A Taxonomy of Platform Envelopment: Revealing Patterns and Particularities

Platform envelopment describes a competitive move whereby a digital platform enters an adjacent market. On one hand, it might enable to dethrone an established platform. On the other hand, it might give rise to the creation of platform conglomerates, which increases the concentration of private power. Therefore, platform envelopment has recently attracted significant attention from regulators and scholars. However, the traditional view of platform envelopment does not consider recent platform envelopment practices observed in research and practice. In this study, we aim to determine and structure the complexity of platform envelopment. We investigated 20 cases and developed a taxonomy of platform envelopment. We further encoded these cases into the comprehensive taxonomy and derived platform envelopment patterns and particularities. Our work contributes to research by establishing a foundation for the conceptual understanding of platform envelopment. Regulators can use this taxonomy to classify platform envelopment cases and determine potentially anti-competitive conduct

Krankenkassen als Partner der kommunalen Gesundheitsförderung und Prävention: Erfolgsbedingungen der Umsetzung des Präventionsgesetzes durch die Kommunen in Nordrhein-Westfalen

Durch das Präventionsgesetz haben sich für die Kommunen neue Möglichkeiten zur Kooperation mit den Krankenkassen im Bereich der Gesundheitsförderung und Prävention ergeben. Ziel des Forschungsprojektes war es, die Erfolgs- und Hinderungsbedingungen dieser Zusammenarbeit zu ermitteln sowie die Steuerungsrolle der Kommunen im Feld der kommunalen Gesundheitsförderung und Prävention zu analysieren. Die hierzu durchgeführte Telefonbefragung der nordrhein-westfälischen Kommunen zeigte sehr heterogene Ausgangsbedingungen bei den Kommunen - insbesondere im Hinblick auf den Grad der Professionalisierung sowie auf die bisherigen Beziehungen zu den Krankenkassen. Die Beziehungen zwischen den Kommunen und Krankenkassen wurden zusätzlich in sechs Fallstudien (drei Städte, drei Kreise) und vier Experteninterviews mit Kassenvertreter_innen vertiefend beleuchtet. In den Fallstudien konnten zudem drei unterschiedliche Steuerungsrollen der Kommunen identifiziert werden.The Prevention Act 2015 created new possibilities for German municipalities to cooperate with the statutory health insurance funds regarding health promotion and disease prevention. The research project aimed at identifying the factors that increase or hinder the chance for this cooperation. Furthermore, the study strived at analyzing the role the municipalities assume in the local governance of health promotion and disease prevention. For these purposes, the authors conducted a telephone survey amongst North Rhine-Westphalian municipalities. The survey revealed a huge diversity amongst municipalities in particular with regard to their degree of professionalism and their previous relationship with health insurance funds. In addition, the authors carried out six case-studies of municipalities and four expert interviews with representatives of health insurance funds to further analyze their relationship. Thus, they also identified three different governance roles amongst municipalities

Krankenkassen als Partner der kommunalen Gesundheitsförderung und Prävention (GFP): Bedingungen für die erfolgreiche Umsetzung des Präventionsgesetzes durch die Kommunen in NRW

Es bestehen große Unterschiede zwischen den Kommunen in Gesundheitsförderung und Prävention. Den Kommunalen Gesundheitskonferenzen kommt als Forum der Zusammenarbeit von Kommunen und Krankenkassen eine besondere Rolle zu. Bereits bestehende Kooperationen, ausreichende Personalressourcen und die entsprechende Anerkennung von GFP in Verwaltung und Politik erscheinen als relevante Einflussfaktoren für die erfolgreiche Umsetzung

Efficient numerical description of the dynamics of interacting multispecies quantum gases

We present a highly efficient method for the numerical solution of coupled Gross-Pitaevskii equations describing the evolution dynamics of a multispecies mixture of Bose-Einstein condensates in time-dependent potentials. This method, based on a grid-scaling technique, compares favorably to a more standard but much more computationally expensive solution based on a frozen-resolution grid. It allows an accurate description of the long-time behavior of interacting, multi-species quantum mixtures including the challenging problem of long free expansions relevant for microgravity and space experiments. We demonstrate a successful comparison to experimental measurements of a binary Rb-K mixture recently performed with the payload of a sounding rocket experiment

Modulation of the sympathetic nervous system by renal denervation prevents reduction of aortic distensibility in atherosclerosis prone ApoE-deficient rats

Apolipoprotein E-deficient (ApoE(-/-)) rodents spontaneously develop severe hypercholesterolemia and increased aortic stiffness, both accepted risk factors for cardiovascular morbidity and mortality in humans. In patients with resistant hypertension renal denervation (RDN) may improve arterial stiffness, however the underlying mechanisms are incompletely understood. This study investigates the impact of RDN on aortic compliance in a novel atherosclerosis prone ApoE(-/-)-rat model.Methods Normotensive, 8 weeks old ApoE−/− and Sprague–Dawley (SD) rats were subjected to bilateral surgical RDN (n = 6 per group) or sham operation (n = 5 per group) and fed with normal chow for 8 weeks. Compliance of the ascending aorta was assessed by magnetic resonance imaging. Vasomotor function was measured by aortic ring tension recordings. Aortic collagen content was quantified histologically and plasma aldosterone levels were measured by enzyme-linked immunosorbent assay (ELISA).Results After 8 weeks, ApoE−/−-sham demonstrated a 58 % decrease in aortic distensibility when compared with SD-sham (0.0051 ± 0.0011 vs. 0.0126 ± 0.0023 1/mmHg; p = 0.02). This was accompanied by an impaired endothelium-dependent relaxation of aortic rings and an increase in aortic medial fibrosis (17.87 ± 1.4 vs. 12.27 ± 1.1 %; p = 0.006). In ApoE−/−-rats, RDN prevented the reduction of aortic distensibility (0.0128 ± 0.002 vs. 0.0051 ± 0.0011 1/mmHg; p = 0.01), attenuated endothelial dysfunction, and decreased aortic medial collagen content (12.71 ± 1.3 vs. 17.87 ± 1.4 %; p = 0.01) as well as plasma aldosterone levels (136.33 ± 6.6 vs. 75.52 ± 8.4 pg/ml; p = 0.0003). Cardiac function and metabolic parameters such as hypercholesterolemia were not influenced by RDN.Conclusion ApoE−/−-rats spontaneously develop impaired vascular compliance. RDN improves aortic distensibility and attenuated endothelial dysfunction in ApoE−/−-rats. This was associated with a reduction in aortic fibrosis formation, and plasma aldosterone levels

