239 research outputs found

    Guns and butter? Military expenditure and health spending on the eve of the Arab Spring

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    We examine the validity of the guns-versus-butter hypothesis in the pre-Arab Spring era. Using panel data from 1995 to 2011–the eve of the Arab uprisings–we find no evidence that increased security needs as measured by the number of domestic terrorist attacks are complemented by increased military spending or more importantly ‘crowd out’ government expenditure on key public goods such as health care. This suggests that both expenditure decisions were determined by other considerations at the government level

    Hear my voice: a community-based participatory study gathering the lived experiences of people with disabilities and older people in Tanzania

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    This is the final version of the article. Available from the publisher via the URL in this record.This study provides evidence on the specific nature and experiences of people with disabilities and older people from their own perspectives in rural and urban settings in Tanzania. Its aim was to better inform efforts to provide services for and improve the lives of people living in those regions. A community-based participatory approach was used, involving collaboration with the community. Peer researchers and research partners collected and analysed interviews with people with disabilities and older people, leading to policy and advocacy recommendations and early stage plans. Findings were framed in terms of experiences of participation and inclusion as impacted by physical, social and attitudinal factors, as well presented at individual, interpersonal and societal levels. They demonstrate how lack of access to healthcare and education, social limitations and powerful community attitudes were interwoven and exacerbated poverty in these contexts. Policy recommendations cover issues such as halting persecution and killings of people with albinism, support and guidance for families of children with disabilities, national policy on ageing legislation, and implementing and monitoring the UN Convention on the Rights of Persons with Disabilities

    Differential participation of plant ribosomal proteins from the small ribosomal subunit in protein translation under stress

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    Abstract Upon exposure to biotic and abiotic stress, plants have developed strategies to adapt to the challenges imposed by these unfavorable conditions. The energetically demanding translation process is one of the main elements regulated to reduce energy consumption and to selectively synthesize proteins involved in the establishment of an adequate response. Emerging data have shown that ribosomes remodel to adapt to stresses. In Arabidopsis thaliana, ribosomes consist of approximately eighty-one distinct ribosomal proteins (RPs), each of which is encoded by two to seven genes. Recent research has revealed that a mutation in a given single RP in plants can not only affect the functions of the RP itself but can also influence the properties of the ribosome, which could bring about changes in the translation to varying degrees. However, a pending question is whether some RPs enable ribosomes to preferentially translate specific mRNAs. To reveal the role of ribosomal proteins from the small subunit (RPS) in a specific translation, we developed a novel approach to visualize the effect of RPS silencing on the translation of a reporter mRNA (GFP) combined to the 5’UTR of different housekeeping and defense genes. The silencing of genes encoding for NbRPSaA, NbRPS5A, and NbRPS24A in Nicotiana benthamiana decreased the translation of defense genes. The NbRACK1A-silenced plant showed compromised translations of specific antioxidant enzymes. However, the translations of all tested genes were affected in NbRPS27D-silenced plants. These findings suggest that some RPS may be potentially involved in the control of protein translation

    Patrawidya Vol.17 No.1

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    1. The communist ideas of Economic Development the PKI's intellectual growth during the guided democracy period 1959-1965 2. Talk more, do more': mimbar penerangan magazine and government communication in immediate post-revolutionary Indonesia 3. Politik identitas dan konstruksi kebangsaan masyarakat perbatasan Indonesia-Malaysia di pulau Sebatik, Kalimantan Utara 4. Di Antara klakah-klakah: kemandirian petani garam perempuan desa Jono kecamatan Tawangharjo, Kabupaten Grobogan tahun 2004-2014 5. Peran dan relasi gender masyarakat using dalam lakon barong Kemiren-Banyuwangi 6. Kehidupan anak-anak kefamenanu dalam kajian etnofografi 7. Sinkretisme budaya dalam seni reog di Brijo Lor, Trucuk, Klate

    Ethnic Identity Among Arab Americans: An Examination of Contextual Influences and Psychological Well-Being

