24 research outputs found
Catching GRBs with atmospheric Cherenkov telescopes
Fermi has shown GRBs to be a source of >10 GeV photons. We present an
estimate of the detection rate of GRBs with a next generation Cherenkov
telescope. Our predictions are based on the observed properties of GRBs
detected by Fermi, combined with the spectral properties and redshift
determinations for the bursts population by instruments operating at lower
energies. While detection of VHE emission from GRBs has eluded ground-based
instruments thus far, our results suggest that ground-based detection may be
within reach of the proposed Cherenkov Telescope Array (CTA), albeit with a low
rate, 0.25 - 0.5/yr. Such a detection would help constrain the emission
mechanism of gamma-ray emission from GRBs. Photons at these energies from
distant GRBs are affected by the UV-optical background light, and a
ground-based detection could also provide a valuable probe of the Extragalactic
Background Light (EBL) in place at high redshift.Comment: 4 pages, 3 figures, to appear in the Proceedings of "Gamma Ray Bursts
2010", held Nov. 1-4, 2010 in Annapolis, M
Incidence of HIV-related anal cancer remains increased despite long-term combined antiretroviral treatment: results from the french hospital database on HIV.
PURPOSE: To study recent trends in the incidence of anal cancer in HIV-infected patients receiving long-term combined antiretroviral treatment (cART) compared with the general population. PATIENTS AND METHODS: From the French Hospital Database on HIV, we identified 263 cases of invasive anal squamous cell carcinoma confirmed histologically between 1992 and 2008. We compared incidence rates of anal cancer across four calendar periods: 1992-1996 (pre-cART period), 1997-2000 (early cART period), and 2001-2004 and 2005-2008 (recent cART periods). Standardized incidence ratios (SIRs) were calculated by using general population incidence data from the French Network of Cancer Registries. RESULTS: In HIV-infected patients, the hazard ratio (HR) in the cART periods versus the pre-cART period was 2.5 (95% CI, 1.28 to 4.98). No difference was observed across the cART calendar periods (HR, 0.9; 95% CI, 0.6 to 1.3). In 2005-2008, HIV-infected patients compared with the general population had an excess risk of anal cancer, with SIRs of 109.8 (95% CI, 84.6 to 140.3), 49.2 (95% CI, 33.2 to 70.3), and 13.1 (95% CI, 6.8 to 22.8) for men who have sex with men (MSM), other men, and women, respectively. Among patients with CD4 cell counts above 500/ÎŒL for at least 2 years, SIRs were 67.5 (95% CI, 41.2 to 104.3) when the CD4 nadir was less than 200/ÎŒL for more than 2 years and 24.5 (95% CI, 17.1 to 34.1) when the CD4 nadir was more than 200/ÎŒL. CONCLUSION: Relative to that in the general population, the risk of anal cancer in HIV-infected patients is still extremely high, even in patients with high current CD4 cell counts. cART appears to have no preventive effect on anal cancer, particularly in MSM
Photosensor Characterization for the Cherenkov Telescope Array: Silicon Photomultiplier versus Multi-Anode Photomultiplier Tube
Photomultiplier tube technology has been the photodetector of choice for the
technique of imaging atmospheric Cherenkov telescopes since its birth more than
50 years ago. Recently, new types of photosensors are being contemplated for
the next generation Cherenkov Telescope Array. It is envisioned that the array
will be partly composed of telescopes using a Schwarzschild-Couder two mirror
design never built before which has significantly improved optics. The camera
of this novel optical design has a small plate scale which enables the use of
compact photosensors. We present an extensive and detailed study of the two
most promising devices being considered for this telescope design: the silicon
photomultiplier and the multi-anode photomultiplier tube. We evaluated their
most critical performance characteristics for imaging gamma-ray showers, and we
present our results in a cohesive manner to clearly evaluate the advantages and
disadvantages that both types of device have to offer in the context of GeV-TeV
gamma-ray astronomy.Comment: submitted to SPIE Optics+Photonics proceeding
Modeling GeV Observations of Gamma-ray Bursts
Fermi has shown GRBs to be a source of >10 GeV photons. We present an estimate of the detection rate of GRBs with the future Cherenkov Telescope Array (CTA). Our predictions are based on the observed properties of GRBs detected by Fermi, combined with the spectral properties and redshift determinations for the bursts population by in struments operating at lower energies. We develop two model for high energy prompt and early afterglow emission, and show how the probability of detection is affected by instrument effecti ve area, response time, and energy threshold. While detection of VHE emission from GRBs has eluded ground-based instruments thus far, our results suggest that ground-based detection may be within reach of CTA, though detections would be infrequent even with prompt followup to all valid satellite triggers. We estimate a rate of one GRB every 2 â 3 years based on the trigger rate from the Swift satellite, provided that no spectral softening or cutoff features below 100 GeV exist in a significant number of GRBs. Such a detection would help constrain the emission mechanism of gamma-ray emission from GRBs. Photons at these energies from distant GRBs are affected by the UV-optical background light, and a ground-based detection could also provide a valuable probe of the Extragalactic Background Light (EBL) in place at high redshift
IACT observations of gamma-ray bursts: prospects for the Cherenkov Telescope Array
Gamma rays at rest frame energies as high as 90 GeV have been reported from
gamma-ray bursts (GRBs) by the Fermi Large Area Telescope (LAT). There is
