Anestesia epidural em um Ferret com fratura de fêmur submetido a osteossíntese

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Elastic scattering and total reaction cross section of 6He + 120Sn

The elastic scattering of 6He on 120Sn has been measured at four energies above the Coulomb barrier using the 6He beam produced at the RIBRAS (Radioactive Ion Beams in Brasil) facility. The elastic angular distributions have been analyzed with the optical model and three- and four-body continuum-discretized coupled-channels calculations. The total reaction cross sections have been derived and compared with other systems of similar masses.Ministerio de Educación y Ciencia PCI2006-A7-0654Ministerio de Ciencia e Innovación FPA2006-13807-c02-01Junta de Andalucía P07-FQM-02894Programa Consolider-Ingenio 2010 CSD2007-0004

Duplicação cromossômica como alternativa para ganhos de produtividade em mandioca.

A mandioca apresenta propagação vegetativa mediante as manivas, porém essa forma de propagação é lenta e facilita a disseminação de doenças para gerações futuras, além de ser propícia aos ataques de pragas. Dessa forma, programas de melhoramento genético surgem como alternativas para contornar esses problemas e visam obter materiais mais resistentes a pragas e doenças, além de aumentos significativos na produtividade

Experimental study of He6+Be9 elastic scattering at low energies

New data for the He6+Be9 reaction at Elab=16.2 and 21.3 MeV have been taken and analyzed. The effect of the collective couplings to the excited states of the target has been studied by means of coupled-channels calculations, using a double-folding potential for the bare interaction between the colliding nuclei, supplemented with a phenomenological imaginary part of Woods-Saxon type. In addition, three- and four-body continuum-discretized coupled-channels calculations have been performed to investigate the effect of the projectile breakup on the elastic scattering. Both effects, the coupling to target and projectile excited states, are found to affect significantly the elastic scattering. The trivial local polarization potential extracted from the continuum-discretized coupled-channels calculations indicates that continuum couplings produce a repulsive real part and a long-range imaginary part in the projectile-target interaction. © 2011 American Physical Society.This work has been partially supported by the Spanish Ministerio de Ciencia e Innovacion´ under Projects FPA2009-07653 and PCI2006-A7-0654 and by the Spanish Consolider-Ingenio 2010 Programme CPAN (CSD2007-00042).Peer Reviewe

Mapping of Mycobacterium tuberculosis Complex Genetic Diversity Profiles in Tanzania and Other African Countries

The aim of this study was to assess and characterize Mycobacterium tuberculosis complex (MTBC) genotypic diversity in Tanzania, as well as in neighbouring East and other several African countries. We used spoligotyping to identify a total of 293 M. tuberculosis clinical isolates (one isolate per patient) collected in the Bunda, Dar es Salaam, Ngorongoro and Serengeti areas in Tanzania. The results were compared with results in the SITVIT2 international database of the Pasteur Institute of Guadeloupe. Genotyping and phylogeographical analyses highlighted the predominance of the CAS, T, EAI, and LAM MTBC lineages in Tanzania. The three most frequent Spoligotype International Types (SITs) were: SIT21/CAS1-Kili (n = 76; 25.94%), SIT59/LAM11-ZWE (n = 22; 7.51%), and SIT126/EAI5 tentatively reclassified as EAI3-TZA (n = 18; 6.14%). Furthermore, three SITs were newly created in this study (SIT4056/EAI5 n = 2, SIT4057/T1 n = 1, and SIT4058/EAI5 n = 1). We noted that the East-African-Indian (EAI) lineage was more predominant in Bunda, the Manu lineage was more common among strains isolated in Ngorongoro, and the Central-Asian (CAS) lineage was more predominant in Dar es Salaam (p-value<0.0001). No statistically significant differences were noted when comparing HIV status of patients vs. major lineages (p-value = 0.103). However, when grouping lineages as Principal Genetic Groups (PGG), we noticed that PGG2/3 group (Haarlem, LAM, S, T, and X) was more associated with HIV-positive patients as compared to PGG1 group (Beijing, CAS, EAI, and Manu) (p-value = 0.03). This study provided mapping of MTBC genetic diversity in Tanzania (containing information on isolates from different cities) and neighbouring East African and other several African countries highlighting differences as regards to MTBC genotypic distribution between Tanzania and other African countries. This work also allowed underlining of spoligotyping patterns tentatively grouped within the newly designated EAI3-TZA lineage (remarkable by absence of spacers 2 and 3, and represented by SIT126) which seems to be specific to Tanzania. However, further genotyping information would be needed to confirm this specificity

