Malignant disease in childhood : the price of cure : late physical and socioeconomic effects of treatment

The aim of cancer therapy in childhood is to achieve a lasting cure without physical and psychosocial harm and, preferably, at a low financial cost. Although cure is possible in many types of childhood cancer, this is often accompanied by complications as a consequence of intensive therapy. These late effects primarily affect fertility, the cardio-respiratory and endocrinological systems. Psychosocial adverse effects may have serious implications on the marriage and employment prospects of those patients surviving into adulthood. Furthermore, the risk of treatment-induced, secondary malignancies may increase as survival improves. With current intensive chemotherapy and radiotherapy, the attainment of cure rates in (EXC)ess of 60-70% is, inevitably, associated with significant morbidity. Indeed, recent developments in cancer therapy have focused on ways of reducing this morbidity, whilst still maintaining the overall improvement in survival.peer-reviewe

TangiBoard: a toolkit to reduce the implementation burden of tangible user interfaces in education

The use of Tangible User Interfaces (TUI) as an educational technology has gained sustained interest over the years with common agreement on its innate ability to engage and intrigue students in active-learning pedagogies. Whilst encouraging results have been obtained in research, the widespread adoption of TUI architectures is still hindered by a myriad of implementation burdens imposed by current toolkits. To this end, this paper presents an innovative TUI toolkit: TangiBoard, which enables the deployment of an interactive TUI system using low-cost, and presently available educational technology. Apart from curtailing setup costs and technical expertise required for adopting TUI systems, the toolkit provides an application framework to facilitate system calibration and development integration with GUI applications. This is enabled by a robust computer vision application that tracks a contributed passive marker set providing a range of tangible interactions to TUI frameworks. The effectiveness of this toolkit was evaluated by computer systems developers with respect to alternate toolkits for TUI design. Open-source versions of the TangiBoard toolkit together with marker sets are provided online through research licens

Comparison of minimally invasive parathyroidectomy under local anaesthesia and minimally invasive video-assisted parathyroidectomy for primary hyperparathyroidism: A cost analysis

Background: Primary hyperparathyroidism (PHPT) origins from a solitary adenoma in 70-95% of cases. Moreover, the advances in methods for localizing an abnormal parathyroid gland made minimally invasive techniques more prominent. This study presents a micro-cost analysis of two parathyroidectomy techniques. Patients and methods: 72 consecutive patients who underwent minimally invasive parathyroidectomy, video-assisted (MIVAP, group A, 52 patients) or "open" under local anaesthesia (OMIP, group B, 20 patients) for PHPT were reviewed. Operating room, consumable, anaesthesia, maintenance costs, equipment depreciation and surgeons/anaesthesiologists fees were evaluated. The patient's satisfaction and the rate of conversion to conventional parathyroidectomy were investigated. T-Student's, Kolmogorov-Smirnov tests and Odds Ratio were used for statistical analysis. Results: 1 patient of the group A and 2 of the group B were excluded from the cost analysis because of the conversion to the conventional technique. Concerning the remnant patients, the overall average costs were: for Operative Room, 1186,69 \u20ac for the MIVAP group (51 patients) and 836,11 \u20ac for the OMIP group (p<0,001); for the Team, 122,93 \u20ac (group A) and 90,02 \u20ac (group B) (p<0,001); the other operative costs were 1388,32 \u20ac (group A) and 928,23 \u20ac (group B) (p<0,001). The patient's satisfaction was very strongly in favour of the group B (Odds Ratio 20,5 with a 95% confidence interval). Conclusions: MIVAP is more expensive compared to the "open" parathyroidectomy under local anaesthesia due to the costs of general anaesthesia and the longer operative time. Moreover, the patients generally prefer the local anaesthesia. Nevertheless, the rate of conversion to the conventional parathyroidectomy was relevant in the group of the local anaesthesia compared to the MIVAP, since the latter allows a four-gland exploration

