129 research outputs found
Gravitationally lensed quasars in Gaia: I. Resolving small-separation lenses
Gaia’s exceptional resolution (FWHM ~ 0.1 arcsec) allows identification and cataloguing of the multiple images of gravitationally lensed quasars. We investigate a sample of 49 known lensed quasars in the Sloan Digital Sky Survey (SDSS) footprint, with image separations less than 2 arcsec, and find that eight are detected with multiple components in the first Gaia data release. In the case of the 41 single Gaia detections, we generally are able to distinguish these lensed quasars from single quasars when comparing Gaia flux and position measurements to those of Pan-STARRS and SDSS. This is because the multiple images of these lensed quasars are typically blended in ground-based imaging and therefore the total flux and a flux-weighted centroid are measured, which can differ significantly from the fluxes and centroids of the individual components detected by Gaia. We compare the fluxes through an empirical fit of Pan-STARRS griz photometry to the wide optical Gaia bandpass values using a sample of isolated quasars. The positional offsets are calculated from a recalibrated astrometric SDSS catalogue. Applying flux and centroid difference criteria to spectroscopically confirmed quasars, we discover four new sub-arcsecond-separation lensed quasar candidates which have two distinct components of similar colour in archival Canada–France–Hawaii Telescope or Hyper Suprime Cam data. Our method based on single Gaia detections can be used to identify the ~1400 lensed quasars with image separation above 0.5 arcsec, expected to have only one image bright enough to be detected by Gaia
Gravitationally lensed quasars in Gaia - II. Discoveryof 24 lensed quasars
We report the discovery, spectroscopic confirmation and preliminary
characterisation of 24 gravitationally lensed quasars identified using Gaia
observations. Candidates were selected in the Pan-STARRS footprint with
quasar-like WISE colours or as photometric quasars from SDSS, requiring either
multiple detections in Gaia or a single Gaia detection near a morphological
galaxy. The Pan-STARRS grizY images were modelled for the most promising
candidates and 60 candidate systems were followed up with the William Herschel
Telescope. 13 of the lenses were discovered as Gaia multiples and 10 as single
Gaia detections near galaxies. We also discover 1 lens identified through a
quasar emission line in an SDSS galaxy spectrum. The lenses have median image
separation 2.13 arcsec and the source redshifts range from 1.06 to 3.36. 4
systems are quadruply-imaged and 20 are doubly-imaged. Deep CFHT data reveal an
Einstein ring in one double system. We also report 12 quasar pairs, 10 of which
have components at the same redshift and require further follow-up to rule out
the lensing hypothesis. We compare the properties of these lenses and other
known lenses recovered by our search method to a complete sample of simulated
lenses to show the lenses we are missing are mainly those with small
separations and higher source redshifts. The initial Gaia data release only
catalogues all images of ~ 30% of known bright lensed quasars, however the
improved completeness of Gaia data release 2 will help find all bright lensed
quasars on the sky
The discovery of a five-image lensed quasar at z = 3.34 using PanSTARRS1 and Gaia
We report the discovery, spectroscopic confirmation, and mass modelling of
the gravitationally lensed quasar system PS J0630-1201. The lens was discovered
by matching a photometric quasar catalogue compiled from Pan-STARRS and WISE
photometry to the Gaia DR1 catalogue, exploiting the high spatial resolution of
the latter (FWHM 0.1") to identify the three brightest components of the
lens. Follow-up spectroscopic observations with the WHT confirm the multiple
objects are quasars at redshift . Further follow-up with Keck AO
high-resolution imaging reveals that the system is composed of two lensing
galaxies and the quasar is lensed into a 2.8" separation four-image cusp
configuration with a fifth image clearly visible, and a 1.0" arc due to the
lensed quasar host galaxy. The system is well-modelled with two singular
isothermal ellipsoids, reproducing the position of the fifth image. We discuss
future prospects for measuring time delays between the images and constraining
any offset between mass and light using the faintly detected Einstein arcs
associated with the quasar host galaxy
The joint influence of area income, income inequality, and immigrant density on adverse birth outcomes: a population-based study
<p>Abstract</p> <p>Background</p> <p>The association between area characteristics and birth outcomes is modified by race. Whether such associations vary according to social class indicators beyond race has not been assessed.</p> <p>Methods</p> <p>This study evaluated effect modification by maternal birthplace and education of the relationship between neighbourhood characteristics and birth outcomes of newborns from 1999–2003 in the province of Québec, Canada (N = 353,120 births). Areas (N = 143) were defined as administrative local health service delivery districts. Multi-level logistic regression was used to model the association between three area characteristics (median household income, immigrant density and income inequality) and the two outcomes preterm birth (PTB) and small-for-gestational age (SGA) birth. Effect modification by social class indicators was evaluated in analyses stratified according to maternal birthplace and education.