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    Existing theories and research have indicated that ethnic identity is crucial for ethnic minority young adults because ethnicity is an important component of their personal identity that is likely to influence various aspects of their development. Given the centrality of this construct, the overarching aim of the present study was to examine ethnic identity and psychological well-being among members of an ethnic group that have long been ignored in the psychological literature: Arab Americans. Specifically, the goals of the study were threefold. The first goal was to examine the association between multiple contextual factors (such as students’ perceptions of their parents’ style of parenting, family ethnic socialization, perceived discrimination, and generational status) and ethnic identity. The second goal was to explore the potential role of ethnic identity to promote psychological adjustment and well-being: self-esteem and depressive symptoms are indices of psychological functioning that were examined in the study. The final goal of the study was to examine whether ethnic identity can serve as a protective factor, mitigating the negative effects of discrimination on psychological well-being. Methods: Participants (N= 323) were recruited through advertisements and flyers placed on bulletin boards across the Wayne State University (WSU) campus and through announcements placed on WSU pipeline and on the Arab American Student Association as well as the Egyptian Student Association Facebook pages. All flyers included the online study website (surveymonkey.com) to allow students to access the survey and complete it. Inclusion criteria for participants were: being between the ages of 18 and 25 years, of Arab or Middle Eastern descent, living in the United States, and registered as a full-time or part-time student at Wayne State University. The survey consisted of a package of 7 batteries: Demographic Questionnaire, Familial Ethnic Socialization Measure (FESM), Parental Authority Questionnaire (PAQ), Perceived Ethnic Discrimination Questionnaire (PEDQ), Multigroup Ethnic Identity Measure (MEIM), Rosenberg Self-Esteem Scale (RSES), and Center for Epidemiologic Studies – Depression Scale (CES-D Scale). Results: Pearson correlation analyses revealed that higher family ethnic socialization, authoritative parenting, authoritarian parenting, and lower generational status were all significantly associated with higher ethnic identity (r= .55, r=.51, r= .16, r=-.19, respectively). Further mediation analyses revealed that the relation between generational status and ethnic identity was fully mediated by family ethnic socialization. With respect to the relation between ethnic identity, perceived discrimination, and psychological well-being, results from the correlational analyses revealed that higher ethnic identity was associated with higher self-esteem (r = .45, p \u3c .01) and lower depressive symptoms (r = -.23, p \u3c .01) whereas perceived discrimination was associated with lower self-esteem (r = -.33, p \u3c .01) and higher depressive symptoms (r = .49, p \u3c .01). Finally, with respect to the potential protective role of ethnic identity, hierarchical multiple regression analyses revealed that ethnic identity moderated the relationship between perceived discrimination and psychological well-being. Specifically, perceived ethnic discrimination was negatively associated with self-esteem among participants with high ethnic identity; however, this relationship was even stronger among participants with low ethnic identity. Similarly, perceived ethnic discrimination was positively associated with depressive symptoms among participants with high ethnic identity; however, this relationship was even stronger among participants with low ethnic identity. Discussion: Our findings suggest that ethnic discrimination takes a toll on Arab American young adults, but, for this population, having a salient ethnic identity may have profound mental health benefits as ethnic identity may serve as valuable resource to help them deal with negative discriminatory experiences

    Patrawidya: seri penerbitan penelitian sejarah dan budaya

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    Berisikan beberapa artikel yaitu: 1.The Communist Ideas of Economic Development the PKI’s Intellectual Growth During the Guided Democracy Period 1959-1965 oleh Farabi Fakih (hlm. 1-22). 2.’Talk More, Do More’: Mimbar Penerangan Magazine and Government Communication in Immediate Post-Revolutionary Indonesia oleh Muhammad Yuanda Zara (hlm.23-43). 3.Politik Identitas dan Konstruksi Kebangsaan Masyarakat Perbatasan Indonesia-Malaysia di Pulau Sebatik, Kalimantan Utara oleh Lina Puryanti dan Sarkawi B. Husain (hlm. 45-61). 4.Di Antara Klakah-klakah: Kemandirian Petani Garam Perempuan Desa Jono, Kecamatan Tawangharjo, Kabupaten Grobogan Tahun 2004-2014 oleh Lucia Juningsih (hlm. 63-80). 5.Peran dan Relasi Gender Masyarakat Using dalam Lakon Barong Kemiren-Banyuwangi oleh Wiwin Indiarti, dan Abdul Muni(hlm. 81-103). 6.Kehidupan Anak-anak Kefamenanu dalam Kajian Etnofografi oleh Prayanto Widyo Harsanto (hlm. 105-118. 7.Sinkretisme Budaya dalam Seni Reog di Brijo Lor, Trucuk, Klaten oleh Sutiyono (hlm. 119-138)

