Short Communication: Variability of amygdalin content in seeds of sweet and bitter apricot cultivars in Turkey

In this study, amygdalin contents in the seeds of ten different bitter or sweet apricot cultivars were determined by high performance liquid chromatography (HPLC) for two years. The seeds of apricot cultivars were obtained from the Malatya Fruit Research Institute in Turkey. The results indicated that genetic variation was found among the cultivars. The amygdalin contents of bitter cultivars were found to be higher than those of sweet cultivars. As the average of two years, the amygdalin contents of the cultivars were determined as 6.354 g/100 g in Paviot (bitter), 5.914 g/100 g in Karacabey (bitter), 4.411 g/100 g in Alyanak (bitter), 1.584 g/100 g in Cologlu (sweet), 0.970 g/100 g in Cataloglu (sweet), 0.820 g/100 g in Aprikoz (sweet), 0.729 g/100 g in Sekerpare (sweet), 0.709 g/100 g in Kabaasi (sweet), 0.610 g/100 g in Ismailaga (sweet) and 0.604 g/100 g in Hacihaliloglu (sweet).Key words: Apricot (Prunus armeniaca L.), seed, amygdalin content

First evidence for Wollemi Pine-type pollen (Dilwynites: Araucariaceae) in South America

We report the first fossil pollen from South America of the lineage that includes the recently discovered, extremely rare Australian Wollemi Pine, Wollemia nobilis (Araucariaceae). The grains are from the late Paleocene to early middle Eocene Ligorio Márquez Formation of Santa Cruz, Patagonia, Argentina, and are assigned to Dilwynites, the fossil pollen type that closely resembles the pollen of modern Wollemia and some species of its Australasian sister genus, Agathis. Dilwynites was formerly known only from Australia, New Zealand, and East Antarctica. The Patagonian Dilwynites occurs with several taxa of Podocarpaceae and a diverse range of cryptogams and angiosperms, but not Nothofagus. The fossils greatly extend the known geographic range of Dilwynites and provide important new evidence for the Antarctic region as an early Paleogene portal for biotic interchange between Australasia and South America.Mike Macphail, Raymond J. Carpenter, Ari Iglesias, Peter Wil

Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries

Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely

The taxonomy and palaeobiogeography of small chorate dinoflagellate cysts from the Late Cretaceous to Quaternary of Antarctica

Small chorate dinoflagellate cysts are common in Upper Cretaceous to Quaternary sedimentary successions around the Antarctic margin. Taxonomic confusion surrounding dinoflagellate cysts and acritarchs of similar morphology throughout the southern high palaeolatitudes has hitherto limited investigation of their palaeoecological significance. This study aims to solve the taxonomic problems, and to allow a new assessment of dinoflagellate cyst acmes. A detailed morphological study of new material from the López de Bertodano Formation of Seymour Island, Antarctic Peninsula, is presented. These dinoflagellate cysts are identified as Impletosphaeridium clavusWrenn & Hart 1988 emend. nov. Their gross morphology and their vast abundances in the James Ross Basin are strongly suggestive of dinoflagellate blooms. This scenario implies similarities to modern dinoflagellate cysts from the polar regions