785 research outputs found
Design of Ebb and Flow Automatic Hydroponic System for Chilli Pepper Cultivation
Ebb and flowhydroponic systemgenerally used a timer to controlnutrient addition. The use of the timer, howeverhas major disadvantage including inefficiency of nutrient USAge. This research aimed at designing of ebb andflow automatic hydroponic system which able to turn on/off the pump based on the moisture content usingmicrocontroller.The research was conducted at Greenhouse Facility of the Integrated Field Lab of AgricultureSchool, the University of Lampung from April - June 2014. The procedure begins with the manufacture ofinstrument, calibration, system design tool, the power supply circuit, equipment test and field test. The resultsshowed that has been successfully realized automatic ebb and flow hydroponic system working based on themoisture content. The value of setting point obtained for controling water content for turning on the pump was 69.83%. Cultivation testusingchilli pepper resulted thatautomatic ebband flowhydroponic systemwas significally better thanmanually systemone, interms of plantheight and numberof leaves
Are "EIT Waves" Fast-Mode MHD Waves?
We examine the nature of large-scale, coronal, propagating wave fronts (``EIT
waves'') and find they are incongruous with solutions using fast-mode MHD
plane-wave theory. Specifically, we consider the following properties:
non-dispersive single pulse manifestions, observed velocities below the local
Alfven speed, and different pulses which travel at any number of constant
velocities, rather than at the ``predicted'' fast-mode speed. We discuss the
possibility of a soliton-like explanation for these phenomena, and show how it
is consistent with the above-mentioned aspects.Comment: to be published in the Astrophysical Journa
Bernstein modes in a weakly relativistic electron-positron plasma
The kinetic theory of weakly relativistic electron-positron plasmas, producing dispersion relations for the electrostatic Bernstein modes was addressed. The treatment presented preserves the full momentum dependence of the cyclotron frequency, albeit with a relaxation on the true relativistic form of the distribution function. The implications of this new treatment were confined largely to astrophysical plasmas, where relativistic electronpositron plasmas occur naturally
Ion acoustic waves in a collisional plasma
Damping of ion-acoustic waves by Coulomb collisions of ion and electron combination
Isoscalar dipole coherence at low energies and forbidden E1 strength
In 16O and 40Ca an isoscalar, low-energy dipole transition (IS-LED)
exhausting approximately 4% of the isoscalar dipole (ISD) energy-weighted sum
rule is experimentally known, but conspicuously absent from recent theoretical
investigations of ISD strength. The IS-LED mode coincides with the so-called
isospin-forbidden E1 transition. We report that for N=Z nuclei up to 100Sn the
fully self-consistent Random-Phase-Approximation with finite-range forces,
phenomenological and realistic, yields a collective IS-LED mode, typically
overestimating its excitation energy, but correctly describing its IS strength
and electroexcitation form factor. The presence of E1 strength is solely due to
the Coulomb interaction between the protons and the resulting isospin-symmetry
breaking. The smallness of its value is related to the form of the transition
density, due to translational invariance. The calculated values of E1 and ISD
strength carried by the IS-LED depend on the effective interaction used.
Attention is drawn to the possibility that in N-not-equal-Z nuclei this
distinct mode of IS surface vibration can develop as such or mix strongly with
skin modes and thus influence the pygmy dipole strength as well as the ISD
strength function. In general, theoretical models currently in use may be unfit
to predict its precise position and strength, if at all its existence.Comment: 9 pages, 6 figures, EPJA submitte
Idiopathic epilepsies with seizures precipitated by fever and SCN1A abnormalities.
Epilepsia. 2007 Sep;48(9):1678-85. Epub 2007 Jun 11.
Idiopathic epilepsies with seizures precipitated by fever and SCN1A abnormalities.
Marini C, Mei D, Temudo T, Ferrari AR, Buti D, Dravet C, Dias AI, Moreira A, Calado E, Seri S, Neville B, Narbona J, Reid E, Michelucci R, Sicca F, Cross HJ, Guerrini R.
SourceEpilepsy, Neurophysiology and Neurogenetic Unit, Institute of Child Neurology and Psychiatry, IRCCS Stella Maris Foundation, Calambrone, Pisa, Italy.
Abstract
PURPOSE: SCN1A is the most clinically relevant epilepsy gene, most mutations lead to severe myoclonic epilepsy of infancy (SMEI) and generalized epilepsy with febrile seizures plus (GEFS+). We studied 132 patients with epilepsy syndromes with seizures precipitated by fever, and performed phenotype-genotype correlations with SCN1A alterations.
