tool to look for fingerprints of nuclear deformation.Comment: 20 pages, 11 figures. To be published in Physical Review

Teoría oralista y análisis oral

Sin resume

Narrador y estilo directo en Homero y los Himnos Homéricos: a propósito de un dato cuantitativo.

Este estudio analiza, en términos cuantitativos, el papel asignado a la voz del narrador y al estilo directo en los Himnos Homéricos; se establece una comparación con la situación en el caso de los poemas homéricos canónicos (Ilíada y Odisea). Las diferencias que el autor descubre en este punto entre Homero y los Himnos deben explicarse probablemente como diferencias de género literario

Multiresistant Salmonella enterica serovar 4,[5],12:i:- in Europe: a new pandemic strain?

A marked increase in the prevalence of S. enterica serovar 4,[5],12:i:- with resistance to ampicillin, streptomycin, sulphonamides and tetracyclines (R-type ASSuT) has been noted in food-borne infections and in pigs/pig meat in several European countries in the last ten years. One hundred and sixteen strains of S. enterica serovar 4,[5],12:i:- from humans, pigs and pig meat isolated in England and Wales, France, Germany, Italy, Poland, Spain and the Netherlands were further subtyped by phage typing, pulsed-field gel electrophoresis and multilocus variable number tandem repeat analysis to investigate the genetic relationship among strains. PCR was performed to identify the fljB flagellar gene and the genes encoding resistance to ampicillin, streptomycin, sulphonamides and tetracyclines. Class 1 and 2 integrase genes were also sought. Results indicate that genetically related serovar 4,[5],12:i:- strains of definitive phage types DT193 and DT120 with ampicillin, streptomycin, sulphonamide and tetracycline resistance encoded by blaTEM, strA-strB, sul2 and tet(B) have emerged in several European countries, with pigs the likely reservoir of infection. Control measures are urgently needed to reduce spread of infection to humans via the food chain and thereby prevent the possible pandemic spread of serovar 4,[5],12:i:- of R-type ASSuT as occurred with S. Typhimurium DT104 during the 1990s

Griffiths Inequalities for Ising Spin Glasses on the Nishimori Line

The Griffiths inequalities for Ising spin glasses are proved on the Nishimori line with various bond randomness which includes Gaussian and $\pm J$ bond randomness. The proof for Ising systems with Gaussian bond randomness has already been carried out by Morita et al, which uses not only the gauge theory but also the properties of the Gaussian distribution, so that it cannot be directly applied to the systems with other bond randomness. The present proof essentially uses only the gauge theory, so that it does not depend on the detail properties of the probability distribution of random interactions. Thus, the results obtained from the inequalities for Ising systems with Gaussian bond randomness do also hold for those with various bond randomness, especially with $\pm J$ bond randomness.Comment: 13pages. Submitted to J. Phys. Soc. Jp