Online identification of Mysida through NeMys

Identification of specimens is a task that every biologist is confronted with. The process of identification in many cases delivers many problems due to unavailability of keys, difficult specialised keys or old keys.Within NeMys (http://intramar.ugent.be/nemys) recently a new identification module has been added. Based upon morphological data derived from published literature, polytomous digital identification keys are made. This kind of keys has the advantage that users are not forced to follow a predefined pathway (as in dichotomous keys), users can choose their best suitable characteristics to work with and the keys can be easily updated with new insights through a fully online key-generation system.By using internet technologies, the identification keys are at any time anywhere available for use. As the data used in the keys is derived from the database system NeMys, it is also possible to check the identification process at any level, with literature sources, images, distribution patterns, … on the website of NeMys.This kind of technology opens new possibilities for biologists to share their taxonomic knowledge with a broader audience without being forced to go through the difficult process of creating dichotomous paper-based keys

Neuroimaging Biomarkers and Cognitive Function in Non-CNS Cancer and Its Treatment: Current Status and Recommendations for Future Research

Cognitive changes in patients undergoing treatment for non-central nervous system (CNS) cancers have been recognized for several decades, yet the underlying mechanisms are not well understood. Structural, functional and molecular neuroimaging has the potential to help clarify the neural bases of these cognitive abnormalities. Structural magnetic resonance imaging (MRI), functional MRI (fMRI), diffusion tensor imaging (DTI), MR spectroscopy (MRS), and positron emission tomography (PET) have all been employed in the study of cognitive effects of cancer treatment, with most studies focusing on breast cancer and changes thought to be induced by chemotherapy. Articles in this special issue of Brain Imaging and Behavior are devoted to neuroimaging studies of cognitive changes in patients with non-CNS cancer and include comprehensive critical reviews and novel research findings. The broad conclusions that can be drawn from past studies and the present body of new research is that there are structural and functional changes associated with cancer and various treatments, particularly systemic cytotoxic chemotherapy, although some cognitive and fMRI studies have identified changes at pre-treatment baseline. Recommendations to accelerate progress include well-powered multicenter neuroimaging studies, a better standardized definition of the cognitive phenotype and extension to other cancers. A systems biology framework incorporating multimodality neuroimaging, genetics and other biomarkers will be highly informative regarding individual differences in risk and protective factors and disease- and treatment-related mechanisms. Studies of interventions targeting cognitive changes are also needed. These next steps are expected to identify novel protective strategies and facilitate a more personalized medicine for cancer patients

Grip Force Reveals the Context Sensitivity of Language-Induced Motor Activity during “Action Words

Studies demonstrating the involvement of motor brain structures in language processing typically focus on \ud time windows beyond the latencies of lexical-semantic access. Consequently, such studies remain inconclusive regarding whether motor brain structures are recruited directly in language processing or through post-linguistic conceptual imagery. In the present study, we introduce a grip-force sensor that allows online measurements of language-induced motor activity during sentence listening. We use this tool to investigate whether language-induced motor activity remains constant or is modulated in negative, as opposed to affirmative, linguistic contexts. Our findings demonstrate that this simple experimental paradigm can be used to study the online crosstalk between language and the motor systems in an ecological and economical manner. Our data further confirm that the motor brain structures that can be called upon during action word processing are not mandatorily involved; the crosstalk is asymmetrically\ud governed by the linguistic context and not vice versa

Effect of Temporary Grasslands of Different Age, Composition and Management on Winter Wheat Yields in a Crop Rotation

Organic nitrogen (N) accumulates in the soil in temporary grasslands. This accumulation is especially important when mineral N fertilisation is high. Legume-based temporary grasslands may also supply the soil with nitrogen through fixation of atmospheric N, for instance in organic farming. When ploughing temporary grassland, great amounts of mineral nitrogen can be released through the process of decomposition and mineralisation of soil organic matter. This mineral nitrogen can be taken up by succeeding crops. The aim of this experiment was to evaluate the effect of temporary grasslands of different ages, N fertilisation levels and legume contents on winter wheat yields in a crop rotation

Assessment of the Nitrogen Nutrition Index (NNI) by the Nitrogen Concentration of the Upper Part of the Sward

The Nitrogen Nutrition Index (NNI) is based on the concept of a critical nitrogen concentration, defined as the minimum N concentration in the aerial biomass necessary to obtain maximum yield. Values of Ncrit are high at the start of the growing period and decline during growth, in relation to dry matter accumulation (t DM/ha) according to the equation of Lemaire & Salette (1984): Ncrit(%) = 4.8(DM)-0.32. The NNI is calculated as the ratio of the actual N concentration of the sward to the N concentration required at a similar biomass to sustain non-limiting growth and biomass accumulation (Lemaire & Gastal, 1997). However, the evaluation of NNI requires the determination of aerial biomass per unit area, in addition to the determination of N concentration. This is time-consuming and is a practical limit to using NNI on farms. The objective of this experiment was to assess NNI by a more practical and easier method based on the determination of the N concentration in the upper leaves, as proposed by Gastal et al. (2001)

Epidermolysa bullosa in Danish Hereford calves is caused by a deletion in LAMC2 gene