METHODS: We included patients with SMEI including borderline SMEI (SMEB), GEFS+, febrile seizures (FS), or other seizure types precipitated by fever. We performed a clinical and genetic study focusing on SCN1A, using dHPLC, gene sequencing, and MLPA to detect genomic deletions/duplications on SMEI/SMEB patients.
RESULTS: We classified patients as: SMEI/SMEB = 55; GEFS+= 26; and other phenotypes = 51. SCN1A analysis by dHPLC/sequencing revealed 40 mutations in 37 SMEI/SMEB (67%) and 3 GEFS+ (11.5%) probands. MLPA showed genomic deletions in 2 of 18 SMEI/SMEB. Most mutations were de novo (82%). SMEB patients carrying mutations (8) were more likely to have missense mutations (62.5%), conversely SMEI patients (31) had more truncating, splice site or genomic alterations (64.5%). SMEI/SMEB with truncating, splice site or genomic alterations had a significantly earlier age of onset of FS compared to those with missense mutations and without mutations (p = 0.00007, ANOVA test). None of the remaining patients with seizures precipitated by fever carried SCN1A mutations.
CONCLUSION: We obtained a frequency of 71%SCN1A abnormalities in SMEI/SMEB and of 11.5% in GEFS+ probands. MLPA complements DNA sequencing of SCN1A increasing the mutation detection rate. SMEI/SMEB with truncating, splice site or genomic alterations had a significantly earlier age of onset of FS. This study confirms the high sensitivity of SCN1A for SMEI/SMEB phenotypes
Worker remittances and the global preconditions of ‘smart development’
With the growing environmental crisis affecting our globe, ideas to weigh economic or social progress by the ‘energy input’ necessary to achieve it are increasingly gaining acceptance. This question is intriguing and is being dealt with by a growing number of studies, focusing on the environmental price of human progress. Even more intriguing, however, is the question of which factors of social organization contribute to a responsible use of the resources of our planet to achieve a given social result (‘smart development’). In this essay, we present the first systematic study on how migration – or rather, more concretely, received worker remittances per GDP – helps the nations of our globe to enjoy social and economic progress at a relatively small environmental price. We look at the effects of migration on the balance sheets of societal accounting, based on the ‘ecological price’ of the combined performance of democracy, economic growth, gender equality, human development, research and development, and social cohesion. Feminism in power, economic freedom, population density, the UNDP education index as well as the receipt of worker remittances all significantly contribute towards a ‘smart overall development’, while high military expenditures and a high world economic openness are a bottleneck for ‘smart overall development’
Effectiveness and safety of sofosbuvir‐based regimens plus an NS5A inhibitor for patients with HCV genotype 3 infection and cirrhosis: results of a multicenter real‐life cohort
[Abstract] Patients with HCV genotype 3 (GT3) infection and cirrhosis are currently the most difficult to cure. We report our experience with sofosbuvir+daclatasvir (SOF+DCV) or sofosbuvir/ledipasvir (SOF/LDV), with or without ribavirin (RBV) in clinical practice in this population. This was a multicenter observational study including cirrhotic patients infected by HCV GT3, treated with sofosbuvir plus an NS5A inhibitor (May 2014‐October 2015). In total, 208 patients were included: 98 (47%) treatment‐experienced, 42 (20%) decompensated and 55 (27%) MELD score >10. In 131 (63%), treatment was SOF+DCV and in 77 (37%), SOF/LDV. Overall, 86% received RBV. RBV addition and extension to 24 weeks was higher in the SOF/LDV group (95% vs 80%, P=.002 and 83% vs 72%, P=.044, respectively). A higher percentage of decompensated patients were treated with DCV than LDV (25% vs 12%, P=.013). Overall, SVR12 was 93.8% (195/208): 94% with SOF+DCV and 93.5% with SOF/LDV. SVR12 was achieved in 90.5% of decompensated patients. Eleven treatment failures: 10 relapses and one breakthrough. RBV addition did not improve SVR (RR: 1.08; P=.919). The single factor associated with failure to achieve SVR was platelet count <75×10E9/mL (RR: 3.50, P=.019). In patients with MELD <10, type of NS5A inhibitor did not impact on SVR12 (94% vs 97%; adjusted RR: 0.49). Thirteen patients (6.3%) had serious adverse events, including three deaths (1.4%) and one therapy discontinuation (0.5%), higher in decompensated patients (16.7% vs 3.6%, P<.006). In patients with GT3 infection and cirrhosis, SVR12 rates were high with both SOF+DCV and SOF/LDV, with few serious adverse events
Soft Tissue Substitutes at Immediate Postextractive Implants to Reduce Tissue Shrinkage – 3-year Results From a Randomized Controlled Trial
