Simple and Efficient Protocol for the Synthesis of Novel Dihydro-1H-Pyrano[2,3-C]Pyrazol-6-Ones via a one-Pot Four-Component Reaction

Ba(OH)2 catalyzed simple and efficient one-pot four-component reaction of Meldrums acid, ethyl acetoacetate, hydrazine hydrate, and aromatic aldehydes to give 3-methyl-4-aryl-4,5-dihydro-1H-pyrano[2,3-c]pyrazol-6-ones in refluxing water is reported. The yields are high and the reactions go to completion in 1-2 h

ChemInform Abstract: Microwave‐Assisted, Mild, Facile, and Rapid One‐Pot Three‐Component Synthesis of Some Novel Pyrano[2,3‐d]pyrimidine‐2,4,7‐triones.

Novel pyrano[2,3-d]pyrimidine-2,4,7-triones were synthesized in 90–97% yield via a three-component reaction of an aromatic aldehyde, Meldrums acid, and barbituric acid in the presence of 10 mol % K2CO3 under microwave irradiation. This is the first protocol to be reported for the synthesis of title compounds and the significant features of the present protocol are simplicity, high yields, short reaction time, involvement of aqueous work-up procedure, environmentally benign nature, and no chromatographic purification

ChemInform Abstract: One‐Pot Four‐Component Synthesis of Some Novel Octahydroquinolindiones Using ZnO as an Efficient Catalyst in Water

ZnO has been shown to be an inexpensive, efficient, readily available, and mild catalyst for a one-pot four-component synthesis of some novel octahydroquinolindione-3-carboxylic acid ethyl esters using diethylmalonate, dimedone, ammonium acetate, and appropriate aromatic aldehydes in water at reflux. ZnO acts as a recyclable heterogeneous catalyst to afford the products in excellent yield in short reaction duration

GREEN, RAPID, SIMPLE, AND AN EFFECTIVE ONE-POT MULTICOMPONENT STRATEGY FOR SYNTHESIS OF NOVEL DIHYDROPYRANO[2,3-C]PYRAZOL-6-AMINES IN AQUEOUS MEDIUM

Objectives:  A series of new dihydropyrano [2,3-c]pyrazol-6-amines in this investigation  study, are synthesized  by the strategy of one-pot four component reaction in an aqueous medium. Methods:  After getting optimum conditions the reaction of different substituted aromatic aldehydes, ethyl acetoacetate, hydrazine hydrate,  and phenylacetonitrile catalysed by Sodium hydrogen sulphate NaHSO4 (0.5 m mol) by refluxing in ethanol-water (1:1) (5 ml) and heated at 80 oC. The synthesized molecules product was filtered, washed with water to get nearly pure product in excellent yield. Results:  The pure products which were got in a short duration, with excellent yield (80 – 87%). Those new compounds were identified by using spectroscopic techniques FT-IR, 1H-NMR and 13C-NMR. Conclusion: In conclusion, the usefulness of this one-pot multicomponents protocol include easily available starting materials, facile, simple and environment-friendly procedure, and easier separation of products by filtration.                                   Peer Review History: Received 5 March 2020; Revised 11 April; Accepted 9 May, Available online 15 May 2020 Academic Editor: Dr. Asia Selman Abdullah, Al-Razi university, Department of Pharmacy, Yemen, [email protected] UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file:                Reviewer's Comments: Average Peer review marks at initial stage: 5.0/10 Average Peer review marks at publication stage: 7.0/10 Reviewer(s) detail: Prof Cyprian Ogbonna ONYEJI, Obafemi Awolowo University, Ile-Ife, Nigeria, [email protected] Dr. Md. Shahidul Islam, USTC, Chittagong, Bangladesh, [email protected] Similar Articles: TOXICITY AND ANTITRYPANOSOMAN ACTIVITY OF HEMI SYNTHESIS PRODUCTS OBTAINED FROM BIOACTIVE COMPOUNDS OF MITRACARPUS SCABER HARVESTED SOUTH OF BENI

Microwave-Assisted Direct Synthesis of Nitriles from Aromatic Aldehydes under Solvent-Free Condition

A simple and convenient one - pot protocol for preparing nitriles by treating different aromatic aldehydes with hydroxylamine hydrochloride in the presence of Na 2 CO 3 - a simple, mild, and inexpensive catalyst, without any s olvent under microwave irradiation is reported. The significant features of the present protocol are simplicity, high yields, short reaction time, involvement of non - aqueous work - up procedure, environmentally benign nature, using of microwave reactor and n o chromatographic purification