4,316 research outputs found
Pluralism in qualitative research: the impact of different researchers and qualitative approaches on the analysis of qualitative data.
Qualitative approaches to research in psychology and the social sciences are increasingly used. The variety of approaches incorporates different epistemologies, theoretical traditions and practices with associated analysis techniques spanning a range of theoretical and empirical frameworks. Despite the increase in mixed method approaches it is unusual for qualitative methods to be used in combination with each other. The Pluralism in Qualitative Research project (PQR) was developed in order to investigate the benefits and creative tensions of integrating diverse qualitative approaches. Amongst other objectives it seeks to interrogate the contributions and impact of researchers and methods on data analysis. The paper presents our pluralistic analysis of a single semi-structured interview transcript. Analyses were carried out by different researchers using grounded theory, Foucauldian discourse analysis, interpretative phenomenological analysis and narrative analysis. We discuss the variation and agreement in the analysis of the data. The implications of the findings on the conduct, writing and presentation of qualitative research are discussed
Diffractive orbits in isospectral billiards
Isospectral domains are non-isometric regions of space for which the spectra
of the Laplace-Beltrami operator coincide. In the two-dimensional Euclidean
space, instances of such domains have been given. It has been proved for these
examples that the length spectrum, that is the set of the lengths of all
periodic trajectories, coincides as well. However there is no one-to-one
correspondence between the diffractive trajectories. It will be shown here how
the diffractive contributions to the Green functions match nevertheless in a
''one-to-three'' correspondence.Comment: 20 pages, 6 figure
‘It’s better than daytime television’: questioning the socio-spatial impacts of massage parlours on residential communities
It has been shown that street sex work is problematic for some communities, but there is less evidence of the effects of brothels. Emerging research also suggests that impact discourses outlined by residential communities and in regulatory policies should be critiqued, because they are often based on minority community voices, and limited tangible evidence is used to masquerade wider moral viewpoints about the place of sex work. Using a study of residents living in close proximity to brothels in Blackpool, this paper argues that impact is socially and spatially fluid. Impact needs to be evaluated in a more nuanced manner, which is considerate of the heterogeneity of (even one type of) sex work, and the community in question. Brothels in Blackpool had a variety of roles in the everyday socio-spatial fabric; thus also questioning the common assumption that sex work only impacts negatively on residential communities
Simvastatin reduces bone turnover in hypercholesterolemic subjects independent of its effects on LDL oxidation and inflammatory markers
Progress in marine geoconservation in Scotland’s seas : assessment of key interests and their contribution to Marine Protected Area network planning
This study was part-funded by Marine Scotland and was undertaken as part of the Scottish Marine Protected Areas (MPA) Programme, a joint initiative between Marine Scotland, Historic Scotland, Scottish Natural Heritage (SNH) and the Joint Nature Conservation Committee (JNCC).Geoconservation in the marine environment has been largely overlooked, despite a wealth of accumulated information on marine geology and geomorphology and clear links between many terrestrial and marine features. As part of the wider characterisation of Scotland’s seas, this study developed criteria and a methodology that follow the established principles of the terrestrial, Great Britain-wide geoconservation audit, the Geological Conservation Review, to assess geodiversity key areas on the seabed. Using an expert judgement approach, eight geodiversity feature categories were identified to represent the geological and geomorphological processes that have influenced the evolution and present-day morphology of the Scottish seabed: Quaternary of Scotland; Submarine Mass Movement; Marine Geomorphology of the Scottish Deep-Ocean Seabed; Seabed Fluid and Gas Seep; Cenozoic Structures of the Atlantic Margin; Marine Geomorphology of the Scottish Shelf Seabed; Coastal Geomorphology of Scotland; and Biogenic Structures of the Scottish Seabed. Within these categories, 35 key areas were prioritised for their scientific value. Specific interests range from large-scale landforms (e.g. submarine landslides, sea-mounts and trenches) to fine-scale dynamic features (e.g. sand waves). Although these geodiversity interests provided supporting evidence for the identification and selection of a suite of Nature Conservation Marine Protected Areas (MPAs) containing important marine natural features, they are only partially represented in these MPAs and existing protected areas. Nevertheless, a pragmatic approach is emerging to integrate as far as possible the conservation management of marine geodiversity with that of biodiversity and based on evidence of the sensitivity and vulnerability geological and geomorphological features on the seabed.PostprintPeer reviewe
Articular condrocalcinosis in hospital population: An Australian experience
A group of hospital patients aged 55 years or over (53 men, 74 women) were screened for articular chondrocalcinosis (ACC) with high-resolution radiographs of knees, wrists, hand and pelvis. Two men (4%) aged 79 and 86 years had ACC involving knees, wrists and symphysis pubis. Both had clinical joint disease and radiological osteoarthritis (OA). Eighteen women (24%) had ACC with sites affected including the knees (89%), wrists (39%) and symphysis pubis (44%). Metabolic screening did not reveal any predisposing factors in patients with ACC. Symptoms and signs of joint disease were not significantly more common in women with ACC compared to those without ACC, and 44% of those with knee calcification were clinically asymptomatic and had no evidence of OA radiologically. However, the presence of knee ACC significantly increased the risk for OA in the same knee by a factor of three-to-four while knee calcification was associated with the more severe grades of radiographic OA
Baseline and longitudinal grey matter changes in newly diagnosed Parkinson\u27s disease: ICICLE-PD study