Meta-analysis of tumor- and T cell-intrinsic mechanisms of sensitization to checkpoint inhibition

Checkpoint inhibitors (CPIs) augment adaptive immunity. Systematic pan-tumor analyses may reveal the relative importance of tumor-cell-intrinsic and microenvironmental features underpinning CPI sensitization. Here, we collated whole-exome and transcriptomic data for >1,000 CPI-treated patients across seven tumor types, utilizing standardized bioinformatics workflows and clinical outcome criteria to validate multivariable predictors of CPI sensitization. Clonal tumor mutation burden (TMB) was the strongest predictor of CPI response, followed by total TMB and CXCL9 expression. Subclonal TMB, somatic copy alteration burden, and histocompatibility leukocyte antigen (HLA) evolutionary divergence failed to attain pan-cancer significance. Dinucleotide variants were identified as a source of immunogenic epitopes associated with radical amino acid substitutions and enhanced peptide hydrophobicity/immunogenicity. Copy-number analysis revealed two additional determinants of CPI outcome supported by prior functional evidence: 9q34 (TRAF2) loss associated with response and CCND1 amplification associated with resistance. Finally, single-cell RNA sequencing (RNA-seq) of clonal neoantigen-reactive CD8 tumor-infiltrating lymphocytes (TILs), combined with bulk RNA-seq analysis of CPI-responding tumors, identified CCR5 and CXCL13 as T-cell-intrinsic markers of CPI sensitivity

Study of the 6He+9Be and 7Be+9Be collisions

We present elastic scattering angular distributions of the 6He+9Be and 7Be+9Be reactions at Elab =16.2 MeV and Elab =23.7 MeV respectively. The 6He+9Be measurements have been performed at the Pelletron Laboratory of the Institute of Physics of the University of Sao Paulo, Brazil, using the Radioactive Ion Beams in Brasil (RIBRAS) facility and the 7Be+9Be system has beenmeasured at CRC Radioactive Beam Facility at Louvain-la-Neuve,Belgium. An OpticalModel analysis has been performed to obtain the nuclear potentials for both systems. A coupled-channel calculation was performed for the 7Be+9Be system taking into account the coupling to the first excited state and breakup channels of the 7Be nucleus. Keywords: Radioctive Beams. Exotic Nuclei. Nuclear Halo. Long range absorption. Elastic Scattering. Optical potential. Coupled channels calculations. PACS: 25.60.-t,25.60.Bx,25.70.Bc,29.38.-c,24.10.E

Study of key resonances in the 30P(p,γ)31S reaction in classical novae

Among reactions with strong impact on classical novae model predictions, 30P(p,γ)31S is one of the few remained that are worthy to be measured accurately, because of their rate uncertainty, as like as 18F(p,α)15O and 25Al(pγ)26Si. To reduce the nuclear uncertainties associated to this reaction, we performed an experiment at ALTO facility of Orsay using the 31P(3He,t)31S reaction to populate 31S excited states of astrophysical interest and detect in coincidence the protons coming from the decay of the populated states in order to extract the proton branching ratios. After a presentation of the astrophysical context of this work, the current situation of the 30P(p,γ)31S reaction rate will be discussed. Then the experiment set-up of this work and the analysis of the single events will be presented