War of the Worlds: Music and Cosmological Battles in the Balinese Cremation Procession

Abstract This article explores processional action as a form of cosmological intervention in Hindu-Balinese cremation processions, focusing on the multiple and intersecting functions of a particular type of Balinese instrumental music ensemble: the gamelan beleganjur. It explores the alternately “enlivening and protective aspects” (DeVale 1990, 62) that underlie the use of beleganjur music in the ngaben, or cremation ritual, showing how beleganjur’s sonic power and rhythmic drive serve to combat malevolent spirit beings, strengthen and inspire processional participants in their efforts to meet challenging ritual obligations, and grant courage to the souls of deceased individuals embarking on their perilous afterlife journeys

The Musicality of Stimming: Promoting Neurodiversity in the Ethnomusicology of Autism

In the symptomatology of autism spectrum disorders (ASDs), the practice of “odd, unusual, or repetitive behaviors” such as hand flapping and body rocking is referred to as stimming (Hammel and Hourigan 2013: 75). Stimming is routinely cast as problematic and targeted for reduction or elimination in therapeutic modalities for autistic individuals, including music therapy. In an alternate frame of reference grounded in the epistemological foundations of neurodiversity, however, stimming is subject to a very different kind of interpretation in which such behaviours are embraced as productive, communicative, pleasurable and even socially valuable for those who perform them—as manifestations of difference, not symptoms of deficit. This mode of interpretation forms the basis of the present article, which highlights the words and views of a 10-year-old girl on the autism spectrum who plays music and stims, and which more broadly draws upon theoretical and methodological premises of ethnomusicology to advance a neurodiverse perspective on autism.Résumé: Dans la symptomatologie des troubles du spectre autistique (TSA), les « comportements étranges, inhabituels ou répétitifs » tels que les battements de main ou le balancement du corps sont appelés gestes répétitifs ou stimming (Hammel et Hourigan 2013 : 75). Ces gestes répétitifs sont le plus souvent considérés comme problématiques et les modalités thérapeutiques, y compris la thérapie musicale, s’efforcent de les réduire ou de les éliminer chez les individus autistes. Mais dans un cadre de référence alternatif, issu des fondements épistémologiques de la neurodiversité, les gestes répétitifs font l’objet d’une interprétation totalement différente, à savoir que ces comportements sont considérés comme productifs, communicatifs, sources de plaisir, voire même comme ayant une valeur sociale pour ceux qui s’y livrent, en tant que manifestations de la différence et non comme symptômes d’un handicap. Ce mode d’interprétation constitue la base de cet article qui souligne, sur le spectre de l’autisme, les mots et les points de vue d’une petite fille de dix ans qui joue de la musique et fait des gestes répétitifs ; cet article, plus largement, se fonde sur les prémisses théoriques et méthodologiques de l’ethnomusicologie pour proposer un nouveau point de vue sur l’autisme, incluant la neurodiversité

Structured matrices, continued fractions, and root localization of polynomials

We give a detailed account of various connections between several classes of objects: Hankel, Hurwitz, Toeplitz, Vandermonde and other structured matrices, Stietjes and Jacobi-type continued fractions, Cauchy indices, moment problems, total positivity, and root localization of univariate polynomials. Along with a survey of many classical facts, we provide a number of new results.Comment: 79 pages; new material added to the Introductio

The complications of ‘hiring a hubby’: gender relations and the commoditisation of home maintenance in New Zealand

This paper examines the commoditization of traditionally male domestic tasks through interviews with handymen who own franchises in the company ‘Hire a Hubby’ in New Zealand and homeowners who have paid for home repair tasks to be done. Discussions of the commoditization of traditionally female tasks in the home have revealed the emotional conflicts of paying others to care as well as the exploitative and degrading conditions that often arise when work takes place behind closed doors. By examining the working conditions and relationships involved when traditionally male tasks are paid for, this paper raises important questions about the valuing of reproductive labour and the production of gendered identities. The paper argues that while working conditions and rates of pay for ‘hubbies’ are better than those for people undertaking commoditized forms of traditionally female domestic labour, the negotiation of this work is still complex and implicated in gendered relations and identities. Working on the home was described by interviewees as an expression of care for family and a performance of the ‘right’ way to be a ‘Kiwi bloke’ and a father. Paying others to do this labour can imply a failure in a duty of care and in the performance of masculinity