Mild cognitive impairment in Parkinson\u27s disease is associated with progression to dementia (Parkinson\u27s disease dementia) in a majority of patients. Determining structural imaging biomarkers associated with prodromal Parkinson\u27s disease dementia may allow for the earlier identification of those at risk, and allow for targeted disease modifying therapies. One hundred and five non-demented subjects with newly diagnosed idiopathic Parkinson\u27s disease and 37 healthy matched controls had serial 3 T structural magnetic resonance imaging scans with clinical and neuropsychological assessments at baseline, which were repeated after 18 months. The Movement Disorder Society Task Force criteria were used to classify the Parkinson\u27s disease subjects into Parkinson\u27s disease with mild cognitive impairment (n = 39) and Parkinson\u27s disease with no cognitive impairment (n = 66). Freesurfer image processing software was used to measure cortical thickness and subcortical volumes at baseline and follow-up. We compared regional percentage change of cortical thinning and subcortical atrophy over 18 months. At baseline, cases with Parkinson\u27s disease with mild cognitive impairment demonstrated widespread cortical thinning relative to controls and atrophy of the nucleus accumbens compared to both controls and subjects with Parkinson\u27s disease with no cognitive impairment. Regional cortical thickness at baseline was correlated with global cognition in the combined Parkinson\u27s disease cohort. Over 18 months, patients with Parkinson\u27s disease with mild cognitive impairment demonstrated more severe cortical thinning in frontal and temporo-parietal cortices, including hippocampal atrophy, relative to those with Parkinson\u27s disease and no cognitive impairment and healthy controls, whereas subjects with Parkinson\u27s disease and no cognitive impairment showed more severe frontal cortical thinning compared to healthy controls. At baseline, Parkinson\u27s disease with no cognitive impairment converters showed bilateral temporal cortex thinning relative to the Parkinson\u27s disease with no cognitive impairment stable subjects. Although loss of both cortical and subcortical volume occurs in non-demented Parkinson\u27s disease, our longitudinal analyses revealed that Parkinson\u27s disease with mild cognitive impairment shows more extensive atrophy and greater percentage of cortical thinning compared to Parkinson\u27s disease with no cognitive impairment. In particular, an extension of cortical thinning in the temporo-parietal regions in addition to frontal atrophy could be a biomarker in therapeutic studies of mild cognitive impairment in Parkinson\u27s disease for progression towards dementia
The youngest massive protostars in the Large Magellanic Cloud
We demonstrate the unique capabilities of Herschel to study very young
luminous extragalactic young stellar objects (YSOs) by analyzing a central
strip of the Large Magellanic Cloud obtained through the HERITAGE Science
Demonstration Program. We combine PACS 100 and 160, and SPIRE 250, 350, and 500
microns photometry with 2MASS (1.25-2.17 microns) and Spitzer IRAC and MIPS
(3.6-70 microns) to construct complete spectral energy distributions (SEDs) of
compact sources. From these, we identify 207 candidate embedded YSOs in the
observed region, ~40% never-before identified. We discuss their position in
far-infrared color-magnitude space, comparing with previously studied,
spectroscopically confirmed YSOs and maser emission. All have red colors
indicating massive cool envelopes and great youth. We analyze four example
YSOs, determining their physical properties by fitting their SEDs with
radiative transfer models. Fitting full SEDs including the Herschel data
requires us to increase the size and mass of envelopes included in the models.
This implies higher accretion rates (greater than or equal to 0.0001 M_sun/yr),
in agreement with previous outflow studies of high-mass protostars. Our results
show that Herschel provides reliable longwave SEDs of large samples of
high-mass YSOs; discovers the youngest YSOs whose SEDs peak in Herschel bands;
and constrains the physical properties and evolutionary stages of YSOs more
precisely than was previously possible.Comment: Main text: 4 pages, 3 figures, 1 table; Online material: 3 figures, 1
table; to appear in the A&A Herschel Special Issu
Protocol for the Foot in Juvenile Idiopathic Arthritis trial (FiJIA): a randomised controlled trial of an integrated foot care programme for foot problems in JIA
<b>Background</b>:
Foot and ankle problems are a common but relatively neglected manifestation of juvenile idiopathic arthritis. Studies of medical and non-medical interventions have shown that clinical outcome measures can be improved. However existing data has been drawn from small non-randomised clinical studies of single interventions that appear to under-represent the adult population suffering from juvenile idiopathic arthritis. To date, no evidence of combined therapies or integrated care for juvenile idiopathic arthritis patients with foot and ankle problems exists.
<b>Methods/design</b>:
An exploratory phase II non-pharmacological randomised controlled trial where patients including young children, adolescents and adults with juvenile idiopathic arthritis and associated foot/ankle problems will be randomised to receive integrated podiatric care via a new foot care programme, or to receive standard podiatry care. Sixty patients (30 in each arm) including children, adolescents and adults diagnosed with juvenile idiopathic arthritis who satisfy the inclusion and exclusion criteria will be recruited from 2 outpatient centres of paediatric and adult rheumatology respectively. Participants will be randomised by process of minimisation using the Minim software package. The primary outcome measure is the foot related impairment measured by the Juvenile Arthritis Disability Index questionnaire's impairment domain at 6 and 12 months, with secondary outcomes including disease activity score, foot deformity score, active/limited foot joint counts, spatio-temporal and plantar-pressure gait parameters, health related quality of life and semi-quantitative ultrasonography score for inflammatory foot lesions. The new foot care programme will comprise rapid assessment and investigation, targeted treatment, with detailed outcome assessment and follow-up at minimum intervals of 3 months. Data will be collected at baseline, 6 months and 12 months from baseline. Intention to treat data analysis will be conducted.
A full health economic evaluation will be conducted alongside the trial and will evaluate the cost effectiveness of the intervention. This will consider the cost per improvement in Juvenile Arthritis Disability Index, and cost per quality adjusted life year gained. In addition, a discrete choice experiment will elicit willingness to pay values and a cost benefit analysis will also be undertaken
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