Search for strongly interacting massive particles generating trackless jets in proton-proton collisions at s = 13 TeV

A search for dark matter in the form of strongly interacting massive particles (SIMPs) using the CMS detector at the LHC is presented. The SIMPs would be produced in pairs that manifest themselves as pairs of jets without tracks. The energy fraction of jets carried by charged particles is used as a key discriminator to suppress efficiently the large multijet background, and the remaining background is estimated directly from data. The search is performed using proton-proton collision data corresponding to an integrated luminosity of 16.1 fb - 1 , collected with the CMS detector in 2016. No significant excess of events is observed above the expected background. For the simplified dark matter model under consideration, SIMPs with masses up to 100 GeV are excluded and further sensitivity is explored towards higher masses

On the WABL defuzzification method for intuitionistic fuzzy numbers

International Conference on Intelligent and Fuzzy Systems, INFUS 2019 -- 23 July 2019 through 25 July 2019 -- 228529Intuitionistic fuzzy sets (IFSs) have been proposed by Atanassov as an extension of classical fuzzy sets (FSs) originated from an early work of Zadeh. The main advantage of the IFSs is their property to deal with the uncertainty that may be included by information. IFSs have two types of functions: membership function which is also employed to describe the conventional FSs and non-membership function. With these two functions, IFSs better describe the real status of the information. IFSs especially Intuitionistic Fuzzy Numbers (IFNs) have found application in various areas such as edge detection, image segmentation, decision making, fault-tree analysis, pattern recognition etc. Most of the applications of these areas are performed in digitalized environments. But, still our computers are designed to work with crisp numbers. That means we are still in need of well-defined defuzzification methods for IFNs. In this study, we adopted WABL (Weighted Averaging Based on Levels) defuzzification method into IFNs. We exposed some useful properties of WABL method in order to make its usage easier in application fields. © 2020, Springer Nature Switzerland AG

Mouse embryonic stem cell–based functional assay to evaluate mutations in BRCA2

Individuals with mutations in breast cancer susceptibility genes BRCA1 and BRCA2 have up to an 80% risk of developing breast cancer by the age of 70. Sequencing-based genetic tests are now available to identify mutation carriers in an effort to reduce mortality through prevention and early diagnosis. However, lack of a suitable functional assay hinders the risk assessment of more than 1,900 BRCA1 and BRCA2 variants in the Breast Cancer Information Core database that do not clearly disrupt the gene product. We have established a simple, versatile and reliable assay to test for the functional significance of mutations in BRCA2 using mouse embryonic stem cells (ES cells) and bacterial artificial chromosomes and have used it to classify 17 sequence variants. The assay is based on the ability of human BRCA2 to complement the loss of endogenous Brca2 in mouse ES cells. This technique may also serve as a paradigm for functional analysis of mutations found in other genes linked to human diseases. © 2008 Nature Publishing Group.Link_to_subscribed_fulltex