The Smeed Report and road pricing : the case of Valletta, Malta

In 1964 the Ministry of Transport in the UK published a seminal paper on Road Pricing, namely „Road Pricing: The Economic and Technical Possibilities‟ which became known as the Smeed Report, named after Reuben Smeed the Chair of the Panel on Road Pricing and who, at the time, was Head of Traffic and Safety Division within the UK Road Research Laboratory. The Report detailed seventeen requirements for a road pricing system, which were seen as either important or desirable. These requirements are as relevant today as they which have failed to advance beyond the drawing board. One scheme that has been successfully implemented recently in Malta is the Valletta road pricing scheme, referred to as the Controlled Vehicular Access (CVA) system. The aim of this paper is to compare the Valletta scheme against the requirements for a road pricing system outlined in the Smeed Report (hereinafter referred to as the Smeed Requirements), with the intention of ascertaining whether there are any lessons that can be learnt which are of benefit to those, world-wide, considering the introduction of a road pricing scheme.peer-reviewe

Designing a marker set for vertical tangible user interfaces

Tangible User Interfaces (TUI)s extend the domain of reality-based human-computer interaction by providing users the ability to manipulate digital data using physical objects which embody representational significance. Whilst various advancements have been registered over the past years through the development and availability of TUI toolkits, these have mostly converged towards the deployment of tabletop TUI architectures. In this context, markers used in current toolkits can only be placed underneath the tangible objects to provide recognition. Albeit being effective in various literature studies, the limitations and challenges of deploying tabletop architectures have significantly hindered the proliferation of TUI technology due to the limited audience reach such systems can provide. Furthermore, available marker sets restrict the placement and use of tangible objects since if placed on top of the tangible object, the marker will interfere with the shape and texture of the object limiting the effect the TUI has on the end-user. To this end, this paper proposes the design and development of an innovative tangible marker set specifically designed towards the development of vertical TUIs. The proposed marker set design was optimized through a genetic algorithms to ensure robustness in scale invariance, the capability of being successfully detected with distances of up to 3.5 meters and a true occlusion resistance of up to 25%, where the marker is recognized and not tracked. Open-source versions of the marker set are provided through research license on www.geoffslab.com/tangiboard_marker_set

The effects of road user charges in the context of weak parking policies : the case of Malta

Road user charging is often thought of as a first best travel demand management solution for dealing with the issue of congestion, when compared to the use of parking charges. The case for this is that parking charges are more likely to result in improvements in the situation rather than an optimal outcome. One of the reasons is that parking can be seen as a complement to vehicle travel impacting on the termination point of a journey as opposed to charging directly for the use of road space as in the case of road user charging. In saying this parking charges are used extensively as a demand management measure and there are still only a few road user charging schemes worldwide. One scheme that has moved from a parking charge to a road user charge is the Controlled Vehicular Access system in Valletta, Malta where a fixed annual charge (V-licence) for access and parking into the city was replaced by a time-based road user charge implemented in May 2007. The aim of this paper is to assess the effects of road user charging in the context of ineffective parking policies, using the case of Valletta. The paper is based on scheme documentation, semi-structured interviews with key stakeholders, supplemented by personal observations of one of the authors directly involved in the process of developing and implementing the road user charging system. The research concludes that the overall impacts of the road user charge in the City were positive but more effort will have to be made to strengthen the road charging scheme and parking policy to effectively manage the travel demands of the islands’ population.peer-reviewe

