Impact of Mueusems in Cultural Scoiety - A Case Study

Museums with strong brands or those that inhabit iconic buildings are increasingly used as cultural motifs in the destination-marketing strategies of public tourist bodies. Recent examples include the use of the British Museum in Visit Britain's Culture is Great campaign, or the Turner Contemporary as a symbol of Margate's brand enhancement. The latest figures from the Association of Leading Visitor Attractions (ALVA) once again underlined the importance of museums to the visitor economy. Meanwhile, the new Arts Council England and Visit England partnership, which aims to help destinations develop their cultural tourism, provides an opportunity for museums to take a strategic lead in this area. But could it also result in greater reliance on marketing-orientated approaches that might not benefit the entire museum sector

Pengaruh Pemberian Ekstrak Jambe (Areca Catechu) Terhadap Pertambahan Berat Badan Ayam Kampung Jantan

ABSTRAK Telah dilakukan percobaan mengenai pengaruh ekstrak jambe untuk meningkatkan berat badan ayam kampung jantan. Percobaan dilakukan di Laboratorium Patologi Fakultas Kedokteran Hewan Universitas Gadjah Mada Yogyakarta. Percobaan dilakukan dengan 12 ekor ayam yang diberi perlakuan ekstrak jambe secara oral. Hewan dibagi menjadi tiga kelompok dengan satu kelompok sebanyak 4 ekor. Perlakuan pertama diberi ekstrak jambe peroral sebesar 1 ml, perlakuan kedua sebesar 2 ml dan kontrol diberi plasebo. Hasil penelitian menunjukkan bahwa perlakuan kontrol tidak terdapat pengaruh terhadap peristiwa spermatogenesis pada testis dari 4 sampel perlakuan dan terjadi peningkatan berat badan sebesar 425 gram. Perlakuan I terdapat pengaruh terhadap spermatogenesis sebesar 2 sampel dari 4 ekor dan efek peningkatan berat badan sebesar 542,188 gram dan perlakuan II terdapat pengaruh terhadap spermatogenesis sebesar 1 dari 4 perlakuan dan terdapat peningkatan berat badan sebesar 431,25 gram. Dengan test anova di dapat P hasil sebesar 0,1665 ( P>0,1)

Investigation of Solar Photovoltaic-Thermal (PVT) and Solar Photovoltaic (PV) Performance: A Case Study in Ghana

publishedVersio

The evolution of university governance in Ghana: implications for education policy and practice

The relationship between education and public policy is two way: (1) economic development of a nation depends on the human capital produced by the education system of that nation and (2) public spending and management of the education system is crucial to the welfare of the nation. Changes in this relationship generate public concerns about university governance and its implications to national development. Therefore, this study explores the questions: (1) Have the role and purpose of university governance changed since its inception? (2) Are there differences between the old and the new system of university governance? (3) What larger ramifications does this have on university governance? The study was conducted within the framework of qualitative research design. The researchers adopted the social constructivist worldview with phenomenology approach to inquiry. Participants who were mainly eminent former senior university administrators and regulators with management, administrative and governance experience in public and private university were interviewed. Data was transcribed and read repeatedly over time to make sense of issues raised by informants. Significant statements were selected, interpreted and used in the text to highlight key issues as well as to provide voice of the informants. The findings of the study suggest that remedies for the changes realized in governance should take into account measures such as strengthening institutional capacities; balancing between the interests of the private and public sector actors in university education; and safeguarding the policy space of the ordinary people to participate in university education affairs that concern or affect them

A humanized mouse model identifies key amino acids for low immunogenicity of H7N9 vaccines

Influenza vaccines of H7N9 subtype are consistently less immunogenic in humans than vaccines developed for other subtypes. Although prior immunoinformatic analysis identified T-cell epitopes in H7 hemagglutinin (HA) which potentially enhance regulatory T cell response due to conservation with the human genome, the links between the T-cell epitopes and low immunogenicity of H7 HA remains unknown due to the lack of animal models reproducing the response observed in humans. Here, we utilized a humanized mouse model to recapitulate the low immunogenicity of H7 HA. Our analysis demonstrated that modification of a single H7 epitope by changing 3 amino acids so that it is homologous with a known H3 immunogenic epitope sequence significantly improved the immunogenicity of the H7 HA in the humanized mouse model, leading to a greater than 4-fold increase in HA-binding IgG responses. Thus, we provide experimental evidence for the important contribution of this H7-specific T cell epitope in determining the immunogenicity of an influenza vaccine. Furthermore, this study delineates strategies that can be used for screening and selecting vaccine strains using immunoinformatics tools and a humanized mouse model

Antimicrobial resistance profiling of Salmonella enterica distinct serotypes isolated from pork in São Paulo

Salmonellosis still is one of the most important worldwide zoonosis due to its high endemicity, mortality, and difficulty in control (Stevens et al., 2009). In the São Paulo city, different realities regarding good production practices and quality control of animal products coexists, especially when considering points of direct consumer sales. The aim of this study was to evaluate the antimicrobial resistance profiles of Salmonella enterica distinct serotypes isolated from pork in São Paulo

Incompetence of Neutrophils to Invasive Group A streptococcus Is Attributed to Induction of Plural Virulence Factors by Dysfunction of a Regulator

