Comments on "Limits on Dark Matter Using Ancient Mica"

To appear in Phys. Rev. Lett. together with the author's Reply.Comment: Compressed PostScript (filename.ps.Z), 3 pages, no figure

Efficacy of live attenuated seasonal and pandemic influenza vaccine in school-age children: a randomized controlled trial

Poster Presentation: SPA5 - How to Evaluate Vaccine Effectiveness and Efficacy?: abstract no. A508PBACKGROUND: A novel pandemic influenza A(H1N1) virus emerged in North America in early 2009 and rapidly spread worldwide. Monovalent pH1N1 vaccines were licensed later in 2009 based on preliminary studies demonstrating their immunogenicity and safety. In this study we report the efficacy of live attenuated monovalent pH1N1 vacc...postprin

Optimizing OCT acquisition parameters for assessments of vitreous haze for application in uveitis

Detection and evaluation of inflammatory activity in uveitis is essential to the management of the condition, and yet continues to be largely dependent on subjective clinical measures. Optical coherence tomography (OCT) measurement of vitreous activity is an alternative to clinical vitreous haze scoring and has passed a number of early validation studies. In this study we aimed to evaluate the impact of ‘operator factors’ on the variability of the technique as part of the validation process, and to help evaluate its suitability for ‘real world’ use. Vitreous haze index was calculated as a ratio between the reflectivity of the vitreous and of the outer retina in each scan. Different scanning conditions were tested and their effect on the measurement is reported. Our results show that the ‘quantitative imaging’ technique of OCT-measured vitreous activity had good reliability in normal subjects under a range of ‘real world’ conditions, such as when the operator changes the averaging value. The technique was however vulnerable to highly inaccurate focussing or abnormal downward displacement of the image. OCT-based quantification of vitreous activity is a promising alternative to current subjective clinical estimates, with sufficient ‘tolerance’ to be used in routine clinical practice as well as clinical trials

The clinical features of the piriformis syndrome: a systematic review

Piriformis syndrome, sciatica caused by compression of the sciatic nerve by the piriformis muscle, has been described for over 70 years; yet, it remains controversial. The literature consists mainly of case series and narrative reviews. The objectives of the study were: first, to make the best use of existing evidence to estimate the frequencies of clinical features in patients reported to have PS; second, to identify future research questions. A systematic review was conducted of any study type that reported extractable data relevant to diagnosis. The search included all studies up to 1 March 2008 in four databases: AMED, CINAHL, Embase and Medline. Screening, data extraction and analysis were all performed independently by two reviewers. A total of 55 studies were included: 51 individual and 3 aggregated data studies, and 1 combined study. The most common features found were: buttock pain, external tenderness over the greater sciatic notch, aggravation of the pain through sitting and augmentation of the pain with manoeuvres that increase piriformis muscle tension. Future research could start with comparing the frequencies of these features in sciatica patients with and without disc herniation or spinal stenosis

A bovine lymphosarcoma cell line infected with theileria annulata exhibits an irreversible reconfiguration of host cell gene expression

Theileria annulata, an intracellular parasite of bovine lymphoid cells, induces substantial phenotypic alterations to its host cell including continuous proliferation, cytoskeletal changes and resistance to apoptosis. While parasite induced modulation of host cell signal transduction pathways and NFκB activation are established, there remains considerable speculation on the complexities of the parasite directed control mechanisms that govern these radical changes to the host cell. Our objectives in this study were to provide a comprehensive analysis of the global changes to host cell gene expression with emphasis on those that result from direct intervention by the parasite. By using comparative microarray analysis of an uninfected bovine cell line and its Theileria infected counterpart, in conjunction with use of the specific parasitacidal agent, buparvaquone, we have identified a large number of host cell gene expression changes that result from parasite infection. Our results indicate that the viable parasite can irreversibly modify the transformed phenotype of a bovine cell line. Fifty percent of genes with altered expression failed to show a reversible response to parasite death, a possible contributing factor to initiation of host cell apoptosis. The genes that did show an early predicted response to loss of parasite viability highlighted a sub-group of genes that are likely to be under direct control by parasite infection. Network and pathway analysis demonstrated that this sub-group is significantly enriched for genes involved in regulation of chromatin modification and gene expression. The results provide evidence that the Theileria parasite has the regulatory capacity to generate widespread change to host cell gene expression in a complex and largely irreversible manner

