Design procedures of reinforced concrete framed buildings in Nepal and its impact on seismic safety

The present paper analyses the design procedure and its impact on seismic safety of the structures. For this, a representative reinforced concrete frame building (WDS) is designed and the results are compared with similar buildings detailed with: i) Current Construction Practices (CCP); ii) the Nepal Building Code (NBC) and iii) the Modified Nepal Building Code (NBC+) recommendations. The seismic performance evaluation is done with global strength, inter-storey drift and displacement of the structures. Likewise, the sensitivity of the structural and geometrical parameters of the RC frame building is studied through nonlinear analysis. The study parameters considered for parametric analysis are column size, beam size, inter-storey height, bay length, bay width, and compressive strength of concrete. The results show that the influence on the structural behaviour, particularly by variation in column size and inter-storey height. Additionally, the influence of the seismic zone factor on reinforcement demand of the structure is studied. The result shows that structures designed for high to medium seismic hazard demands double the reinforcement in beams compared to structures in low seismic zone

Hotel customers’ behavioral intentions toward service robots: the role of utilitarian and hedonic values

Purpose: This study aims to investigate the effects of hotel customers’ perceived utilitarian and hedonic values on their intention to use service robots. In addition, the influences of innovativeness, ease of use and compatibility on hotel customers’ perceived utilitarian and hedonic values were examined. Design/methodology/approach: The data of the current study was collected from 11 countries including the USA, UK, Turkey, Spain, Romania, Japan, Israel, India, Greece, Canada and Brazil. A structural equation modeling was used to test the study hypotheses. Findings: The results indicated that hotel customers’ intention to use service robots was positively influenced by their utilitarian and hedonic value perceptions. In addition, customers’ perceptions of robots’ ease of use and compatibility had a positive impact on their perceived utilitarian and hedonic values. Originality/value: The findings of the current study provide unique contributions in the context of hospitality robotics technology adoption literature. In addition, this study provides valuable insights and novel opportunities for hospitality decision-makers to capitalize on, as they strive to strategize the integration of robot-based services into their operations

Knowledge Priorities on Climate Change and Water in the Upper Indus Basin: A Horizon Scanning Exercise to Identify the Top 100 Research Questions in Social and Natural Sciences

River systems originating from the Upper Indus Basin (UIB) are dominated by runoff from snow and glacier melt and summer monsoonal rainfall. These water resources are highly stressed as huge populations of people living in this region depend on them, including for agriculture, domestic use, and energy production. Projections suggest that the UIB region will be affected by considerable (yet poorly quantified) changes to the seasonality and composition of runoff in the future, which are likely to have considerable impacts on these supplies. Given how directly and indirectly communities and ecosystems are dependent on these resources and the growing pressure on them due to ever-increasing demands, the impacts of climate change pose considerable adaptation challenges. The strong linkages between hydroclimate, cryosphere, water resources, and human activities within the UIB suggest that a multi- and inter-disciplinary research approach integrating the social and natural/environmental sciences is critical for successful adaptation to ongoing and future hydrological and climate change. Here we use a horizon scanning technique to identify the Top 100 questions related to the most pressing knowledge gaps and research priorities in social and natural sciences on climate change and water in the UIB. These questions are on the margins of current thinking and investigation and are clustered into 14 themes, covering three overarching topics of ‘governance, policy, and sustainable solutions’, ‘socioeconomic processes and livelihoods’, and ‘integrated Earth System processes’. Raising awareness of these cutting-edge knowledge gaps and opportunities will hopefully encourage researchers, funding bodies, practitioners, and policy makers to address them

Response reduction factor of irregular RC buildings in Kathmandu valley

Most current seismic design includes the nonlinear response of a structure through a response reduction factor (R). This allows the designer to use a linear elastic force-based approach while accounting for nonlinear behavior and deformation limits. In fact, the response reduction factor is used in modern seismic codes to scale down the elastic response of a structure. This study focuses on estimating the actual ‘R’ value for engineered design/construction of reinforced concrete (RC) buildings in Kathmandu valley. The ductility and overstrength of representative RC buildings in Kathmandu are investigated. Nonlinear pushover analysis was performed on structural models in order to evaluate the seismic performance of buildings. Twelve representative engineered irregular buildings with a variety of characteristics located in the Kathmandu valley were selected and studied. Furthermore, the effects of overstrength on the ductility factor, beam column capacity ratio on the building ductility, and load path on the response reduction factor, are examined. Finally, the results are further analyzed and compared with different structural parameters of the buildings

Daratumumab binds to mobilized CD34+ cells of myeloma patients in vitro without cytotoxicity or impaired progenitor cell growth.

