The spectral catalogue of INTEGRAL gamma-ray bursts: results of the joint IBIS/SPI spectral analysis

We present the updated INTEGRAL catalogue of gamma-ray bursts (GRBs) observed between December 2002 and February 2012. The catalogue contains the spectral parameters for 59 GRBs localized by the INTEGRAL Burst Alert System (IBAS). We used the data from the two main instruments on board the INTEGRAL satellite: the spectrometer SPI (SPectrometer on INTEGRAL) nominally covering the energy range 18 keV - 8 MeV, and the imager IBIS (the Imager on Board the INTEGRAL Satellite) operating in the range from 15 keV to 10 MeV. For the spectral analysis we applied a new data extraction technique, developed in order to explore the energy regions of highest sensitivity for both instruments, SPI and IBIS. It allowed us to perform analysis of the GRB spectra over a broad energy range and to determine the bursts' spectral peak energies. The spectral analysis was performed on the whole sample of GRBs triggered by IBAS, including all the events observed in period December 2002 - February 2012. The catalogue contains the trigger times, burst coordinates, positional errors, durations and peak fluxes for 28 unpublished GRBs observed between September 2008 and February 2012. The light curves in 20 - 200 keV energy band of these events were derived using IBIS data. We compare the prompt emission properties of the INTEGRAL GRB sample with the BATSE and Fermi samples.Comment: 16 pages, 40 figures, accepted for publication in Astronomy & Astrophysic

Estrus Induction in Sexually Mature Gilts with Different Hormonal Treatments

The aim of this study was to determine the effectiveness of the synchronized estrus induction in sexually mature gilts, after treatment with different hormonal treatments, given in the unknown phase of a spontaneous estrus cycle. Sexually mature gilts were used, with at least one spontaneous estrous cycle. A total of 90 gilts were treated with single i/m injection of 1,000 IU eCG (Folligon®), 40 gilts were treated with two separate i/m injection of 1 ml PGF2α (Dinolytic®), at an interval of 11 days, and 40 gilts were treated orally (within diet) with 20 mg of synthetic progestagen preparation Altrenogest (Regumate®), during 18 days. Estrus was detected twice daily, in the 10h to 12h intervals, by direct contact with the teaser boar. The best induction of synchronized estrus (in 90% of gilts), which appeared within the first 7 days (mean 5.3 days) after treatment, was found in gilts treated with progestagen preparations. In the three repetitions of treatment with eCG, within the first 7 days (mean 4.2 days) after the treatment, estrus was detected in 65%, 40% or 33% of the treated gilts. After treatment with luteolytic preparation PGF2α (Dynolitic®), estrus was detected in 40% of gilts, on average 5.5 days after treatment. The obtained results clearly show that the successful induction of synchronized estrus in sexually mature gilts can be done only by the method for prolongation of the luteal phase of the spontaneous estrous cycles, using progestagen preparations

\u3ci\u3eIn Vitro and In Vivo\u3c/i\u3e Correlation of Skin and Cellular Responses to Nucleic Acid Delivery

Skin, the largest organ in the body, provides a passive physical barrier against infection and contains elements of the innate and adaptive immune systems. Skin consists of various cells, including keratinocytes, fibroblasts, endothelial cells and immune cells. This diversity of cell types could be important to gene therapies because DNA transfection could elicit different responses in different cell types. Previously, we observed the upregulation and activation of cytosolic DNA sensing pathways in several non-tumor and tumor cell types as well in tumors after the electroporation (electrotransfer) of plasmid DNA (pDNA). Based on this research and the innate immunogenicity of skin, we correlated the effects of pDNA electrotransfer to fibroblasts and keratinocytes to mouse skin using reverse transcription real-time PCR (RT-qPCR) and several types of protein quantification. After pDNA electrotransfer, the mRNAs of the putative DNA sensors DEAD (AspGlu-Ala-Asp) box polypeptide 60 (Ddx60), absent in melanoma 2 (Aim2), Z-DNA binding protein 1 (Zbp1), interferon activated gene 202 (Ifi202), and interferon-inducible protein 204 (Ifi204) were upregulated in keratinocytes, while Ddx60, Zbp1 and Ifi204 were upregulated in fibroblasts. Increased levels of the mRNAs and proteins of several cytokines and chemokines were detected and varied based on cell type. Mouse skin experiments in vivo confirmed our in vitro results with increased expression of putative DNA sensor mRNAs and of the mRNAs and proteins of several cytokines and chemokines. Finally, with immunofluorescent staining, we demonstrated that skin keratinocytes, fibroblasts and macrophages contribute to the immune response observed after pDNA electrotransfer

