Associations of the lipidome with ageing, cognitive decline and exercise behaviours

One of the most recognisable features of ageing is a decline in brain health and cognitive dysfunction, which is associated with perturbations to regular lipid homeostasis. Although ageing is the largest risk factor for several neurodegenerative diseases such as dementia, a loss in cognitive function is commonly observed in adults over the age of 65. Despite the prevalence of normal age-related cognitive decline, there is a lack of effective methods to improve the health of the ageing brain. In light of this, exercise has shown promise for positively influencing neurocognitive health and associated lipid profiles. This review summarises age-related changes in several lipid classes that are found in the brain, including fatty acyls, glycerolipids, phospholipids, sphingolipids and sterols, and explores the consequences of age-associated pathological cognitive decline on these lipid classes. Evidence of the positive effects of exercise on the affected lipid profiles are also discussed to highlight the potential for exercise to be used therapeutically to mitigate age-related changes to lipid metabolism and prevent cognitive decline in later life

A model integrating longshore and cross-shore processes for predicting long-term shoreline responses to climate change

We present a shoreline change model for coastal hazard assessment and management planning. The model, CoSMoS-COAST (Coastal One-line Assimilated Simulation Tool), is a transect-based, one-line model that predicts short-term and long-term shoreline response to climate change in the 21st century. The proposed model represents a novel, modular synthesis of process-based models of coastline evolution due to longshore and cross-shore transport by waves and sea level rise. Additionally, the model uses an extended Kalman filter for data assimilation of historical shoreline positions to improve estimates of model parameters and thereby improve confidence in long-term predictions. We apply CoSMoS-COAST to simulate sandy shoreline evolution along 500 km of coastline in Southern California, which hosts complex mixtures of beach settings variably backed by dunes, bluffs, cliffs, estuaries, river mouths, and urban infrastructure, providing applicability of the model to virtually any coastal setting. Aided by data assimilation, the model is able to reproduce the observed signal of seasonal shoreline change for the hindcast period of 1995–2010, showing excellent agreement between modeled and observed beach states. The skill of the model during the hindcast period improves confidence in the model’s predictive capability when applied to the forecast period (2010–2100) driven by GCM-projected wave and sea level conditions. Predictions of shoreline change with limited human intervention indicate that 31% to 67% of Southern California beaches may become completely eroded by 2100 under sea level rise scenarios of 0.93 to 2.0 m

The Resolved Asteroid Program - Size, shape, and pole of (52) Europa

With the adaptive optics (AO) system on the 10 m Keck-II telescope, we acquired a high quality set of 84 images at 14 epochs of asteroid (52) Europa on 2005 January 20. The epochs covered its rotation period and, by following its changing shape and orientation on the plane of sky, we obtained its triaxial ellipsoid dimensions and spin pole location. An independent determination from images at three epochs obtained in 2007 is in good agreement with these results. By combining these two data sets, along with a single epoch data set obtained in 2003, we have derived a global fit for (52) Europa of diameters (379x330x249) +/- (16x8x10) km, yielding a volume-equivalent spherical-diameter of 315 +/- 7 km, and a rotational pole within 7 deg of [RA; Dec] = [257,+12] in an Equatorial J2000 reference frame (ECJ2000: 255,+35). Using the average of all mass determinations available forEuropa, we derive a density of 1.5 +/- 0.4, typical of C-type asteroids. Comparing our images with the shape model of Michalowski et al. (A&A 416, 2004), derived from optical lightcurves, illustrates excellent agreement, although several edge features visible in the images are not rendered by the model. We therefore derived a complete 3-D description of Europa's shape using the KOALA algorithm by combining our imaging epochs with 4 stellar occultations and 49 lightcurves. We use this 3-D shape model to assess these departures from ellipsoidal shape. Flat facets (possible giant craters) appear to be less distinct on (52) Europa than on other C-types that have been imaged in detail. We show that fewer giant craters, or smaller craters, is consistent with its expected impact history. Overall, asteroid (52) Europa is still well modeled as a smooth triaxial ellipsoid with dimensions constrained by observations obtained over several apparitions.Comment: Accepted for publication in Icaru

A Flourishing Brain in the 21st Century: A Scoping Review of the Impact of Developing Good Habits for Mind, Brain, Well-Being, and Learning

