De novo Cryoglobulinaemic Mononeuritis Multiplex during Treatment of Chronic Hepatitis C Infection: A Viral Effect or Induced by Pegylated Interferon Alpha?

Cryoglobulinaemic mononeuritis multiplex (MNM) is an extrahepatic manifestation of chronic hepatitis C virus (HCV) infection for which interferon-based antiviral therapy is currently the treatment of choice. Rarely MNM can be associated with HCV treatment though generally in the setting of pre-existing cryoglobulinaemia and detectable HCV viraemia. We report an unusual case of de novo MNM occurring late during the course of pegylated interferon and ribavirin therapy for chronic HCV infection, following a prolonged period of viral suppression. The patient had no evidence of cryoglobulinaemia prior to HCV treatment and undetectable HCV RNA levels at the time of presentation with MNM. The case raises the possibility that MNM could develop as an adverse immunomodulatory effect of pegylated interferon therapy

Improved Crystal Method for Photon Beam Linear Polarization Measurement at High Energies

A method for photon linear polarization determination based on the measurement of the asymmetry of pairs produced by polarized photons in single crystals within the optimal intervals of pair particles energies is proposed. In difference to the well known methods the asymmetry in this case is essentially larger. The optimal orientation of crystal is found which provides the maximal values for analyzing power and figure of merit as well as minimal measurement time.Comment: 8 pages, 5 figure

Magnetic field effects on the density of states of orthorhombic superconductors

The quasiparticle density of states in a two-dimensional d-wave superconductor depends on the orientation of the in-plane external magnetic field H. This is because. in the region of the gap nodes, the Doppler shift due to the circulating supercurrents around a vortex depend on the direction of H. For a tetragonal system the induced pattern is four-fold symmetric and, at zero energy, the density of states exhibits minima along the node directions. But YBa_2C_3O_{6.95} is orthorhombic because of the chains and the pattern becomes two-fold symmetric with the position of the minima occuring when H is oriented along the Fermi velocity at a node on the Fermi surface. The effect of impurity scattering in the Born and unitary limit is discussed.Comment: 24 pages, 11 Figure

Magnetic levitation stabilized by streaming fluid flows

We demonstrate that the ubiquitous laboratory magnetic stirrer provides a simple passive method of magnetic levitation, in which the so-called “flea” levitates indefinitely. We study the onset of levitation and quantify the flea’s motion (a combination of vertical oscillation, spinning and “waggling”), finding excellent agreement with a mechanical analytical model. The waggling motion drives recirculating flow, producing a centripetal reaction force that stabilized the flea. Our findings have implications for the locomotion of artificial swimmers and the development of bidirectional microfluidic pumps, and they provide an alternative to sophisticated commercial levitators

Généralisation du diagramme de Voronoï et placement de formes géométriques complexes dans un nuage de points.

La géométrie algorithmique est une discipline en pleine expansion dont l'objet est la conception d'algorithmes résolvant des problèmes géométriques. De tels algorithmes sont très utiles notamment dans l'ingénierie, l'industrie et le multimédia. Pour être performant, il est fréquent qu'un algorithme géométrique utilise des structures de données spécialisées.Nous nous sommes intéressés à une telle structure : le diagramme de Voronoï et avons proposé une généralisation de celui-ci. Ladite généralisation résulte d'une extension du prédicat du disque vide (prédicat propre à toute région de Voronoï) à une union de disques. Nous avons analysé les régions basées sur le prédicat étendu et avons proposé des méthodes pour les calculer par ordinateur.Par ailleurs, nous nous sommes intéressés aux problèmes de placement de formes , thème récurrent en géométrie algorithmique. Nous avons introduit un formalisme universel pour de tels problèmes et avons, pour la première fois, proposé une méthode de résolution générique, en ce sens qu'elle est apte à résoudre divers problèmes de placement suivant un même algorithme.Nos travaux présentent, d'une part, l'avantage d'élargir le champ d'application de structures de données basées sur Voronoï. D'autre part, ils facilitent de manière générale l'utilisation de la géométrie algorithmique, en unifiant définitions et algorithmes associés aux problèmes de placement de formes.Computational geometry is an active branch of computer science whose goal is the design of efficient algorithms solving geometric problems. Such algorithms are useful in domains like engineering, industry and multimedia. In order to be efficient, algorithms often use special data structures.In this thesis we focused on such a structure: the Voronoi diagram. We proposed a new generalized diagram. We have proceeded by extending the empty disk predicate (satisfied by every Voronoi region) to an arbitrary union of disks. We have analyzed the new plane regions based on the extended predicate, and we designed algorithms for computing them.Then, we have considered another topic, which is related to the first one: shape placement problems. Such problems have been studied repeatedly by researchers in computational geometry. We introduced new notations along with a global framework for such problems. We proposed, for the first time a generic method, which is able to solve various placement problems using a single algorithm.Thus, our work extend the scope of Voronoi based data structures. It also simplifies the practical usage of placement techniques by unifying the associated definitions and algorithms.MULHOUSE-SCD Sciences (682242102) / SudocSudocFranceF