    Modelling the impact of interventions on imported, introduced and indigenous malaria infections in Zanzibar, Tanzania

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    Malaria cases can be classified as imported, introduced or indigenous cases. The World Health Organization's definition of malaria elimination requires an area to demonstrate that no new indigenous cases have occurred in the last three years. Here, we present a stochastic metapopulation model of malaria transmission that distinguishes between imported, introduced and indigenous cases, and can be used to test the impact of new interventions in a setting with low transmission and ongoing case importation. We use human movement and malaria prevalence data from Zanzibar, Tanzania, to parameterise the model. We test increasing the coverage of interventions such as reactive case detection; implementing new interventions including reactive drug administration and treatment of infected travellers; and consider the potential impact of a reduction in transmission on Zanzibar and mainland Tanzania. We find that the majority of new cases on both major islands of Zanzibar are indigenous cases, despite high case importation rates. Combinations of interventions that increase the number of infections treated through reactive case detection or reactive drug administration can lead to substantial decreases in malaria incidence, but for elimination within the next 40 years, transmission reduction in both Zanzibar and mainland Tanzania is necessary

    The impact of reactive case detection on malaria transmission in Zanzibar in the presence of human mobility

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    Malaria persists at low levels on Zanzibar despite the use of vector control and case management. We use a metapopulation model to investigate the role of human mobility in malaria persistence on Zanzibar, and the impact of reactive case detection. The model was parameterized using survey data on malaria prevalence, reactive case detection, and travel history. We find that in the absence of imported cases from mainland Tanzania, malaria would likely cease to persist on Zanzibar. We also investigate potential intervention scenarios that may lead to elimination, especially through changes to reactive case detection. While we find that some additional cases are removed by reactive case detection, a large proportion of cases are missed due to many infections having a low parasite density that go undetected by rapid diagnostic tests, a low rate of those infected with malaria seeking treatment, and a low rate of follow up at the household level of malaria cases detected at health facilities. While improvements in reactive case detection would lead to a reduction in malaria prevalence, none of the intervention scenarios tested here were sufficient to reach elimination. Imported cases need to be treated to have a substantial impact on prevalence

    Safety of selective internal radiation therapy (SIRT) with yttrium-90 microspheres combined with systemic anticancer agents: expert consensus

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    Selective internal radiation therapy (SIRT) with microspheres labelled with the β-emitter yttrium-90 (Y-90) enables targeted delivery of radiation to hepatic tumors. SIRT is primarily used to treat inoperable primary or metastatic liver tumors. Eligible patients have usually been exposed to a variety of systemic anticancer therapies, including cytotoxic agents, targeted biologics, immunotherapy and peptide receptor radionuclide therapy (PRRT). All these treatments have potential interactions with SIRT; however, robust evidence on the safety of these potential combinations is lacking. This paper provides current clinical experiences and expert consensus guidelines for the use of SIRT in combination with the anticancer treatment agents likely to be encountered in clinical practice. It was agreed by the expert panel that precautions need to be taken with certain drugs, but that, in general, systemic therapies do not necessarily have to be stopped to perform SIRT. The authors recommend stopping vascular endothelial growth factor inhibitors 4-6 weeks before SIRT, and restart after the patient has recovered from the procedure. It may also be prudent to stop potent radiosensitizers such as gemcitabine therapy 4 weeks before SIRT, and restart treatment at least 2‒4 weeks later. Data from phase III studies combining SIRT with fluorouracil (5FU) or folinic acid/5FU/oxaliplatin (FOLFOX) suggest that hematological toxicity is more common from the combination than it is from chemotherapy without SIRT. There is no evidence to suggest that chemotherapy increases SIRT-specific gastro-intestinal or liver toxicities
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