BACKGROUND Heritable forms of epidermolysis bullosa (EB) constitute a heterogeneous group of skin disorders of genetic aetiology that are characterised by skin and mucous membrane blistering and ulceration in response to even minor trauma. Here we report the occurrence of EB in three Danish Hereford cattle from one herd. RESULTS Two of the animals were necropsied and showed oral mucosal blistering, skin ulcerations and partly loss of horn on the claws. Lesions were histologically characterized by subepidermal blisters and ulcers. Analysis of the family tree indicated that inbreeding and the transmission of a single recessive mutation from a common ancestor could be causative. We performed whole genome sequencing of one affected calf and searched all coding DNA variants. Thereby, we detected a homozygous 2.4 kb deletion encompassing the first exon of the LAMC2 gene, encoding for laminin gamma 2 protein. This loss of function mutation completely removes the start codon of this gene and is therefore predicted to be completely disruptive. The deletion co-segregates with the EB phenotype in the family and absent in normal cattle of various breeds. Verifying the homozygous private variants present in candidate genes allowed us to quickly identify the causative mutation and contribute to the final diagnosis of junctional EB in Hereford cattle. CONCLUSIONS Our investigation confirms the known role of laminin gamma 2 in EB aetiology and shows the importance of whole genome sequencing in the analysis of rare diseases in livestock

Field Measurements of Terrestrial and Martian Dust Devils

Surface-based measurements of terrestrial and martian dust devils/convective vortices provided from mobile and stationary platforms are discussed. Imaging of terrestrial dust devils has quantified their rotational and vertical wind speeds, translation speeds, dimensions, dust load, and frequency of occurrence. Imaging of martian dust devils has provided translation speeds and constraints on dimensions, but only limited constraints on vertical motion within a vortex. The longer mission durations on Mars afforded by long operating robotic landers and rovers have provided statistical quantification of vortex occurrence (time-of-sol, and recently seasonal) that has until recently not been a primary outcome of more temporally limited terrestrial dust devil measurement campaigns. Terrestrial measurement campaigns have included a more extensive range of measured vortex parameters (pressure, wind, morphology, etc.) than have martian opportunities, with electric field and direct measure of dust abundance not yet obtained on Mars. No martian robotic mission has yet provided contemporaneous high frequency wind and pressure measurements. Comparison of measured terrestrial and martian dust devil characteristics suggests that martian dust devils are larger and possess faster maximum rotational wind speeds, that the absolute magnitude of the pressure deficit within a terrestrial dust devil is an order of magnitude greater than a martian dust devil, and that the time-of-day variation in vortex frequency is similar. Recent terrestrial investigations have demonstrated the presence of diagnostic dust devil signals within seismic and infrasound measurements; an upcoming Mars robotic mission will obtain similar measurement types

Prediction of Red Clover Content in Mixed Swards by Near-Infrared Reflectance Spectroscopy

Because of the legume fixation capacity, their high protein content, digestibility and intake characteristics, more and more attention is paid to grassland clover content. In field experiments, clover content must often be determined, for example to quantify nitrogen flux or the best practices to manage such species (Stilmant et al., 2004). However hand sorting of clover and grass, even if accurate, is time-consuming and has a high labour cost. In comparison, accuracy of visual estimation of clover content, directly in the field, varies according to training and experience. Near-infrared reflectance spectroscopy (NIRS) has been proposed as a method for the rapid determination of sward botanical (Petersen et al., 1987; Pitman et al., 1991) and morphological composition (Leconte et al., 1999; Stilmant et al., 2005). This paper describes the performance of a NIRS calibration developed to characterise red clover (Trifolium pratense) content when associated to different grass species and this at different phenological stages

Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism

Genome-wide association studies (GWASs) have identified 19 susceptibility loci for Alzheimer’s disease (AD). However, understanding how these genes are involved in the pathophysiology of AD is one of the main challenges of the “post-GWAS” era. At least 123 genes are located within the 19 susceptibility loci; hence, a conventional approach (studying the genes one by one) would not be time- and cost-effective. We therefore developed a genome-wide, high-content siRNA screening approach and used it to assess the functional impact of gene under-expression on APP metabolism. We found that 832 genes modulated APP metabolism. Eight of these genes were located within AD susceptibility loci. Only FERMT2 (a β3-integrin co-activator) was also significantly associated with a variation in cerebrospinal fluid Aβ peptide levels in 2886 AD cases. Lastly, we showed that the under-expression of FERMT2 increases Aβ peptide production by raising levels of mature APP at the cell surface and facilitating its recycling. Taken as a whole, our data suggest that FERMT2 modulates the AD risk by regulating APP metabolism and Aβ peptide production

Коррекция двигательных и поведенческих функций в лечении и реабилитации больных шизотипическим расстройством

На основании особенностей невербального поведения больных шизотипическим расстройством разработаны поведенческие методы, применение которых в их комплексной терапии позволяет добиться более полной редукции психопатологической симптоматики.Behavioral methods were worked out basing of the peculiarities of non−verbal behavior of the patients with schizotypical disorders. The use of the methods in complex therapy allows to achieve more complete reduction in psychopathological signs