New and emerging technologies for the treatment of inherited retinal diseases: a horizon scanning review.

The horizon scanning review aimed to identify new and emerging technologies in development that have the potential to slow or stop disease progression and/or reverse sight loss in people with inherited retinal diseases (IRDs). Potential treatments were identified using recognized horizon scanning methods. These included a combination of online searches using predetermined search terms, suggestions from clinical experts and patient and carer focus groups, and contact with commercial developers. Twenty-nine relevant technologies were identified. These included 9 gene therapeutic approaches, 10 medical devices, 5 pharmacological agents, and 5 regenerative and cell therapies. A further 11 technologies were identified in very early phases of development (typically phase I or pre-clinical) and were included in the final report to give a complete picture of developments 'on the horizon'. Clinical experts and patient and carer focus groups provided helpful information and insights, such as the availability of specialised services for patients, the potential impacts of individual technologies on people with IRDs and their families, and helped to identify additional relevant technologies. This engagement ensured that important areas of innovation were not missed. Most of the health technologies identified are still at an early stage of development and it is difficult to estimate when treatments might be available. Further, well designed trials that generate data on efficacy, applicability, acceptability, and costs of the technologies, as well as the long-term impacts for various conditions are required before these can be considered for adoption into routine clinical practice

Ranking Significant Discrepancies in Clinical Reports

Medical errors are a major public health concern and a leading cause of death worldwide. Many healthcare centers and hospitals use reporting systems where medical practitioners write a preliminary medical report and the report is later reviewed, revised, and finalized by a more experienced physician. The revisions range from stylistic to corrections of critical errors or misinterpretations of the case. Due to the large quantity of reports written daily, it is often difficult to manually and thoroughly review all the finalized reports to find such errors and learn from them. To address this challenge, we propose a novel ranking approach, consisting of textual and ontological overlaps between the preliminary and final versions of reports. The approach learns to rank the reports based on the degree of discrepancy between the versions. This allows medical practitioners to easily identify and learn from the reports in which their interpretation most substantially differed from that of the attending physician (who finalized the report). This is a crucial step towards uncovering potential errors and helping medical practitioners to learn from such errors, thus improving patient-care in the long run. We evaluate our model on a dataset of radiology reports and show that our approach outperforms both previously-proposed approaches and more recent language models by 4.5% to 15.4%.Comment: ECIR 2020 (short

Search for eta-mesic Helium with the WASA-at-COSY detector

A search for the 4He-eta bound state via exclusive measurement of the excitation function for the dd->3Heppi- reaction, was performed at the Cooler Synchrotron COSY-Juelich with the WASA-at-COSY detection system. The data were taken during a slow acceleration of the beam from 2.185 GeV/c to 2.400 GeV/c crossing the kinematic threshold for the eta production in the dd -> 4He-eta reaction at 2.336 GeV/c. The corresponding excess energy in the 4He-eta system varied from -51.4 MeV to 22 MeV. The shape of the excitation function for the dd -> 3Heppi- was examined. No signal of the 4He-eta bound state was observed in the excitation function.Comment: 4 pages, 5 figures, to appear in proceedings of MESON201

Effective communication in eliciting and responding to suicidal thoughts: a systematic review protocol

Background In the UK, over 6500 people die by suicide each year. In England alone, this is one person every 2 h. Professionals assess risk of suicide in face-to-face contacts with people potentially at risk. The National Confidential Inquiry into Suicide found that most people who took their life were classified as ‘low risk’ in their final contact with mental health services. Training for front-line staff in reducing suicide is a NHS priority. While there is considerable evidence on what to assess when exploring suicidal ideation, there is little evidence on how to ask sensitive questions to effectively identify suicide risk and how to respond in the treatment encounter to reduce patient distress and suicidal ideation. This is critical for identifying risk and putting appropriate care in place. Methods An electronic search will be conducted using MEDLINE, CINAHL, Cochrane Library, EMBASE and PsycINFO databases. Controlled studies of effectiveness will be identified using a predefined search strategy. The focus will be on suicidal thoughts/feelings rather than self-harm without intent to die. Two authors will independently screen articles using predefined inclusion and exclusion criteria and relevant data will be extracted using the Cochrane Collaboration data extraction form for randomised controlled trials (RCTs). Discrepancies between the two authors will be resolved by consensus or by consulting a third author at all levels of screening. We will assess the quality of evidence as well as risk of bias. A meta-analysis will be conducted if participants, interventions and comparisons are sufficiently similar, and we will perform the meta-analysis using Stata data analysis and statistical software. Discussion The results of this systematic review will be used to guide training and practice for health care professionals

Bone mechanical stimulation with piezoelectric materials

This chapter summarized explores in vivo use of a piezoelectric polymer for bone mechanical stimulatio

Swift J164449.3+573451 event: generation in the collapsing star cluster?

We discuss the multiband energy release in a model of a collapsing galactic nucleus, and we try to interpret the unique super-long cosmic gamma-ray event Swift J164449.3+573451 (GRB 110328A by early classification) in this scenario. Neutron stars and stellar-mass black holes can form evolutionary a compact self-gravitating subsystem in the galactic center. Collisions and merges of these stellar remnants during an avalanche contraction and collapse of the cluster core can produce powerful events in different bands due to several mechanisms. Collisions of neutron stars and stellar-mass black holes can generate gamma-ray bursts (GRBs) similar to the ordinary models of short GRB origin. The bright peaks during the first two days may also be a consequence of multiple matter supply (due to matter release in the collisions) and accretion onto the forming supermassive black hole. Numerous smaller peaks and later quasi-steady radiation can arise from gravitational lensing, late accretion of gas onto the supermassive black hole, and from particle acceleration by shock waves. Even if this model will not reproduce exactly all the Swift J164449.3+573451 properties in future observations, such collapses of galactic nuclei can be available for detection in other events.Comment: 7 pages, replaced by the final versio

Implementing the Dream: Lessons from the Houston Community College

With a commitment to affordable, open access education, community colleges provide a key access point to higher education, especially for low-income students and students of color. Using a qualitative approach, this report analyzes the experiences of six Houston area community colleges that are participating in Achieving the Dream, a national initiative designed to use data-driven decision-making to promote student success

Performance Evaluation of Multi-gigabit Indoor Visible Light Communication System

This paper presents a performance evaluation of a mobile multi-gigabit visible light communication (VLC) system in two different environments. The VLC channel characteristics and links were evaluated under the diverse situations of an empty room and a room with very strong shadowing effects resulting from mini cubicle offices. RGB laser diodes (LDs) were used to mitigate the low modulation bandwidth of conventional transmitters (light emitting diodes, LEDs) in the VLC system. In addition, an angle diversity receiver (ADR) was introduced to mitigate intersymbol- interference (ISI). Furthermore, a delay adaptation technique was used to further reduce the effect of ISI and multipath dispersion. The combination of delay adaptation and ADR (DAT ADR system) added a degree of freedom to the link design, which resulted in a VLC system that has the ability to provide high data rates (i.e. 5 Gbps) in the considered harsh indoor environment. Our proposed system used a simple on-off keying (OOK) modulation format and it was able to provide data rates of 5 Gbps and a bit-error-rate (BER) of 10-3 in the worst case scenario in the considered realistic indoor environment

Event Reconstruction for a DIRC

Monte Carlo simulations were made for a possible DIRC at the WASA detector at COSY. A statistical method for pattern recognition is presented and the possible angle resolution and velocity precision achieved are discussed.Comment: Minor changes in text. Figures updated. accepted by JINS