</p> <p>Results</p> <p>Relative to the lowest tertile, high median household income was associated with SGA birth among Canadian-born mothers (odds ratio (OR) 1.13, 95% confidence interval (CI) 1.06, 1.20) and mothers with high school education or less (OR 1.13, 95% CI 1.02, 1.24). Associations between median household income and PTB were weaker. Relative to the highest tertile, low immigrant density was associated with a lower odds of PTB among foreign-born mothers (OR 0.79, 95% CI 0.63, 1.00) but a higher odds of PTB among Canadian-born mothers (OR 1.14, 95% CI 1.07, 1.21). Associations with income inequality were weak or absent.</p> <p>Conclusion</p> <p>The association between area factors and birth outcomes is modified by maternal birthplace and education. Studies have found that race interacts in a similar manner. Public health policies focussed on perinatal health must consider the interaction between individual and area characteristics.</p
Determining the neurotransmitter concentration profile at active synapses
Establishing the temporal and concentration profiles of neurotransmitters during synaptic release is an essential step towards understanding the basic properties of inter-neuronal communication in the central nervous system. A variety of ingenious attempts has been made to gain insights into this process, but the general inaccessibility of central synapses, intrinsic limitations of the techniques used, and natural variety of different synaptic environments have hindered a comprehensive description of this fundamental phenomenon. Here, we describe a number of experimental and theoretical findings that has been instrumental for advancing our knowledge of various features of neurotransmitter release, as well as newly developed tools that could overcome some limits of traditional pharmacological approaches and bring new impetus to the description of the complex mechanisms of synaptic transmission
A review of elliptical and disc galaxy structure, and modern scaling laws
A century ago, in 1911 and 1913, Plummer and then Reynolds introduced their
models to describe the radial distribution of stars in `nebulae'. This article
reviews the progress since then, providing both an historical perspective and a
contemporary review of the stellar structure of bulges, discs and elliptical
galaxies. The quantification of galaxy nuclei, such as central mass deficits
and excess nuclear light, plus the structure of dark matter halos and cD galaxy
envelopes, are discussed. Issues pertaining to spiral galaxies including dust,
bulge-to-disc ratios, bulgeless galaxies, bars and the identification of
pseudobulges are also reviewed. An array of modern scaling relations involving
sizes, luminosities, surface brightnesses and stellar concentrations are
presented, many of which are shown to be curved. These 'redshift zero'
relations not only quantify the behavior and nature of galaxies in the Universe
today, but are the modern benchmark for evolutionary studies of galaxies,
whether based on observations, N-body-simulations or semi-analytical modelling.
For example, it is shown that some of the recently discovered compact
elliptical galaxies at 1.5 < z < 2.5 may be the bulges of modern disc galaxies.Comment: Condensed version (due to Contract) of an invited review article to
appear in "Planets, Stars and Stellar
Systems"(www.springer.com/astronomy/book/978-90-481-8818-5). 500+ references
incl. many somewhat forgotten, pioneer papers. Original submission to
Springer: 07-June-201
VDES J2325-5229 a z=2.7 gravitationally lensed quasar discovered using morphology independent supervised machine learning
We present the discovery and preliminary characterization of a gravitationally lensed quasar with a source redshift = 2.74 and image separation of 2.9 arcsec lensed by a foreground = 0.40 elliptical galaxy. Since optical observations of gravitationally lensed quasars show the lens system as a superposition of multiple point sources and a foreground lensing galaxy, we have developed a morphology-independent multi-wavelength approach to the photometric selection of lensed quasar candidates based on Gaussian Mixture Models (GMM) supervised machine learning. Using this technique and multicolour photometric observations from the Dark Energy Survey (DES), near-IR photometry from the VISTA Hemisphere Survey (VHS) and WISE mid-IR photometry, we have identified a candidate system with two catalogue components with = 18.61 and = 20.44 comprising an elliptical galaxy and two blue point sources. Spectroscopic follow-up with NTT and the use of an archival AAT spectrum show that the point sources can be identified as a lensed quasar with an emission line redshift of = 2.739 ± 0.003 and a foreground early-type galaxy with = 0.400 ± 0.002. We model the system as a single isothermal ellipsoid and find the Einstein radius θE ∼ 1.47 arcsec, enclosed mass enc ∼ 4 × 10⊙ and a time delay of ∼52 d. The relatively wide separation, month scale time delay duration and high redshift make this an ideal system for constraining the expansion rate beyond a redshift of 1.FO is supported jointly by CAPES (the Science without Borders programme) and the Cambridge Commonwealth Trust. RGM, CAL, MWA, MB, SLR acknowledge the support of UK Science and Technology Research Council (STFC). AJC acknowledges the support of a Raymond and Beverly Sackler visiting fellowship at the Institute of Astronomy.
