1,908 research outputs found
Perceptions about the elisa test of people diagnosed at the aids stage
IndexaciĂłn: Web of Science; Scopus; Scielo.Background: The delay in the diagnosis of AIDS results in higher treatment costs. Aim: To reveal the experiences of people who were diagnosed in the AIDS stage about the access to the ELISA test. Material and Methods: In depth interviews were carried out to 15 participants from public hospitals who were in the AIDS stage at the moment of the diagnosis. The main questions asked were about the motivations to take the test, the barriers found and the help received from the health care personnel. All interviews were recorded and analyzed according to Kripperdorff. Results: The three categories that emerged were the motivations to take the test, the facilitators found and the difficulties to access to the test. The main motivation was a condition of vulnerability due to the suspicion or certainty of being infected. The main facilitator was the sensation of being accepted and not discriminated. The main difficulties were the fear of having a positive test and of being discriminated and the lack of information. Conclusions: Knowing these experiences will help to improve the early detection of HIV infections.http://ref.scielo.org/m53w8
Conservative and disruptive modes of adolescent change in human brain functional connectivity
Adolescent changes in human brain function are not entirely understood. Here, we used multiecho functional MRI (fMRI) to measure developmental change in functional connectivity (FC) of resting-state oscillations between pairs of 330 cortical regions and 16 subcortical regions in 298 healthy adolescents scanned 520 times. Participants were aged 14 to 26 y and were scanned on 1 to 3 occasions at least 6 mo apart. We found 2 distinct modes of age-related change in FC: âconservativeâ and âdisruptive.â Conservative development was characteristic of primary cortex, which was strongly connected at 14 y and became even more connected in the period from 14 to 26 y. Disruptive development was characteristic of association cortex and subcortical regions, where connectivity was remodeled: connections that were weak at 14 y became stronger during adolescence, and connections that were strong at 14 y became weaker. These modes of development were quantified using the maturational index (MI), estimated as Spearmanâs correlation between edgewise baseline FC (at 14 y, FC14) and adolescent change in FC (ÎFC14â26), at each region. Disruptive systems (with negative MI) were activated by social cognition and autobiographical memory tasks in prior fMRI data and significantly colocated with prior maps of aerobic glycolysis (AG), AG-related gene expression, postnatal cortical surface expansion, and adolescent shrinkage of cortical thickness. The presence of these 2 modes of development was robust to numerous sensitivity analyses. We conclude that human brain organization is disrupted during adolescence by remodeling of FC between association cortical and subcortical areas
Comparing theories: the dynamics of changing vocabulary. A case-study in relativity theory
There are several first-order logic (FOL) axiomatizations of special
relativity theory in the literature, all looking essentially different but
claiming to axiomatize the same physical theory. In this paper, we elaborate a
comparison, in the framework of mathematical logic, between these FOL theories
for special relativity. For this comparison, we use a version of mathematical
definability theory in which new entities can also be defined besides new
relations over already available entities. In particular, we build an
interpretation of the reference-frame oriented theory SpecRel into the
observationally oriented Signalling theory of James Ax. This interpretation
provides SpecRel with an operational/experimental semantics. Then we make
precise, "quantitative" comparisons between these two theories via using the
notion of definitional equivalence. This is an application of logic to the
philosophy of science and physics in the spirit of Johan van Benthem's work.Comment: 27 pages, 8 figures. To appear in Springer Book series Trends in
Logi
A Geometrical Characterization of the Twin Paradox and its Variants
The aim of this paper is to provide a logic-based conceptual analysis of the
twin paradox (TwP) theorem within a first-order logic framework. A geometrical
characterization of TwP and its variants is given. It is shown that TwP is not
logically equivalent to the assumption of the slowing down of moving clocks,
and the lack of TwP is not logically equivalent to the Newtonian assumption of
absolute time. The logical connection between TwP and a symmetry axiom of
special relativity is also studied.Comment: 22 pages, 3 figure
Teachersâ development of professional knowledge through action research and the facilitation of this by teacher educators
Wetensch. publicatieICLO
Twin Paradox and the logical foundation of relativity theory
We study the foundation of space-time theory in the framework of first-order
logic (FOL). Since the foundation of mathematics has been successfully carried
through (via set theory) in FOL, it is not entirely impossible to do the same
for space-time theory (or relativity). First we recall a simple and streamlined
FOL-axiomatization SpecRel of special relativity from the literature. SpecRel
is complete with respect to questions about inertial motion. Then we ask
ourselves whether we can prove usual relativistic properties of accelerated
motion (e.g., clocks in acceleration) in SpecRel. As it turns out, this is
practically equivalent to asking whether SpecRel is strong enough to "handle"
(or treat) accelerated observers. We show that there is a mathematical
principle called induction (IND) coming from real analysis which needs to be
added to SpecRel in order to handle situations involving relativistic
acceleration. We present an extended version AccRel of SpecRel which is strong
enough to handle accelerated motion, in particular, accelerated observers.
Among others, we show that the Twin Paradox becomes provable in AccRel, but it
is not provable without IND.Comment: 24 pages, 6 figure
Phase 2 study of combination SPI-1620 with docetaxel as second-line advanced biliary tract cancer treatment
Axiomatizing relativistic dynamics without conservation postulates
A part of relativistic dynamics (or mechanics) is axiomatized by simple and
purely geometrical axioms formulated within first-order logic. A geometrical
proof of the formula connecting relativistic and rest masses of bodies is
presented, leading up to a geometric explanation of Einstein's famous .
The connection of our geometrical axioms and the usual axioms on the
conservation of mass, momentum and four-momentum is also investigated.Comment: 21 pages, 7 figure
Trapped lipopolysaccharide and LptD intermediates reveal lipopolysaccharide translocation steps across the Escherichia coli outer membrane
Lipopolysaccharide (LPS) is a main component of the outer membrane of Gram-negative bacteria, which is essential for the vitality of most Gram-negative bacteria and plays a critical role for drug resistance. LptD/E complex forms a N-terminal LPS transport slide, a hydrophobic intramembrane hole and the hydrophilic channel of the barrel, for LPS transport, lipid A insertion and core oligosaccharide and O-antigen polysaccharide translocation, respectively. However, there is no direct evidence to confirm that LptD/E transports LPS from the periplasm to the external leaflet of the outer membrane. By replacing LptD residues with an unnatural amino acid p-benzoyl-L-phenyalanine (pBPA) and UV-photo-cross-linking in E.coli, the translocon and LPS intermediates were obtained at the N-terminal domain, the intramembrane hole, the lumenal gate, the lumen of LptD channel, and the extracellular loop 1 and 4, providing the first direct evidence and âsnapshotsâ to reveal LPS translocation steps across the outer membrane
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