considerable hope that a confirmed GRB detection will be possible with the
upcoming Cherenkov Telescope Array (CTA), which will have a larger effective
area and better low-energy sensitivity than current-generation imaging
atmospheric Cherenkov telescopes (IACTs). To estimate the likelihood of such a
detection, we have developed a phenomenological model for GRB emission between
1 GeV and 1 TeV that is motivated by the high-energy GRB detections of
Fermi-LAT, and allows us to extrapolate the statistics of GRBs seen by lower
energy instruments such as the Swift-BAT and BATSE on the Compton Gamma-ray
Observatory. We show a number of statistics for detected GRBs, and describe how
the detectability of GRBs with CTA could vary based on a number of parameters,
such as the typical observation delay between the burst onset and the start of
ground observations. We also consider the possibility of using GBM on Fermi as
a finder of GRBs for rapid ground follow-up. While the uncertainty of GBM
localization is problematic, the small field-of-view for IACTs can potentially
be overcome by scanning over the GBM error region. Overall, our results
indicate that CTA should be able to detect one GRB every 20 to 30 months with
our baseline instrument model, assuming consistently rapid pursuit of GRB
alerts, and provided that spectral breaks below 100 GeV are not a common
feature of the bright GRB population. With a more optimistic instrument model,
the detection rate can be as high as 1 to 2 GRBs per year.Comment: 28 pages, 24 figures, 4 tables, submitted to Experimental Astronom
A population of gamma-ray emitting globular clusters seen with the Fermi Large Area Telescope
Globular clusters with their large populations of millisecond pulsars (MSPs)
are believed to be potential emitters of high-energy gamma-ray emission. Our
goal is to constrain the millisecond pulsar populations in globular clusters
from analysis of gamma-ray observations. We use 546 days of continuous
sky-survey observations obtained with the Large Area Telescope aboard the Fermi
Gamma-ray Space Telescope to study the gamma-ray emission towards 13 globular
clusters. Steady point-like high-energy gamma-ray emission has been
significantly detected towards 8 globular clusters. Five of them (47 Tucanae,
Omega Cen, NGC 6388, Terzan 5, and M 28) show hard spectral power indices and clear evidence for an exponential cut-off in the range
1.0-2.6 GeV, which is the characteristic signature of magnetospheric emission
from MSPs. Three of them (M 62, NGC 6440 and NGC 6652) also show hard spectral
indices , however the presence of an exponential cut-off
can not be unambiguously established. Three of them (Omega Cen, NGC 6388, NGC
6652) have no known radio or X-ray MSPs yet still exhibit MSP spectral
properties. From the observed gamma-ray luminosities, we estimate the total
number of MSPs that is expected to be present in these globular clusters. We
show that our estimates of the MSP population correlate with the stellar
encounter rate and we estimate 2600-4700 MSPs in Galactic globular clusters,
commensurate with previous estimates. The observation of high-energy gamma-ray
emission from a globular cluster thus provides a reliable independent method to
assess their millisecond pulsar populations that can be used to make
constraints on the original neutron star X-ray binary population, essential for
understanding the importance of binary systems in slowing the inevitable core
collapse of globular clusters.Comment: Accepted for publication in A&A. Corresponding authors: J.
Kn\"odlseder, N. Webb, B. Pancraz
Methods to Investigate the Global Atmospheric Microbiome
The interplay between microbes and atmospheric physical and chemical conditions is an open field of research that can only be fully addressed using multidisciplinary approaches. The lack of coordinated efforts to gather data at representative temporal and spatial scales limits aerobiology to help understand large scale patterns of global microbial biodiversity and its causal relationships with the environmental context. This paper presents the sampling strategy and analytical protocols developed in order to integrate different fields of research such as microbiology, âomics biology, atmospheric chemistry, physics and meteorology to characterize atmospheric microbial life. These include control of chemical and microbial contaminations from sampling to analysis and identification of experimental procedures for characterizing airborne microbial biodiversity and its functioning from the atmospheric samples collected at remote sites from low cell density environments. We used high-volume sampling strategy to address both chemical and microbial composition of the atmosphere, because it can help overcome low aerosol and microbial cell concentrations. To account for contaminations, exposed and unexposed control filters were processed along with the samples. We present a method that allows for the extraction of chemical and biological data from the same quartz filters. We tested different sampling times, extraction kits and methods to optimize DNA yield from filters. Based on our results, we recommend supplementary sterilization steps to reduce filter contamination induced by handling and transport. These include manipulation under laminar flow hoods and UV sterilization. In terms of DNA extraction, we recommend a vortex step and a heating step to reduce binding to the quartz fibers of the filters. These steps have led to a 10-fold increase in DNA yield, allowing for downstream omics analysis of air samples. Based on our results, our method can be integrated into pre-existing long-term monitoring field protocols for the atmosphere both in terms of atmospheric chemistry and biology. We recommend using standardized air volumes and to develop standard operating protocols for field users to better control the operational quality