Investigation of the Carbon Monoxide Gas Sensing Characteristics of Tin Oxide Mixed Cerium Oxide Thin Films

Thin films of tin oxide mixed cerium oxide were grown on unheated substrates by physical vapor deposition. The films were annealed in air at 500 °C for two hours, and were characterized using X-ray photoelectron spectroscopy, atomic force microscopy and optical spectrophotometry. X-ray photoelectron spectroscopy and atomic force microscopy results reveal that the films were highly porous and porosity of our films was found to be in the range of 11.6–21.7%. The films were investigated for the detection of carbon monoxide, and were found to be highly sensitive. We found that 430 °C was the optimum operating temperature for sensing CO gas at concentrations as low as 5 ppm. Our sensors exhibited fast response and recovery times of 26 s and 30 s, respectively

Factors affecting the prevalence of ticks in cattle and acaricidal activity of Nicotiana tabacum extracts

ΔΕΝ ΔΙΑΤΙΘΕΤΑΙ ΠΕΡΙΛΗΨΗThe present study was designed to determine factors affecting the prevalence of ticks (Hyalomma and Rhipicephalus) in cattle in district Loralai of Balochistan and to evaluate the acaricidal activity of chloroform and methanol extracts of tobacco (Nicotiana tabacum). A total of 670 cattle of different breeds, age and gender were examined for tick infestation with overall prevalence of 21.49% in Loralai. Friesian was more infected (26.15%) as compare to non-descriptive (22%) and Sahiwal (12.80%) breeds. Similarly, cattle less than one year old were most infected (27.90%) followed by those between 1-2 year (26.88%); the least prevalence was in cattle more than 2 years of age (19.34%). Higher prevalence was noticed in female cattle (21.98%) as compare to male cattle (16.92%). Three concentrations of (Nicotiana tabacum) (12.5mg/mL, 25mg/mL and 50mg/mL) were prepared in chloroform and methanol. The acaricidal activity of these extracts was determined by egg laying index and percentage inhibition of egg laying. The decline in egg laying index was significantly more by chloroform extract (10.048%, 17.378% and 25.143%) as compare to methanol extract (6.367%, 13.152% and 20.827%). Hatchability of eggs in chloroform extract was less than that in methanol extract (67.5%, 43.5% 17% and 77.5%, 47.5% and 23%) respectively. We concluded that the prevalence of ticks in cattle is affected by their age, breed and gender and that chloroform extract of Nicotiana tabacum is more acaricidal as compared to the methanol extract

Forage yield of berseem (Trifolium alaxandrium) as affected by phosphorus and potassium fertilization

This research was conducted with the aim to quantify the effect of phosphorus and potassium fertilization on forage yield of berseem (Trifolium alaxandrium). The experiment was carried out at the Research Farm of Khyber Pakhtunkhwa, Agricultural University Peshawar, Pakistan during the cropping season of 2004 to 2005. Randomized complete block design (RCBD) having four replications was used for the experiment. Significant differences were found among the treatments for number of branches per plant, fresh forage yield and dry forage yield. The highest number of branches per plant (9.15), fresh forage yield (6077 kg ha-1) and dry forage yield (156.83 kg ha-1) were recorded in plots with 60 kg P ha-1 x 30 kg K ha-1 treatments, while the lowest values of 6.93, 5430 kg ha-1 and 153.80 kg ha-1 for branches per plant, fresh forage yield and dry forage yield, respectively were recorded in the plots with no fertilizer (control). Emergence (m-2) and plant height of berseem were non-significantly affected by phosphorus and potassium fertilization. So, it was concluded that berseem showed better performance in terms of higher forage yield under 60 kg P ha-1 x 30 kg K ha-1 levels in Peshawar valley.Key words: Phosphorus, potassium, forage yield, berseem