Matthias Grawehr, Eine Bronzewerkstatt des 1. Jhs. n. Chr. von ez Zantur in Petra/Jordanien, Petra –ez Zantur IV, Ergebnisse der Schweizerisch-Liechtensteinischen Ausgrabungen

Matthias Grawehr est l’auteur, dans la même série, d’une étude très bien documentée et fort utile sur les lampes (dans Petra -ez Zantur III, Teil 2. Die Lampen der Grabungen auf ez Zantur in Petra = Terra Archaeologica, Band V, Mayence, 2006). Il expose ici ses recherches sur un atelier de bronzier nabatéen fouillé sur ce site. L’ouvrage est, comme tous ses prédécesseurs, magnifiquement édité : l’illustration est abondante et de qualité (26 tabl. et 205 ill., dessins et photogr. n/b d’excelle..

Letter to the Editor: 1 H, 15 N and 13 C chemical shift assignments of the Pleckstrin Homology domain of the Human Protein Kinase B (PKB/Akt)

International audienc

De Reqem à Pétra : investigations au cœur de la Cité rose

Mentionnée brièvement dans les textes aux ive-iiie siècles avant notre ère, Reqem ou Pétra, cité caravanière et capitale d’un royaume unifié, connaît une longue histoire marquée par la royauté nabatéenne puis par l’intégration à l’Empire romain en 106 de notre ère, mettant fin à son statut d’état-client. Le tremblement de terre de 363 marque un tournant décisif dans le développement de la cité qui sombrera par la suite progressivement dans l’oubli au moment de l’avènement de l’islam. Redécouv..

Combining gene mapping and phenotype assessment for fast mutation finding in non consanguineous autosomal recessive retinitis pigmentosa: mutation finding in non consanguineous families

International audienceAmong inherited retinal dystrophies, autosomal recessive retinitis pigmentosa (arRP) is the most genetically heterogenous condition with 32 genes currently known that account for ~60 % of patients. Molecular diagnosis thus requires the tedious systematic sequencing of 506 exons. To rapidly identify the causative mutations, we devised a strategy that combines gene mapping and phenotype assessment in small non consanguineous families. Two unrelated sibships with arRP had whole-genome scan using SNP microchips. Chromosomal regions were selected by calculating a score based on SNP coverage and genotype identity of affected patients. Candidate genes from the regions with the highest scores were then selected based on phenotype concordance of affected patients with previously described phenotype for each candidate gene. For families RP127 and RP1459, 33 and 40 chromosomal regions showed possible linkage, respectively. By comparing the scores with the phenotypes, we ended with one best candidate gene for each family, namely TULP1 and C2ORF71 for RP127 and RP1459, respectively. We found that RP127 patients were compound heterozygous for 2 novel TULP1 mutations, p.Arg311Gln and p.Arg342Gln, and that RP1459 patients were compound heterozygous for 2 novel C2ORF71 mutations, p.Leu777PhefsX34 and p.Leu777AsnfsX28. Phenotype assessment showed that TULP1 patients had severe early onset arRP and that C2ORF71 patients had a cone rod dystrophy type of arRP. Only 2 affected individuals in each sibship were sufficient to lead to mutation identification by screening the best candidate gene selected by a combination of gene mapping and phenotype characterization

Reading Across Cultures: Global Narratives, Hotels and Railway Stations

This is the final version of the article. Available from Springer Verlag via the DOI in this record.This article takes its cue from the English critic, novelist and painter John Berger. He argues that what we know determines what we see. Hotels and railway stations, though they differ in size, design and appearance, are places of temporary national and international congress that are recognized by everyone. They become visible or even iconic once their history or their role is turned into at least part of a wider narrative—in literature, film or in other arts. This provides a representative focus by which we may read a city’s or a nation’s past. In exemplifying such connections I focus first on the long-term history of Friedrichstraße station and some of the surrounding hotels in the context of the history of Berlin, situating them within the national and, by implication, also the international context. Secondly, I will consider the outbreak of the First World War in 1914 as an event in which the role of railway stations generated both personal and collective memories across cultures and over several decades

A novel locus (CORD12) for autosomal dominant cone-rod dystrophy on chromosome 2q24.2-2q33.1

<p>Abstract</p> <p>Background</p> <p>Rod-cone dystrophy, also known as retinitis pigmentosa (RP), and cone-rod dystrophy (CRD) are degenerative retinal dystrophies leading to blindness. To identify new genes responsible for these diseases, we have studied one large non consanguineous French family with autosomal dominant (ad) CRD.</p> <p>Methods</p> <p>Family members underwent detailed ophthalmological examination. Linkage analysis using microsatellite markers and a whole-genome SNP analysis with the use of Affymetrix 250 K SNP chips were performed. Five candidate genes within the candidate region were screened for mutations by direct sequencing.</p> <p>Results</p> <p>We first excluded the involvement of known adRP and adCRD genes in the family by genotyping and linkage analysis. Then, we undertook a whole-genome scan on 22 individuals in the family. The analysis revealed a 41.3-Mb locus on position 2q24.2-2q33.1. This locus was confirmed by linkage analysis with specific markers of this region. The maximum LOD score was 2.86 at θ = 0 for this locus. Five candidate genes, <it>CERKL</it>, <it>BBS5, KLHL23, NEUROD1</it>, and <it>SF3B1 </it>within this locus, were not mutated.</p> <p>Conclusion</p> <p>A novel locus for adCRD, named <it>CORD12</it>, has been mapped to chromosome 2q24.2-2q33.1 in a non consanguineous French family.</p

Construction, assembly and tests of the ATLAS electromagnetic barrel calorimeter

The construction and assembly of the two half barrels of the ATLAS central electromagnetic calorimeter and their insertion into the barrel cryostat are described. The results of the qualification tests of the calorimeter before installation in the LHC ATLAS pit are given

Roman Arabia

The new province of Arabia created by Trajan united the old Nabatene with Transjordanian territories formerly dependent on the province of Syria, including several cities of the ancient Decapolis. Its capital was Bostra in southern Syria, and the construction between 111 and 114, probably for military reasons, of the via nova Traiana connecting Aqaba with Bostra confirmed this focus (fig. III.14). Petra, despite its title of “Metropolis” and Hadrian’s visit, played only a secondary role (plat..

The Nabataean Age (4th century BC - 1st century AD)

We do not know the exact origins of the Nabataeans; they are a nomadic people from Arabia who settled in present-day Jordan between the 6th and 4th centuries BC. In 312, they already occupied the former lands of the Edomites, between Wadi al-Hasa (Zered) and the Gulf of Aqaba (Aila), and resisted Antigone, one of Alexander’s successors. The control of trade routes ensured their wealth. During the Hellenistic period, Petra, a storage area and shelter, became the capital of a kingdom that exten..

23. Geissen (Angelo). Katalog Alexandrinischer Kaisermünzen der Sammlung des Instituts für Altertumskunde der Universitat zu Köln. Band I, Augustus-Trajan (Nr. 1-740)

Augé Christian. 23. Geissen (Angelo). Katalog Alexandrinischer Kaisermünzen der Sammlung des Instituts für Altertumskunde der Universitat zu Köln. Band I, Augustus-Trajan (Nr. 1-740). In: Revue des Études Grecques, tome 89, fascicule 424-425, Janvier-juin 1976. pp. 133-135