A simulation experiment for comparing tests of regression transformation

AbstractAn example is given of the use of graphical methods in the analysis of a simulation experiment. Comments are made on the design of such studies

DD-optimal saturated designs: a simulation study

In this work we focus on saturated $D$-optimal designs. Using recent results, we identify $D$-optimal designs with the solutions of an optimization problem with linear constraints. We introduce new objective functions based on the geometric structure of the design and we compare them with the classical $D$-efficiency criterion. We perform a simulation study. In all the test cases we observe that designs with high values of $D$-efficiency have also high values of the new objective functions.Comment: 8 pages. Preliminary version submitted to the 7th IWS Proceeding

Quark gap equation within the analytic approach to QCD

The compatibility between the QCD analytic invariant charge and chiral symmetry breaking is examined in detail. The coupling in question incorporates asymptotic freedom and infrared enhancement into a single expression, and contains only one adjustable parameter with dimension of mass. When inserted into the standard form of the quark gap-equation it gives rise to solutions displaying singular confining behavior at the origin. By relating these solutions to the pion decay constant, a rough estimate of about 880 MeV is obtained for the aforementioned mass-scale.Comment: Talk given by J.P. at 12th International QCD Conference (QCD05), 4 - 9 July 2005, Montpellier, France; 4 pages, 3 figure

D-optimal designs via a cocktail algorithm

A fast new algorithm is proposed for numerical computation of (approximate) D-optimal designs. This "cocktail algorithm" extends the well-known vertex direction method (VDM; Fedorov 1972) and the multiplicative algorithm (Silvey, Titterington and Torsney, 1978), and shares their simplicity and monotonic convergence properties. Numerical examples show that the cocktail algorithm can lead to dramatically improved speed, sometimes by orders of magnitude, relative to either the multiplicative algorithm or the vertex exchange method (a variant of VDM). Key to the improved speed is a new nearest neighbor exchange strategy, which acts locally and complements the global effect of the multiplicative algorithm. Possible extensions to related problems such as nonparametric maximum likelihood estimation are mentioned.Comment: A number of changes after accounting for the referees' comments including new examples in Section 4 and more detailed explanations throughou

Numerical Study of the Ghost-Gluon Vertex in Landau gauge

We present a numerical study of the ghost-gluon vertex and of the corresponding renormalization function \widetilde{Z}_1(p^2) in minimal Landau gauge for SU(2) lattice gauge theory. Data were obtained for three different lattice volumes (V = 4^4, 8^4, 16^4) and for three lattice couplings \beta = 2.2, 2.3, 2.4. Gribov-copy effects have been analyzed using the so-called smeared gauge fixing. We also consider two different sets of momenta (orbits) in order to check for possible effects due to the breaking of rotational symmetry. The vertex has been evaluated at the asymmetric point (0;p,-p) in momentum-subtraction scheme. We find that \widetilde{Z}_1(p^2) is approximately constant and equal to 1, at least for momenta p > ~ 1 GeV. This constitutes a nonperturbative verification of the so-called nonrenormalization of the Landau ghost-gluon vertex. Finally, we use our data to evaluate the running coupling constant \alpha_s(p^2).Comment: 19 pages, 6 figures, 9 tables, using axodraw.sty; minor modifications in the abstract, introduction and conclusion

The Cytomegalovirus gB/MF59 vaccine candidate induces antibodies against an antigenic domain controlling cell-to-cell spread

Vaccination against human cytomegalovirus (CMV) infection remains high priority. A recombinant form of a protein essential for CMV entry, glycoprotein B (gB), demonstrated partial protection in a clinical trial (NCT00299260) when delivered with the MF59 adjuvant. Although the antibody titre against gB correlated with protection poor neutralising responses against the 5 known antigenic domains (AD) of gB were evident. Here, we show that vaccination of CMV seronegative patients induces an antibody response against a region of gB we term AD-6. Responses to the polypeptide AD-6 are detected in >70% of vaccine recipients yet in <5% of naturally infected people. An AD-6 antibody binds to gB and to infected cells but not the virion directly. Consistent with this, the AD-6 antibody is non-neutralising but, instead, prevents cell-cell spread of CMV in vitro. The discovery of AD-6 responses has the potential to explain part of the protection mediated by gB vaccines against CMV following transplantation

Spectral and Transport Properties of d-Wave Superconductors With Strong Impurities

One of the remarkable features of disordered d-wave superconductors is strong sensitivity of long range properties to the microscopic realization of the disorder potential. Particularly rich phenomenology is observed for the -- experimentally relevant -- case of dilute distributions of isolated impurity centers. Building on earlier diagrammatic analyses, the present paper derives and analyses a low energy effective field theory of this system. Specifically, the results of previous diagrammatic T-matrix approaches are extended into the perturbatively inaccessible low energy regimes, and the long range (thermal) transport behaviour of the system is discussed. It turns out that in the extreme case of a half-filled tight binding band and infinitely strong impurities (impurities at the unitary limit), the system is in a delocalized phase.Comment: 14 pages, two figures include

Clinician vs Patient Reporting of Baseline and Postbaseline Symptoms for Adverse Event Assessment in Cancer Clinical Trials

Many patients enter cancer clinical trials with baseline symptoms. Notably, the current clinician reporting mechanism for symptomatic adverse events (AEs) via the Common Terminology Criteria for Adverse Events (CTCAE) does not formally distinguish between symptoms present at baseline vs those that develop during a trial. Therefore, AE estimation in clinical trials may include symptoms that predate trial entry. This raises concern that the cumulative incidence of patient-reported AEs may be high, particularly if preexisting symptoms related to other causes (eg, comorbidities, prior treatment) are attributed to study drugs

The Gribov-Zwanziger action in the presence of the gauge invariant, nonlocal mass operator Tr∫d4xFμν(D2)−1FμνTr \int d^4x F_{\mu\nu} (D^2)^{-1} F_{\mu\nu} in the Landau gauge

We prove that the nonlocal gauge invariant mass dimension two operator $F_{\mu\nu} (D^2)^{-1} F_{\mu\nu}$ can be consistently added to the Gribov-Zwanziger action, which implements the restriction of the path integral's domain of integration to the first Gribov region when the Landau gauge is considered. We identify a local polynomial action and prove the renormalizability to all orders of perturbation theory by employing the algebraic renormalization formalism. Furthermore, we also pay attention to the breaking of the BRST invariance, and to the consequences that this has for the Slavnov-Taylor identity.Comment: 30 page