The four weeks before lockdown during the COVID-19 pandemic in Germany: A weekly serial cross-sectional survey on risk perceptions, knowledge, public trust and behaviour, 3 to 25 March 2020

Background: During the COVID-19 pandemic, public perceptions and behaviours have had to adapt rapidly to new risk scenarios and radical behavioural restrictions. Aim: To identify major drivers of acceptance of protective behaviours during the 4-week transition from virtually no COVID-19 cases to the nationwide lockdown in Germany (3–25 March 2020). Methods: A serial cross-sectional online survey was administered weekly to ca 1,000 unique individuals for four data collection rounds in March 2020 using non-probability quota samples, representative of the German adult population between 18 and 74 years in terms of age × sex and federal state (n = 3,910). Acceptance of restrictions was regressed on sociodemographic variables, time and psychological variables, e.g. trust, risk perceptions, self-efficacy. Extraction of homogenous clusters was based on knowledge and behaviour. Results: Acceptance of restrictive policies increased with participants’ age and employment in the healthcare sector; cognitive and particularly affective risk perceptions were further significant predictors. Acceptance increased over time, as trust in institutions became more relevant and trust in media became less relevant. The cluster analysis further indicated that having a higher education increased the gap between knowledge and behaviour. Trust in institutions was related to conversion of knowledge into action. Conclusion: Identifying relevant principles that increase acceptance will remain crucial to the development of strategies that help adjust behaviour to control the pandemic, possibly for years to come. Based on our findings, we provide operational recommendations for health authorities regarding data collection, health communication and outreach

Global characteristics of GRBs observed with INTEGRAL and the inferred large population of low-luminosity GRBs

INTEGRAL has two sensitive gamma-ray instruments that have detected 46 gamma-ray bursts (GRBs) up to July 2007. We present the spectral, spatial, and temporal properties of the bursts in the INTEGRAL GRB catalogue using data from the imager, IBIS, and spectrometer, SPI. Spectral properties of the GRBs are determined using power-law, Band model and quasithermal model fits to the prompt emission. Spectral lags, i.e. the time delay in the arrival of low-energy gamma-rays with respect to high-energy gamma-rays, are measured for 31 of the GRBs. The photon index distribution of power-law fits to the prompt emission spectra is consistent with that obtained by Swift. The peak flux distribution shows that INTEGRAL detects proportionally more weak GRBs than Swift because of its higher sensitivity in a smaller field of view. The all-sky rate of GRBs above ~0.15 ph cm^-2 s^-1 is ~1400 yr^-1 in the fully coded field of view of IBIS. Two groups are identified in the spectral lag distribution, one with short lags <0.75 s (between 25-50 keV and 50-300 keV) and one with long lags >0.75 s. Most of the long-lag GRBs are inferred to have low redshifts because of their long spectral lags, their tendency to have low peak energies and their faint optical and X-ray afterglows. They are mainly observed in the direction of the supergalactic plane with a quadrupole moment of Q=-0.225+/-0.090 and hence reflect the local large-scale structure of the Universe. The rate of long-lag GRBs with inferred low luminosity is ~25% of Type Ib/c supernovae. Some of these bursts could be produced by the collapse of a massive star without a supernova or by a different progenitor, such as the merger of two white dwarfs or a white dwarf with a neutron star or black hole, possibly in the cluster environment without a host galaxy.Comment: 22 pages, 13 figures and appendix, accepted for publication in A&A, added and updated reference