The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity

Background: We characterized the biologic effects of a novel small molecule STAT3 pathway inhibitor that is derived from the natural product curcumin. We hypothesized this lead compound would specifically inhibit the STAT3 signaling pathway to induce apoptosis in melanoma cells. Results: FLLL32 specifically reduced STAT3 phosphorylation at Tyr705 (pSTAT3) and induced apoptosis at micromolar amounts in human melanoma cell lines and primary melanoma cultures as determined by annexin V/propidium iodide staining and immunoblot analysis. FLLL32 treatment reduced expression of STAT3-target genes, induced caspase-dependent apoptosis, and reduced mitochondrial membrane potential. FLLL32 displayed specificity for STAT3 over other homologous STAT proteins. In contrast to other STAT3 pathway inhibitors (WP1066, JSI-124, Stattic), FLLL32 did not abrogate IFN-γ-induced pSTAT1 or downstream STAT1-mediated gene expression as determined by Real Time PCR. In addition, FLLL32 did not adversely affect the function or viability of immune cells from normal donors. In peripheral blood mononuclear cells (PBMCs), FLLL32 inhibited IL-6-induced pSTAT3 but did not reduce signaling in response to immunostimulatory cytokines (IFN-γ, IL 2). Treatment of PBMCs or natural killer (NK) cells with FLLL32 also did not decrease viability or granzyme b and IFN-γ production when cultured with K562 targets as compared to vehicle (DMSO). Conclusions: These data suggest that FLLL32 represents a lead compound that could serve as a platform for further optimization to develop improved STAT3 specific inhibitors for melanoma therapy

Fabrication of Supramolecular n/p-Nanowires via Coassembly of Oppositely Charged Peptide-Chromophore Systems in Aqueous Media

Fabrication of supramolecular electroactive materials at the nanoscale with well-defined size, shape, composition, and organization in aqueous medium is a current challenge. Herein we report construction of supramolecular charge-transfer complex one-dimensional (1D) nanowires consisting of highly ordered mixed-stack π-electron donor-acceptor (D-A) domains. We synthesized n-type and p-type β-sheet forming short peptide-chromophore conjugates, which assemble separately into well-ordered nanofibers in aqueous media. These complementary p-type and n-type nanofibers coassemble via hydrogen bonding, charge-transfer complex, and electrostatic interactions to generate highly uniform supramolecular n/p-coassembled 1D nanowires. This molecular design ensures highly ordered arrangement of D-A stacks within n/p-coassembled supramolecular nanowires. The supramolecular n/p-coassembled nanowires were found to be formed by A-D-A unit cells having an association constant (KA) of 5.18 × 105 M-1. In addition, electrical measurements revealed that supramolecular n/p-coassembled nanowires are approximately 2400 and 10 times more conductive than individual n-type and p-type nanofibers, respectively. This facile strategy allows fabrication of well-defined supramolecular electroactive nanomaterials in aqueous media, which can find a variety of applications in optoelectronics, photovoltaics, organic chromophore arrays, and bioelectronics. © 2017 American Chemical Society

Situationally edited empathy: an effect of socio-economic structure on individual choice

Criminological theory still operates with deficient models of the offender as agent, and of social influences on the agent’s decision-making process. This paper takes one ‘emotion’, empathy, which is theoretically of considerable importance in influencing the choices made by agents; particularly those involving criminal or otherwise harmful action. Using a framework not of rational action, but of ‘rationalised action’, the paper considers some of the effects on individual psychology of social, economic, political and cultural structure. It is suggested that the climate-setting effects of these structures promote normative definitions of social situations which allow unempathic, harmful action to be rationalised through the situational editing of empathy. The ‘crime is normal’ argument can therefore be extended to include the recognition that the uncompassionate state of mind of the criminal actor is a reflection of the self-interested values which govern non-criminal action in wider society