PURPOSE. The aim of this parallel randomized controlled trial (RCT) was to evaluate whether placement of a soft tissue graft substitute (STGS) could decrease peri-implant tissue shrinkage at immediate post-extractive implants. MATERIALS AND METHODS. Twenty patients with one missing tooth between two adja-cent healthy teeth in aesthetic areas and at least 4 mm of bone apically to the tooth apex were randomly allocated after tooth extraction to receive or not a subepithelial buccal STGS. Implants were inserted with a torque of at least 30 Ncm and sites were grafted with a cancellous particulate allograft. Ten patients received a buccal STGS and 10 patients did not (control group). All patients were restored with non-occluding immediate provisional screw-retained crowns, replaced after 6 months by definitive metal-ceramic crowns, and were followed to 3-year after grafting/loading. RESULTS. Three-year after loading, no drop-out, crown or implant failure or complication occurred. No statistically significant difference or trends in aesthetics (difference = 0.2, 95% CI:-0.81 to 1.21; P = 0.97), peri-implant marginal bone loss (difference = 0.14 mm; 95% CI:-0.27 to 0.57; P = 0.58) and keratinized mucosa heights (difference = 0.8 mm; 95% CI:-1.79 to 3.39; P = 0.57) between the two groups were observed. CONCLUSIONS. Acknowledging that the sample size was small, no clinical benefits could be observed using a soft tissue graft substitute at immediate post-extractive implants up to 3-year after grafting. CONFLICT OF INTEREST STATEMENT. The manufacturer (BEGO Implant Systems, Bremen, Germany) of the implants used in this investigation, partially supported this trial, however data belonged to the authors and by no means the sponsor interfered with the conduct of the trial or the publication of its results
Immediate loading of occluding definitive partial fixed prostheses versus nonoccluding provisional prostheses: 10-year post-loading results from a multicentre randomized controlled trial
PURPOSE. To compare the clinical outcomes of dental implants restored with definitive occluding partial fixed prostheses within one week after implant placement versus immediate loading with non-occluding provisional restorations replaced by definitive prostheses after four months. MATERIALS AND METHODS. Forty partially edentulous patients treated with one to three dental implants, of length at least 8.5 mm and width 4.0 mm and inserted with a torque of at least 35 Ncm, were randomized to two groups of 20 patients each. Patients from one group received one definitive screw-retained metal-ceramic prosthesis in occlusion within one week after placement (occlusion group), while those in the other group received one non-occluding provisional acrylic reinforced prosthesis within 24 hours after implant placement (non-occlusion group); after four months, provisional prostheses were replaced by definitive ones. The follow-up for all patients was 10 years post-loading. Outcome measures were prosthesis and implant failures, any complications, peri-implant marginal bone level changes, aesthetics, patient satisfaction, chairside time and number of visits to the clinic from implant placement to delivery of definitive restorations. RESULTS. At 10-year follow-up, nine patients had dropped out, four from the non-occlu-sion group and five from the occlusion group. Two implants from the latter, along with their definitive prostheses, failed early (difference in proportions = 0.1; 95% CI =-0.08 to 0.26; P = 0.487). Five patients from the occlusion group were affected by seven complications versus five patients (five complications) in the non-occlusion group, with no statistically significant difference in proportions (difference in proportions =-0.01; 95% CI =-0.28 to 0.26; P = 1). Ten years after loading, patients subjected to occlusal loading lost an average of 0.94 mm of peri-implant bone versus 0.90 mm in patients initially restored with non-occluding provisional prostheses. There were no statistically significant differences in marginal bone level changes between the two groups (mean difference = 0.17 mm; 95% CI-0.25 to 0.58; P = 0.416). Likewise, there were no significant differences in either pink aesthetic scores (5.32 versus 4.45; P = 0.496) or patients’ satisfaction with aesthetics (Fisher’s exact probability test P = 1), and all patients in both groups declared being fully satisfied with function. However, patients immediately loaded with a definitive prosthesis required significantly less chairside time (mean difference-38.00; 95% CI-58.96 to-17.04; P = 0.001) and fewer visits (mean difference-2.15; 95% CI-2.77 to-1.53; P <0.001). CONCLUSIONS. Although unable to provide a definitive conclusion due to the insufficient sample size, the results do suggest that immediate loading in occlusion with definitive partial fixed prostheses is not only a viable therapeutic option for patients, but requires fewer appointments and less chairside time
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