Edge Detection by Adaptive Splitting II. The Three-Dimensional Case

In Llanas and Lantarón, J. Sci. Comput. 46, 485–518 (2011) we proposed an algorithm (EDAS-d) to approximate the jump discontinuity set of functions defined on subsets of ℝ d . This procedure is based on adaptive splitting of the domain of the function guided by the value of an average integral. The above study was limited to the 1D and 2D versions of the algorithm. In this paper we address the three-dimensional problem. We prove an integral inequality (in the case d=3) which constitutes the basis of EDAS-3. We have performed detailed computational experiments demonstrating effective edge detection in 3D function models with different interface topologies. EDAS-1 and EDAS-2 appealing properties are extensible to the 3D cas

Development of an international survey attitude scale: measurement equivalence, reliability, and predictive validity

Declining response rates worldwide have stimulated interest in understanding what may be influencing this decline and how it varies across countries and survey populations. In this paper, we describe the development and validation of a short 9-item survey attitude scale that measures three important constructs, thought by many scholars to be related to decisions to participate in surveys, that is, survey enjoyment, survey value, and survey burden. The survey attitude scale is based on a literature review of earlier work by multiple authors. Our overarching goal with this study is to develop and validate a concise and effective measure of how individuals feel about responding to surveys that can be implemented in surveys and panels to understand the willingness to participate in surveys and improve survey effectiveness. The research questions relate to factor structure, measurement equivalence, reliability, and predictive validity of the survey attitude scale. The data came from three probability-based panels: the German GESIS and PPSM panels and the Dutch LISS panel. The survey attitude scale proved to have a replicable three-dimensional factor structure (survey enjoyment, survey value, and survey burden). Partial scalar measurement equivalence was established across three panels that employed two languages (German and Dutch) and three measurement modes (web, telephone, and paper mail). For all three dimensions of the survey attitude scale, the reliability of the corresponding subscales (enjoyment, value, and burden) was satisfactory. Furthermore, the scales correlated with survey response in the expected directions, indicating predictive validity

Symptoms of depression in parents after discharge from NICU associated with family-centred care

AimsThe aim of this study was to examine the potential association of family-centred care as perceived by parents during a NICU stay with parents’ depressive symptoms at discharge and at 4 months corrected for infant age.DesignA longitudinal, multicentre cohort study was conducted from 2018 to 2020 in 23 NICUs across 15 countries.MethodsParents (n = 635 mothers, n = 466, fathers) of infants (n = 739) born before 35 weeks of gestation and admitted to the participating NICUs were enrolled to the study during the first weeks of their infants’ hospitalizations. They responded to Digi-FCC daily text messages inquiring about their perception of family-centred care provided by NICU staff. In addition, they completed a questionnaire assessing their overall perception of family-centred care at discharge. Parents’ depressive symptoms were measured by the Edinburgh Postnatal Depression Scale at discharge and again after discharge when their infants were at 4 months corrected for age.ResultsThe mothers’ and the fathers’ perceptions of family-centred care were associated with their depressive symptoms at discharge and at 4 months corrected age, controlling for gestational age, multiple birth, parent education and relationship status. Parents’ participation in infant care, care-related decisions and emotional support provided to parents by staff explained the variation in the parents’ perceptions of family-centred care. The factors facilitating the implementation of family-centred care included unlimited access to the unit for the parents and for their significant others, as well as amenities for parents.ConclusionsOur study shows that family-centred NICU care associates with parents’ depressive symptoms after a NICU stay.ImpactDepression is common in parents of preterm infants. The provision of family-centred care may protect the mental well-being of parents of preterm infants.</p