Group A streptococcus (GAS) causes variety of diseases ranging from common pharyngitis to life-threatening severe invasive diseases, including necrotizing fasciitis and streptococcal toxic shock-like syndrome. The characteristic of invasive GAS infections has been thought to attribute to genetic changes in bacteria, however, no clear evidence has shown due to lack of an intriguingly study using serotype-matched isolates from clinical severe invasive GAS infections. In addition, rare outbreaks of invasive infections and their distinctive pathology in which infectious foci without neutrophil infiltration hypothesized us invasive GAS could evade host defense, especially neutrophil functions. Herein we report that a panel of serotype-matched GAS, which were clinically isolated from severe invasive but not from non-invaive infections, could abrogate functions of human polymorphnuclear neutrophils (PMN) in at least two independent ways; due to inducing necrosis to PMN by enhanced production of a pore-forming toxin streptolysin O (SLO) and due to impairment of PMN migration via digesting interleukin-8, a PMN attracting chemokine, by increased production of a serine protease ScpC. Expression of genes was upregulated by a loss of repressive function with the mutation of csrS gene in the all emm49 severe invasive GAS isolates. The csrS mutants from clinical severe invasive GAS isolates exhibited high mortality and disseminated infection with paucity of neutrophils, a characteristic pathology seen in human invasive GAS infection, in a mouse model. However, GAS which lack either SLO or ScpC exhibit much less mortality than the csrS-mutated parent invasive GAS isolate to the infected mice. These results suggest that the abilities of GAS to abrogate PMN functions can determine the onset and severity of invasive GAS infection

PGL-III, a rare intermediate of Mycobacterium leprae phenolic glycolipid biosynthesis, is a potent Mincle ligand

Although leprosy(Hansen's disease) is one ofthe oldestknown diseases, the pathogenicity of Mycobacterium leprae (M. leprae) remains enigmatic. Indeed, the cellwall components responsible for the immune response against M. leprae are as yet largely unidentified. We reveal herephenolic glycolipid-III (PGL-III) as an M. leprae-specific ligand for the immune receptor Mincle. PGL-III is a scarcelypresent trisaccharide intermediate in the biosynthetic pathway toPGL-I, an abundant and characteristic M. leprae glycolipid.Using activity-based purification, we identified PGL-III as a Mincleligand that is more potent than the well-known M. tuberculosis trehalose dimycolate. The cocrystal structure of Mincle and a syntheticPGL-III analogue revealed a unique recognition mode, implying thatit can engage multiple Mincle molecules. In Mincle-deficient miceinfected with M. leprae, increased bacterial burdenwith gross pathologies were observed. These results show that PGL-IIIis a noncanonical ligand recognized by Mincle, triggering protectiveimmunity.PGL-III, a potent immunostimulatory glycolipid,is limitedin M. leprae by the quick addition of a single methylgroup to convert it into immunosuppressive PGL-I, which confers immuneescape.Bio-organic Synthesi

Higher Expression of CCL2, CCL4, CCL5, CCL21, and CXCL8 Chemokines in the Skin Associated with Parasite Density in Canine Visceral Leishmaniasis

Several previous studies correlated immunopathological aspects of canine visceral leishmaniasis (CVL) with tissue parasite load and/or the clinical status of the disease. Recently, different aspects of the immune response in Leishmania-infected dogs have been studied, particularly the profile of cytokines in distinct compartments. However, the role of chemokines in disease progression or parasite burdens of the visceralising species represents an important approach for understanding immunopathology in CVL. We found an increase in inflammatory infiltrate, which was mainly composed of mononuclear cells, in the skin of animals presenting severe forms of CVL and high parasite density. Our data also demonstrated that enhanced parasite density is positively correlated with the expression of CCL2, CCL4, CCL5, CCL21, and CXCL8. In contrast, there was a negative correlation between parasite density and CCL24 expression. These findings represent an advance in the knowledge of the involvement of skin inflammatory infiltrates in CVL and the systemic consequences and may contribute to developing a rational strategy for the design of new and more efficient prophylactic tools and immunological therapies against CVL

Destruction of Lymphoid Organ Architecture and Hepatitis Caused by CD4+ T Cells

Immune responses have the important function of host defense and protection against pathogens. However, the immune response also causes inflammation and host tissue injury, termed immunopathology. For example, hepatitis B and C virus infection in humans cause immunopathological sequel with destruction of liver cells by the host's own immune response. Similarly, after infection with lymphocytic choriomeningitis virus (LCMV) in mice, the adaptive immune response causes liver cell damage, choriomeningitis and destruction of lymphoid organ architecture. The immunopathological sequel during LCMV infection has been attributed to cytotoxic CD8+ T cells. However, we now show that during LCMV infection CD4+ T cells selectively induced the destruction of splenic marginal zone and caused liver cell damage with elevated serum alanin-transferase (ALT) levels. The destruction of the splenic marginal zone by CD4+ T cells included the reduction of marginal zone B cells, marginal zone macrophages and marginal zone metallophilic macrophages. Functionally, this resulted in an impaired production of neutralizing antibodies against LCMV. Furthermore, CD4+ T cells reduced B cells with an IgMhighIgDlow phenotype (transitional stage 1 and 2, marginal zone B cells), whereas other B cell subtypes such as follicular type 1 and 2 and germinal center/memory B cells were not affected. Adoptive transfer of CD4+ T cells lacking different important effector cytokines and cytolytic pathways such as IFNγ, TNFα, perforin and Fas-FasL interaction did reveal that these cytolytic pathways are redundant in the induction of immunopathological sequel in spleen. In conclusion, our results define an important role of CD4+ T cells in the induction of immunopathology in liver and spleen. This includes the CD4+ T cell mediated destruction of the splenic marginal zone with consecutively impaired protective neutralizing antibody responses