Modulation of the sympathetic nervous system by renal denervation prevents reduction of aortic distensibility in atherosclerosis prone ApoE-deficient rats

Apolipoprotein E-deficient (ApoE(-/-)) rodents spontaneously develop severe hypercholesterolemia and increased aortic stiffness, both accepted risk factors for cardiovascular morbidity and mortality in humans. In patients with resistant hypertension renal denervation (RDN) may improve arterial stiffness, however the underlying mechanisms are incompletely understood. This study investigates the impact of RDN on aortic compliance in a novel atherosclerosis prone ApoE(-/-)-rat model.Methods Normotensive, 8 weeks old ApoE−/− and Sprague–Dawley (SD) rats were subjected to bilateral surgical RDN (n = 6 per group) or sham operation (n = 5 per group) and fed with normal chow for 8 weeks. Compliance of the ascending aorta was assessed by magnetic resonance imaging. Vasomotor function was measured by aortic ring tension recordings. Aortic collagen content was quantified histologically and plasma aldosterone levels were measured by enzyme-linked immunosorbent assay (ELISA).Results After 8 weeks, ApoE−/−-sham demonstrated a 58 % decrease in aortic distensibility when compared with SD-sham (0.0051 ± 0.0011 vs. 0.0126 ± 0.0023 1/mmHg; p = 0.02). This was accompanied by an impaired endothelium-dependent relaxation of aortic rings and an increase in aortic medial fibrosis (17.87 ± 1.4 vs. 12.27 ± 1.1 %; p = 0.006). In ApoE−/−-rats, RDN prevented the reduction of aortic distensibility (0.0128 ± 0.002 vs. 0.0051 ± 0.0011 1/mmHg; p = 0.01), attenuated endothelial dysfunction, and decreased aortic medial collagen content (12.71 ± 1.3 vs. 17.87 ± 1.4 %; p = 0.01) as well as plasma aldosterone levels (136.33 ± 6.6 vs. 75.52 ± 8.4 pg/ml; p = 0.0003). Cardiac function and metabolic parameters such as hypercholesterolemia were not influenced by RDN.Conclusion ApoE−/−-rats spontaneously develop impaired vascular compliance. RDN improves aortic distensibility and attenuated endothelial dysfunction in ApoE−/−-rats. This was associated with a reduction in aortic fibrosis formation, and plasma aldosterone levels

Efficient numerical description of the dynamics of interacting multispecies quantum gases

We present a highly efficient method for the numerical solution of coupled Gross-Pitaevskii equations describing the evolution dynamics of a multi-species mixture of Bose-Einstein condensates in time-dependent potentials. This method, based on a moving and expanding reference frame, compares favorably to a more standard but much more computationally expensive solution based on a frozen frame. It allows an accurate description of the long-time behavior of interacting, multi-species quantum mixtures including the challenging problem of long free expansions relevant to microgravity and space experiments. We demonstrate a successful comparison to experimental measurements of a binary Rb-K mixture recently performed with the payload of a sounding rocket experiment

Genomic Profiling of Childhood Tumor Patient-Derived Xenograft Models to Enable Rational Clinical Trial Design.

Accelerating cures for children with cancer remains an immediate challenge as a result of extensive oncogenic heterogeneity between and within histologies, distinct molecular mechanisms evolving between diagnosis and relapsed disease, and limited therapeutic options. To systematically prioritize and rationally test novel agents in preclinical murine models, researchers within the Pediatric Preclinical Testing Consortium are continuously developing patient-derived xenografts (PDXs)-many of which are refractory to current standard-of-care treatments-from high-risk childhood cancers. Here, we genomically characterize 261 PDX models from 37 unique pediatric cancers; demonstrate faithful recapitulation of histologies and subtypes; and refine our understanding of relapsed disease. In addition, we use expression signatures to classify tumors for TP53 and NF1 pathway inactivation. We anticipate that these data will serve as a resource for pediatric oncology drug development and will guide rational clinical trial design for children with cancer

Emerging Avenues for Utilization of Exotic Germplasm

Breeders have been successful in increasing crop performance by exploiting genetic diversity over time. However, the reported annual yield increases are not sufficient in view of rapid human population growth and global environmental changes. Exotic germplasm possesses high levels of genetic diversity for valuable traits. However, only a small fraction of naturally occurring genetic diversity is utilized. Moreover, the yield gap between elite and exotic germplasm widens, which increases the effort needed to use exotic germplasm and to identify beneficial alleles and for their introgression. The advent of high-throughput genotyping and phenotyping technologies together with emerging biotechnologies provide new opportunities to explore exotic genetic variation. This review will summarize potential challenges for utilization of exotic germplasm and provide solutions