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Long-term efficacy of botulinum toxin A for treatment of blepharospasm,hemifacial spasm, and spastic entropion: a multicentre study using two drug-dose escalation indexes
PURPOSE: To investigate the long-term effectiveness and safety of botulinum
neurotoxin A (BoNT-A) treatment in patients with blepharospasm (BEB), hemifacial
spasm (HFS), and entropion (EN) and to use for the first time two modified indexes, 'botulin toxin escalation index-U' (BEI-U) and 'botulin toxin escalation
index percentage' (BEI-%), in the dose-escalation evaluation. METHODS: All
patients in this multicentre study were followed for at least 10 years and main
outcomes were clinical efficacy, duration of relief, BEI-U and BEI-%, and
frequency of adverse events. RESULTS: BEB, HFS, and EN patients received a mean
BoNT-A dose with a significant inter-group difference (P<0.0005, respectively).
The mean (+/-SD) effect duration was statistically different (P=0.009) among
three patient groups. Regarding the BoNT-A escalation indexes, the mean (+/-SD)
values of BEI-U and BEI-% were statistically different (P=0.035 and 0.047,
respectively) among the three groups. In BEB patients, the BEI-% was
significantly increased in younger compared with older patients (P=0.008). The
most frequent adverse events were upper lid ptosis, diplopia, ecchymosis, and
localized bruising. CONCLUSIONS: This long-term multicentre study supports a high
efficacy and good safety profile of BoNT-A for treatment of BEB, HFS, and EN. The
BEI indexes indicate a significantly greater BoNT-A-dose escalation for BEB
patients compared with HFS or EN patients and a significantly greater BEI-% in
younger vsolder BEB patients. These results confirm a greater efficacy in the
elderly and provide a framework for long-term studies with a more flexible and
reliable evaluation of drug-dose escalation
Alcohol Exposure Decreases CREB Binding Protein Expression and Histone Acetylation in the Developing Cerebellum
Fetal alcohol exposure affects 1 in 100 children making it the leading cause of mental retardation in the US. It has long been known that alcohol affects cerebellum development and function. However, the underlying molecular mechanism is unclear.We demonstrate that CREB binding protein (CBP) is widely expressed in granule and Purkinje neurons of the developing cerebellar cortex of naïve rats. We also show that exposure to ethanol during the 3(rd) trimester-equivalent of human pregnancy reduces CBP levels. CBP is a histone acetyltransferase, a component of the epigenetic mechanism controlling neuronal gene expression. We further demonstrate that the acetylation of both histone H3 and H4 is reduced in the cerebellum of ethanol-treated rats.These findings indicate that ethanol exposure decreases the expression and function of CBP in the developing cerebellum. This effect of ethanol may be responsible for the motor coordination deficits that characterize fetal alcohol spectrum disorders
Discovery of the lensed quasar system DES J0408-5354
We report the discovery and spectroscopic confirmation of the quad-like lensed quasar system DES J0408-5354 found in the Dark Energy Survey (DES) Year 1 (Y1) data. This system was discovered during a search for DES Y1 strong lensing systems using a method that identified candidates as red galaxies with multiple blue neighbors. DES J0408-5354 consists of a central red galaxy surrounded by three bright (i<20) blue objects and a fourth red object. Subsequent spectroscopic observations using the Gemini South telescope confirmed that the three blue objects are indeed the lensed images of a quasar with redshift z = 2.375, and that the central red object is an early-type lensing galaxy with redshift z = 0.597. DES J0408-5354 is the first quad lensed quasar system to be found in DES and begins to demonstrate the potential of DES to discover and dramatically increase the sample size of these very rare objects
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