Financial Fraud of Older Adults During the Early Months of the COVID-19 Pandemic

BACKGROUND AND OBJECTIVES: Coronavirus disease 2019 (COVID-19) created a "perfect storm" for financial fraud targeting older adults. Guided by the Contextual Theory of Elder Abuse, we focused on individual and systemic contexts to examine how older adults became prey to financial fraud. RESEARCH DESIGN AND METHODS: In July 2020, 998 adults who were 60-98 years of age (93% White; 64% female) completed an online survey about experiences with financial fraud. Participants were recruited from gerontology research registries at Florida State University, University of Pittsburg, Virginia Tech, and Wayne State University. RESULTS: Over half (65.9%) of the respondents experienced a COVID-19-related scam attempt, with charity contributions (49%) and COVID-19 treatments (42%) being the most common. Perpetrators commonly contacted older adults electronically (47%) two or more times (64%). Although most respondents ignored the request (i.e., hung up the phone and deleted text/e-mail), 11.3% sent a requested payment, and 5.3% provided personal information. Predictors of vulnerability included contentment with financial situation, concern about finances in the aftermath of the pandemic, and wishing to talk to someone about financial decisions. Respondents targeted for a non-COVID-19 scam attempt were less likely to be targets of a COVID-19-related scam. DISCUSSION AND IMPLICATIONS: Older adults who were financially secure, worried about their financial situation, or wished they could speak with someone about their financial decisions appeared susceptible to falling victim to a fraud attempt. The high number of attempts indicates a need for a measurable and concerted effort to prevent the financial fraud of older adults

A pleurocidin analogue with greater conformational flexibility, enhanced antimicrobial potency and in vivo therapeutic efficacy.

Antimicrobial peptides (AMPs) are a potential alternative to classical antibiotics that are yet to achieve a therapeutic breakthrough for treatment of systemic infections. The antibacterial potency of pleurocidin, an AMP from Winter Flounder, is linked to its ability to cross bacterial plasma membranes and seek intracellular targets while also causing membrane damage. Here we describe modification strategies that generate pleurocidin analogues with substantially improved, broad spectrum, antibacterial properties, which are effective in murine models of bacterial lung infection. Increasing peptide-lipid intermolecular hydrogen bonding capabilities enhances conformational flexibility, associated with membrane translocation, but also membrane damage and potency, most notably against Gram-positive bacteria. This negates their ability to metabolically adapt to the AMP threat. An analogue comprising D-amino acids was well tolerated at an intravenous dose of 15 mg/kg and similarly effective as vancomycin in reducing EMRSA-15 lung CFU. This highlights the therapeutic potential of systemically delivered, bactericidal AMPs

Stable isotope food-web analysis and mercury biomagnification in polar bears ( Ursus maritimus )

Mercury (Hg) biomagnification occurs in many ecosystems, resulting in a greater potential for toxicological effects in higher-level trophic feeders. However, Hg transport pathways through different food-web channels are not well known, particularly in high-latitude systems affected by the atmospheric Hg deposition associated with snow and ice. Here, we report on stable carbon and nitrogen isotope ratios, and Hg concentrations, determined for 26, late 19th and early 20th century, polar bear ( Ursus maritimus ) hair specimens, collected from catalogued museum collections. These data elucidate relationships between the high-latitude marine food-web structure and Hg concentrations in polar bears. The carbon isotope compositions of polar bear hairs suggest that polar bears derive nutrition from coupled food-web channels, based in pelagic and sympagic primary producers, whereas the nitrogen isotope compositions indicate that polar bears occupy > fourth-level trophic positions. Our results show a positive correlation between polar bear hair Hg concentrations and δ 15 N. Interpretation of the stable isotope data in combination with Hg concentrations tentatively suggests that polar bears participating in predominantly pelagic food webs exhibit higher mercury concentrations than polar bears participating in predominantly sympagic food webs.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73930/1/j.1751-8369.2009.00114.x.pd

Learning from multimedia and hypermedia

Computer-based multimedia and hypermedia resources (e.g., the world wide web) have become one of the primary sources of academic information for a majority of pupils and students. In line with this expansion in the field of education, the scientific study of learning from multimedia and hypermedia has become a very active field of research. In this chapter we provide a short overview with regard to research on learning with multimedia and hypermedia. In two review sections, we describe the educational benefits of multiple representations and of learner control, as these are the two defining characteristics of hypermedia. In a third review section we describe recent scientific trends in the field of multimedia/hypermedia learning. In all three review sections we will point to relevant European work on multimedia/hypermedia carried out within the last 5 years, and often carried out within the Kaleidoscope Network of Excellence. According to the interdisciplinary nature of the field this work might come not only from psychology, but also from technology or pedagogy. Comparing the different research activities on multimedia and hypermedia that have dominated the international scientific discourse in the last decade reveals some important differences. Most important, a gap seems to exist between researchers mainly interested in a “serious” educational use of multimedia/ hypermedia and researchers mainly interested in “serious” experimental research on learning with multimedia/hypermedia. Recent discussions about the pros and cons of “design-based research” or “use-inspired basic research” can be seen as a direct consequence of an increasing awareness of the tensions within these two different cultures of research on education