Investigating effect of Helicobacter pylori treatment on improvement of non-alcoholic fatty liver parameters: a randomized trial

Background and objective: The correlation between the eradication of Helicobacter pylori (HP) and non-alcoholic fatty liver disease (NAFLD) is a controversial one. The aim of this study is to investigate the effect of Helicobacter pylori treatment on liver function tests and lipid profiles and to compare its effects with exercise therapy and diet alone. Method: This was a double-blind randomized clinical trial conducted at Qazvin University of Medical Sciences. One hundred patients with NAFLD having a positive test for urea breath testing were randomly assigned into one of the intervention and comparison groups. The diet and physical activity program were given to two groups of patients for 8 weeks, three sessions per week. In addition to the above therapy, the patients in the intervention group also received HP treatment for 2weeks. The data corresponding to anthropometric and clinical features before and after the intervention were collected in both groups and compared using appropriate statistical methods. Results: After the treatment interventions, the variables of weight, BMI, blood glucose, triglyceride, AST, ALT, total cholesterol, and LDL-C were significantly decreased in both groups (p < .05). In the between-group comparisons, only ALT was significantly lower in the intervention group (HP) (p < .05). Conclusion: Findings of this study showed that the eradication of Helicobacter pylori could significantly improve the ALT index, but it had no additional effect on changes in metabolic indicators. Trial registration: Registration number: IRCT2015042020951N2 Name of trial registry: The study of treatment of Helicobacter pylori in improvement of non-alcoholic fatty liver disease The date of registration: 2015-05-12 Where the full trial protocol can be accessed: https://fa.irct.ir/trial/18489 Keywords: Non-alcoholic fatty liver disease, Helicobacter pylori, Alanine transaminase, Aspartate aminotransferase

Comparison of serum lead level in oral opium addicts with healthy control group

Lead poisoning can effect on the nervous system, endocrine, renal, reproductive and hematopoiesis. Present study is planned for investigating this issue between patients that use from oral opium and they are at risk of chronic lead poisoning. Materials and methods: present study was historical cohort in terms of lead poisoning in which patients admitted to the oral opium. 20 number of these patients selected after getting consent for participate in this study randomly. They assessed and compared with control group for lead poisoning symptoms, examination for possible symptoms of lead poisoning, laboratory studies included blood lead level, U/A in terms of protein, Glucose and Phosphate, CBC, RETIC Uric Acid, BUN, PBS lipid profile and LFT after registration of personal details. Findings: the average of blood lead level was 8.49± 5.34 Microgram per deciliter in case group and 4.2 ±4.1 Microgram per deciliter in control group that was significant difference on base of Mann_Whitney U test (p- value=0.005). Difference of WBC and MCV between case group and control group was significant. Difference between two groups was not significant For another variables. Results: present study findings show that blood lead level were higher than control group and difference was significant in terms of statistically despite of none of approved signs were found by lead poisoning laboratory in consumers of oral opium. It seems that these people should be evaluated periodically in terms of lead poisoning possibility. Keywords: Lead, Chronic poisoning, Opiu

Investigating effect of Helicobacter pylori treatment on improvement of nonalcoholic fatty liver parameters: a randomized trial

Background and objective: The correlation between the eradication of Helicobacter pylori (HP) and non-alcoholic fatty liver disease (NAFLD) is a controversial one. The aim of this study is to investigate the effect of Helicobacter pylori treatment on liver function tests and lipid profiles and to compare its effects with exercise therapy and diet alone. Method: This was a double-blind randomized clinical trial conducted at Qazvin University of Medical Sciences. One hundred patients with NAFLD having a positive test for urea breath testing were randomly assigned into one of the intervention and comparison groups. The diet and physical activity program were given to two groups of patients for 8 weeks, three sessions per week. In addition to the above therapy, the patients in the intervention group also received HP treatment for 2weeks. The data corresponding to anthropometric and clinical features before and after the intervention were collected in both groups and compared using appropriate statistical methods. Results: After the treatment interventions, the variables of weight, BMI, blood glucose, triglyceride, AST, ALT, total cholesterol, and LDL-C were significantly decreased in both groups (p < .05). In the between-group comparisons, only ALT was significantly lower in the intervention group (HP) (p < .05). Conclusion: Findings of this study showed that the eradication of Helicobacter pylori could significantly improve the ALT index, but it had no additional effect on changes in metabolic indicators. Trial registration: Registration number: IRCT2015042020951N2 Name of trial registry: The study of treatment of Helicobacter pylori in improvement of non-alcoholic fatty liver disease The date of registration: 2015-05-12 Where the full trial protocol can be accessed: https://fa.irct.ir/trial/18489 Keywords: Non-alcoholic fatty liver disease, Helicobacter pylori, Alanine transaminase, Aspartate aminotransferase

Integrated analysis of anatomical and electrophysiological human intracranial data

Contains fulltext : 195381.pdf (Publisher’s version ) (Open Access)25 p