Cows fed hydroponic fodder and conventional diet: effects on milk quality

The technology of green fodder production is especially important in arid and semiarid regions. Hydroponics improves on average the amount of crops in the same space, as traditional soil-based farming and can reduce water consumption compared to traditional farming methods. Limited research has been carried out on the use of hydroponic fodder and milk quality. A comparative study of traditional (Malta farm) and hydroponic fodder (Gozo farm) was conducted in Malta with 20 cows of the Holstein\u2013Friesian breed from two farms. Individual and bulk-tank milk samples were collected once a week for a period of 1 month in order to evaluate physical (pH, conductivity, density, freezing point) and chemical (fat, protein, ash, lactose, solid nonfat) parameters as well as mineral (Zn, Cu, Pb, Ba) content. Milk proximate and physical data were processed by analysis of variance (ANOVA) for repeated measures and an ANOVA procedure with farm and time as effects for minerals. The results indicated differences in fat content and pH, showing higher values (P &lt; 0.05) in milk samples of cows fed with the hydroponic rather than the traditional fodder; a significant time effect (P &lt; 0.001) was found in all qualitative analyses except for lactose and salts. Minerals were in the range as reported elsewhere; Cu and Pb content was significantly higher (P &lt; 0.001) in the Gozo farm than the one in Malta, whereas Zn content showed higher values in Malta (P &lt; 0.001) than Gozo. Although the proximate results were similar for both farms, except for the higher fat content for the Gozo farm, principal component analysis (PCA) revealed that milk quality for the Gozo farm was superior to that of the Malta farm. However, further studies are needed to determine the effects of different hydroponic fodder using a large herd size

Magnetic Field Structure around Low-Mass Class 0 Protostars: B335, L1527 and IC348-SMM2

We report new 350 micron polarization observations of the thermal dust emission from the cores surrounding the low-mass, Class 0 YSOs L1527, IC348-SMM2 and B335. We have inferred magnetic field directions from these observations, and have used them together with results in the literature to determine whether magnetically regulated core-collapse and star-formation models are consistent with the observations. These models predict a pseudo-disk with its symmetry axis aligned with the core magnetic field. The models also predict a magnetic field pinch structure on a scale less than or comparable to the infall radii for these sources. In addition, if the core magnetic field aligns (or nearly aligns) the core rotation axis with the magnetic field before core collapse, then the models predict the alignment (or near alignment) of the overall pinch field structure with the bipolar outflows in these sources. We show that if one includes the distorting effects of bipolar outflows on magnetic fields, then in general the observational results for L1527 and IC348-SMM2 are consistent with these magnetically regulated models. We can say the same for B335 only if we assume the distorting effects of the bipolar outflow on the magnetic fields within the B335 core are much greater than for L1527 and IC348-SMM2. We show that the energy densities of the outflows in all three sources are large enough to distort the magnetic fields predicted by magnetically regulated models.Comment: Accepted for publication in The Astrophysical Journa

Consequences of anisotropy in electrical charge storage: application to the characterization by the mirror method of TiO2 rutile

This article is devoted first to anisotropic distributions of stored electric charges in isotropic materials, second to charge trapping and induced electrostatic potential in anisotropic dielectrics. On the one hand, we examine the case of anisotropic trapped charge distributions in linear homogeneous isotropic (LHI) insulators, obtained after an electron irradiation in a scanning electron microscope. This injection leads to the formation of a mirror image

Personalization of prostate cancer prevention and therapy: are clinically qualified biomarkers in the horizon?

Prostate cancer remains the most common malignancy among men and the second leading cause of male cancer-related mortality. Death from this disease is invariably due to resistance to androgen deprivation therapy. Our improved understanding of the biology of prostate cancer has heralded a new era in molecular anticancer drug development, with multiple novel anticancer drugs for castration resistant prostate cancer now entering the clinic. These include the taxane cabazitaxel, the vaccine sipuleucel-T, the CYP17 inhibitor abiraterone, the novel androgen receptor antagonist MDV-3100 and the radionuclide alpharadin. The management and therapeutic landscape of prostate cancer has now been transformed with this growing armamentarium of effective antitumor agents. This review discusses strategies for the prevention and personalization of prostate cancer therapy, with a focus on the development of predictive and intermediate endpoint biomarkers, as well as novel clinical trial designs that will be crucial for the optimal development of such anticancer therapeutics