ACTUAL PROBLEMS OF THE STRUCTURAL REFORM IN BULGARIAN AGRICULTURE

A structural reform is underway in Bulgarian agriculture. The aim is to bring the sector out of the grave crisis. The paper presents the main directions of the structural reform in the sector, basing on the analysis of its current situation: - providing of due legislation; - development of the land market and rent relations; - development of operative production structures; - regulating the functions of the administrative and branch organizations governing the implementation of the agrarian policy

Pseudo-plateau bursting and mixed-mode oscillations in a model of developing inner hair cells

This is the final version. Available on open access from Elsevier via the DOI in this recordInner hair cells (IHCs) are excitable sensory cells in the inner ear that encode acoustic information. Before the onset of hearing IHCs fire calcium-based action potentials that trigger transmitter release onto developing spiral ganglion neurones. There is accumulating experimental evidence that these spontaneous firing patterns are associated with maturation of the IHC synapses and hence involved in the development of hearing. The dynamics organising the IHCs’ electrical activity are therefore of interest. Building on our previous modelling work we propose a three-dimensional, reduced IHC model and carry out non-dimensionalisation. We show that there is a significant range of parameter values for which the dynamics of the reduced (three-dimensional) model map well onto the dynamics observed in the original biophysical (four-dimensional) IHC model. By estimating the typical time scales of the variables in the reduced IHC model we demonstrate that this model could be characterised by two fast and one slow or one fast and two slow variables depending on biophysically relevant parameters that control the dynamics. Specifically, we investigate how changes in the conductance of the voltage-gated calcium channels as well as the parameter corresponding to the fraction of free cytosolic calcium concentration in the model affect the oscillatory model bahaviour leading to transition from pseudo-plateau bursting to mixed-mode oscillations. Hence, using fast-slow analysis we are able to further our understanding of this model and reveal a path in the parameter space connecting pseudo-plateau bursting and mixed-mode oscillations by varying a single parameter in the model.Engineering and Physical Sciences Research Council (EPSRC

CHANGES IN THE ACTIVITY OF SOME SERUM ENZYMES IN CHRONI CLIVER DISEASES

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Changing frames of obesity in the UK press 2008–2017

Obesity is a persistently newsworthy topic for the UK press and in recent years levels of coverage have increased. In this study, we examine the ways in which obesity has been framed by the press over a ten-year period (2008–2017), focussing both on areas of stability and change. The analysis is based on a ~36 million-word database of all UK newspaper articles mentioning the words ‘obese’ or ‘obesity’ published within this time frame and draws upon techniques from corpus linguistics – a collection of computational methods for examining recurrent linguistic patterns in large bodies of language data. Our analysis shows that, over time, obesity is represented increasingly as a biomedical problem that is both caused and should be prevented by individual action. Meanwhile, focus on wider environmental determinants of health, including the role of Government and the food industry, decreases over time. In the paper, we situate these trends within the wider context of UK society and argue that they both represent the increasing dominance of neoliberal models of health but also have the potential to contribute to weight stigma and the blaming of individuals. Accordingly, it is argued that the press should seek greater balance in its reporting of the potential causes of and solutions to obesity, as well as closer alignment with scientific evidence. By doing so, the press could begin to report on obesity in a way that raises useful public awareness around the topic and which challenges some of the stigma that currently attends to this social justice issue

Mental health and the media: from illness to wellbeing

The media are a main source of information about mental health for many people and an ever-growing body of literature is evaluating their coverage of the topic. To help keep track of such research, several comprehensive but now dated literature reviews have been published. We assess more recent studies (2007-2017) and suggest future directions by integrating (1) the ‘circuit of mass communication’ model from media and communication studies which posits that production, content and reception need to be analysed for an in-depth understanding of the media, (2) the holistic view of mental health as comprising both illness and wellbeing and (3) the critical psychiatry literature questioning the assumptions underlying psychiatric knowledge and practice. We find that recent studies have focused on content and ‘the illness side’ of mental health by examining the representation of particular mental disorders and events involving individuals with specific diagnoses. We identify as a promising development the growing interest in ‘the wellbeing side’ of mental health whereby authors have started to analyse recovery messages. We invite more production and reception research and more critical content studies which use diagnostic labels cautiously and analyse the representation of people with mental health problems as the victims of violence

TRIC-B channels display labile gating: evidence from the TRIC-A knockout mouse model.

The online version of this article (doi:10.1007/s00424-013-1251-y) contains supplementary material, which is available to authorized usersPublished online: 7 March 2013. ©The Author(s) 2013. This article is published with open access at Springerlink.com via: doi:10.1007/s00424-013-1251-y)Available under Open AccessSarcoplasmic/endoplasmic reticulum (SR) and nuclear membranes contain two related cation channels named TRIC-A and TRIC-B. In many tissues, both subtypes are co-expressed, making it impossible to distinguish the distinct single-channel properties of each subtype. We therefore incorporated skeletal muscle SR vesicles derived from Tric-a-knockout mice into bilayers in order to characterise the biophysical properties of native TRIC-B without possible misclassification of the channels as TRIC-A, and without potential distortion of functional properties by detergent purification protocols. The native TRIC-B channels were ideally selective for cations. In symmetrical 210 mM K(+), the maximum (full) open channel level (199 pS) was equivalent to that observed when wild-type SR vesicles were incorporated into bilayers. Analysis of TRIC-B gating revealed complex and variable behaviour. Four main sub-conductance levels were observed at approximately 80 % (161 pS), 60 % (123 pS), 46 % (93 pS), and 30 % (60 pS) of the full open state. Seventy-five percent of the channels were voltage sensitive with Po being markedly reduced at negative holding potentials. The frequent, rapid transitions between TRIC-B sub-conductance states prevented development of reliable gating models using conventional single-channel analysis. Instead, we used mean-variance plots to highlight key features of TRIC-B gating in a more accurate and visually useful manner. Our study provides the first biophysical characterisation of native TRIC-B channels and indicates that this channel would be suited to provide counter current in response to Ca(2+) release from the SR. Further experiments are required to distinguish the distinct functional properties of TRIC-A and TRIC-B and understand their individual but complementary physiological roles.British Heart FoundationEngineering and Physical Sciences Research Council (EPSRC)Japan Society for the Promotion of Scienc