Emerging scientific knowledge such as the role of epigenetics and neuroplasticity—the brain\u27s capability to constantly rewire with every action, experience, and thought—is fundamentally changing our understanding of the potential impact we can have on our brain. Our brain is formed by our habits in interaction with our body, the environment, influenced by our lifestyle, successes, failures, and traumas. Neuroplasticity proves that every student\u27s brain is a work in progress, and it is never too late to take better care of one\u27s cognitive fitness. This review presents a repertoire of good habits (GHs). Combined, we suggest that these GHs provide conditions for optimal brain health, by acting as a “Mental Vaccine” which enhances the brain\u27s resilience to brain health-degrading challenges. We argue that schools have a crucial role to play in empowering students to increase their own stress resilience, well-being, and learning by developing their own GHs profile

Reconciling social norms with personal interests: indigenous styles of identity formation among Pakistani youth

Research on identity formation has been conducted mostly in Western contexts. We extend and complement such research by exploring qualitatively the strategies and styles of identity formation employed by emerging adults in Pakistan. Whereas Western theories of identity formation often provide a negative view of normative orientation as “blind obedience” without exploring alternatives, our thematic analysis of semi-structured interviews with 12 Pakistani emerging adults suggests a much more complex interplay between personal interests and normative influences on identity formation. Participants described various ways of reconciling normative expectations (parental, religious, and cultural) with their personal interests, preferences, and explorations, when deciding about their careers, relationships, and values. In Pakistani culture, normative influences seem to play a more positive and flexible role in identity formation than is suggested by previous Western research

Global-scale changes to extreme ocean wave events due to anthropogenic warming

Extreme surface ocean waves are often primary drivers of coastal flooding and erosion over various time scales. Hence, understanding future changes in extreme wave events owing to global warming is of socio-economic and environmental significance. However, our current knowledge of potential changes in high-frequency (defined here as having return periods of less than 1 year) extreme wave events are largely unknown, despite being strongly linked to coastal hazards across time scales relevant to coastal management. Here, we present global climate-modeling evidence, based on the most comprehensive multi-method, multi-model wave ensemble, of projected changes in a core set of extreme wave indices describing high-frequency, extra-tropical storm-driven waves. We find changes in high-frequency extreme wave events of up to ∼50%-100% under RCP8.5 high-emission scenario; which is nearly double the expected changes for RCP4.5 scenario, when globally integrated. The projected changes exhibit strong inter-hemispheric asymmetry, with strong increases in extreme wave activity across the tropics and high latitudes of the Southern Hemisphere region, and a widespread decrease across most of the Northern Hemisphere. We find that the patterns of projected increase across these extreme wave events over the Southern Hemisphere region resemble their historical response to the positive anomaly of the Southern Annular Mode. Our findings highlight that many countries with low-adaptive capacity are likely to face increasing exposure to much more frequent extreme wave events in the future

The changing nature of risk and risk management: the challenge of borders, uncertainty and resilience

No abstract available

Ground-based photometry of space-based transit detections: Photometric follow-up of the CoRoT mission

The motivation, techniques and performance of the ground-based photometric follow-up of transit detections by the CoRoT space mission are presented. Its principal raison d'\^{e}tre arises from the much higher spatial resolution of common ground-based telescopes in comparison to CoRoT's cameras. This allows the identification of many transit candidates as arising from eclipsing binaries that are contaminating CoRoT's lightcurves, even in low-amplitude transit events that cannot be detected with ground-based obervations. For the ground observations, 'on'-'off' photometry is now largely employed, in which only a short timeseries during a transit and a section outside a transit is observed and compared photometrically. CoRoT planet candidates' transits are being observed by a dedicated team with access to telescopes with sizes ranging from 0.2 to 2 m. As an example, the process that led to the rejection of contaminating eclipsing binaries near the host star of the Super-Earth planet CoRoT-7b is shown. Experiences and techniques from this work may also be useful for other transit-detection experiments, when the discovery instrument obtains data with a relatively low angular resolution.Comment: Accepted for the A&A special issue on CoRo

Direct reaction measurements with a 132Sn radioactive ion beam

The (d,p) neutron transfer and (d,d) elastic scattering reactions were measured in inverse kinematics using a radioactive ion beam of 132Sn at 630 MeV. The elastic scattering data were taken in a region where Rutherford scattering dominated the reaction, and nuclear effects account for less than 8% of the cross section. The magnitude of the nuclear effects was found to be independent of the optical potential used, allowing the transfer data to be normalized in a reliable manner. The neutron-transfer reaction populated a previously unmeasured state at 1363 keV, which is most likely the single-particle 3p1/2 state expected above the N=82 shell closure. The data were analyzed using finite range adiabatic wave calculations and the results compared with the previous analysis using the distorted wave Born approximation. Angular distributions for the ground and first excited states are consistent with the previous tentative spin and parity assignments. Spectroscopic factors extracted from the differential cross sections are similar to those found for the one neutron states beyond the benchmark doubly-magic nucleus 208Pb.Comment: 22 pages, 7 figure