BackgroundThe monoclonal antibody daratumumab, approved for treating myeloma, targets CD38, a protein on myeloma and also on CD34+ hematopoietic progenitor cells. Because mobilized CD34+ cells are critical for stem cell transplant, we investigated the in vitro activity of daratumumab on mobilized CD34+ cells from myeloma patients with no prior exposure to daratumumab.MethodsWe determined the number of CD38 molecules per CD34+ cell, and whether daratumumab bound to CD34+ cells, whether C1q bound to daratumumab-coated CD34+ cells and whether daratumumab-related complement-dependent cytotoxicity (CDC) occurred. We also examined CD34+ cell progenitor cell colony capacity in assays with pre-plating incubation of CD34+ cells with daratumumab alone or with daratumumab and the CD59 inhibitory antibody BRIC229, and also assessed CD34+ cell responses to increasing doses of daratumumab in caspase 3/7 activity assays.ResultsAlthough 75% of mobilized CD34+ cells co-express CD38, CD38 was minimally present on CD34+ cells compared to Daudi and KG-1 controls, C1q did not bind to daratumumab-coated CD34+ cells, and CDC did not occur. CD34+ cells incubated in complement-rich human serum with daratumumab alone or with daratumumab and BRIC229, and then plated in progenitor cell assays, produced similar numbers of colonies as controls. In progenitor cell assays with cryopreserved or fresh unselected or CD34-selected cells, daratumumab did not affect progenitor cell capacity, and in caspase 3/7 activity assays CD34+ cells were not affected by increasing doses of daratumumab.ConclusionIn vitro, daratumumab is not toxic to mobilized CD34+ progenitor cells from myeloma patients

First radiative shock experiments on the SG-II laser

We report on the design and first results from experiments looking at the formation of radiative shocks on the Shenguang-II (SG-II) laser at the Shanghai Institute of Optics and Fine Mechanics in China. Laser-heating of a two-layer CH/CH-Br foil drives a $\sim$40 km/s shock inside a gas-cell filled with argon at an initial pressure of 1 bar. The use of gas-cell targets with large (several mm) lateral and axial extent allows the shock to propagate freely without any wall interactions, and permits a large field of view to image single and colliding counter-propagating shocks with time resolved, point-projection X-ray backlighting ($\sim20$ $\mu$m source size, 4.3 keV photon energy). Single shocks were imaged up to 100 ns after the onset of the laser drive allowing to probe the growth of spatial non-uniformities in the shock apex. These results are compared with experiments looking at counter-propagating shocks, showing a symmetric drive which leads to a collision and stagnation from $\sim$40 ns onward. We present a preliminary comparison with numerical simulations with the radiation hydrodynamics code ARWEN, which provides expected plasma parameters for the design of future experiments in this facility

Characterization of Zn X-Ray Laser at PALS Centre, Its Applications in Dense Plasma Probing and Astrophysics

International audienceThis report presents the results from experiments at PALS Centre using a Zn X-ray laser with the pulse length of 0.15 ns and the wavelength of 21.2 nm, working in single or double pass regime with the output energy of 0.4 mJ or 4 mJ per pulse, respectively. The current X-ray laser was experimentally examined to obtain its temporal coherence and spectral width using a path-difference interferometer. The double pass regime shows that QSS plasma based source-amplifier is promising for "short" fs soft X-ray pulses. The X-ray laser is commonly used for user's experiments. Its advantages can be shown in applications such as probing of dense plasmas (up to 2.5 x 10(24) cm(-3)) or single shot experiments (4 x 10(14) photons/pulse). The simple technique based on Talbot effect was used to obtain the gradients of electron densities of line plasmas produced under conditions corresponding to XRL's amplifiers operating in TCE and QSS regime. To investigate radiative shock wave in laboratory is challenging in aspects of the optimization of experimental parameters. Due to the high electron density (10(22) cm(-3)) produced in the gas medium propagated by the shock wave, the velocity of the shock wave, and the absorption losses on optical elements, it is necessary to use the energetic single shot probe